Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder / Chanaka N. KAHATHUDUWA in Journal of Autism and Developmental Disorders, 49-12 (December 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.4751-4760 Titre : Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chanaka N. KAHATHUDUWA, Auteur ; B. WEST, Auteur ; A. MASTERGEORGE, Auteur Article en page(s) : p.4751-4760 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Brain  Connectome  Functional neuroimaging  Magnetic resonance imaging  Obesity  Overweight Index. décimale : PER Périodiques Résumé : Evidence on neurophysiological correlates of coexisting autism spectrum disorders (ASD) and overweight/obesity may elucidate mechanisms leading to the observed greater risk of obesity in children with ASD. An exploratory secondary data analysis was performed on resting state functional magnetic resonance imaging (rs-fMRI) data of children downloaded from the ABIDE Preprocessed database (n = 81). Children with isolated ASD showed hypo-connectivity between anterior and posterior default mode network (DMN) (p = 0.003; FWER). Children with coexisting ASD and overweight/obesity showed hyper-connectivity between anterior and posterior DMN (p = 0.015; FWER). More evidence is needed to confirm these contrasting rs-fMRI connectivity profiles and to explicate causal inferences regarding neurophysiological mechanisms associated with coexisting ASD and overweight/obesity. En ligne : http://dx.doi.org/10.1007/s10803-019-04187-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411 [article] Effects of Overweight or Obesity on Brain Resting State Functional Connectivity of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Chanaka N. KAHATHUDUWA, Auteur ; B. WEST, Auteur ; A. MASTERGEORGE, Auteur . - p.4751-4760. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-12 (December 2019) . - p.4751-4760 Mots-clés : Autism spectrum disorder  Brain  Connectome  Functional neuroimaging  Magnetic resonance imaging  Obesity  Overweight Index. décimale : PER Périodiques Résumé : Evidence on neurophysiological correlates of coexisting autism spectrum disorders (ASD) and overweight/obesity may elucidate mechanisms leading to the observed greater risk of obesity in children with ASD. An exploratory secondary data analysis was performed on resting state functional magnetic resonance imaging (rs-fMRI) data of children downloaded from the ABIDE Preprocessed database (n = 81). Children with isolated ASD showed hypo-connectivity between anterior and posterior default mode network (DMN) (p = 0.003; FWER). Children with coexisting ASD and overweight/obesity showed hyper-connectivity between anterior and posterior DMN (p = 0.015; FWER). More evidence is needed to confirm these contrasting rs-fMRI connectivity profiles and to explicate causal inferences regarding neurophysiological mechanisms associated with coexisting ASD and overweight/obesity. En ligne : http://dx.doi.org/10.1007/s10803-019-04187-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411

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