Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue Mice / Wei LI in Autism - Open Access, 2-S ([01/12/2012])  

Public ISBD [article]  inAutism - Open Access > 2-S [01/12/2012] . - 7 p. Titre : Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue Mice Type de document : Texte imprimé et/ou numérique Auteurs : Wei LI, Auteur ; Lucas POZZO-MILLER, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Rett syndrome (RTT) is one of the leading causes of intellectual disabilities in women. In addition to a few autistic features, characteristic symptoms that distinguish from classical autism include stereotypic hand movements, motor coordination deficits, breathing abnormalities, seizures and loss of acquired speech as well as purposeful hand use. RTT is highly associated with MECP2, the gene encoding for the transcription factor that binds methylated Cytosine in C-p-G islands in DNA, controlling gene expression and chromatin remodeling. In this review, we will briefly discuss current perspectives on MeCP2 function, and then will describe in detail novel mouse models of RTT based on loss-of-function of Mecp2 and their use for establishing rescue models, wherein we pay close attention to behavioral and morphological phenotypes. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue Mice [Texte imprimé et/ou numérique] / Wei LI, Auteur ; Lucas POZZO-MILLER, Auteur . - 7 p. Langues : Anglais (eng) in Autism - Open Access > 2-S [01/12/2012] . - 7 p. Index. décimale : PER Périodiques Résumé : Rett syndrome (RTT) is one of the leading causes of intellectual disabilities in women. In addition to a few autistic features, characteristic symptoms that distinguish from classical autism include stereotypic hand movements, motor coordination deficits, breathing abnormalities, seizures and loss of acquired speech as well as purposeful hand use. RTT is highly associated with MECP2, the gene encoding for the transcription factor that binds methylated Cytosine in C-p-G islands in DNA, controlling gene expression and chromatin remodeling. In this review, we will briefly discuss current perspectives on MeCP2 function, and then will describe in detail novel mouse models of RTT based on loss-of-function of Mecp2 and their use for establishing rescue models, wherein we pay close attention to behavioral and morphological phenotypes. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Veritable Untruths: Autistic Traits and the Processing of Deception / Wei LI in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4921-4930 Titre : Veritable Untruths: Autistic Traits and the Processing of Deception Type de document : Texte imprimé et/ou numérique Auteurs : Wei LI, Auteur ; Hannah ROHDE, Auteur ; Martin CORLEY, Auteur Article en page(s) : p.4921-4930 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Comprehension  Deception  Eye Movements  Humans  Autism spectrum quotient  Disfluency  Eye-tracking Index. décimale : PER Périodiques Résumé : How do we decide whether a statement is literally true? Here, we contrast participants' eventual evaluations of a speaker's meaning with the real-time processes of comprehension. We record participants' eye movements as they respond to potentially misleading instructions to click on one of two objects which might be concealing treasure (the treasure is behind thee, uh, hat). Participants are less likely to click on the named object when the instructions are disfluent. However, when hearing disfluent utterances, a tendency to fixate the named object early increases with participants' autism quotient scores. This suggests that, even where utterances are equivalently understood, the processes by which interpretations are achieved vary across individuals. En ligne : http://dx.doi.org/10.1007/s10803-021-05347-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Veritable Untruths: Autistic Traits and the Processing of Deception [Texte imprimé et/ou numérique] / Wei LI, Auteur ; Hannah ROHDE, Auteur ; Martin CORLEY, Auteur . - p.4921-4930. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4921-4930 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Comprehension  Deception  Eye Movements  Humans  Autism spectrum quotient  Disfluency  Eye-tracking Index. décimale : PER Périodiques Résumé : How do we decide whether a statement is literally true? Here, we contrast participants' eventual evaluations of a speaker's meaning with the real-time processes of comprehension. We record participants' eye movements as they respond to potentially misleading instructions to click on one of two objects which might be concealing treasure (the treasure is behind thee, uh, hat). Participants are less likely to click on the named object when the instructions are disfluent. However, when hearing disfluent utterances, a tendency to fixate the named object early increases with participants' autism quotient scores. This suggests that, even where utterances are equivalently understood, the processes by which interpretations are achieved vary across individuals. En ligne : http://dx.doi.org/10.1007/s10803-021-05347-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

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