ADHD- and medication-related brain activation effects in concordantly affected parent–child dyads with ADHD / Jeffery N. EPSTEIN in Journal of Child Psychology and Psychiatry, 48-9 (September 2007)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 48-9 (September 2007) . - p.899–913 Titre : ADHD- and medication-related brain activation effects in concordantly affected parent–child dyads with ADHD Type de document : texte imprimé Auteurs : Jeffery N. EPSTEIN, Auteur ; Lisa A. KOTLER, Auteur ; Alan VITOLO, Auteur ; Keith M. SHAFRITZ, Auteur ; Gary GLOVER, Auteur ; Amy S. GARRETT, Auteur ; Julie A. SPICER, Auteur ; Matthew C. DAVIDSON, Auteur ; B.J. CASEY, Auteur ; Allan L. REISS, Auteur ; Stephen P. HINSHAW, Auteur ; Laurence L. GREENHILL, Auteur ; Simon T. TONEV, Auteur ; Matthew A. JARRETT, Auteur Année de publication : 2007 Article en page(s) : p.899–913 Langues : Anglais (eng) Mots-clés : ADHD adolescence adulthood brain-imaging development fMRI methylphenidate neuropsychology children parents Index. décimale : PER Périodiques Résumé : Background: Several studies have documented fronto-striatal dysfunction in children and adolescents with attention deficit/hyperactivity disorder (ADHD) using response inhibition tasks. Our objective was to examine functional brain abnormalities among youths and adults with ADHD and to examine the relations between these neurobiological abnormalities and response to stimulant medication. Method: A group of concordantly diagnosed ADHD parent–child dyads was compared to a matched sample of normal parent–child dyads. In addition, ADHD dyads were administered double-blind methylphenidate and placebo in a counterbalanced fashion over two consecutive days of testing. Frontostriatal function was measured using functional magnetic resonance imaging (fMRI) during performance of a go/no-go task. Results: Youths and adults with ADHD showed attenuated activity in fronto-striatal regions. In addition, adults with ADHD appeared to activate non-fronto-striatal regions more than normals. A stimulant medication trial showed that among youths, stimulant medication increased activation in fronto-striatal and cerebellar regions. In adults with ADHD, increases in activation were observed in the striatum and cerebellum, but not in prefrontal regions. Conclusions: This study extends findings of fronto-striatal dysfunction to adults with ADHD and highlights the importance of frontostriatal and frontocerebellar circuitry in this disorder, providing evidence of an endophenotype for examining the genetics of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01761.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=163 [article] ADHD- and medication-related brain activation effects in concordantly affected parent–child dyads with ADHD [texte imprimé] / Jeffery N. EPSTEIN, Auteur ; Lisa A. KOTLER, Auteur ; Alan VITOLO, Auteur ; Keith M. SHAFRITZ, Auteur ; Gary GLOVER, Auteur ; Amy S. GARRETT, Auteur ; Julie A. SPICER, Auteur ; Matthew C. DAVIDSON, Auteur ; B.J. CASEY, Auteur ; Allan L. REISS, Auteur ; Stephen P. HINSHAW, Auteur ; Laurence L. GREENHILL, Auteur ; Simon T. TONEV, Auteur ; Matthew A. JARRETT, Auteur . - 2007 . - p.899–913. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 48-9 (September 2007) . - p.899–913 Mots-clés : ADHD adolescence adulthood brain-imaging development fMRI methylphenidate neuropsychology children parents Index. décimale : PER Périodiques Résumé : Background: Several studies have documented fronto-striatal dysfunction in children and adolescents with attention deficit/hyperactivity disorder (ADHD) using response inhibition tasks. Our objective was to examine functional brain abnormalities among youths and adults with ADHD and to examine the relations between these neurobiological abnormalities and response to stimulant medication. Method: A group of concordantly diagnosed ADHD parent–child dyads was compared to a matched sample of normal parent–child dyads. In addition, ADHD dyads were administered double-blind methylphenidate and placebo in a counterbalanced fashion over two consecutive days of testing. Frontostriatal function was measured using functional magnetic resonance imaging (fMRI) during performance of a go/no-go task. Results: Youths and adults with ADHD showed attenuated activity in fronto-striatal regions. In addition, adults with ADHD appeared to activate non-fronto-striatal regions more than normals. A stimulant medication trial showed that among youths, stimulant medication increased activation in fronto-striatal and cerebellar regions. In adults with ADHD, increases in activation were observed in the striatum and cerebellum, but not in prefrontal regions. Conclusions: This study extends findings of fronto-striatal dysfunction to adults with ADHD and highlights the importance of frontostriatal and frontocerebellar circuitry in this disorder, providing evidence of an endophenotype for examining the genetics of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01761.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=163

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review / Joseph C. BLADER in Journal of Child Psychology and Psychiatry, 66-4 (April 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-4 (April 2025) . - p.516-546 Titre : Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review Type de document : texte imprimé Auteurs : Joseph C. BLADER, Auteur ; Amy S. GARRETT, Auteur ; Steven R. PLISZKA, Auteur Article en page(s) : p.516-546 Langues : Anglais (eng) Mots-clés : Emotional dysregulation  anger  frustration  hostility  child development Index. décimale : PER Périodiques Résumé : Proliferation of the term ?emotion dysregulation in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired regulatory mechanism. Many cognitive, affective, behavioral, neural, and social processes have been studied to improve understanding of emotion dysregulation. Nevertheless, the defective regulatory mechanism that might underlie it remains unclear. This systematic review of research on processes that affect emotion dysregulation endeavors to develop an integrative framework for the wide variety of factors investigated. It seeks to ascertain which, if any, constitutes an impaired regulatory mechanism. Based on this review, we propose a framework organizing emotion-relevant processes into categories pertaining to stimulus processing, response selection and control, emotion generation, closed- or open-loop feedback-based regulation, and experiential influences. Our review finds scant evidence for closed-loop (automatic) mechanisms to downregulate anger arousal rapidly. Open-loop (deliberate) regulatory strategies seem effective for low-to-moderate arousal. More extensive evidence supports roles for aspects of stimulus processing (sensory sensitivity, salience, appraisal, threat processing, and reward expectancy). Response control functions, such as inhibitory control, show robust associations with emotion dysregulation. Processes relating to emotion generation highlight aberrant features in autonomic, endocrine, reward functioning, and tonic mood states. A large literature on adverse childhood experiences and family interactions shows the unique and joint effects of interpersonal with child-level risks. We conclude that the defective closed-loop regulatory mechanisms that emotion dysregulation implies require further specification. Integrating research on emotion-relevant mechanisms along an axis from input factors through emotion generation to corrective feedback may promote research on (a) heterogeneity in pathogenesis, (b) interrelationships between these factors, and (c) the derivation of better-targeted treatments that address specific pathogenic processes of affected youth. En ligne : https://doi.org/10.1111/jcpp.14126 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550 [article] Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review [texte imprimé] / Joseph C. BLADER, Auteur ; Amy S. GARRETT, Auteur ; Steven R. PLISZKA, Auteur . - p.516-546. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-4 (April 2025) . - p.516-546 Mots-clés : Emotional dysregulation  anger  frustration  hostility  child development Index. décimale : PER Périodiques Résumé : Proliferation of the term ?emotion dysregulation in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired regulatory mechanism. Many cognitive, affective, behavioral, neural, and social processes have been studied to improve understanding of emotion dysregulation. Nevertheless, the defective regulatory mechanism that might underlie it remains unclear. This systematic review of research on processes that affect emotion dysregulation endeavors to develop an integrative framework for the wide variety of factors investigated. It seeks to ascertain which, if any, constitutes an impaired regulatory mechanism. Based on this review, we propose a framework organizing emotion-relevant processes into categories pertaining to stimulus processing, response selection and control, emotion generation, closed- or open-loop feedback-based regulation, and experiential influences. Our review finds scant evidence for closed-loop (automatic) mechanisms to downregulate anger arousal rapidly. Open-loop (deliberate) regulatory strategies seem effective for low-to-moderate arousal. More extensive evidence supports roles for aspects of stimulus processing (sensory sensitivity, salience, appraisal, threat processing, and reward expectancy). Response control functions, such as inhibitory control, show robust associations with emotion dysregulation. Processes relating to emotion generation highlight aberrant features in autonomic, endocrine, reward functioning, and tonic mood states. A large literature on adverse childhood experiences and family interactions shows the unique and joint effects of interpersonal with child-level risks. We conclude that the defective closed-loop regulatory mechanisms that emotion dysregulation implies require further specification. Integrating research on emotion-relevant mechanisms along an axis from input factors through emotion generation to corrective feedback may promote research on (a) heterogeneity in pathogenesis, (b) interrelationships between these factors, and (c) the derivation of better-targeted treatments that address specific pathogenic processes of affected youth. En ligne : https://doi.org/10.1111/jcpp.14126 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550

Neural correlates of emotion processing predict resilience in youth at familial risk for mood disorders / Akua F. NIMARKO in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.1037-1052 Titre : Neural correlates of emotion processing predict resilience in youth at familial risk for mood disorders Type de document : texte imprimé Auteurs : Akua F. NIMARKO, Auteur ; Amy S. GARRETT, Auteur ; Gabrielle A. CARLSON, Auteur ; Manpreet K. SINGH, Auteur Article en page(s) : p.1037-1052 Langues : Anglais (eng) Mots-clés : bipolar disorder  emotion processing  functional connectivity  functional magnetic resonance imaging  major depressive disorder  youth Index. décimale : PER Périodiques Résumé : Aberrant face emotion processing has been demonstrated in youth with and at a familial risk for bipolar and major depressive disorders. However, the neurobiological factors related to emotion processing that underlie resilience from youth-onset mood disorders are not well understood. Functional magnetic resonance imaging data during an implicit emotion processing task were collected at baseline from a sample of 50 youth, ages 8–17, who were healthy but also familially at high risk for either bipolar disorder or major depressive disorder, and 24 healthy controls with no family history of psychopathology (HCL). Participants were reevaluated 3 years later and classified into three groups for analysis: high-risk youth who converted to a psychiatric diagnosis (CVT; N = 23), high-risk youth who were resilient from developing any psychopathology (RES; N = 27), and HCL youth (N = 24) who remained healthy at follow-up. For happy > calm faces, the CVT and RES groups had significantly lower activation in the left inferior parietal lobe (IPL), while the RES group had lower activation in the right supramarginal gyrus. For fear > calm faces, the RES group had lower activation in the right precuneus and inferior frontal gyrus (IFG) compared to the CVT group. Connectivity analyses revealed the RES group exhibited higher left IPL connectivity with visual cortical regions for happy > calm faces, and higher IFG connectivity with frontal, temporal, and limbic regions for fear > calm faces. These connectivities were correlated with improvements in prosocial behaviors and global functioning. Our findings suggest that differential activation and connectivity in the IPL, IFG, and precuneus in response to emotional stimuli may represent distinct resilience and risk markers for youth-onset mood disorders. En ligne : http://dx.doi.org/10.1017/S0954579419000579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Neural correlates of emotion processing predict resilience in youth at familial risk for mood disorders [texte imprimé] / Akua F. NIMARKO, Auteur ; Amy S. GARRETT, Auteur ; Gabrielle A. CARLSON, Auteur ; Manpreet K. SINGH, Auteur . - p.1037-1052. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.1037-1052 Mots-clés : bipolar disorder  emotion processing  functional connectivity  functional magnetic resonance imaging  major depressive disorder  youth Index. décimale : PER Périodiques Résumé : Aberrant face emotion processing has been demonstrated in youth with and at a familial risk for bipolar and major depressive disorders. However, the neurobiological factors related to emotion processing that underlie resilience from youth-onset mood disorders are not well understood. Functional magnetic resonance imaging data during an implicit emotion processing task were collected at baseline from a sample of 50 youth, ages 8–17, who were healthy but also familially at high risk for either bipolar disorder or major depressive disorder, and 24 healthy controls with no family history of psychopathology (HCL). Participants were reevaluated 3 years later and classified into three groups for analysis: high-risk youth who converted to a psychiatric diagnosis (CVT; N = 23), high-risk youth who were resilient from developing any psychopathology (RES; N = 27), and HCL youth (N = 24) who remained healthy at follow-up. For happy > calm faces, the CVT and RES groups had significantly lower activation in the left inferior parietal lobe (IPL), while the RES group had lower activation in the right supramarginal gyrus. For fear > calm faces, the RES group had lower activation in the right precuneus and inferior frontal gyrus (IFG) compared to the CVT group. Connectivity analyses revealed the RES group exhibited higher left IPL connectivity with visual cortical regions for happy > calm faces, and higher IFG connectivity with frontal, temporal, and limbic regions for fear > calm faces. These connectivities were correlated with improvements in prosocial behaviors and global functioning. Our findings suggest that differential activation and connectivity in the IPL, IFG, and precuneus in response to emotional stimuli may represent distinct resilience and risk markers for youth-onset mood disorders. En ligne : http://dx.doi.org/10.1017/S0954579419000579 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

The role of the amygdala in bipolar disorder development / Amy S. GARRETT in Development and Psychopathology, 20-4 (Fall 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-4 (Fall 2008) . - p.1285-1296 Titre : The role of the amygdala in bipolar disorder development Type de document : texte imprimé Auteurs : Amy S. GARRETT, Auteur ; Kiki D. CHANG, Auteur Année de publication : 2008 Article en page(s) : p.1285-1296 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The amygdala has received great interest as a possible neurophysiological substrate of bipolar disorder (BD). This review summarizes information about the structure and function of the amygdala with attention to its role in experienced emotion and mood. We review the evidence for amygdala pathology in psychiatric conditions and discuss the role of the amygdala in BD during development. There appear to be consistent findings in the neuroimaging literature that suggest an etiological model for BD that involves abnormalities in the structure and function of the amygdala, but also depends on the failure of prefrontal cortical regions to modulate amygdala activity. In addition, evidence is accumulating to suggest that this model has flexible outcomes, depending on factors intrinsic and extrinsic to BD, and may follow several possible paths across the course of maturational development. En ligne : http://dx.doi.org/10.1017/s0954579408000618 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=603 [article] The role of the amygdala in bipolar disorder development [texte imprimé] / Amy S. GARRETT, Auteur ; Kiki D. CHANG, Auteur . - 2008 . - p.1285-1296. Langues : Anglais (eng) in Development and Psychopathology > 20-4 (Fall 2008) . - p.1285-1296 Index. décimale : PER Périodiques Résumé : The amygdala has received great interest as a possible neurophysiological substrate of bipolar disorder (BD). This review summarizes information about the structure and function of the amygdala with attention to its role in experienced emotion and mood. We review the evidence for amygdala pathology in psychiatric conditions and discuss the role of the amygdala in BD during development. There appear to be consistent findings in the neuroimaging literature that suggest an etiological model for BD that involves abnormalities in the structure and function of the amygdala, but also depends on the failure of prefrontal cortical regions to modulate amygdala activity. In addition, evidence is accumulating to suggest that this model has flexible outcomes, depending on factors intrinsic and extrinsic to BD, and may follow several possible paths across the course of maturational development. En ligne : http://dx.doi.org/10.1017/s0954579408000618 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=603

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