Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders / J. FITZGERALD in Journal of Autism and Developmental Disorders, 49-7 (July 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2664-2674 Titre : Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : J. FITZGERALD, Auteur ; L. GALLAGHER, Auteur ; J. MCGRATH, Auteur Article en page(s) : p.2664-2674 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Dti  Diffusion imaging  Fractional anisotropy  Structural connectivity  Tbss Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorders (ASDs) are characterised by impaired social communication and restricted repetitive behaviours. Researchers posit that these core features may be underpinned by disrupted structural connectivity. A tract based spatial statistical analysis of diffusion MRI data was performed to investigate white matter organisation (an indication of structural connectivity) in a well-defined cohort of 45 ASD and 45 age and IQ matched control participants. Aberrant structural connectivity characterised by reduced fractional anisotropy was observed in several fiber pathways in ASD relative to controls. Disrupted white matter organisation was associated with social deficits and restricted repetitive behaviours in ASD. Abnormal structural connectivity is apparent in ASD and may be linked to the core behavioural features of the disorder. En ligne : http://dx.doi.org/10.1007/s10803-016-2803-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 [article] Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / J. FITZGERALD, Auteur ; L. GALLAGHER, Auteur ; J. MCGRATH, Auteur . - p.2664-2674. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-7 (July 2019) . - p.2664-2674 Mots-clés : Autism spectrum disorders  Dti  Diffusion imaging  Fractional anisotropy  Structural connectivity  Tbss Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorders (ASDs) are characterised by impaired social communication and restricted repetitive behaviours. Researchers posit that these core features may be underpinned by disrupted structural connectivity. A tract based spatial statistical analysis of diffusion MRI data was performed to investigate white matter organisation (an indication of structural connectivity) in a well-defined cohort of 45 ASD and 45 age and IQ matched control participants. Aberrant structural connectivity characterised by reduced fractional anisotropy was observed in several fiber pathways in ASD relative to controls. Disrupted white matter organisation was associated with social deficits and restricted repetitive behaviours in ASD. Abnormal structural connectivity is apparent in ASD and may be linked to the core behavioural features of the disorder. En ligne : http://dx.doi.org/10.1007/s10803-016-2803-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401

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