Atypical resting state neuromagnetic connectivity and spectral power in very preterm children / N. KOZHEMIAKO in Journal of Child Psychology and Psychiatry, 60-9 (September 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.975-987 Titre : Atypical resting state neuromagnetic connectivity and spectral power in very preterm children Type de document : Texte imprimé et/ou numérique Auteurs : N. KOZHEMIAKO, Auteur ; A. NUNES, Auteur ; V. A. VAKORIN, Auteur ; C. M. Y. CHAU, Auteur ; A. MOISEEV, Auteur ; U. RIBARY, Auteur ; R. E. GRUNAU, Auteur ; S. M. DOESBURG, Auteur Article en page(s) : p.975-987 Langues : Anglais (eng) Mots-clés : Very preterm  children  early adversity  magnetoencephalography  neonatal stress  pain  resting state connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Children born very preterm often display selective cognitive difficulties at school age even in the absence of major brain injury. Alterations in neurophysiological activity underpinning such difficulties, as well as their relation to specific aspects of adverse neonatal experience, remain poorly understood. In the present study, we examined interregional connectivity and spectral power in very preterm children at school age, and their relationship with clinical neonatal variables and long-term outcomes (IQ, executive functions, externalizing/internalizing behavior, visual-motor integration). METHODS: We collected resting state magnetoencephalographic (MEG) and psychometric data from a cohort at the age of 8 years followed prospectively since birth, which included three groups: Extremely Low Gestational Age (ELGA, 24-28 weeks GA n = 24, age 7.7 +/- 0.38, 10 girls), Very Low Gestational Age (VLGA, 29-32 weeks GA n = 37, age 7.7 +/- 0.39, 24 girls), and full-term children (38-41 weeks GA n = 39, age 7.9 +/- 1.02, 24 girls). Interregional phase synchrony and spectral power were tested for group differences, and associations with neonatal and outcome variables were examined using mean-centered and behavioral Partial Least Squares (PLS) analyses, respectively. RESULTS: We found greater connectivity in the theta band in the ELGA group compared to VLGA and full-term groups, primarily involving frontal connections. Spectral power analysis demonstrated overall lower power in the ELGA and VLGA compared to full-term group. PLS indicated strong associations between neurophysiological connectivity at school age, adverse neonatal experience and cognitive performance, and behavior. Resting spectral power was associated only with behavioral scores. CONCLUSIONS: Our findings indicate significant atypicalities of neuromagnetic brain activity and connectivity in very preterm children at school age, with alterations in connectivity mainly observed only in the ELGA group. We demonstrate a significant relationship between connectivity, adverse neonatal experience, and long-term outcome, indicating that the disruption of developing neurophysiological networks may mediate relationships between neonatal events and cognitive and behavioral difficulties at school age. En ligne : http://dx.doi.org/10.1111/jcpp.13026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Atypical resting state neuromagnetic connectivity and spectral power in very preterm children [Texte imprimé et/ou numérique] / N. KOZHEMIAKO, Auteur ; A. NUNES, Auteur ; V. A. VAKORIN, Auteur ; C. M. Y. CHAU, Auteur ; A. MOISEEV, Auteur ; U. RIBARY, Auteur ; R. E. GRUNAU, Auteur ; S. M. DOESBURG, Auteur . - p.975-987. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-9 (September 2019) . - p.975-987 Mots-clés : Very preterm  children  early adversity  magnetoencephalography  neonatal stress  pain  resting state connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Children born very preterm often display selective cognitive difficulties at school age even in the absence of major brain injury. Alterations in neurophysiological activity underpinning such difficulties, as well as their relation to specific aspects of adverse neonatal experience, remain poorly understood. In the present study, we examined interregional connectivity and spectral power in very preterm children at school age, and their relationship with clinical neonatal variables and long-term outcomes (IQ, executive functions, externalizing/internalizing behavior, visual-motor integration). METHODS: We collected resting state magnetoencephalographic (MEG) and psychometric data from a cohort at the age of 8 years followed prospectively since birth, which included three groups: Extremely Low Gestational Age (ELGA, 24-28 weeks GA n = 24, age 7.7 +/- 0.38, 10 girls), Very Low Gestational Age (VLGA, 29-32 weeks GA n = 37, age 7.7 +/- 0.39, 24 girls), and full-term children (38-41 weeks GA n = 39, age 7.9 +/- 1.02, 24 girls). Interregional phase synchrony and spectral power were tested for group differences, and associations with neonatal and outcome variables were examined using mean-centered and behavioral Partial Least Squares (PLS) analyses, respectively. RESULTS: We found greater connectivity in the theta band in the ELGA group compared to VLGA and full-term groups, primarily involving frontal connections. Spectral power analysis demonstrated overall lower power in the ELGA and VLGA compared to full-term group. PLS indicated strong associations between neurophysiological connectivity at school age, adverse neonatal experience and cognitive performance, and behavior. Resting spectral power was associated only with behavioral scores. CONCLUSIONS: Our findings indicate significant atypicalities of neuromagnetic brain activity and connectivity in very preterm children at school age, with alterations in connectivity mainly observed only in the ELGA group. We demonstrate a significant relationship between connectivity, adverse neonatal experience, and long-term outcome, indicating that the disruption of developing neurophysiological networks may mediate relationships between neonatal events and cognitive and behavioral difficulties at school age. En ligne : http://dx.doi.org/10.1111/jcpp.13026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces / F. MAMASHLI in Autism Research, 14-6 (June 2021)  

Public ISBD [article]  inAutism Research > 14-6 (June 2021) . - p.1101-1114 Titre : Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces Type de document : Texte imprimé et/ou numérique Auteurs : F. MAMASHLI, Auteur ; N. KOZHEMIAKO, Auteur ; S. KHAN, Auteur ; A. S. NUNES, Auteur ; N. M. MCGUIGGAN, Auteur ; A. LOSH, Auteur ; R. M. JOSEPH, Auteur ; Jyrki AHVENINEN, Auteur ; S. M. DOESBURG, Auteur ; M. S. HÄMÄLÄINEN, Auteur ; T. KENET, Auteur Article en page(s) : p.1101-1114 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/diagnostic imaging  Child  Gamma Rhythm  Humans  Magnetic Resonance Imaging  Magnetoencephalography  Prefrontal Cortex  autism spectrum disorder  functional connectivity  inverted faces  phase-amplitude coupling Index. décimale : PER Périodiques Résumé : The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the neurophysiological abnormalities associated with processing inverted faces in ASD. We used magnetoencephalography (MEG) to study both long-range and local functional connectivity, with the latter assessed using local cross-frequency coupling, in response to inverted faces stimuli, in 7-18?years old individuals with ASD and age and IQ matched typically developing (TD) individuals. We found abnormally reduced coupling between the phase of the alpha rhythm and the amplitude of the gamma rhythm in the fusiform face area (FFA) in response to inverted faces, as well as reduced long-range functional connectivity between the FFA and the inferior frontal gyrus (IFG) in response to inverted faces in the ASD group. These group differences were absent in response to upright faces. The magnitude of functional connectivity between the FFA and the IFG was significantly correlated with the severity of ASD, and FFA-IFG long-range functional connectivity increased with age in TD group, but not in the ASD group. Our findings suggest that both local and long-range functional connectivity are abnormally reduced in children with ASD when processing inverted faces, and that the pattern of abnormalities associated with the processing of inverted faces differs from the pattern of upright faces in ASD, likely due to the presumed greater reliance on top-down regulations necessary for efficient processing of inverted faces. LAY SUMMARY: We found alterations in the neurophysiological responses to inverted faces in children with ASD, that were not reflected in the evoked responses, and were not observed in the responses to upright faces. These alterations included reduced local functional connectivity in the fusiform face area (FFA), and decreased long-range alpha-band modulated functional connectivity between the FFA and the left IFG. The magnitude of long-range functional connectivity between the FFA and the inferior frontal gyrus was correlated with the severity of ASD. En ligne : http://dx.doi.org/10.1002/aur.2497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces [Texte imprimé et/ou numérique] / F. MAMASHLI, Auteur ; N. KOZHEMIAKO, Auteur ; S. KHAN, Auteur ; A. S. NUNES, Auteur ; N. M. MCGUIGGAN, Auteur ; A. LOSH, Auteur ; R. M. JOSEPH, Auteur ; Jyrki AHVENINEN, Auteur ; S. M. DOESBURG, Auteur ; M. S. HÄMÄLÄINEN, Auteur ; T. KENET, Auteur . - p.1101-1114. Langues : Anglais (eng) in Autism Research > 14-6 (June 2021) . - p.1101-1114 Mots-clés : Adolescent  Autism Spectrum Disorder/diagnostic imaging  Child  Gamma Rhythm  Humans  Magnetic Resonance Imaging  Magnetoencephalography  Prefrontal Cortex  autism spectrum disorder  functional connectivity  inverted faces  phase-amplitude coupling Index. décimale : PER Périodiques Résumé : The processing of information conveyed by faces is a critical component of social communication. While the neurophysiology of processing upright faces has been studied extensively in autism spectrum disorder (ASD), less is known about the neurophysiological abnormalities associated with processing inverted faces in ASD. We used magnetoencephalography (MEG) to study both long-range and local functional connectivity, with the latter assessed using local cross-frequency coupling, in response to inverted faces stimuli, in 7-18?years old individuals with ASD and age and IQ matched typically developing (TD) individuals. We found abnormally reduced coupling between the phase of the alpha rhythm and the amplitude of the gamma rhythm in the fusiform face area (FFA) in response to inverted faces, as well as reduced long-range functional connectivity between the FFA and the inferior frontal gyrus (IFG) in response to inverted faces in the ASD group. These group differences were absent in response to upright faces. The magnitude of functional connectivity between the FFA and the IFG was significantly correlated with the severity of ASD, and FFA-IFG long-range functional connectivity increased with age in TD group, but not in the ASD group. Our findings suggest that both local and long-range functional connectivity are abnormally reduced in children with ASD when processing inverted faces, and that the pattern of abnormalities associated with the processing of inverted faces differs from the pattern of upright faces in ASD, likely due to the presumed greater reliance on top-down regulations necessary for efficient processing of inverted faces. LAY SUMMARY: We found alterations in the neurophysiological responses to inverted faces in children with ASD, that were not reflected in the evoked responses, and were not observed in the responses to upright faces. These alterations included reduced local functional connectivity in the fusiform face area (FFA), and decreased long-range alpha-band modulated functional connectivity between the FFA and the left IFG. The magnitude of long-range functional connectivity between the FFA and the inferior frontal gyrus was correlated with the severity of ASD. En ligne : http://dx.doi.org/10.1002/aur.2497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

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