3 recherche sur le mot-clé 'Metabolic syndrome'

Systematic review investigating the relationship between autism spectrum disorder and metabolic dysfunction / Angela Y. CHIEH in Research in Autism Spectrum Disorders, 86 (August 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 86 (August 2021) . - 101821 Titre : Systematic review investigating the relationship between autism spectrum disorder and metabolic dysfunction Type de document : Texte imprimé et/ou numérique Auteurs : Angela Y. CHIEH, Auteur ; Bianca M. BRYANT, Auteur ; Jung Won KIM, Auteur ; Li LI, Auteur Article en page(s) : 101821 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Metabolic dysfunction  Metabolic syndrome  Type 2 diabetes  Hypertension  Dyslipidemia Index. décimale : PER Périodiques Résumé : The objective of this systematic review is to examine metabolic dysfunction, specifically metabolic syndrome and its components, as well as type 2 diabetes mellitus (T2DM) as it relates to individuals with a diagnosis of Autism Spectrum Disorder (ASD). We searched PubMed, Embase, Cochrane, PsychInfo, and Scopus from January 1, 1998 to October 12, 2018 for English, peer-reviewed, original articles containing adult and pediatric populations with any form of ASD and metabolic dysfunction, including T2DM, hyperglycemia, hypertension, dyslipidemia, or central obesity. Exclusion criteria included studies without ASD-specific results, basic science research, review papers, case studies, and medication clinical trials. Eight studies were included in this review, with a total of 70,503 participants with ASD and 2,281,891 in comparison groups. Within ASD populations, higher prevalence for metabolic syndrome components hyperglycemia, hypertension, and dyslipidemia were observed, as well as increased incidence and prevalence of T2DM. However, heterogeneity of study definitions and measurements should be noted. While there is evidence of increased prevalence of T2DM, hyperglycemia, hypertension, and dyslipidemia for those with ASD, the relationship is poorly understood. There is also lack of research investigating central obesity and risk of metabolic syndrome as a diagnosis. More research addressing these gaps is warranted to evaluate the risk of metabolic dysfunction in populations with ASD. En ligne : https://doi.org/10.1016/j.rasd.2021.101821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Systematic review investigating the relationship between autism spectrum disorder and metabolic dysfunction [Texte imprimé et/ou numérique] / Angela Y. CHIEH, Auteur ; Bianca M. BRYANT, Auteur ; Jung Won KIM, Auteur ; Li LI, Auteur . - 101821. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 86 (August 2021) . - 101821 Mots-clés : Autism spectrum disorder  Metabolic dysfunction  Metabolic syndrome  Type 2 diabetes  Hypertension  Dyslipidemia Index. décimale : PER Périodiques Résumé : The objective of this systematic review is to examine metabolic dysfunction, specifically metabolic syndrome and its components, as well as type 2 diabetes mellitus (T2DM) as it relates to individuals with a diagnosis of Autism Spectrum Disorder (ASD). We searched PubMed, Embase, Cochrane, PsychInfo, and Scopus from January 1, 1998 to October 12, 2018 for English, peer-reviewed, original articles containing adult and pediatric populations with any form of ASD and metabolic dysfunction, including T2DM, hyperglycemia, hypertension, dyslipidemia, or central obesity. Exclusion criteria included studies without ASD-specific results, basic science research, review papers, case studies, and medication clinical trials. Eight studies were included in this review, with a total of 70,503 participants with ASD and 2,281,891 in comparison groups. Within ASD populations, higher prevalence for metabolic syndrome components hyperglycemia, hypertension, and dyslipidemia were observed, as well as increased incidence and prevalence of T2DM. However, heterogeneity of study definitions and measurements should be noted. While there is evidence of increased prevalence of T2DM, hyperglycemia, hypertension, and dyslipidemia for those with ASD, the relationship is poorly understood. There is also lack of research investigating central obesity and risk of metabolic syndrome as a diagnosis. More research addressing these gaps is warranted to evaluate the risk of metabolic dysfunction in populations with ASD. En ligne : https://doi.org/10.1016/j.rasd.2021.101821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder / Deborah A. BILDER in Journal of Autism and Developmental Disorders, 49-11 (November 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4572-4583 Titre : Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Deborah A. BILDER, Auteur ; M. S. ESPLIN, Auteur ; H. COON, Auteur ; P. BURGHARDT, Auteur ; E. A. S. CLARK, Auteur ; A. FRASER, Auteur ; K. R. SMITH, Auteur ; Whitney WORSHAM, Auteur ; K. CHAPPELLE, Auteur ; T. RAYNER, Auteur ; Amanda V. BAKIAN, Auteur Article en page(s) : p.4572-4583 Langues : Anglais (eng) Mots-clés : Autism  Biomarkers  Metabolic syndrome  Prenatal risk factors Index. décimale : PER Périodiques Résumé : Epidemiologic studies link increased autism spectrum disorder (ASD) risk to obstetrical conditions associated with inflammation and steroid dysregulation, referred to as prenatal metabolic syndrome (PNMS). This pilot study measured steroid-related biomarkers in early second trimester maternal serum collected during the first and second trimester evaluation of risk study. ASD case and PNMS exposure status of index offspring were determined through linkage with autism registries and birth certificate records. ASD case (N = 53) and control (N = 19) groups were enriched for PNMS exposure. Higher estradiol and lower sex hormone binding globulin (SHBG) were significantly associated with increased ASD risk. Study findings provide preliminary evidence to link greater placental estradiol activity with ASD and support future investigations of the prenatal steroid environment in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04162-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Deborah A. BILDER, Auteur ; M. S. ESPLIN, Auteur ; H. COON, Auteur ; P. BURGHARDT, Auteur ; E. A. S. CLARK, Auteur ; A. FRASER, Auteur ; K. R. SMITH, Auteur ; Whitney WORSHAM, Auteur ; K. CHAPPELLE, Auteur ; T. RAYNER, Auteur ; Amanda V. BAKIAN, Auteur . - p.4572-4583. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4572-4583 Mots-clés : Autism  Biomarkers  Metabolic syndrome  Prenatal risk factors Index. décimale : PER Périodiques Résumé : Epidemiologic studies link increased autism spectrum disorder (ASD) risk to obstetrical conditions associated with inflammation and steroid dysregulation, referred to as prenatal metabolic syndrome (PNMS). This pilot study measured steroid-related biomarkers in early second trimester maternal serum collected during the first and second trimester evaluation of risk study. ASD case and PNMS exposure status of index offspring were determined through linkage with autism registries and birth certificate records. ASD case (N = 53) and control (N = 19) groups were enriched for PNMS exposure. Higher estradiol and lower sex hormone binding globulin (SHBG) were significantly associated with increased ASD risk. Study findings provide preliminary evidence to link greater placental estradiol activity with ASD and support future investigations of the prenatal steroid environment in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04162-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Mitochondria, Microbiome and Their Potential Psychiatric Modulation / Christopher SNYDER in Autism - Open Access, 5-2 ([01/03/2015])  

Public ISBD [article]  inAutism - Open Access > 5-2 [01/03/2015] . - 4 p. Titre : Mitochondria, Microbiome and Their Potential Psychiatric Modulation Type de document : Texte imprimé et/ou numérique Auteurs : Christopher SNYDER, Auteur ; Richard M. KREAM, Auteur ; Radek PTACEK, Auteur ; George B. STEFAN, Auteur Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : Gut  Microbiome  Mitochondria  Metabolic Syndrome  Autism Index. décimale : PER Périodiques Résumé : Pervasive developmental disorders, or autism spectrum disorders, are multifaceted and have a high rate of occurrence. Additionally, the origin of Autism appears to be multidimensional and largely unknown. Thus, it would appear novel approaches and concepts are needed in this area of scientific endeavor. In this regard, microbial cells harbored within the human gut and elsewhere are being studied to understand their multi-functional properties and their ability to affect physiological activities in their “host” organism. The communities of approximately 10 trillion microbial cells that live within the gut are involved in functions such as metabolism, nutrition and immune regulation. We and others surmise this microbiota can contribute to disruption of normal activities, causing harmful pathologies such as gastrointestinal complications, obesity, and diabetes and autism. They have the ability to trigger inappropriate immune activation, especially macrophages, which can travel from the gut and penetrate the blood brain barrier and communicate inappropriately with neural cells, altering behavior. Normally these immune cells can enter the brain and become microglia. However, being abnormally stimulated, many more can enter the brain, awakening the sentinel microglia and establishing a pro inflammatory state, inducing hypoxia (altering mitochondrial performance). Thus, the microbiome has the potential to extend its influence into the brain, suggesting this may also take place within the parameters of normal activity. In part, the behavioral outcome of such an inappropriate invasion would depend on the region(s) penetrated, manifesting itself with a multidimensional behavioral profile such as occurs in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Mitochondria, Microbiome and Their Potential Psychiatric Modulation [Texte imprimé et/ou numérique] / Christopher SNYDER, Auteur ; Richard M. KREAM, Auteur ; Radek PTACEK, Auteur ; George B. STEFAN, Auteur . - 4 p. Langues : Anglais (eng) in Autism - Open Access > 5-2 [01/03/2015] . - 4 p. Mots-clés : Gut  Microbiome  Mitochondria  Metabolic Syndrome  Autism Index. décimale : PER Périodiques Résumé : Pervasive developmental disorders, or autism spectrum disorders, are multifaceted and have a high rate of occurrence. Additionally, the origin of Autism appears to be multidimensional and largely unknown. Thus, it would appear novel approaches and concepts are needed in this area of scientific endeavor. In this regard, microbial cells harbored within the human gut and elsewhere are being studied to understand their multi-functional properties and their ability to affect physiological activities in their “host” organism. The communities of approximately 10 trillion microbial cells that live within the gut are involved in functions such as metabolism, nutrition and immune regulation. We and others surmise this microbiota can contribute to disruption of normal activities, causing harmful pathologies such as gastrointestinal complications, obesity, and diabetes and autism. They have the ability to trigger inappropriate immune activation, especially macrophages, which can travel from the gut and penetrate the blood brain barrier and communicate inappropriately with neural cells, altering behavior. Normally these immune cells can enter the brain and become microglia. However, being abnormally stimulated, many more can enter the brain, awakening the sentinel microglia and establishing a pro inflammatory state, inducing hypoxia (altering mitochondrial performance). Thus, the microbiome has the potential to extend its influence into the brain, suggesting this may also take place within the parameters of normal activity. In part, the behavioral outcome of such an inappropriate invasion would depend on the region(s) penetrated, manifesting itself with a multidimensional behavioral profile such as occurs in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000144 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409