Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
5 recherche sur le mot-clé 'pupil dilation'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Pupil dilation during visuospatial orienting differentiates between autism spectrum disorder and attention-deficit/hyperactivity disorder / Sara BOXHOORN in Journal of Child Psychology and Psychiatry, 61-5 (May 2020)
[article]
Titre : Pupil dilation during visuospatial orienting differentiates between autism spectrum disorder and attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sara BOXHOORN, Auteur ; Nico BAST, Auteur ; Hans SUPER, Auteur ; Leonie POLZER, Auteur ; Hannah CHOLEMKERY, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.614-624 Langues : Anglais (eng) Mots-clés : Attention LC-NE system attention-deficit/hyperactivity disorder autism spectrum disorder pupil dilation Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research demonstrated atypical attention in children with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Regarding visual orienting, findings suggest a differential impairment: Atypical orienting to relatively unexpected targets in ASD, and atypical processing of alerting cues in ADHD. The locus coeruleus-norepinephrine (LC-NE) system plays an important role in exploiting alerting cues to increase attention and task performance. The present study's aim was to examine differential subcortical processes underlying visual orienting in ASD and ADHD with pupil dilation (PD) as index of LC activity. METHODS: Pupil dilation (PD) progression metrics during visual orienting were calculated for task-evoked PD locked to cue, stimulus onset, and behavioral response. Group differences in PD and reaction time (RT) were compared between children with ASD without ADHD (ASD-) (N = 18), ADHD without ASD (ADHD-) (N = 28), both disorders (ASD + ADHD) (N = 14), and typically developing children (TD) (N = 31) using linear mixed models (LMM). To further explore the modulatory role of the LC-NE system group differences in the effect of task-evoked PD metrics on RT were examined exploratively. RESULTS: ASD (+ADHD) showed slower orienting responses to relatively unexpected spatial target stimuli as compared to TD, which was accompanied by higher PD amplitudes relative to ADHD- and TD. In ADHD-, shorter cue-evoked PD latencies relative to ASD-, ASD + ADHD, and TD were found. Group differences in the effect of cue- and stimulus-evoked PD amplitudes on RT were found in ASD- relative to TD. CONCLUSIONS: Study findings provide new evidence for a specific role of the LC-NE system in impaired reflexive orienting responses in ASD, and atypical visual processing of alerting cues in ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422
in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.614-624[article] Pupil dilation during visuospatial orienting differentiates between autism spectrum disorder and attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Sara BOXHOORN, Auteur ; Nico BAST, Auteur ; Hans SUPER, Auteur ; Leonie POLZER, Auteur ; Hannah CHOLEMKERY, Auteur ; Christine M. FREITAG, Auteur . - p.614-624.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.614-624
Mots-clés : Attention LC-NE system attention-deficit/hyperactivity disorder autism spectrum disorder pupil dilation Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous research demonstrated atypical attention in children with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Regarding visual orienting, findings suggest a differential impairment: Atypical orienting to relatively unexpected targets in ASD, and atypical processing of alerting cues in ADHD. The locus coeruleus-norepinephrine (LC-NE) system plays an important role in exploiting alerting cues to increase attention and task performance. The present study's aim was to examine differential subcortical processes underlying visual orienting in ASD and ADHD with pupil dilation (PD) as index of LC activity. METHODS: Pupil dilation (PD) progression metrics during visual orienting were calculated for task-evoked PD locked to cue, stimulus onset, and behavioral response. Group differences in PD and reaction time (RT) were compared between children with ASD without ADHD (ASD-) (N = 18), ADHD without ASD (ADHD-) (N = 28), both disorders (ASD + ADHD) (N = 14), and typically developing children (TD) (N = 31) using linear mixed models (LMM). To further explore the modulatory role of the LC-NE system group differences in the effect of task-evoked PD metrics on RT were examined exploratively. RESULTS: ASD (+ADHD) showed slower orienting responses to relatively unexpected spatial target stimuli as compared to TD, which was accompanied by higher PD amplitudes relative to ADHD- and TD. In ADHD-, shorter cue-evoked PD latencies relative to ASD-, ASD + ADHD, and TD were found. Group differences in the effect of cue- and stimulus-evoked PD amplitudes on RT were found in ASD- relative to TD. CONCLUSIONS: Study findings provide new evidence for a specific role of the LC-NE system in impaired reflexive orienting responses in ASD, and atypical visual processing of alerting cues in ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 Increased pupil dilation to happy faces in children with hyperactive/impulsive symptoms of ADHD / Johan Lundin KLEBERG in Development and Psychopathology, 33-3 (August 2021)
[article]
Titre : Increased pupil dilation to happy faces in children with hyperactive/impulsive symptoms of ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Johan Lundin KLEBERG, Auteur ; Matilda A. FRICK, Auteur ; Karin C. BROCKI, Auteur Article en page(s) : p.767-777 Langues : Anglais (eng) Mots-clés : arousal attention-deficit/hyperactivity disorder (ADHD) face perception positive emotionality pupil dilation Index. décimale : PER Périodiques Résumé : Attention-deficit/hyperactivity disorder (ADHD) is associated with disrupted emotional processes including impaired regulation of approach behavior and positive affect, irritability, and anger. Enhanced reactivity to emotional cues may be an underlying process. Pupil dilation is an indirect index of arousal, modulated by the autonomic nervous system and activity in the locus coeruleus-noradrenergic system. In the current study, pupil dilation was recorded while 8- to 12- year old children (n = 71, 26 with a diagnosis of ADHD and 45 typically developing), viewed images of emotional faces. Parent-rated hyperactive/impulsive symptoms were uniquely linked to higher pupil dilation to happy, but not fearful, angry, or neutral faces. This was not explained by comorbid externalizing symptoms. Together, these results suggest that hyperactive/impulsive symptoms are associated with hyperresponsiveness to approach-related emotional cues across a wide range of symptom severity. En ligne : http://dx.doi.org/10.1017/S0954579420000036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457
in Development and Psychopathology > 33-3 (August 2021) . - p.767-777[article] Increased pupil dilation to happy faces in children with hyperactive/impulsive symptoms of ADHD [Texte imprimé et/ou numérique] / Johan Lundin KLEBERG, Auteur ; Matilda A. FRICK, Auteur ; Karin C. BROCKI, Auteur . - p.767-777.
Langues : Anglais (eng)
in Development and Psychopathology > 33-3 (August 2021) . - p.767-777
Mots-clés : arousal attention-deficit/hyperactivity disorder (ADHD) face perception positive emotionality pupil dilation Index. décimale : PER Périodiques Résumé : Attention-deficit/hyperactivity disorder (ADHD) is associated with disrupted emotional processes including impaired regulation of approach behavior and positive affect, irritability, and anger. Enhanced reactivity to emotional cues may be an underlying process. Pupil dilation is an indirect index of arousal, modulated by the autonomic nervous system and activity in the locus coeruleus-noradrenergic system. In the current study, pupil dilation was recorded while 8- to 12- year old children (n = 71, 26 with a diagnosis of ADHD and 45 typically developing), viewed images of emotional faces. Parent-rated hyperactive/impulsive symptoms were uniquely linked to higher pupil dilation to happy, but not fearful, angry, or neutral faces. This was not explained by comorbid externalizing symptoms. Together, these results suggest that hyperactive/impulsive symptoms are associated with hyperresponsiveness to approach-related emotional cues across a wide range of symptom severity. En ligne : http://dx.doi.org/10.1017/S0954579420000036 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis / Maja RUDLING in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)
[article]
Titre : Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Maja RUDLING, Auteur ; Pär NYSTRÖM, Auteur ; Sven BÖLTE, Auteur ; Terje FALCK-YTTER, Auteur Article en page(s) : p.793-801 Langues : Anglais (eng) Mots-clés : Attention/physiology Auditory Perception/physiology Autism Spectrum Disorder/diagnosis Autistic Disorder Female Humans Infant Pupil/physiology Autism spectrum disorder auditory attention infancy pupil dilation Index. décimale : PER Périodiques Résumé : BACKGROUND: Studies of infants with an elevated likelihood of autism spectrum disorder can identify basic developmental processes that are associated with subsequently emerging clinical symptoms. Atypical responsiveness to sounds in infancy is such a potential early marker of autism. Here, we used pupillometry to quantify reactivity to social and nonsocial sounds in infants with a subsequent diagnosis. Previous research suggest that pupil dilation reflects attentional alerting, and link it to the locus coeruleus norepinephrine system. METHODS: We measured pupil dilation responses to child-directed speech and the sound of running water; sounds infants often hear in their everyday life. The final sample consisted of 99 ten-month-old infants (52 girls), of whom 68 had an elevated likelihood of autism and 31 were typically developing low-likelihood infants. At follow-up (36?months of age), 18 children in the elevated-likelihood group were diagnosed with autism. RESULTS: Compared to infants without diagnosis, the infants who were subsequently diagnosed with autism had larger pupil dilation when listening to nonsocial sounds, while reactivity to speech was strikingly similar between groups. In the total sample, more pupil dilation to the nonsocial sound was associated with higher levels of autistic symptoms. We also found that on a trial-by-trial basis, across all conditions and groups, more pupil dilation was associated with making fewer gaze shifts. CONCLUSIONS: This study did not find evidence of atypical pupillary reactivity to child-directed speech early in life in autism. Instead, the results suggest that certain nonsocial sounds elicit atypically strong alerting responses in infants with a subsequent autism diagnosis. These findings may have important theoretical and clinical implications. En ligne : http://dx.doi.org/10.1111/jcpp.13520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.793-801[article] Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis [Texte imprimé et/ou numérique] / Maja RUDLING, Auteur ; Pär NYSTRÖM, Auteur ; Sven BÖLTE, Auteur ; Terje FALCK-YTTER, Auteur . - p.793-801.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.793-801
Mots-clés : Attention/physiology Auditory Perception/physiology Autism Spectrum Disorder/diagnosis Autistic Disorder Female Humans Infant Pupil/physiology Autism spectrum disorder auditory attention infancy pupil dilation Index. décimale : PER Périodiques Résumé : BACKGROUND: Studies of infants with an elevated likelihood of autism spectrum disorder can identify basic developmental processes that are associated with subsequently emerging clinical symptoms. Atypical responsiveness to sounds in infancy is such a potential early marker of autism. Here, we used pupillometry to quantify reactivity to social and nonsocial sounds in infants with a subsequent diagnosis. Previous research suggest that pupil dilation reflects attentional alerting, and link it to the locus coeruleus norepinephrine system. METHODS: We measured pupil dilation responses to child-directed speech and the sound of running water; sounds infants often hear in their everyday life. The final sample consisted of 99 ten-month-old infants (52 girls), of whom 68 had an elevated likelihood of autism and 31 were typically developing low-likelihood infants. At follow-up (36?months of age), 18 children in the elevated-likelihood group were diagnosed with autism. RESULTS: Compared to infants without diagnosis, the infants who were subsequently diagnosed with autism had larger pupil dilation when listening to nonsocial sounds, while reactivity to speech was strikingly similar between groups. In the total sample, more pupil dilation to the nonsocial sound was associated with higher levels of autistic symptoms. We also found that on a trial-by-trial basis, across all conditions and groups, more pupil dilation was associated with making fewer gaze shifts. CONCLUSIONS: This study did not find evidence of atypical pupillary reactivity to child-directed speech early in life in autism. Instead, the results suggest that certain nonsocial sounds elicit atypically strong alerting responses in infants with a subsequent autism diagnosis. These findings may have important theoretical and clinical implications. En ligne : http://dx.doi.org/10.1111/jcpp.13520 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Validation of the Movie for the Assessment of Social Cognition in Adolescents with ASD: Fixation Duration and Pupil Dilation as Predictors of Performance / Nico MÜLLER in Journal of Autism and Developmental Disorders, 46-9 (September 2016)
[article]
Titre : Validation of the Movie for the Assessment of Social Cognition in Adolescents with ASD: Fixation Duration and Pupil Dilation as Predictors of Performance Type de document : Texte imprimé et/ou numérique Auteurs : Nico MÜLLER, Auteur ; Sarah BAUMEISTER, Auteur ; Isabel DZIOBEK, Auteur ; Tobias BANASCHEWSKI, Auteur ; Luise POUSTKA, Auteur Article en page(s) : p.2831-2844 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Eye-tracking Adolescence Pupil dilation Social cognition Ecological validity Index. décimale : PER Périodiques Résumé : Impaired social cognition is one of the core characteristics of autism spectrum disorders (ASD). Appropriate measures of social cognition for high-functioning adolescents with ASD are, however, lacking. The Movie for the Assessment of Social Cognition (MASC) uses dynamic social stimuli, ensuring ecological validity, and has proven to be a sensitive measure in adulthood. In the current study, 33 adolescents with ASD and 23 controls were administered the MASC, while concurrent eye tracking was used to relate gaze behavior to performance levels. The ASD group exhibited reduced MASC scores, with social cognition performance being explained by shorter fixation duration on eyes and decreased pupil dilation. These potential diagnostic markers are discussed as indicators of different processing of social information in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2828-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292
in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.2831-2844[article] Validation of the Movie for the Assessment of Social Cognition in Adolescents with ASD: Fixation Duration and Pupil Dilation as Predictors of Performance [Texte imprimé et/ou numérique] / Nico MÜLLER, Auteur ; Sarah BAUMEISTER, Auteur ; Isabel DZIOBEK, Auteur ; Tobias BANASCHEWSKI, Auteur ; Luise POUSTKA, Auteur . - p.2831-2844.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-9 (September 2016) . - p.2831-2844
Mots-clés : Autism spectrum disorder Eye-tracking Adolescence Pupil dilation Social cognition Ecological validity Index. décimale : PER Périodiques Résumé : Impaired social cognition is one of the core characteristics of autism spectrum disorders (ASD). Appropriate measures of social cognition for high-functioning adolescents with ASD are, however, lacking. The Movie for the Assessment of Social Cognition (MASC) uses dynamic social stimuli, ensuring ecological validity, and has proven to be a sensitive measure in adulthood. In the current study, 33 adolescents with ASD and 23 controls were administered the MASC, while concurrent eye tracking was used to relate gaze behavior to performance levels. The ASD group exhibited reduced MASC scores, with social cognition performance being explained by shorter fixation duration on eyes and decreased pupil dilation. These potential diagnostic markers are discussed as indicators of different processing of social information in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2828-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 Pupillary reactivity to emotional stimuli in children of depressed and anxious mothers / Katie L. BURKHOUSE in Journal of Child Psychology and Psychiatry, 55-9 (September 2014)
[article]
Titre : Pupillary reactivity to emotional stimuli in children of depressed and anxious mothers Type de document : Texte imprimé et/ou numérique Auteurs : Katie L. BURKHOUSE, Auteur ; Greg J. SIEGLE, Auteur ; Brandon E. GIBB, Auteur Article en page(s) : p.1009-1016 Langues : Anglais (eng) Mots-clés : Pupil dilation vulnerability depression anxiety intergenerational transmission Index. décimale : PER Périodiques Résumé : Background The primary aim of this study was to examine differences in physiological reactivity (measured via pupillometry) to emotional stimuli between children of depressed versus nondepressed mothers. A second goal was to examine differences in pupil dilation to emotional stimuli between children of anxious versus nonanxious mothers. Method Participants included 117 mother–child pairs drawn from the community. Children were between the ages of 8 and 14. Pupil dilation was assessed using an eye-tracker while participants viewed angry, happy, or sad faces. Results Children of mothers with a history of major depression (MDD) exhibited increased pupil dilation to sad, but not happy or angry, faces compared with children of nondepressed mothers. Second, we found that children of anxious mothers exhibited increased pupil dilation to angry, but not happy or sad, faces compared to youth of nonanxious mothers. Conclusions The current findings add to the growing body of research suggesting that differences in physiological reactivity to depression- and anxiety-relevant cues may represent an important mechanism in the intergenerational transmission of MDD and anxiety. En ligne : http://dx.doi.org/10.1111/jcpp.12225 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238
in Journal of Child Psychology and Psychiatry > 55-9 (September 2014) . - p.1009-1016[article] Pupillary reactivity to emotional stimuli in children of depressed and anxious mothers [Texte imprimé et/ou numérique] / Katie L. BURKHOUSE, Auteur ; Greg J. SIEGLE, Auteur ; Brandon E. GIBB, Auteur . - p.1009-1016.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-9 (September 2014) . - p.1009-1016
Mots-clés : Pupil dilation vulnerability depression anxiety intergenerational transmission Index. décimale : PER Périodiques Résumé : Background The primary aim of this study was to examine differences in physiological reactivity (measured via pupillometry) to emotional stimuli between children of depressed versus nondepressed mothers. A second goal was to examine differences in pupil dilation to emotional stimuli between children of anxious versus nonanxious mothers. Method Participants included 117 mother–child pairs drawn from the community. Children were between the ages of 8 and 14. Pupil dilation was assessed using an eye-tracker while participants viewed angry, happy, or sad faces. Results Children of mothers with a history of major depression (MDD) exhibited increased pupil dilation to sad, but not happy or angry, faces compared with children of nondepressed mothers. Second, we found that children of anxious mothers exhibited increased pupil dilation to angry, but not happy or sad, faces compared to youth of nonanxious mothers. Conclusions The current findings add to the growing body of research suggesting that differences in physiological reactivity to depression- and anxiety-relevant cues may represent an important mechanism in the intergenerational transmission of MDD and anxiety. En ligne : http://dx.doi.org/10.1111/jcpp.12225 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238