Altered Pre-reflective Sense of Agency in Autism Spectrum Disorders as Revealed by Reduced Intentional Binding / Marco SPERDUTI in Journal of Autism and Developmental Disorders, 44-2 (February 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-2 (February 2014) . - p.343-352 Titre : Altered Pre-reflective Sense of Agency in Autism Spectrum Disorders as Revealed by Reduced Intentional Binding Type de document : Texte imprimé et/ou numérique Auteurs : Marco SPERDUTI, Auteur ; Marie PIERON, Auteur ; Marion LEBOYER, Auteur ; Tiziana ZALLA, Auteur Article en page(s) : p.343-352 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Sense of agency  Intentional binding  Self  Predictive mechanisms Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are neurodevelopmental conditions that severely affect social interaction, communication and several behavioural and cognitive functions, such as planning and monitoring motor actions. A renewed interest in intrapersonal cognition has recently emerged suggesting a putative dissociation between impaired declarative processes, such as autobiographical memory, and spared implicit processes, such as the sense of agency (SoA) in ASDs. However, so far only a few studies have investigated the integrity of SoA using tasks exclusively tapping reflective mechanisms. Since pre-reflective processes of SoA are based on the same predictive internal models that are involved in planning and monitoring actions, we hypothesized that pre-reflective aspects of SoA, as measured by the intentional binding effect, would be altered in adults with high functioning autism spectrum disorders, relative to volunteers with typical development. Here, in accordance with our hypothesis, we report reduced IB in participants with ASDs. En ligne : http://dx.doi.org/10.1007/s10803-013-1891-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223 [article] Altered Pre-reflective Sense of Agency in Autism Spectrum Disorders as Revealed by Reduced Intentional Binding [Texte imprimé et/ou numérique] / Marco SPERDUTI, Auteur ; Marie PIERON, Auteur ; Marion LEBOYER, Auteur ; Tiziana ZALLA, Auteur . - p.343-352. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-2 (February 2014) . - p.343-352 Mots-clés : Autism spectrum disorders  Sense of agency  Intentional binding  Self  Predictive mechanisms Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are neurodevelopmental conditions that severely affect social interaction, communication and several behavioural and cognitive functions, such as planning and monitoring motor actions. A renewed interest in intrapersonal cognition has recently emerged suggesting a putative dissociation between impaired declarative processes, such as autobiographical memory, and spared implicit processes, such as the sense of agency (SoA) in ASDs. However, so far only a few studies have investigated the integrity of SoA using tasks exclusively tapping reflective mechanisms. Since pre-reflective processes of SoA are based on the same predictive internal models that are involved in planning and monitoring actions, we hypothesized that pre-reflective aspects of SoA, as measured by the intentional binding effect, would be altered in adults with high functioning autism spectrum disorders, relative to volunteers with typical development. Here, in accordance with our hypothesis, we report reduced IB in participants with ASDs. En ligne : http://dx.doi.org/10.1007/s10803-013-1891-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=223

An Association Between Serotonin 1A Receptor, Gray Matter Volume, and Sociability in Healthy Subjects and in Autism Spectrum Disorder / Arthur LEFEVRE in Autism Research, 13-11 (November 2020)  

Public ISBD [article]  inAutism Research > 13-11 (November 2020) . - p.1843-1855 Titre : An Association Between Serotonin 1A Receptor, Gray Matter Volume, and Sociability in Healthy Subjects and in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Arthur LEFEVRE, Auteur ; Nathalie RICHARD, Auteur ; Raphaelle MOTTOLESE, Auteur ; Marion LEBOYER, Auteur ; Angela SIRIGU, Auteur Article en page(s) : p.1843-1855 Langues : Anglais (eng) Mots-clés : Mri  PET scan  autism  gray matter volume  serotonin 1A receptor  sociality Index. décimale : PER Périodiques Résumé : Central serotonin is an important molecular pathway, involved in the regulation of social behavior and gray matter volume (GMV). In men with autism spectrum disorders (ASD), the serotonergic system and the GMV have been found disrupted. Here, we investigated the relation between serotonin, GMV, and social personality in men with typical development (TD) and in men with ASD. We combined anatomical magnetic resonance imaging, Positron emission tomography scan with 2'-methoxyphenyl-(N-2'-pyridinyl)-p-18F-fluoro-benzamidoethylpiperazine radioligand and revised NEO personality inventory personality questionnaire to examine the association between serotonin 1A receptor (5-HT(1A) R) binding potential, GMV and social personality in 24 adult male TD subjects and 18 male men with ASD. In both groups, we found a positive correlation between 5-HT(1A) R binding potential and GMV in a region dependent manner. In the TD group, we observed a negative correlation between 5-HT(1A) R and GMV in the left and right posterior putamen. 5HT(1A) R binding and GMV in the putamen further correlated with social personality scores in the TD group. None of these associations were found in men with ASD, although no differences were observed for 5-HT(1A) R concentration among the two groups. Our findings point to a deregulation of 5-HT(1A) R density in the striatum of men with ASD, a failure that might contribute to their social disturbances. Serotonin is suspected to be involved in the pathophysiology of autism. We provide evidence for a role of serotonin 1A receptor in social behavior through a specific regulation of GMV in the putamen region in neurotypical subjects but not in men with autism. This suggests a potential impairment of the serotonergic system in men with autism which may contribute to patients' social disturbances. Our findings suggest further investigation on the role of serotonin 1A receptor and its activity in the striatum to regulate social behavior. Autism Res 2020, 13: 1843-1855. © 2020 International Society for Autism Research and Wiley Periodicals LLC LAY SUMMARY: Serotonin is suspected to be involved in the pathophysiology of autism. We provide evidence for a role of serotonin 1A receptor in social behavior through a specific regulation of gray matter volume in the putamen region in neurotypical subjects but not in men with autism. This suggests a potential impairment of the serotonergic system in men with autism which may contribute to patients' social disturbances. Our findings suggest further investigation on the role of serotonin 1A receptor and its activity in the striatum to regulate social behavior. En ligne : http://dx.doi.org/10.1002/aur.2360 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] An Association Between Serotonin 1A Receptor, Gray Matter Volume, and Sociability in Healthy Subjects and in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Arthur LEFEVRE, Auteur ; Nathalie RICHARD, Auteur ; Raphaelle MOTTOLESE, Auteur ; Marion LEBOYER, Auteur ; Angela SIRIGU, Auteur . - p.1843-1855. Langues : Anglais (eng) in Autism Research > 13-11 (November 2020) . - p.1843-1855 Mots-clés : Mri  PET scan  autism  gray matter volume  serotonin 1A receptor  sociality Index. décimale : PER Périodiques Résumé : Central serotonin is an important molecular pathway, involved in the regulation of social behavior and gray matter volume (GMV). In men with autism spectrum disorders (ASD), the serotonergic system and the GMV have been found disrupted. Here, we investigated the relation between serotonin, GMV, and social personality in men with typical development (TD) and in men with ASD. We combined anatomical magnetic resonance imaging, Positron emission tomography scan with 2'-methoxyphenyl-(N-2'-pyridinyl)-p-18F-fluoro-benzamidoethylpiperazine radioligand and revised NEO personality inventory personality questionnaire to examine the association between serotonin 1A receptor (5-HT(1A) R) binding potential, GMV and social personality in 24 adult male TD subjects and 18 male men with ASD. In both groups, we found a positive correlation between 5-HT(1A) R binding potential and GMV in a region dependent manner. In the TD group, we observed a negative correlation between 5-HT(1A) R and GMV in the left and right posterior putamen. 5HT(1A) R binding and GMV in the putamen further correlated with social personality scores in the TD group. None of these associations were found in men with ASD, although no differences were observed for 5-HT(1A) R concentration among the two groups. Our findings point to a deregulation of 5-HT(1A) R density in the striatum of men with ASD, a failure that might contribute to their social disturbances. Serotonin is suspected to be involved in the pathophysiology of autism. We provide evidence for a role of serotonin 1A receptor in social behavior through a specific regulation of GMV in the putamen region in neurotypical subjects but not in men with autism. This suggests a potential impairment of the serotonergic system in men with autism which may contribute to patients' social disturbances. Our findings suggest further investigation on the role of serotonin 1A receptor and its activity in the striatum to regulate social behavior. Autism Res 2020, 13: 1843-1855. © 2020 International Society for Autism Research and Wiley Periodicals LLC LAY SUMMARY: Serotonin is suspected to be involved in the pathophysiology of autism. We provide evidence for a role of serotonin 1A receptor in social behavior through a specific regulation of gray matter volume in the putamen region in neurotypical subjects but not in men with autism. This suggests a potential impairment of the serotonergic system in men with autism which may contribute to patients' social disturbances. Our findings suggest further investigation on the role of serotonin 1A receptor and its activity in the striatum to regulate social behavior. En ligne : http://dx.doi.org/10.1002/aur.2360 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Anomalies immuno-inflammatoires et troubles du spectre autistique (TSA) / Marion LEBOYER in Bulletin Scientifique de l'arapi (Le), 40 (Hiver 2017)

Public ISBD [article]  inBulletin Scientifique de l'arapi (Le) > 40 (Hiver 2017) . - p.41-43 Titre : Anomalies immuno-inflammatoires et troubles du spectre autistique (TSA) Type de document : Texte imprimé et/ou numérique Auteurs : Marion LEBOYER, Auteur ; Ryad TAMOUZA, Auteur ; Laure TABOUY, Auteur Année de publication : 2017 Article en page(s) : p.41-43 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=373 [article] Anomalies immuno-inflammatoires et troubles du spectre autistique (TSA) [Texte imprimé et/ou numérique] / Marion LEBOYER, Auteur ; Ryad TAMOUZA, Auteur ; Laure TABOUY, Auteur . - 2017 . - p.41-43. Langues : Français (fre) in Bulletin Scientifique de l'arapi (Le) > 40 (Hiver 2017) . - p.41-43 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=373

Atypical Social Judgment and Sensitivity to Perceptual Cues in Autism Spectrum Disorders / Baudouin FORGEOT D'ARC in Journal of Autism and Developmental Disorders, 46-5 (May 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-5 (May 2016) . - p.1574-1581 Titre : Atypical Social Judgment and Sensitivity to Perceptual Cues in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Baudouin FORGEOT D'ARC, Auteur ; Franck RAMUS, Auteur ; Aline LEFEBVRE, Auteur ; Delphine BROTTIER, Auteur ; Tiziana ZALLA, Auteur ; Sanaa MOUKAWANE, Auteur ; Frédérique AMSELLEM, Auteur ; Laurence LETELLIER, Auteur ; Hugo PEYRE, Auteur ; Marie-Christine MOUREN, Auteur ; Marion LEBOYER, Auteur ; Richard DELORME, Auteur Article en page(s) : p.1574-1581 Langues : Anglais (eng) Mots-clés : Autism  Social judgment  Face processing  Social cognition  Perception Index. décimale : PER Périodiques Résumé : Evaluation of faces is an important dimension of social relationships. A degraded sensitivity to facial perceptual cues might contribute to atypical social interactions in autism spectrum disorder (ASD). The current study investigated whether face based social judgment is atypical in ASD and if so, whether it could be related to a degraded sensitivity to facial perceptual cues. Individuals with ASD (n = 33) and IQ- and age-matched controls (n = 38) were enrolled in this study. Watching a series of photographic or synthetic faces, they had to judge them for “kindness”. In synthetic stimuli, the amount of perceptual cues available could be either large or small. We observed that social judgment was atypical in the ASD group on photographic stimuli, but, contrarily to the prediction based on the degraded sensitivity hypothesis, analyses on synthetic stimuli found a similar performance and a similar effect of the amount of perceptual cues in both groups. Further studies on perceptual differences between photographs and synthetic pictures of faces might help understand atypical social judgment in ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2208-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Atypical Social Judgment and Sensitivity to Perceptual Cues in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Baudouin FORGEOT D'ARC, Auteur ; Franck RAMUS, Auteur ; Aline LEFEBVRE, Auteur ; Delphine BROTTIER, Auteur ; Tiziana ZALLA, Auteur ; Sanaa MOUKAWANE, Auteur ; Frédérique AMSELLEM, Auteur ; Laurence LETELLIER, Auteur ; Hugo PEYRE, Auteur ; Marie-Christine MOUREN, Auteur ; Marion LEBOYER, Auteur ; Richard DELORME, Auteur . - p.1574-1581. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-5 (May 2016) . - p.1574-1581 Mots-clés : Autism  Social judgment  Face processing  Social cognition  Perception Index. décimale : PER Périodiques Résumé : Evaluation of faces is an important dimension of social relationships. A degraded sensitivity to facial perceptual cues might contribute to atypical social interactions in autism spectrum disorder (ASD). The current study investigated whether face based social judgment is atypical in ASD and if so, whether it could be related to a degraded sensitivity to facial perceptual cues. Individuals with ASD (n = 33) and IQ- and age-matched controls (n = 38) were enrolled in this study. Watching a series of photographic or synthetic faces, they had to judge them for “kindness”. In synthetic stimuli, the amount of perceptual cues available could be either large or small. We observed that social judgment was atypical in the ASD group on photographic stimuli, but, contrarily to the prediction based on the degraded sensitivity hypothesis, analyses on synthetic stimuli found a similar performance and a similar effect of the amount of perceptual cues in both groups. Further studies on perceptual differences between photographs and synthetic pictures of faces might help understand atypical social judgment in ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2208-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Autisme infantile / Marion LEBOYER

Public ISBD Titre : Autisme infantile : Faits et modèles Type de document : Texte imprimé et/ou numérique Auteurs : Marion LEBOYER, Auteur Editeur : Paris [France] : PUF - Presses Universitaires de France Année de publication : 1985 Collection : Psychiatrie Ouverte, ISSN 0242-7842 Importance : 144 p. Format : 15cm x 21,6cm x 1,3cm ISBN/ISSN/EAN : 978-2-13-039242-2 Note générale : Bibliogr. Langues : Français (fre) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Résumé : Depuis la description princeps de l'autisme par Kanner, quarante ans se sont écoulés. De nombreuses recherches ont été consacrées à ce syndrome et la polémique reste vive, notamment sur l'étiologie de l'autisme. C'est le moment de faire le point et de préciser le statut des modèles de l'autisme. Sans préjugé ni a priori, ce livre aborde aussi bien les aspects cliniques et nosographiques que les schémas psychodynamiques, génétiques et organiques, les données biologiques et psychologiques pour mieux cerner ainsi la complexité de ce syndrome. [Résumé d'Auteur/Editeur] Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240 Autisme infantile : Faits et modèles [Texte imprimé et/ou numérique] / Marion LEBOYER, Auteur . - Paris [France] : PUF - Presses Universitaires de France, 1985 . - 144 p. ; 15cm x 21,6cm x 1,3cm. - (Psychiatrie Ouverte, ISSN 0242-7842) . ISBN : 978-2-13-039242-2 Bibliogr. Langues : Français (fre) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Résumé : Depuis la description princeps de l'autisme par Kanner, quarante ans se sont écoulés. De nombreuses recherches ont été consacrées à ce syndrome et la polémique reste vive, notamment sur l'étiologie de l'autisme. C'est le moment de faire le point et de préciser le statut des modèles de l'autisme. Sans préjugé ni a priori, ce livre aborde aussi bien les aspects cliniques et nosographiques que les schémas psychodynamiques, génétiques et organiques, les données biologiques et psychologiques pour mieux cerner ainsi la complexité de ce syndrome. [Résumé d'Auteur/Editeur] Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240

Exemplaires (1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
DOC0002955	AUT-B LEB	Livre	Centre d'Information et de Documentation du CRA Rhône-Alpes	AUT - L'Autisme	Disponible

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Autisme, la piste génétique se confirme / Thomas BOURGERON in Enfance, 2009-1 (janvier-mars 2009)  

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Autisme et psychopharmacologie : l'hypothèse opiacée / Nadia CHABANE in Psychologie Française, 43-2 (Juin 1998)

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Complex nature of apparently balanced chromosomal rearrangements in patients with autism spectrum disorder / Anne-Claude TABET in Molecular Autism, (March 2015)  

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Correction: Understanding the relationship between cerebellar structure and social abilities / Dorothea L. FLORIS ; Pierrick COUPÉ ; Edouard DUCHESNAY ; Angeline MIHAILOV ; Antoine GRIGIS ; Indrit BÈGUE ; Julie VICTOR ; Vincent FROUIN ; Marion LEBOYER ; Josselin HOUENOU ; Charles LAIDI in Molecular Autism, 14 (2023)  

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Episodic memory and self-awareness in Asperger Syndrome: Analysis of memory narratives / Valérie CHAPUT in Research in Autism Spectrum Disorders, 7-9 (September 2013)  

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Exploring the multidimensional nature of repetitive and restricted behaviors and interests (RRBI) in autism: neuroanatomical correlates and clinical implications / Nicolas TRAUT ; Amandine PEDOUX ; Anna MARUANI ; Anita BEGGIATO ; Monique ELMALEH ; David GERMANAUD ; Anouck AMESTOY ; Myriam LY-LE MOAL ; Christopher CHATHAM ; Lorraine MURTAGH ; Manuel BOUVARD ; Marianne ALISSON ; Marion LEBOYER ; Thomas BOURGERON ; Roberto TORO ; Guillaume DUMAS ; Clara MOREAU ; Richard DELORME in Molecular Autism, 14 (2023)  

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Faux Pas Detection and Intentional Action in Asperger Syndrome. A Replication on a French Sample / Tiziana ZALLA in Journal of Autism and Developmental Disorders, 39-2 (February 2009)  

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Gaze direction detection in autism spectrum disorder / Baudouin FORGEOT D'ARC in Autism, 21-1 (January 2017)  

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Gender differences in autism spectrum disorders: Divergence among specific core symptoms / Anita BEGGIATO in Autism Research, 10-4 (April 2017)  

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La génétique de l'autisme / Richard DELORME in Cerveau & Psycho, 51 (Mai-Juin 2012)

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