Thinning faster? Age-related cortical thickness differences in adults with autism spectrum disorder / B. Blair BRADEN in Research in Autism Spectrum Disorders, 64 (August 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 64 (August 2019) . - p.31-38 Titre : Thinning faster? Age-related cortical thickness differences in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : B. Blair BRADEN, Auteur ; Cory RIECKEN, Auteur Article en page(s) : p.31-38 Langues : Anglais (eng) Mots-clés : ASD  Autism  Aging  Cortical thickness  MRI  Temporal lobe  Brain  Gray matter Index. décimale : PER Périodiques Résumé : Background Over the course of the last 30 years, autism spectrum disorder (ASD) diagnoses have increased, thus identifying a large group of aging individuals with ASD. Currently, little is known regarding how aging will affect these individual's neuroanatomy, compared to the neurotypical (NT) population. Because of the anatomical overlap of ASD-related cortical pathology and age-related cortical thinning, both following an anterior-to-posterior severity gradient, we hypothesize adults with ASD will show larger age-related cortical thinning than NT adults. Methods We analyzed cortical measurements using available data from the multi-site Autism Brain Imaging Data Exchange I (ABIDE I; n?=?282) and our own cohort of middle-age to older adults with and without ASD (n?=?47) mostly available in ABIDE II (n?=?35). We compared correlations between cortical measures and age in right-handed adults with ASD (n?=?157) and similar NT adults (n?=?172), controlling for IQ and site. Participants were 18–64 years of age (mean?=?29.8 years; median?=?26 years). Results We found significant differences between diagnosis groups in the relationship between age and cortical thickness for areas of left frontal lobe (pars opercularis), temporal lobe (inferior gyrus, middle gyrus, banks of the superior temporal sulcus, and entorhinal cortex), parietal lobe (inferior gyrus), and lateral occipital lobe. For all areas, adults with ASD showed a greater negative correlation between age and cortical thickness than NT adults. Conclusion As hypothesized, adults with ASD demonstrated exacerbated age-related cortical thinning, compared to NT adults. These differences were the largest and most extensive in the left temporal lobe. Future longitudinal work is warranted to investigate whether differences in brain age trajectories will translate to unique behavioral needs in older adults with ASD. En ligne : https://doi.org/10.1016/j.rasd.2019.03.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=399 [article] Thinning faster? Age-related cortical thickness differences in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / B. Blair BRADEN, Auteur ; Cory RIECKEN, Auteur . - p.31-38. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 64 (August 2019) . - p.31-38 Mots-clés : ASD  Autism  Aging  Cortical thickness  MRI  Temporal lobe  Brain  Gray matter Index. décimale : PER Périodiques Résumé : Background Over the course of the last 30 years, autism spectrum disorder (ASD) diagnoses have increased, thus identifying a large group of aging individuals with ASD. Currently, little is known regarding how aging will affect these individual's neuroanatomy, compared to the neurotypical (NT) population. Because of the anatomical overlap of ASD-related cortical pathology and age-related cortical thinning, both following an anterior-to-posterior severity gradient, we hypothesize adults with ASD will show larger age-related cortical thinning than NT adults. Methods We analyzed cortical measurements using available data from the multi-site Autism Brain Imaging Data Exchange I (ABIDE I; n?=?282) and our own cohort of middle-age to older adults with and without ASD (n?=?47) mostly available in ABIDE II (n?=?35). We compared correlations between cortical measures and age in right-handed adults with ASD (n?=?157) and similar NT adults (n?=?172), controlling for IQ and site. Participants were 18–64 years of age (mean?=?29.8 years; median?=?26 years). Results We found significant differences between diagnosis groups in the relationship between age and cortical thickness for areas of left frontal lobe (pars opercularis), temporal lobe (inferior gyrus, middle gyrus, banks of the superior temporal sulcus, and entorhinal cortex), parietal lobe (inferior gyrus), and lateral occipital lobe. For all areas, adults with ASD showed a greater negative correlation between age and cortical thickness than NT adults. Conclusion As hypothesized, adults with ASD demonstrated exacerbated age-related cortical thinning, compared to NT adults. These differences were the largest and most extensive in the left temporal lobe. Future longitudinal work is warranted to investigate whether differences in brain age trajectories will translate to unique behavioral needs in older adults with ASD. En ligne : https://doi.org/10.1016/j.rasd.2019.03.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=399

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