Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors / N. M. FAVA in Development and Psychopathology, 31-4 (October 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-4 (October 2019) . - p.1439-1450 Titre : Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors Type de document : texte imprimé Auteurs : N. M. FAVA, Auteur ; E. M. TRUCCO, Auteur ; M. E. MARTZ, Auteur ; L. M. COPE, Auteur ; Jennifer M. JESTER, Auteur ; R. A. ZUCKER, Auteur ; Mary M. HEITZEG, Auteur Article en page(s) : p.1439-1450 Langues : Anglais (eng) Mots-clés : anterior cingulate cortex  childhood adversity  externalizing behavior  inhibitory control  substance use Index. décimale : PER Périodiques Résumé : Childhood adversity can negatively impact development across various domains, including physical and mental health. Adverse childhood experiences have been linked to aggression and substance use; however, developmental pathways to explain these associations are not well characterized. Understanding early precursors to later problem behavior and substance use can inform preventive interventions. The aim of the current study was to examine neurobiological pathways through which childhood adversity may lead to early adolescent problem behavior and substance use in late adolescence by testing two prospective models. Our first model found that early adolescent externalizing behavior mediates the association between childhood adversity and alcohol, cigarette, and marijuana use in late adolescence. Our second model found that activation in the anterior cingulate cortex (ACC) during an inhibitory control task mediates the association between childhood adversity and early adolescent externalizing behavior, with lower ACC activation associated with higher levels of adversity and more externalizing behavior. Together these findings indicate that the path to substance use in late adolescence from childhood adversity may operate through lower functioning in the ACC related to inhibitory control and externalizing behavior. Early life stressors should be considered an integral component in the etiology and prevention of early and problematic substance use. En ligne : http://dx.doi.org/10.1017/s0954579418001025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors [texte imprimé] / N. M. FAVA, Auteur ; E. M. TRUCCO, Auteur ; M. E. MARTZ, Auteur ; L. M. COPE, Auteur ; Jennifer M. JESTER, Auteur ; R. A. ZUCKER, Auteur ; Mary M. HEITZEG, Auteur . - p.1439-1450. Langues : Anglais (eng) in Development and Psychopathology > 31-4 (October 2019) . - p.1439-1450 Mots-clés : anterior cingulate cortex  childhood adversity  externalizing behavior  inhibitory control  substance use Index. décimale : PER Périodiques Résumé : Childhood adversity can negatively impact development across various domains, including physical and mental health. Adverse childhood experiences have been linked to aggression and substance use; however, developmental pathways to explain these associations are not well characterized. Understanding early precursors to later problem behavior and substance use can inform preventive interventions. The aim of the current study was to examine neurobiological pathways through which childhood adversity may lead to early adolescent problem behavior and substance use in late adolescence by testing two prospective models. Our first model found that early adolescent externalizing behavior mediates the association between childhood adversity and alcohol, cigarette, and marijuana use in late adolescence. Our second model found that activation in the anterior cingulate cortex (ACC) during an inhibitory control task mediates the association between childhood adversity and early adolescent externalizing behavior, with lower ACC activation associated with higher levels of adversity and more externalizing behavior. Together these findings indicate that the path to substance use in late adolescence from childhood adversity may operate through lower functioning in the ACC related to inhibitory control and externalizing behavior. Early life stressors should be considered an integral component in the etiology and prevention of early and problematic substance use. En ligne : http://dx.doi.org/10.1017/s0954579418001025 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Leveraging bifactor modeling to test prospective direct and indirect effects of adolescent alcohol use and externalizing symptoms on the development of task-general executive functioning / L. M. COPE ; J. E. HARDEE ; M. M. HEITZEG ; M. E. SOULES ; A. S. WEIGARD ; Craig R. COLDER in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.1782-1803 Titre : Leveraging bifactor modeling to test prospective direct and indirect effects of adolescent alcohol use and externalizing symptoms on the development of task-general executive functioning Type de document : texte imprimé Auteurs : L. M. COPE, Auteur ; J. E. HARDEE, Auteur ; M. M. HEITZEG, Auteur ; M. E. SOULES, Auteur ; A. S. WEIGARD, Auteur ; Craig R. COLDER, Auteur Article en page(s) : p.1782-1803 Langues : Anglais (eng) Mots-clés : Adolescence  alcohol use  bifactor modeling  executive functioning  externalizing Index. décimale : PER Périodiques Résumé : Adolescence is a period of substantial maturation in brain regions underlying Executive Functioning (EF). Adolescence is also associated with initiation and escalation of Alcohol Use (AU), and adolescent AU has been proposed to produce physiological and neurobiological events that derail healthy EF development. However, support has been mixed, which may be due to (1) failure to consider co-occurring externalizing symptoms (including other drug use) and poor social adaptation, and (2) heterogeneity and psychometric limitations in EF measures. We aimed to clarify the AU-EF association by: (1) distinguishing general externalizing symptoms from specific symptoms (AU, aggression, drug use) using bifactor modeling, (2) testing prospective associations between general externalizing symptoms and specific symptoms, and task-general EF, as indexed by a well-validated computational modeling framework (diffusion decision model), and (3) examining indirect pathways from externalizing symptoms to deficits in task-general EF through poor social adaptation. A high-risk longitudinal sample (N = 919) from the Michigan Longitudinal Study was assessed at four time-points spanning early adolescence (10-13 years) to young adulthood (22-25). Results suggested a critical role of social adaptation within peer and school contexts in promoting healthy EF. There was no evidence that specific, neurotoxic effects of alcohol or drug use derailed task-general EF development. En ligne : https://dx.doi.org/10.1017/S095457942400138X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Leveraging bifactor modeling to test prospective direct and indirect effects of adolescent alcohol use and externalizing symptoms on the development of task-general executive functioning [texte imprimé] / L. M. COPE, Auteur ; J. E. HARDEE, Auteur ; M. M. HEITZEG, Auteur ; M. E. SOULES, Auteur ; A. S. WEIGARD, Auteur ; Craig R. COLDER, Auteur . - p.1782-1803. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.1782-1803 Mots-clés : Adolescence  alcohol use  bifactor modeling  executive functioning  externalizing Index. décimale : PER Périodiques Résumé : Adolescence is a period of substantial maturation in brain regions underlying Executive Functioning (EF). Adolescence is also associated with initiation and escalation of Alcohol Use (AU), and adolescent AU has been proposed to produce physiological and neurobiological events that derail healthy EF development. However, support has been mixed, which may be due to (1) failure to consider co-occurring externalizing symptoms (including other drug use) and poor social adaptation, and (2) heterogeneity and psychometric limitations in EF measures. We aimed to clarify the AU-EF association by: (1) distinguishing general externalizing symptoms from specific symptoms (AU, aggression, drug use) using bifactor modeling, (2) testing prospective associations between general externalizing symptoms and specific symptoms, and task-general EF, as indexed by a well-validated computational modeling framework (diffusion decision model), and (3) examining indirect pathways from externalizing symptoms to deficits in task-general EF through poor social adaptation. A high-risk longitudinal sample (N = 919) from the Michigan Longitudinal Study was assessed at four time-points spanning early adolescence (10-13 years) to young adulthood (22-25). Results suggested a critical role of social adaptation within peer and school contexts in promoting healthy EF. There was no evidence that specific, neurotoxic effects of alcohol or drug use derailed task-general EF development. En ligne : https://dx.doi.org/10.1017/S095457942400138X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

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