Intention Attribution in Children and Adolescents with Autism Spectrum Disorder: An EEG Study / Magdalena SCHÃœTZ in Journal of Autism and Developmental Disorders, 53-4 (April 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1431-1443 Titre : Intention Attribution in Children and Adolescents with Autism Spectrum Disorder: An EEG Study Type de document : texte imprimé Auteurs : Magdalena SCHÃœTZ, Auteur ; Sara BOXHOORN, Auteur ; Andreas M. MÃœHLHERR, Auteur ; Hannah MÖSSINGER, Auteur ; Christine M. FREITAG, Auteur ; Christina LUCKHARDT, Auteur Article en page(s) : p.1431-1443 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The ability to infer intentions from observed behavior and predict actions based on this inference, known as intention attribution (IA), has been hypothesized to be impaired in individuals with autism spectrum disorder (ASD). The underlying neural processes, however, have not been conclusively determined. The aim of this study was to examine the neural signature of IA in children and adolescents with ASD, and to elucidate potential links to contextual updating processes using electroencephalography. Results did not indicate that IA or early contextual updating was impaired in ASD. However, there was evidence of aberrant processing of expectation violations in ASD, particularly if the expectation was based on IA. Results are discussed within the context of impaired predictive coding in ASD. En ligne : https://doi.org/10.1007/s10803-021-05358-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 [article] Intention Attribution in Children and Adolescents with Autism Spectrum Disorder: An EEG Study [texte imprimé] / Magdalena SCHÃœTZ, Auteur ; Sara BOXHOORN, Auteur ; Andreas M. MÃœHLHERR, Auteur ; Hannah MÖSSINGER, Auteur ; Christine M. FREITAG, Auteur ; Christina LUCKHARDT, Auteur . - p.1431-1443. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1431-1443 Index. décimale : PER Périodiques Résumé : The ability to infer intentions from observed behavior and predict actions based on this inference, known as intention attribution (IA), has been hypothesized to be impaired in individuals with autism spectrum disorder (ASD). The underlying neural processes, however, have not been conclusively determined. The aim of this study was to examine the neural signature of IA in children and adolescents with ASD, and to elucidate potential links to contextual updating processes using electroencephalography. Results did not indicate that IA or early contextual updating was impaired in ASD. However, there was evidence of aberrant processing of expectation violations in ASD, particularly if the expectation was based on IA. Results are discussed within the context of impaired predictive coding in ASD. En ligne : https://doi.org/10.1007/s10803-021-05358-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500

Pupil dilation during visuospatial orienting differentiates between autism spectrum disorder and attention-deficit/hyperactivity disorder / Sara BOXHOORN in Journal of Child Psychology and Psychiatry, 61-5 (May 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.614-624 Titre : Pupil dilation during visuospatial orienting differentiates between autism spectrum disorder and attention-deficit/hyperactivity disorder Type de document : texte imprimé Auteurs : Sara BOXHOORN, Auteur ; Nico BAST, Auteur ; Hans SUPER, Auteur ; Leonie POLZER, Auteur ; Hannah CHOLEMKERY, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.614-624 Langues : Anglais (eng) Mots-clés : Attention  LC-NE system  attention-deficit/hyperactivity disorder  autism spectrum disorder  pupil dilation Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research demonstrated atypical attention in children with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Regarding visual orienting, findings suggest a differential impairment: Atypical orienting to relatively unexpected targets in ASD, and atypical processing of alerting cues in ADHD. The locus coeruleus-norepinephrine (LC-NE) system plays an important role in exploiting alerting cues to increase attention and task performance. The present study's aim was to examine differential subcortical processes underlying visual orienting in ASD and ADHD with pupil dilation (PD) as index of LC activity. METHODS: Pupil dilation (PD) progression metrics during visual orienting were calculated for task-evoked PD locked to cue, stimulus onset, and behavioral response. Group differences in PD and reaction time (RT) were compared between children with ASD without ADHD (ASD-) (N = 18), ADHD without ASD (ADHD-) (N = 28), both disorders (ASD + ADHD) (N = 14), and typically developing children (TD) (N = 31) using linear mixed models (LMM). To further explore the modulatory role of the LC-NE system group differences in the effect of task-evoked PD metrics on RT were examined exploratively. RESULTS: ASD (+ADHD) showed slower orienting responses to relatively unexpected spatial target stimuli as compared to TD, which was accompanied by higher PD amplitudes relative to ADHD- and TD. In ADHD-, shorter cue-evoked PD latencies relative to ASD-, ASD + ADHD, and TD were found. Group differences in the effect of cue- and stimulus-evoked PD amplitudes on RT were found in ASD- relative to TD. CONCLUSIONS: Study findings provide new evidence for a specific role of the LC-NE system in impaired reflexive orienting responses in ASD, and atypical visual processing of alerting cues in ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Pupil dilation during visuospatial orienting differentiates between autism spectrum disorder and attention-deficit/hyperactivity disorder [texte imprimé] / Sara BOXHOORN, Auteur ; Nico BAST, Auteur ; Hans SUPER, Auteur ; Leonie POLZER, Auteur ; Hannah CHOLEMKERY, Auteur ; Christine M. FREITAG, Auteur . - p.614-624. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.614-624 Mots-clés : Attention  LC-NE system  attention-deficit/hyperactivity disorder  autism spectrum disorder  pupil dilation Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research demonstrated atypical attention in children with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Regarding visual orienting, findings suggest a differential impairment: Atypical orienting to relatively unexpected targets in ASD, and atypical processing of alerting cues in ADHD. The locus coeruleus-norepinephrine (LC-NE) system plays an important role in exploiting alerting cues to increase attention and task performance. The present study's aim was to examine differential subcortical processes underlying visual orienting in ASD and ADHD with pupil dilation (PD) as index of LC activity. METHODS: Pupil dilation (PD) progression metrics during visual orienting were calculated for task-evoked PD locked to cue, stimulus onset, and behavioral response. Group differences in PD and reaction time (RT) were compared between children with ASD without ADHD (ASD-) (N = 18), ADHD without ASD (ADHD-) (N = 28), both disorders (ASD + ADHD) (N = 14), and typically developing children (TD) (N = 31) using linear mixed models (LMM). To further explore the modulatory role of the LC-NE system group differences in the effect of task-evoked PD metrics on RT were examined exploratively. RESULTS: ASD (+ADHD) showed slower orienting responses to relatively unexpected spatial target stimuli as compared to TD, which was accompanied by higher PD amplitudes relative to ADHD- and TD. In ADHD-, shorter cue-evoked PD latencies relative to ASD-, ASD + ADHD, and TD were found. Group differences in the effect of cue- and stimulus-evoked PD amplitudes on RT were found in ASD- relative to TD. CONCLUSIONS: Study findings provide new evidence for a specific role of the LC-NE system in impaired reflexive orienting responses in ASD, and atypical visual processing of alerting cues in ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study / Christina LUCKHARDT in Autism Research, 18-9 (September 2025)  

Public ISBD [article]  inAutism Research > 18-9 (September 2025) . - p.1861-1876 Titre : Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study Type de document : texte imprimé Auteurs : Christina LUCKHARDT, Auteur ; Magdalena SCHÃœTZ, Auteur ; Andreas M. MÃœHLHERR, Auteur ; Sara BOXHOORN, Auteur ; Christine ECKER, Auteur ; Hanna MÖSSINGER, Auteur ; Julia SIEMANN, Auteur ; Fabienne SCHLECHTER, Auteur ; Miguel CASTELO-BRANCO, Auteur ; Helena C. PEREIRA, Auteur ; Marianne LATINUS, Auteur ; Camille RICOU, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Ricardo SALVADOR, Auteur ; Giulio RUFFINI, Auteur ; Rafal NOWAK, Auteur ; Michael SINIATCHKIN, Auteur ; Astrid DEMPFLE, Auteur ; Christine M. FREITAG, Auteur ; Magdalena SCHÃœTZ, Auteur Article en page(s) : p.1861-1876 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham-controlled, double-blind parallel-group Phase-IIa trial, we investigated feasibility, safety, and effect sizes of 10 sessions of anodal tDCS of the bilateral TPJ at 2 mA as an add-on to computer-based social cognitive training in 10- to 17-year-old youth with autism. Feasibility of recruitment was low, with only 11% of screened individuals being randomized to tDCS (N=12) or sham (N=12). In contrast, retention in the study, data collection, intervention adherence, and technical feasibility were mostly excellent. No serious adverse events occurred, and stimulation was well tolerated. There were no differences in the prespecified primary outcome social responsiveness between sham and tDCS immediately after the intervention (standardized estimated effect size [ES]=0.098; 95%-confidence interval [95% CI] 1.043;1.240), but the sham group showed a trend for better social responsiveness at the 4 week follow-up (ES=1.106; 95% CI 0.054; 2.270). Secondary outcomes including questionnaires and event-related potentials showed improved compulsive behavior and quality of life by tDCS. High technical feasibility, participant retention, and safety highlight the potential of tDCS in autism and may inform future improvements in the feasibility of recruitment. The differential pattern of effect estimates indicates positive, but also potential negative effects of tDCS, which may vary due to tDCS stimulation parameters. The trial was prospectively registered in the German Clinical Trials Register (Deutsches Register für klinische Studien, DRKS, DRKS00014732). En ligne : https://doi.org/10.1002/aur.70084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study [texte imprimé] / Christina LUCKHARDT, Auteur ; Magdalena SCHÃœTZ, Auteur ; Andreas M. MÃœHLHERR, Auteur ; Sara BOXHOORN, Auteur ; Christine ECKER, Auteur ; Hanna MÖSSINGER, Auteur ; Julia SIEMANN, Auteur ; Fabienne SCHLECHTER, Auteur ; Miguel CASTELO-BRANCO, Auteur ; Helena C. PEREIRA, Auteur ; Marianne LATINUS, Auteur ; Camille RICOU, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Ricardo SALVADOR, Auteur ; Giulio RUFFINI, Auteur ; Rafal NOWAK, Auteur ; Michael SINIATCHKIN, Auteur ; Astrid DEMPFLE, Auteur ; Christine M. FREITAG, Auteur ; Magdalena SCHÃœTZ, Auteur . - p.1861-1876. Langues : Anglais (eng) in Autism Research > 18-9 (September 2025) . - p.1861-1876 Index. décimale : PER Périodiques Résumé : ABSTRACT Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham-controlled, double-blind parallel-group Phase-IIa trial, we investigated feasibility, safety, and effect sizes of 10 sessions of anodal tDCS of the bilateral TPJ at 2 mA as an add-on to computer-based social cognitive training in 10- to 17-year-old youth with autism. Feasibility of recruitment was low, with only 11% of screened individuals being randomized to tDCS (N=12) or sham (N=12). In contrast, retention in the study, data collection, intervention adherence, and technical feasibility were mostly excellent. No serious adverse events occurred, and stimulation was well tolerated. There were no differences in the prespecified primary outcome social responsiveness between sham and tDCS immediately after the intervention (standardized estimated effect size [ES]=0.098; 95%-confidence interval [95% CI] 1.043;1.240), but the sham group showed a trend for better social responsiveness at the 4 week follow-up (ES=1.106; 95% CI 0.054; 2.270). Secondary outcomes including questionnaires and event-related potentials showed improved compulsive behavior and quality of life by tDCS. High technical feasibility, participant retention, and safety highlight the potential of tDCS in autism and may inform future improvements in the feasibility of recruitment. The differential pattern of effect estimates indicates positive, but also potential negative effects of tDCS, which may vary due to tDCS stimulation parameters. The trial was prospectively registered in the German Clinical Trials Register (Deutsches Register für klinische Studien, DRKS, DRKS00014732). En ligne : https://doi.org/10.1002/aur.70084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

---

1 (1 - 3 / 3) Par page : 25 50 100 200