Dépouillements

Editorial : Allostatic load / Dante CICCHETTI in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.723-724 Titre : Editorial : Allostatic load Type de document : Texte imprimé et/ou numérique Auteurs : Dante CICCHETTI, Auteur Année de publication : 2011 Article en page(s) : p.723-724 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579411000277 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Editorial : Allostatic load [Texte imprimé et/ou numérique] / Dante CICCHETTI, Auteur . - 2011 . - p.723-724. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.723-724 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579411000277 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development / Robert-Paul JUSTER in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.725-776 Titre : A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development Type de document : Texte imprimé et/ou numérique Auteurs : Robert-Paul JUSTER, Auteur ; Gustav BIZIK, Auteur ; Martin PICARD, Auteur ; Genevieve ARSENAULT-LAPIERRE, Auteur ; Shireen SINDI, Auteur ; Lyane TREPANIER, Auteur ; Marie-France MARIN, Auteur ; Nathalie WAN, Auteur ; Zoran SEKEROVIC, Auteur ; Catherine LORD, Auteur ; Alexandra J. FIOCCO, Auteur ; Pierrich PLUSQUELLEC, Auteur ; Bruce S. MCEWEN, Auteur ; Sonia J. LUPIEN, Auteur Année de publication : 2011 Article en page(s) : p.725-776 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The allostatic load (AL) model represents an interdisciplinary approach to comprehensively conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle. This article first reviews the AL model, followed by interactions among early adversity, genetics, environmental toxins, as well as distinctions among sex, gender, and sex hormones as integral antecedents of AL. We next explore perspectives on severe mental illness, dementia, and caregiving as unique human models of AL that merit future investigations in the field of developmental psychopathology. A complimenting transdisciplinary perspective is applied throughout, whereby we argue that the AL model goes beyond traditional stress–disease theories toward the advancement of person-centered research and practice that promote not only physical health but also mental health. En ligne : http://dx.doi.org/10.1017/S0954579411000289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development [Texte imprimé et/ou numérique] / Robert-Paul JUSTER, Auteur ; Gustav BIZIK, Auteur ; Martin PICARD, Auteur ; Genevieve ARSENAULT-LAPIERRE, Auteur ; Shireen SINDI, Auteur ; Lyane TREPANIER, Auteur ; Marie-France MARIN, Auteur ; Nathalie WAN, Auteur ; Zoran SEKEROVIC, Auteur ; Catherine LORD, Auteur ; Alexandra J. FIOCCO, Auteur ; Pierrich PLUSQUELLEC, Auteur ; Bruce S. MCEWEN, Auteur ; Sonia J. LUPIEN, Auteur . - 2011 . - p.725-776. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.725-776 Index. décimale : PER Périodiques Résumé : The allostatic load (AL) model represents an interdisciplinary approach to comprehensively conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle. This article first reviews the AL model, followed by interactions among early adversity, genetics, environmental toxins, as well as distinctions among sex, gender, and sex hormones as integral antecedents of AL. We next explore perspectives on severe mental illness, dementia, and caregiving as unique human models of AL that merit future investigations in the field of developmental psychopathology. A complimenting transdisciplinary perspective is applied throughout, whereby we argue that the AL model goes beyond traditional stress–disease theories toward the advancement of person-centered research and practice that promote not only physical health but also mental health. En ligne : http://dx.doi.org/10.1017/S0954579411000289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

The combined effects of prenatal drug exposure and early adversity on neurobehavioral disinhibition in childhood and adolescence / Philip A. FISHER in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.777-788 Titre : The combined effects of prenatal drug exposure and early adversity on neurobehavioral disinhibition in childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Philip A. FISHER, Auteur ; Barry M. LESTER, Auteur ; David S. DEGARMO, Auteur ; Linda L. LAGASSE, Auteur ; Hai LIN, Auteur ; Seetha SHANKARAN, Auteur ; Henrietta S. BADA, Auteur ; Charles R. BAUER, Auteur ; Jane HAMMOND, Auteur ; Toni WHITAKER, Auteur ; Rosemary HIGGINS, Auteur Année de publication : 2011 Article en page(s) : p.777-788 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The negative effects of prenatal substance exposure on neurobiological and psychological development and of early adversity are clear, but little is known about their combined effects. In this study, multilevel analyses of the effects of prenatal substance exposure and early adversity on the emergence of neurobehavioral disinhibition in adolescence were conducted. Neurobehavioral disinhibition has previously been observed to occur frequently in multiproblem youth from high-risk backgrounds. In the present study, neurobehavioral disinhibition was assessed via behavioral dysregulation and poor executive function composite measures. Data were drawn from a prospective longitudinal investigation of prenatal substance exposure that included 1,073 participants followed from birth through adolescence. The results from latent growth modeling analyses showed mean stability but significant individual differences in behavioral dysregulation and mean decline with individual differences in executive function difficulties. Prior behavioral dysregulation predicted increased executive function difficulties. Prenatal drug use predicted the emergence and growth in neurobehavioral disinhibition across adolescence (directly for behavioral dysregulation and indirectly for executive function difficulties via early adversity and behavioral dysregulation). Prenatal drug use and early adversity exhibited unique effects on growth in behavioral dysregulation; early adversity uniquely predicted executive function difficulties. These results are discussed in terms of implications for theory development, social policy, and prevention science. En ligne : http://dx.doi.org/10.1017/S0954579411000290 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] The combined effects of prenatal drug exposure and early adversity on neurobehavioral disinhibition in childhood and adolescence [Texte imprimé et/ou numérique] / Philip A. FISHER, Auteur ; Barry M. LESTER, Auteur ; David S. DEGARMO, Auteur ; Linda L. LAGASSE, Auteur ; Hai LIN, Auteur ; Seetha SHANKARAN, Auteur ; Henrietta S. BADA, Auteur ; Charles R. BAUER, Auteur ; Jane HAMMOND, Auteur ; Toni WHITAKER, Auteur ; Rosemary HIGGINS, Auteur . - 2011 . - p.777-788. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.777-788 Index. décimale : PER Périodiques Résumé : The negative effects of prenatal substance exposure on neurobiological and psychological development and of early adversity are clear, but little is known about their combined effects. In this study, multilevel analyses of the effects of prenatal substance exposure and early adversity on the emergence of neurobehavioral disinhibition in adolescence were conducted. Neurobehavioral disinhibition has previously been observed to occur frequently in multiproblem youth from high-risk backgrounds. In the present study, neurobehavioral disinhibition was assessed via behavioral dysregulation and poor executive function composite measures. Data were drawn from a prospective longitudinal investigation of prenatal substance exposure that included 1,073 participants followed from birth through adolescence. The results from latent growth modeling analyses showed mean stability but significant individual differences in behavioral dysregulation and mean decline with individual differences in executive function difficulties. Prior behavioral dysregulation predicted increased executive function difficulties. Prenatal drug use predicted the emergence and growth in neurobehavioral disinhibition across adolescence (directly for behavioral dysregulation and indirectly for executive function difficulties via early adversity and behavioral dysregulation). Prenatal drug use and early adversity exhibited unique effects on growth in behavioral dysregulation; early adversity uniquely predicted executive function difficulties. These results are discussed in terms of implications for theory development, social policy, and prevention science. En ligne : http://dx.doi.org/10.1017/S0954579411000290 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Normalizing the development of cortisol regulation in maltreated infants through preventive interventions / Dante CICCHETTI in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.789-800 Titre : Normalizing the development of cortisol regulation in maltreated infants through preventive interventions Type de document : Texte imprimé et/ou numérique Auteurs : Dante CICCHETTI, Auteur ; Fred A. ROGOSCH, Auteur ; Sheree L. TOTH, Auteur ; Melissa L. STURGE-APPLE, Auteur Année de publication : 2011 Article en page(s) : p.789-800 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Longitudinal effects of child maltreatment on cortisol regulation in infants from age 1 to 3 years were investigated in the context of a randomized preventive intervention trial. Thirteen-month-old infants from maltreating families (N = 91) and their mothers were randomly assigned to one of three intervention conditions: child–parent psychotherapy, psychoeducational parenting intervention, and a control group involving standard community services (CS). A fourth group of infants from nonmaltreating families (N = 52) and their mothers comprised a nonmaltreated comparison (NC) group. The two active interventions were combined into one maltreated intervention (MI) group for statistical analyses. Saliva samples were obtained from children at 10:00 a.m. before beginning a laboratory observation session with their mothers when the children were 13 months of age (preintervention), 19 months (midintervention), 26 months (postintervention), and 38 months (1-year postintervention follow-up). At the initial assessment, no significant differences among groups in morning cortisol were observed. Latent growth curve analyses examined trajectories of cortisol regulation over time. Beginning at midintervention, divergence was found among the groups. Whereas the MI group remained indistinguishable from the NC group across time, the CS group progressively evinced lower levels of morning cortisol, statistically differing from the MI and NC groups. Results highlight the value of psychosocial interventions for early child maltreatment in normalizing biological regulatory processes. En ligne : http://dx.doi.org/10.1017/S0954579411000307 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Normalizing the development of cortisol regulation in maltreated infants through preventive interventions [Texte imprimé et/ou numérique] / Dante CICCHETTI, Auteur ; Fred A. ROGOSCH, Auteur ; Sheree L. TOTH, Auteur ; Melissa L. STURGE-APPLE, Auteur . - 2011 . - p.789-800. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.789-800 Index. décimale : PER Périodiques Résumé : Longitudinal effects of child maltreatment on cortisol regulation in infants from age 1 to 3 years were investigated in the context of a randomized preventive intervention trial. Thirteen-month-old infants from maltreating families (N = 91) and their mothers were randomly assigned to one of three intervention conditions: child–parent psychotherapy, psychoeducational parenting intervention, and a control group involving standard community services (CS). A fourth group of infants from nonmaltreating families (N = 52) and their mothers comprised a nonmaltreated comparison (NC) group. The two active interventions were combined into one maltreated intervention (MI) group for statistical analyses. Saliva samples were obtained from children at 10:00 a.m. before beginning a laboratory observation session with their mothers when the children were 13 months of age (preintervention), 19 months (midintervention), 26 months (postintervention), and 38 months (1-year postintervention follow-up). At the initial assessment, no significant differences among groups in morning cortisol were observed. Latent growth curve analyses examined trajectories of cortisol regulation over time. Beginning at midintervention, divergence was found among the groups. Whereas the MI group remained indistinguishable from the NC group across time, the CS group progressively evinced lower levels of morning cortisol, statistically differing from the MI and NC groups. Results highlight the value of psychosocial interventions for early child maltreatment in normalizing biological regulatory processes. En ligne : http://dx.doi.org/10.1017/S0954579411000307 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Interparental aggression and children's adrenocortical reactivity: Testing an evolutionary model of allostatic load / Patrick T. DAVIES in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.801-814 Titre : Interparental aggression and children's adrenocortical reactivity: Testing an evolutionary model of allostatic load Type de document : Texte imprimé et/ou numérique Auteurs : Patrick T. DAVIES, Auteur ; Melissa L. STURGE-APPLE, Auteur ; Dante CICCHETTI, Auteur Année de publication : 2011 Article en page(s) : p.801-814 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Guided by an evolutionary model of allostatic load, this study examined the hypothesis that the association between interparental aggression and subsequent changes in children's cortisol reactivity to interparental conflict is moderated by their temperamental dispositions. Participants of the multimethod, longitudinal study included 201 2-year-old toddlers and their mothers. These children experienced elevated levels of aggression between parents. Consistent with the theory, the results indicated that interparental aggression predicted greater cortisol reactivity over a 1-year period for children who exhibited high levels of temperamental inhibition and vigilance. Conversely, for children with bold, aggressive temperamental characteristics, interparental aggression was marginally associated with diminished cortisol reactivity. Further underscoring its implications for allostatic load, increasing cortisol reactivity over the one year span was related to concomitant increases in internalizing symptoms but decreases in attention and hyperactivity difficulties. In supporting the evolutionary conceptualization, these results further supported the relative developmental advantages and costs associated with escalating and dampened cortisol reactivity to interparental conflict. En ligne : http://dx.doi.org/10.1017/S0954579411000319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Interparental aggression and children's adrenocortical reactivity: Testing an evolutionary model of allostatic load [Texte imprimé et/ou numérique] / Patrick T. DAVIES, Auteur ; Melissa L. STURGE-APPLE, Auteur ; Dante CICCHETTI, Auteur . - 2011 . - p.801-814. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.801-814 Index. décimale : PER Périodiques Résumé : Guided by an evolutionary model of allostatic load, this study examined the hypothesis that the association between interparental aggression and subsequent changes in children's cortisol reactivity to interparental conflict is moderated by their temperamental dispositions. Participants of the multimethod, longitudinal study included 201 2-year-old toddlers and their mothers. These children experienced elevated levels of aggression between parents. Consistent with the theory, the results indicated that interparental aggression predicted greater cortisol reactivity over a 1-year period for children who exhibited high levels of temperamental inhibition and vigilance. Conversely, for children with bold, aggressive temperamental characteristics, interparental aggression was marginally associated with diminished cortisol reactivity. Further underscoring its implications for allostatic load, increasing cortisol reactivity over the one year span was related to concomitant increases in internalizing symptoms but decreases in attention and hyperactivity difficulties. In supporting the evolutionary conceptualization, these results further supported the relative developmental advantages and costs associated with escalating and dampened cortisol reactivity to interparental conflict. En ligne : http://dx.doi.org/10.1017/S0954579411000319 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Marital conflict, respiratory sinus arrhythmia, and allostatic load: Interrelations and associations with the development of children's externalizing behavior / Mona EL-SHEIKH in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.815-829 Titre : Marital conflict, respiratory sinus arrhythmia, and allostatic load: Interrelations and associations with the development of children's externalizing behavior Type de document : Texte imprimé et/ou numérique Auteurs : Mona EL-SHEIKH, Auteur ; J. Benjamin HINNANT, Auteur Année de publication : 2011 Article en page(s) : p.815-829 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Allostatic load theory hypothesizes that stress and the body's responses to stressors contribute to longer term physiological changes in multiple systems over time (allostasis), and that shifts in how these systems function have implications for adjustment and health. We investigated these hypotheses with longitudinal data from two independent samples (n = 413; 219 girls, 194 boys) with repeated measures at ages 8, 9, 10, and 11. Initial parental marital conflict and its change over time indexed children's exposure to an important familial stressor, which was examined in interaction with children's respiratory sinus arrhythmia (RSA) reactivity to laboratory tasks (stress response) to predict children's basal levels of RSA over time. We also investigated children's sex as an additional possible moderator. Our second research question focused on examining whether initial levels and changes in resting RSA over time predicted children's externalizing behavior. Boys with a strong RSA suppression response to a frustrating laboratory task who experienced higher initial marital conflict or increasing marital conflict over time showed decreases in their resting RSA over time. In addition, boys' initial resting RSA (but not changes in resting RSA over time) was negatively related to change over time in externalizing symptoms. Findings for girls were more mixed. Results are discussed in the context of developmental psychobiology, allostatic load, and implications for the development of psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579411000320 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Marital conflict, respiratory sinus arrhythmia, and allostatic load: Interrelations and associations with the development of children's externalizing behavior [Texte imprimé et/ou numérique] / Mona EL-SHEIKH, Auteur ; J. Benjamin HINNANT, Auteur . - 2011 . - p.815-829. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.815-829 Index. décimale : PER Périodiques Résumé : Allostatic load theory hypothesizes that stress and the body's responses to stressors contribute to longer term physiological changes in multiple systems over time (allostasis), and that shifts in how these systems function have implications for adjustment and health. We investigated these hypotheses with longitudinal data from two independent samples (n = 413; 219 girls, 194 boys) with repeated measures at ages 8, 9, 10, and 11. Initial parental marital conflict and its change over time indexed children's exposure to an important familial stressor, which was examined in interaction with children's respiratory sinus arrhythmia (RSA) reactivity to laboratory tasks (stress response) to predict children's basal levels of RSA over time. We also investigated children's sex as an additional possible moderator. Our second research question focused on examining whether initial levels and changes in resting RSA over time predicted children's externalizing behavior. Boys with a strong RSA suppression response to a frustrating laboratory task who experienced higher initial marital conflict or increasing marital conflict over time showed decreases in their resting RSA over time. In addition, boys' initial resting RSA (but not changes in resting RSA over time) was negatively related to change over time in externalizing symptoms. Findings for girls were more mixed. Results are discussed in the context of developmental psychobiology, allostatic load, and implications for the development of psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579411000320 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

The impact of allostatic load on maternal sympathovagal functioning in stressful child contexts: Implications for problematic parenting / Melissa L. STURGE-APPLE in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.831-844 Titre : The impact of allostatic load on maternal sympathovagal functioning in stressful child contexts: Implications for problematic parenting Type de document : Texte imprimé et/ou numérique Auteurs : Melissa L. STURGE-APPLE, Auteur ; Michael A. SKIBO, Auteur ; Fred A. ROGOSCH, Auteur ; Zeljko IGNJATOVIC, Auteur ; Wendi HEINZELMAN, Auteur Année de publication : 2011 Article en page(s) : p.831-844 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The present study applies an allostatic load framework to an examination of the relationship between maternal psychosocial risk factors and maladaptive parenting behaviors. Specifically, the implications of low socioeconomic status and maternal depressive symptoms for maternal sympathovagal functioning during young children's distress were examined, as well as whether that functioning was, in turn, associated with maternal insensitivity, hostility, intrusiveness, and disengagement during mother–child dyadic interaction. Consistent with an allostatic framework, three patterns of sympathovagal functioning were expected to emerge: normative arousal, hyperarousal, and hypoarousal profiles. Furthermore, meaningful associations between maternal psychosocial risk factors, maladaptive parenting behaviors, and the three profiles of sympathovagal functioning were anticipated. Participants included 153 mother–toddler dyads recruited proportionately from lower and middle socioeconomic status backgrounds. Mothers’ sympathovagal response to their child's distress was assessed during the Strange Situation paradigm, and mothers’ parenting behavior was assessed during a dyadic free-play interaction. As hypothesized, normative arousal, hyperarousal, and hypoarousal profiles of maternal sympathovagal functioning were identified. Maternal depressive symptomatology predicted the hyperarousal profile, whereas socioeconomic adversity predicted hypoarousal. Moreover, allostatic load profiles were differentially associated with problematic parenting behaviors. These findings underscore the role of physiological dysregulation as a mechanism in the relationship between proximal risk factors and actual maladaptive parenting behaviors. En ligne : http://dx.doi.org/10.1017/S0954579411000332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] The impact of allostatic load on maternal sympathovagal functioning in stressful child contexts: Implications for problematic parenting [Texte imprimé et/ou numérique] / Melissa L. STURGE-APPLE, Auteur ; Michael A. SKIBO, Auteur ; Fred A. ROGOSCH, Auteur ; Zeljko IGNJATOVIC, Auteur ; Wendi HEINZELMAN, Auteur . - 2011 . - p.831-844. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.831-844 Index. décimale : PER Périodiques Résumé : The present study applies an allostatic load framework to an examination of the relationship between maternal psychosocial risk factors and maladaptive parenting behaviors. Specifically, the implications of low socioeconomic status and maternal depressive symptoms for maternal sympathovagal functioning during young children's distress were examined, as well as whether that functioning was, in turn, associated with maternal insensitivity, hostility, intrusiveness, and disengagement during mother–child dyadic interaction. Consistent with an allostatic framework, three patterns of sympathovagal functioning were expected to emerge: normative arousal, hyperarousal, and hypoarousal profiles. Furthermore, meaningful associations between maternal psychosocial risk factors, maladaptive parenting behaviors, and the three profiles of sympathovagal functioning were anticipated. Participants included 153 mother–toddler dyads recruited proportionately from lower and middle socioeconomic status backgrounds. Mothers’ sympathovagal response to their child's distress was assessed during the Strange Situation paradigm, and mothers’ parenting behavior was assessed during a dyadic free-play interaction. As hypothesized, normative arousal, hyperarousal, and hypoarousal profiles of maternal sympathovagal functioning were identified. Maternal depressive symptomatology predicted the hyperarousal profile, whereas socioeconomic adversity predicted hypoarousal. Moreover, allostatic load profiles were differentially associated with problematic parenting behaviors. These findings underscore the role of physiological dysregulation as a mechanism in the relationship between proximal risk factors and actual maladaptive parenting behaviors. En ligne : http://dx.doi.org/10.1017/S0954579411000332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Allostasis and allostatic load in the context of poverty in early childhood / Clancy BLAIR in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.845-857 Titre : Allostasis and allostatic load in the context of poverty in early childhood Type de document : Texte imprimé et/ou numérique Auteurs : Clancy BLAIR, Auteur ; C. Cybele RAVER, Auteur ; Douglas A. GRANGER, Auteur ; W. Roger MILLS-KOONCE, Auteur ; Leah C. HIBEL, Auteur ; THE FAMILY LIFE PROJECT KEY INVESTIGATORS, Auteur Année de publication : 2011 Article en page(s) : p.845-857 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This paper examined the relation of early environmental adversity associated with poverty to child resting or basal level of cortisol in a prospective longitudinal sample of 1135 children seen at 7, 15, 24, 35, and 48 months of age. We found main effects for poor housing quality, African American ethnicity, and low positive caregiving behavior in which each was uniquely associated with an overall higher level of cortisol from age 7 to 48 months. We also found that two aspects of the early environment in the context of poverty, adult exits from the home and perceived economic insufficiency, were related to salivary cortisol in a time-dependent manner. The effect for the first of these, exits from the home, was consistent with the principle of allostatic load in which the effects of adversity on stress physiology accumulate over time. The effect for perceived economic insufficiency was one in which insufficiency was associated with higher levels of cortisol in infancy but with a typical but steeper decline in cortisol with age at subsequent time points. En ligne : http://dx.doi.org/10.1017/S0954579411000344 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Allostasis and allostatic load in the context of poverty in early childhood [Texte imprimé et/ou numérique] / Clancy BLAIR, Auteur ; C. Cybele RAVER, Auteur ; Douglas A. GRANGER, Auteur ; W. Roger MILLS-KOONCE, Auteur ; Leah C. HIBEL, Auteur ; THE FAMILY LIFE PROJECT KEY INVESTIGATORS, Auteur . - 2011 . - p.845-857. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.845-857 Index. décimale : PER Périodiques Résumé : This paper examined the relation of early environmental adversity associated with poverty to child resting or basal level of cortisol in a prospective longitudinal sample of 1135 children seen at 7, 15, 24, 35, and 48 months of age. We found main effects for poor housing quality, African American ethnicity, and low positive caregiving behavior in which each was uniquely associated with an overall higher level of cortisol from age 7 to 48 months. We also found that two aspects of the early environment in the context of poverty, adult exits from the home and perceived economic insufficiency, were related to salivary cortisol in a time-dependent manner. The effect for the first of these, exits from the home, was consistent with the principle of allostatic load in which the effects of adversity on stress physiology accumulate over time. The effect for perceived economic insufficiency was one in which insufficiency was associated with higher levels of cortisol in infancy but with a typical but steeper decline in cortisol with age at subsequent time points. En ligne : http://dx.doi.org/10.1017/S0954579411000344 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Growth delay as an index of allostatic load in young children: Predictions to disinhibited social approach and diurnal cortisol activity / Anna E. JOHNSON in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.859-871 Titre : Growth delay as an index of allostatic load in young children: Predictions to disinhibited social approach and diurnal cortisol activity Type de document : Texte imprimé et/ou numérique Auteurs : Anna E. JOHNSON, Auteur ; Jacqueline BRUCE, Auteur ; Amanda R. TARULLO, Auteur ; Megan R. GUNNAR, Auteur Année de publication : 2011 Article en page(s) : p.859-871 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The goal of this study was to examine whether growth delay can serve as an index of allostatic load during early development, as it is well known that the activity of stress-mediating systems inhibits growth. The participants were children adopted internationally from institutional care (n = 36), children adopted internationally from foster care (n = 26), and nonadopted children (n = 35). For the adopted children, height for age and weight for height were assessed at adoption; for all children, disinhibited social approach (DSA; termed elsewhere as “indiscriminate friendliness”) and diurnal cortisol were assessed at 6–8 years (M = 6.9 years). For internationally adopted children in general, and postinstitutionalized children specifically, linear growth delay assessed at the time of adoption was associated with more dysregulated behavior in response to an unfamiliar adult (i.e., greater DSA) and a more dysregulated diurnal cortisol rhythm (i.e., higher late afternoon and evening values). Further, among the most growth-delayed children, higher cortisol levels later in the day were correlated with DSA. The potential for using growth delay as an allostatic load indicator and the possible problems and limitations in its use in child populations are discussed. En ligne : http://dx.doi.org/10.1017/S0954579411000356 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Growth delay as an index of allostatic load in young children: Predictions to disinhibited social approach and diurnal cortisol activity [Texte imprimé et/ou numérique] / Anna E. JOHNSON, Auteur ; Jacqueline BRUCE, Auteur ; Amanda R. TARULLO, Auteur ; Megan R. GUNNAR, Auteur . - 2011 . - p.859-871. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.859-871 Index. décimale : PER Périodiques Résumé : The goal of this study was to examine whether growth delay can serve as an index of allostatic load during early development, as it is well known that the activity of stress-mediating systems inhibits growth. The participants were children adopted internationally from institutional care (n = 36), children adopted internationally from foster care (n = 26), and nonadopted children (n = 35). For the adopted children, height for age and weight for height were assessed at adoption; for all children, disinhibited social approach (DSA; termed elsewhere as “indiscriminate friendliness”) and diurnal cortisol were assessed at 6–8 years (M = 6.9 years). For internationally adopted children in general, and postinstitutionalized children specifically, linear growth delay assessed at the time of adoption was associated with more dysregulated behavior in response to an unfamiliar adult (i.e., greater DSA) and a more dysregulated diurnal cortisol rhythm (i.e., higher late afternoon and evening values). Further, among the most growth-delayed children, higher cortisol levels later in the day were correlated with DSA. The potential for using growth delay as an allostatic load indicator and the possible problems and limitations in its use in child populations are discussed. En ligne : http://dx.doi.org/10.1017/S0954579411000356 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Maternal responsiveness moderates the relationship between allostatic load and working memory / Stacey N. DOAN in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.873-880 Titre : Maternal responsiveness moderates the relationship between allostatic load and working memory Type de document : Texte imprimé et/ou numérique Auteurs : Stacey N. DOAN, Auteur ; Gary W. EVANS, Auteur Année de publication : 2011 Article en page(s) : p.873-880 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A substantial amount of research has demonstrated the deleterious effects of chronic stress on memory. However, much less is known about protective factors. In the current study we test the role of maternal responsiveness in buffering the effects of childhood allostatic load on subsequent adolescent working memory. Allostatic load is a marker of cumulative stress on the body that is caused by mobilization of multiple physiological systems in response to chronic environmental demands. Results of the study suggest that allostatic load negatively affects working memory, but that this effect is significantly attenuated in children with responsive mothers. En ligne : http://dx.doi.org/10.1017/S0954579411000368 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Maternal responsiveness moderates the relationship between allostatic load and working memory [Texte imprimé et/ou numérique] / Stacey N. DOAN, Auteur ; Gary W. EVANS, Auteur . - 2011 . - p.873-880. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.873-880 Index. décimale : PER Périodiques Résumé : A substantial amount of research has demonstrated the deleterious effects of chronic stress on memory. However, much less is known about protective factors. In the current study we test the role of maternal responsiveness in buffering the effects of childhood allostatic load on subsequent adolescent working memory. Allostatic load is a marker of cumulative stress on the body that is caused by mobilization of multiple physiological systems in response to chronic environmental demands. Results of the study suggest that allostatic load negatively affects working memory, but that this effect is significantly attenuated in children with responsive mothers. En ligne : http://dx.doi.org/10.1017/S0954579411000368 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Hypocortisolism as a potential marker of allostatic load in children: Associations with family risk and internalizing disorders / Lisa S. BADANES in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.881-896 Titre : Hypocortisolism as a potential marker of allostatic load in children: Associations with family risk and internalizing disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lisa S. BADANES, Auteur ; Sarah E. WATAMURA, Auteur ; Benjamin L. HANKIN, Auteur Année de publication : 2011 Article en page(s) : p.881-896 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although the majority of research attention to the hypothalamic–pituitary–adrenal (HPA) axis in stress-related disorders and as a marker of allostatic load has focused on overactivation of this stress system, theory and data clearly indicate that underactivation is also an important type of dysregulation. In the current study we focused on low cortisol, exploring a constellation of risk factors including stress exposure, maternal depression, and attenuated basal and stress reactive cortisol in two samples of children. The first sample was comprised of 110 preschoolers living in high-stress environments. Cortisol was assessed across the day at home and at child care as well as across two stress paradigms. These data were used to classify whether children's HPA axis activity was attenuated. Serious family financial strain, maternal depression, and attenuated cortisol all made unique contributions in models predicting current clinical levels of internalizing symptoms as rated by mothers and teachers. The second sample was 166 third, sixth, and ninth graders studied five times across a 1-year period. Maternal and child depression were determined through structured clinical interviews, and stress exposure was assessed via checklist and interview techniques with the child and parent. Cortisol was assessed multiple times across a lab visit at Time 1, and these data were combined into a single continuous measure. Cortisol concentrations across the lab visit interacted with stress exposure across the year such that children with lower average cortisol at Time 1 and increased stress across the 12 months showed elevated levels of internalizing symptoms. Based on these and related data we propose that prior to puberty low cortisol may be an important marker of allostatic load, particularly for risk of depression and anxiety. En ligne : http://dx.doi.org/10.1017/S095457941100037X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Hypocortisolism as a potential marker of allostatic load in children: Associations with family risk and internalizing disorders [Texte imprimé et/ou numérique] / Lisa S. BADANES, Auteur ; Sarah E. WATAMURA, Auteur ; Benjamin L. HANKIN, Auteur . - 2011 . - p.881-896. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.881-896 Index. décimale : PER Périodiques Résumé : Although the majority of research attention to the hypothalamic–pituitary–adrenal (HPA) axis in stress-related disorders and as a marker of allostatic load has focused on overactivation of this stress system, theory and data clearly indicate that underactivation is also an important type of dysregulation. In the current study we focused on low cortisol, exploring a constellation of risk factors including stress exposure, maternal depression, and attenuated basal and stress reactive cortisol in two samples of children. The first sample was comprised of 110 preschoolers living in high-stress environments. Cortisol was assessed across the day at home and at child care as well as across two stress paradigms. These data were used to classify whether children's HPA axis activity was attenuated. Serious family financial strain, maternal depression, and attenuated cortisol all made unique contributions in models predicting current clinical levels of internalizing symptoms as rated by mothers and teachers. The second sample was 166 third, sixth, and ninth graders studied five times across a 1-year period. Maternal and child depression were determined through structured clinical interviews, and stress exposure was assessed via checklist and interview techniques with the child and parent. Cortisol was assessed multiple times across a lab visit at Time 1, and these data were combined into a single continuous measure. Cortisol concentrations across the lab visit interacted with stress exposure across the year such that children with lower average cortisol at Time 1 and increased stress across the 12 months showed elevated levels of internalizing symptoms. Based on these and related data we propose that prior to puberty low cortisol may be an important marker of allostatic load, particularly for risk of depression and anxiety. En ligne : http://dx.doi.org/10.1017/S095457941100037X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Social encounters in daily life and 2-year changes in metabolic risk factors in young women / Kharah ROSS in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.897-906 Titre : Social encounters in daily life and 2-year changes in metabolic risk factors in young women Type de document : Texte imprimé et/ou numérique Auteurs : Kharah ROSS, Auteur ; Tara MARTIN, Auteur ; Edith CHEN, Auteur ; Gregory E. MILLER, Auteur Année de publication : 2011 Article en page(s) : p.897-906 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Research shows that poor social ties increase risks of morbidity and mortality from cardiovascular disease (CVD). However, little is known about the nature of everyday social encounters that give rise to this association, or when in the course of development they begin to shape disease-relevant biological processes. In this study, 122 adolescent females recorded the qualities of their everyday social interactions using electronic diaries. At the same time we measured components of the metabolic syndrome, a precursor to CVD that includes central adiposity, high blood pressure, insulin resistance, and lipid dysregulation. Metabolic symptoms were reassessed 12 and 24 months later. Hierarchical linear modeling revealed an association between negative social interactions and metabolic symptom trajectories. To the extent that participants had more intense negative social encounters in daily life, they showed increasing scores on a composite indicator of metabolic risk over 2 years. This association was independent of a variety of potential confounders, and persisted when symptoms of depression and broader personality traits were controlled. There was no association between positive social encounters and metabolic risk trajectories. These findings suggest that even in otherwise healthy adolescents, abrasive social encounters may accelerate the progression of early stages of CVD. En ligne : http://dx.doi.org/10.1017/S0954579411000381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Social encounters in daily life and 2-year changes in metabolic risk factors in young women [Texte imprimé et/ou numérique] / Kharah ROSS, Auteur ; Tara MARTIN, Auteur ; Edith CHEN, Auteur ; Gregory E. MILLER, Auteur . - 2011 . - p.897-906. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.897-906 Index. décimale : PER Périodiques Résumé : Research shows that poor social ties increase risks of morbidity and mortality from cardiovascular disease (CVD). However, little is known about the nature of everyday social encounters that give rise to this association, or when in the course of development they begin to shape disease-relevant biological processes. In this study, 122 adolescent females recorded the qualities of their everyday social interactions using electronic diaries. At the same time we measured components of the metabolic syndrome, a precursor to CVD that includes central adiposity, high blood pressure, insulin resistance, and lipid dysregulation. Metabolic symptoms were reassessed 12 and 24 months later. Hierarchical linear modeling revealed an association between negative social interactions and metabolic symptom trajectories. To the extent that participants had more intense negative social encounters in daily life, they showed increasing scores on a composite indicator of metabolic risk over 2 years. This association was independent of a variety of potential confounders, and persisted when symptoms of depression and broader personality traits were controlled. There was no association between positive social encounters and metabolic risk trajectories. These findings suggest that even in otherwise healthy adolescents, abrasive social encounters may accelerate the progression of early stages of CVD. En ligne : http://dx.doi.org/10.1017/S0954579411000381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

What can allostasis tell us about anabolic–androgenic steroid addiction? / Tom HILDEBRANDT in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.907-919 Titre : What can allostasis tell us about anabolic–androgenic steroid addiction? Type de document : Texte imprimé et/ou numérique Auteurs : Tom HILDEBRANDT, Auteur ; Rachel YEHUDA, Auteur ; Lauren ALFANO, Auteur Année de publication : 2011 Article en page(s) : p.907-919 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Anabolic–androgenic steroids (AASs) are synthetic hormones used by individuals who want to look better or perform better in athletics and at the gym. Their use raises an interesting paradox in which drug use is associated with a number of health benefits, but also the possibility of negative health consequences. Existing models of AAS addiction follow the traditional framework of drug abuse and dependence, which suggest that harmful use occurs as a result of the drug's ability to hijack the motivation–reward system. However, AASs, unlike typical drugs of abuse, are not used for acute intoxication effects or euphoria. Rather, AASs are used to affect the body through changes to the musculoskeletal system and the hypothalamic–pituitary–gonadal axis as opposed to stimulating the reward system. We offer an allostatic model of AAS addiction to resolve this inconsistency between traditional drug addiction and AAS addiction. This allostatic framework provides a way to (a) incorporate exercise into AAS misuse, (b) identify where AAS use transitions from recreational use into a drug problem, and (c) describe individual differences in vulnerability or resilience to AASs. Implications for this model of AAS addiction are discussed. En ligne : http://dx.doi.org/10.1017/S0954579411000393 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] What can allostasis tell us about anabolic–androgenic steroid addiction? [Texte imprimé et/ou numérique] / Tom HILDEBRANDT, Auteur ; Rachel YEHUDA, Auteur ; Lauren ALFANO, Auteur . - 2011 . - p.907-919. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.907-919 Index. décimale : PER Périodiques Résumé : Anabolic–androgenic steroids (AASs) are synthetic hormones used by individuals who want to look better or perform better in athletics and at the gym. Their use raises an interesting paradox in which drug use is associated with a number of health benefits, but also the possibility of negative health consequences. Existing models of AAS addiction follow the traditional framework of drug abuse and dependence, which suggest that harmful use occurs as a result of the drug's ability to hijack the motivation–reward system. However, AASs, unlike typical drugs of abuse, are not used for acute intoxication effects or euphoria. Rather, AASs are used to affect the body through changes to the musculoskeletal system and the hypothalamic–pituitary–gonadal axis as opposed to stimulating the reward system. We offer an allostatic model of AAS addiction to resolve this inconsistency between traditional drug addiction and AAS addiction. This allostatic framework provides a way to (a) incorporate exercise into AAS misuse, (b) identify where AAS use transitions from recreational use into a drug problem, and (c) describe individual differences in vulnerability or resilience to AASs. Implications for this model of AAS addiction are discussed. En ligne : http://dx.doi.org/10.1017/S0954579411000393 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Allostatic processes in the family / Rena L. REPETTI in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.921-938 Titre : Allostatic processes in the family Type de document : Texte imprimé et/ou numérique Auteurs : Rena L. REPETTI, Auteur ; Theodore F. ROBLES, Auteur ; Bridget REYNOLDS, Auteur Année de publication : 2011 Article en page(s) : p.921-938 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The concepts of allostatic load and allostatic processes can help psychologists understand how health trajectories are influenced by stressful childhood experiences in the family. This paper describes psychological pathways and two key allostatic mediators, the hypothalamic–pituitary–adrenal axis and the immune system, through which stressful early rearing conditions may influence adult mental and physical health. The action of meshed gears is introduced as a metaphor to illustrate how responses occurring within a brief time frame, for example, immediate reactions to stressors, can influence developmental and health processes unfolding over much longer spans of time. We identify early-developing psychological and biological response patterns that could link chronic stressors in childhood to later health outcomes. Some of these “precursor outcomes” (e.g., heightened vigilance and preparedness for threats; enhanced inflammatory and humoral responses to infectious microorganisms) appear to be aimed at protection from immediate dangers; they may reflect “adaptive trade-offs” that balance short-term survival advantages under harsh rearing conditions against disadvantages manifested later in development. Our analysis also suggests mechanisms that underlie resilience in risky family environments. En ligne : http://dx.doi.org/10.1017/S095457941100040X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Allostatic processes in the family [Texte imprimé et/ou numérique] / Rena L. REPETTI, Auteur ; Theodore F. ROBLES, Auteur ; Bridget REYNOLDS, Auteur . - 2011 . - p.921-938. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.921-938 Index. décimale : PER Périodiques Résumé : The concepts of allostatic load and allostatic processes can help psychologists understand how health trajectories are influenced by stressful childhood experiences in the family. This paper describes psychological pathways and two key allostatic mediators, the hypothalamic–pituitary–adrenal axis and the immune system, through which stressful early rearing conditions may influence adult mental and physical health. The action of meshed gears is introduced as a metaphor to illustrate how responses occurring within a brief time frame, for example, immediate reactions to stressors, can influence developmental and health processes unfolding over much longer spans of time. We identify early-developing psychological and biological response patterns that could link chronic stressors in childhood to later health outcomes. Some of these “precursor outcomes” (e.g., heightened vigilance and preparedness for threats; enhanced inflammatory and humoral responses to infectious microorganisms) appear to be aimed at protection from immediate dangers; they may reflect “adaptive trade-offs” that balance short-term survival advantages under harsh rearing conditions against disadvantages manifested later in development. Our analysis also suggests mechanisms that underlie resilience in risky family environments. En ligne : http://dx.doi.org/10.1017/S095457941100040X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Early adversity and adult health outcomes / Shelley E. TAYLOR in Development and Psychopathology, 23-3 (August 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-3 (August 2011) . - p.939-954 Titre : Early adversity and adult health outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Shelley E. TAYLOR, Auteur ; Baldwin M. WAY, Auteur ; Teresa E. SEEMAN, Auteur Année de publication : 2011 Article en page(s) : p.939-954 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Adversity in childhood has effects on mental and physical health, not only in childhood but across the lifespan. A chief task of our research has been to define the pathways by which childhood experience has these surprising health outcomes, often decades later. The concept of allostatic load, which refers to dysregulations across major biological regulatory systems that have cumulative interacting adverse effects over time, provides a mechanism for understanding these relations and defining specific pathways. To chart these pathways, we examine early childhood socioeconomic status, family environment, and genetic predispositions as antecedents to socioemotional functioning/psychological distress; and neural responses to threat that have downstream effects on major stress regulatory systems, ultimately culminating in risks to mental and physical health outcomes. This integrative approach to investigating the impact of childhood experience on adult health outcomes illustrates the significance of multilevel integrative approaches to understanding developmental psychopathology more generally. En ligne : http://dx.doi.org/10.1017/S0954579411000411 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Early adversity and adult health outcomes [Texte imprimé et/ou numérique] / Shelley E. TAYLOR, Auteur ; Baldwin M. WAY, Auteur ; Teresa E. SEEMAN, Auteur . - 2011 . - p.939-954. Langues : Anglais (eng) in Development and Psychopathology > 23-3 (August 2011) . - p.939-954 Index. décimale : PER Périodiques Résumé : Adversity in childhood has effects on mental and physical health, not only in childhood but across the lifespan. A chief task of our research has been to define the pathways by which childhood experience has these surprising health outcomes, often decades later. The concept of allostatic load, which refers to dysregulations across major biological regulatory systems that have cumulative interacting adverse effects over time, provides a mechanism for understanding these relations and defining specific pathways. To chart these pathways, we examine early childhood socioeconomic status, family environment, and genetic predispositions as antecedents to socioemotional functioning/psychological distress; and neural responses to threat that have downstream effects on major stress regulatory systems, ultimately culminating in risks to mental and physical health outcomes. This integrative approach to investigating the impact of childhood experience on adult health outcomes illustrates the significance of multilevel integrative approaches to understanding developmental psychopathology more generally. En ligne : http://dx.doi.org/10.1017/S0954579411000411 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132