[article] inJournal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4572-4583
| Titre : |
Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Deborah A. BILDER, Auteur ; M. S. ESPLIN, Auteur ; H. COON, Auteur ; P. BURGHARDT, Auteur ; E. A. S. CLARK, Auteur ; A. FRASER, Auteur ; K. R. SMITH, Auteur ; Whitney WORSHAM, Auteur ; K. CHAPPELLE, Auteur ; T. RAYNER, Auteur ; Amanda V. BAKIAN, Auteur |
| Article en page(s) : |
p.4572-4583 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism Biomarkers Metabolic syndrome Prenatal risk factors |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Epidemiologic studies link increased autism spectrum disorder (ASD) risk to obstetrical conditions associated with inflammation and steroid dysregulation, referred to as prenatal metabolic syndrome (PNMS). This pilot study measured steroid-related biomarkers in early second trimester maternal serum collected during the first and second trimester evaluation of risk study. ASD case and PNMS exposure status of index offspring were determined through linkage with autism registries and birth certificate records. ASD case (N = 53) and control (N = 19) groups were enriched for PNMS exposure. Higher estradiol and lower sex hormone binding globulin (SHBG) were significantly associated with increased ASD risk. Study findings provide preliminary evidence to link greater placental estradiol activity with ASD and support future investigations of the prenatal steroid environment in ASD. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-019-04162-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 |
[article] Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Deborah A. BILDER, Auteur ; M. S. ESPLIN, Auteur ; H. COON, Auteur ; P. BURGHARDT, Auteur ; E. A. S. CLARK, Auteur ; A. FRASER, Auteur ; K. R. SMITH, Auteur ; Whitney WORSHAM, Auteur ; K. CHAPPELLE, Auteur ; T. RAYNER, Auteur ; Amanda V. BAKIAN, Auteur . - p.4572-4583. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4572-4583
| Mots-clés : |
Autism Biomarkers Metabolic syndrome Prenatal risk factors |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Epidemiologic studies link increased autism spectrum disorder (ASD) risk to obstetrical conditions associated with inflammation and steroid dysregulation, referred to as prenatal metabolic syndrome (PNMS). This pilot study measured steroid-related biomarkers in early second trimester maternal serum collected during the first and second trimester evaluation of risk study. ASD case and PNMS exposure status of index offspring were determined through linkage with autism registries and birth certificate records. ASD case (N = 53) and control (N = 19) groups were enriched for PNMS exposure. Higher estradiol and lower sex hormone binding globulin (SHBG) were significantly associated with increased ASD risk. Study findings provide preliminary evidence to link greater placental estradiol activity with ASD and support future investigations of the prenatal steroid environment in ASD. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-019-04162-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 |
|
Faire une suggestion Affiner la rechercheCorrection to: Early Second Trimester Maternal Serum SteroidRelated Biomarkers Associated with Autism Spectrum Disorder / Deborah A. BILDER in Journal of Autism and Developmental Disorders, 49-11 (November 2019)
