Atypical resting state neuromagnetic connectivity and spectral power in very preterm children / Nataliia KOZHEMIAKO in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.975-987 Titre : Atypical resting state neuromagnetic connectivity and spectral power in very preterm children Type de document : texte imprimé Auteurs : Nataliia KOZHEMIAKO, Auteur ; Adonay NUNES, Auteur ; Vasily A. VAKORIN, Auteur ; C.M.Y. CHAU, Auteur ; Alexander MOISEEV, Auteur ; Urs RIBARY, Auteur ; Ruth E. GRUNAU, Auteur ; Sam M. DOESBURG, Auteur Article en page(s) : p.975-987 Langues : Anglais (eng) Mots-clés : Very preterm  children  early adversity  magnetoencephalography  neonatal stress  pain  resting state connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Children born very preterm often display selective cognitive difficulties at school age even in the absence of major brain injury. Alterations in neurophysiological activity underpinning such difficulties, as well as their relation to specific aspects of adverse neonatal experience, remain poorly understood. In the present study, we examined interregional connectivity and spectral power in very preterm children at school age, and their relationship with clinical neonatal variables and long-term outcomes (IQ, executive functions, externalizing/internalizing behavior, visual-motor integration). METHODS: We collected resting state magnetoencephalographic (MEG) and psychometric data from a cohort at the age of 8 years followed prospectively since birth, which included three groups: Extremely Low Gestational Age (ELGA, 24-28 weeks GA n = 24, age 7.7 +/- 0.38, 10 girls), Very Low Gestational Age (VLGA, 29-32 weeks GA n = 37, age 7.7 +/- 0.39, 24 girls), and full-term children (38-41 weeks GA n = 39, age 7.9 +/- 1.02, 24 girls). Interregional phase synchrony and spectral power were tested for group differences, and associations with neonatal and outcome variables were examined using mean-centered and behavioral Partial Least Squares (PLS) analyses, respectively. RESULTS: We found greater connectivity in the theta band in the ELGA group compared to VLGA and full-term groups, primarily involving frontal connections. Spectral power analysis demonstrated overall lower power in the ELGA and VLGA compared to full-term group. PLS indicated strong associations between neurophysiological connectivity at school age, adverse neonatal experience and cognitive performance, and behavior. Resting spectral power was associated only with behavioral scores. CONCLUSIONS: Our findings indicate significant atypicalities of neuromagnetic brain activity and connectivity in very preterm children at school age, with alterations in connectivity mainly observed only in the ELGA group. We demonstrate a significant relationship between connectivity, adverse neonatal experience, and long-term outcome, indicating that the disruption of developing neurophysiological networks may mediate relationships between neonatal events and cognitive and behavioral difficulties at school age. En ligne : http://dx.doi.org/10.1111/jcpp.13026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Atypical resting state neuromagnetic connectivity and spectral power in very preterm children [texte imprimé] / Nataliia KOZHEMIAKO, Auteur ; Adonay NUNES, Auteur ; Vasily A. VAKORIN, Auteur ; C.M.Y. CHAU, Auteur ; Alexander MOISEEV, Auteur ; Urs RIBARY, Auteur ; Ruth E. GRUNAU, Auteur ; Sam M. DOESBURG, Auteur . - p.975-987. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.975-987 Mots-clés : Very preterm  children  early adversity  magnetoencephalography  neonatal stress  pain  resting state connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Children born very preterm often display selective cognitive difficulties at school age even in the absence of major brain injury. Alterations in neurophysiological activity underpinning such difficulties, as well as their relation to specific aspects of adverse neonatal experience, remain poorly understood. In the present study, we examined interregional connectivity and spectral power in very preterm children at school age, and their relationship with clinical neonatal variables and long-term outcomes (IQ, executive functions, externalizing/internalizing behavior, visual-motor integration). METHODS: We collected resting state magnetoencephalographic (MEG) and psychometric data from a cohort at the age of 8 years followed prospectively since birth, which included three groups: Extremely Low Gestational Age (ELGA, 24-28 weeks GA n = 24, age 7.7 +/- 0.38, 10 girls), Very Low Gestational Age (VLGA, 29-32 weeks GA n = 37, age 7.7 +/- 0.39, 24 girls), and full-term children (38-41 weeks GA n = 39, age 7.9 +/- 1.02, 24 girls). Interregional phase synchrony and spectral power were tested for group differences, and associations with neonatal and outcome variables were examined using mean-centered and behavioral Partial Least Squares (PLS) analyses, respectively. RESULTS: We found greater connectivity in the theta band in the ELGA group compared to VLGA and full-term groups, primarily involving frontal connections. Spectral power analysis demonstrated overall lower power in the ELGA and VLGA compared to full-term group. PLS indicated strong associations between neurophysiological connectivity at school age, adverse neonatal experience and cognitive performance, and behavior. Resting spectral power was associated only with behavioral scores. CONCLUSIONS: Our findings indicate significant atypicalities of neuromagnetic brain activity and connectivity in very preterm children at school age, with alterations in connectivity mainly observed only in the ELGA group. We demonstrate a significant relationship between connectivity, adverse neonatal experience, and long-term outcome, indicating that the disruption of developing neurophysiological networks may mediate relationships between neonatal events and cognitive and behavioral difficulties at school age. En ligne : http://dx.doi.org/10.1111/jcpp.13026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces / Fahimeh MAMASHLI in Autism Research, 14-6 (June 2021)  

Public ISBD [article]  inAutism Research > 14-6 (June 2021) . - p.1101-1114 Titre : Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces Type de document : texte imprimé Auteurs : Fahimeh MAMASHLI, Auteur ; Nataliia KOZHEMIAKO, Auteur ; Sheraz KHAN, Auteur ; Adonay NUNES, Auteur ; Nicole M. MCGUIGGAN, Auteur ; Ainsley LOSH, Auteur ; Robert M. JOSEPH, Auteur ; Jyrki AHVENINEN, Auteur ; Sam M. DOESBURG, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur Article en page(s) : p.1101-1114 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/diagnostic imaging  Child  Gamma Rhythm  Humans  Magnetic Resonance Imaging  Magnetoencephalography  Prefrontal Cortex  autism spectrum disorder  functional connectivity  inverted faces  phase-amplitude coupling Index. décimale : PER Périodiques Résumé : The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the neurophysiological abnormalities associated with processing inverted faces in ASD. We used magnetoencephalography (MEG) to study both long-range and local functional connectivity, with the latter assessed using local cross-frequency coupling, in response to inverted faces stimuli, in 7-18 years old individuals with ASD and age and IQ matched typically developing (TD) individuals. We found abnormally reduced coupling between the phase of the alpha rhythm and the amplitude of the gamma rhythm in the fusiform face area (FFA) in response to inverted faces, as well as reduced long-range functional connectivity between the FFA and the inferior frontal gyrus (IFG) in response to inverted faces in the ASD group. These group differences were absent in response to upright faces. The magnitude of functional connectivity between the FFA and the IFG was significantly correlated with the severity of ASD, and FFA-IFG long-range functional connectivity increased with age in TD group, but not in the ASD group. Our findings suggest that both local and long-range functional connectivity are abnormally reduced in children with ASD when processing inverted faces, and that the pattern of abnormalities associated with the processing of inverted faces differs from the pattern of upright faces in ASD, likely due to the presumed greater reliance on top-down regulations necessary for efficient processing of inverted faces. LAY SUMMARY: We found alterations in the neurophysiological responses to inverted faces in children with ASD, that were not reflected in the evoked responses, and were not observed in the responses to upright faces. These alterations included reduced local functional connectivity in the fusiform face area (FFA), and decreased long-range alpha-band modulated functional connectivity between the FFA and the left IFG. The magnitude of long-range functional connectivity between the FFA and the inferior frontal gyrus was correlated with the severity of ASD. En ligne : http://dx.doi.org/10.1002/aur.2497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces [texte imprimé] / Fahimeh MAMASHLI, Auteur ; Nataliia KOZHEMIAKO, Auteur ; Sheraz KHAN, Auteur ; Adonay NUNES, Auteur ; Nicole M. MCGUIGGAN, Auteur ; Ainsley LOSH, Auteur ; Robert M. JOSEPH, Auteur ; Jyrki AHVENINEN, Auteur ; Sam M. DOESBURG, Auteur ; Matti S. HÄMÄLÄINEN, Auteur ; Tal KENET, Auteur . - p.1101-1114. Langues : Anglais (eng) in Autism Research > 14-6 (June 2021) . - p.1101-1114 Mots-clés : Adolescent  Autism Spectrum Disorder/diagnostic imaging  Child  Gamma Rhythm  Humans  Magnetic Resonance Imaging  Magnetoencephalography  Prefrontal Cortex  autism spectrum disorder  functional connectivity  inverted faces  phase-amplitude coupling Index. décimale : PER Périodiques Résumé : The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the neurophysiological abnormalities associated with processing inverted faces in ASD. We used magnetoencephalography (MEG) to study both long-range and local functional connectivity, with the latter assessed using local cross-frequency coupling, in response to inverted faces stimuli, in 7-18 years old individuals with ASD and age and IQ matched typically developing (TD) individuals. We found abnormally reduced coupling between the phase of the alpha rhythm and the amplitude of the gamma rhythm in the fusiform face area (FFA) in response to inverted faces, as well as reduced long-range functional connectivity between the FFA and the inferior frontal gyrus (IFG) in response to inverted faces in the ASD group. These group differences were absent in response to upright faces. The magnitude of functional connectivity between the FFA and the IFG was significantly correlated with the severity of ASD, and FFA-IFG long-range functional connectivity increased with age in TD group, but not in the ASD group. Our findings suggest that both local and long-range functional connectivity are abnormally reduced in children with ASD when processing inverted faces, and that the pattern of abnormalities associated with the processing of inverted faces differs from the pattern of upright faces in ASD, likely due to the presumed greater reliance on top-down regulations necessary for efficient processing of inverted faces. LAY SUMMARY: We found alterations in the neurophysiological responses to inverted faces in children with ASD, that were not reflected in the evoked responses, and were not observed in the responses to upright faces. These alterations included reduced local functional connectivity in the fusiform face area (FFA), and decreased long-range alpha-band modulated functional connectivity between the FFA and the left IFG. The magnitude of long-range functional connectivity between the FFA and the inferior frontal gyrus was correlated with the severity of ASD. En ligne : http://dx.doi.org/10.1002/aur.2497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Differences in sleep EEG coherence and spindle metrics in toddlers with and without receptive/expressive language delay: a prospective observational study / Xinyi HONG in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Differences in sleep EEG coherence and spindle metrics in toddlers with and without receptive/expressive language delay: a prospective observational study Type de document : texte imprimé Auteurs : Xinyi HONG, Auteur ; Cristan FARMER, Auteur ; Nataliia KOZHEMIAKO, Auteur ; Gregory L. HOLMES, Auteur ; Lauren THOMPSON, Auteur ; Stacy MANWARING, Auteur ; Audrey THURM, Auteur ; Ashura BUCKLEY, Auteur Langues : Anglais (eng) Mots-clés : Humans  Electroencephalography  Female  Male  Infant  Language Development Disorders/physiopathology  Child, Preschool  Sleep/physiology  Prospective Studies  Brain/physiopathology  Brain Waves/physiology  Brain development  Cognitive function  Diagnostic markers  Language delay  Neurophysiology  Sleep architecture  by the NIH Institutional Review Board (protocol 11-M-0144  NCT01339767). Consent  was obtained from parents or guardians of participants prior to their  participation. Consent for publication: Not applicable. Competing interests: The  authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Changes in brain connectivity during development are thought to reflect organizational and maturational processes that correspond to skill acquisition in domains like motor, language, and cognition. This theory is supported by findings in typically developing children as well as observations of abnormal connectivity among children with neurodevelopmental differences. However, few coherence studies have capitalized on the potential of sleep electroencephalogram (EEG) to examine the developing brain, especially among very young children for whom formal neurodevelopmental diagnosis is not yet possible. Sleep microarchitecture in young children may offer key insights into neurophysiological abnormalities associated with neurodevelopmental trajectories and potentially aid in early detection and intervention. In this study, we explored sleep EEG coherence and sleep spindles in typically developing toddlers and toddlers at increased risk of later neurodevelopmental diagnoses. METHODS: We investigated EEG coherence and sleep spindles in 16 toddlers with receptive and expressive language delay (LangD) and 39 typically developing (TD) toddlers. Participants were aged 12-22 months at baseline, and 34 (LangD, n=11; TD, n=23) participants were evaluated again at 36 months of age. RESULTS: Average EEG coherence was stronger in the LangD group than the TD group, with differences most prominent during slow-wave sleep. Some age-related increases in coherence were observed, but these did not differ between groups. Sleep spindle density, duration, and frequency changed between baseline and follow-up for both groups, with the LangD group demonstrating a smaller magnitude of change than the TD group. The direction of change was frequency band-dependent for both groups. CONCLUSIONS: These findings indicate that atypical sleep EEG connectivity and sleep spindle development can be detected in toddlers at risk of later neurodevelopmental diagnoses. TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT01339767 ; Registration date: 4/20/2011. En ligne : https://dx.doi.org/10.1186/s11689-024-09586-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Differences in sleep EEG coherence and spindle metrics in toddlers with and without receptive/expressive language delay: a prospective observational study [texte imprimé] / Xinyi HONG, Auteur ; Cristan FARMER, Auteur ; Nataliia KOZHEMIAKO, Auteur ; Gregory L. HOLMES, Auteur ; Lauren THOMPSON, Auteur ; Stacy MANWARING, Auteur ; Audrey THURM, Auteur ; Ashura BUCKLEY, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Electroencephalography  Female  Male  Infant  Language Development Disorders/physiopathology  Child, Preschool  Sleep/physiology  Prospective Studies  Brain/physiopathology  Brain Waves/physiology  Brain development  Cognitive function  Diagnostic markers  Language delay  Neurophysiology  Sleep architecture  by the NIH Institutional Review Board (protocol 11-M-0144  NCT01339767). Consent  was obtained from parents or guardians of participants prior to their  participation. Consent for publication: Not applicable. Competing interests: The  authors declare that they have no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Changes in brain connectivity during development are thought to reflect organizational and maturational processes that correspond to skill acquisition in domains like motor, language, and cognition. This theory is supported by findings in typically developing children as well as observations of abnormal connectivity among children with neurodevelopmental differences. However, few coherence studies have capitalized on the potential of sleep electroencephalogram (EEG) to examine the developing brain, especially among very young children for whom formal neurodevelopmental diagnosis is not yet possible. Sleep microarchitecture in young children may offer key insights into neurophysiological abnormalities associated with neurodevelopmental trajectories and potentially aid in early detection and intervention. In this study, we explored sleep EEG coherence and sleep spindles in typically developing toddlers and toddlers at increased risk of later neurodevelopmental diagnoses. METHODS: We investigated EEG coherence and sleep spindles in 16 toddlers with receptive and expressive language delay (LangD) and 39 typically developing (TD) toddlers. Participants were aged 12-22 months at baseline, and 34 (LangD, n=11; TD, n=23) participants were evaluated again at 36 months of age. RESULTS: Average EEG coherence was stronger in the LangD group than the TD group, with differences most prominent during slow-wave sleep. Some age-related increases in coherence were observed, but these did not differ between groups. Sleep spindle density, duration, and frequency changed between baseline and follow-up for both groups, with the LangD group demonstrating a smaller magnitude of change than the TD group. The direction of change was frequency band-dependent for both groups. CONCLUSIONS: These findings indicate that atypical sleep EEG connectivity and sleep spindle development can be detected in toddlers at risk of later neurodevelopmental diagnoses. TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT01339767 ; Registration date: 4/20/2011. En ligne : https://dx.doi.org/10.1186/s11689-024-09586-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

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