Pubertal development mediates the association between family environment and brain structure and function in childhood / Sandra THIJSSEN in Development and Psychopathology, 32-2 (May 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-2 (May 2020) . - p.687-702 Titre : Pubertal development mediates the association between family environment and brain structure and function in childhood Type de document : Texte imprimé et/ou numérique Auteurs : Sandra THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; Monica LUCIANA, Auteur Article en page(s) : p.687-702 Langues : Anglais (eng) Mots-clés : accelerated development  amygdala–medial prefrontal cortex circuit  family environment  psychosocial acceleration theory  pubertal development Index. décimale : PER Périodiques Résumé : Psychosocial acceleration theory suggests that pubertal maturation is accelerated in response to adversity. In addition, suboptimal caregiving accelerates development of the amygdala-medial prefrontal cortex circuit. These findings may be related. Here, we assess whether associations between family environment and measures of the amygdala-medial prefrontal cortex circuit are mediated by pubertal development in more than 2000 9- and 10-year-old children from the Adolescent Brain Cognitive Development Study (http://dx.doi.org/10.15154/1412097). Using structural equation modeling, demographic, child-reported, and parent-reported data on family dynamics were compiled into a higher level family environment latent variable. Magnetic resonance imaging preprocessing and compilations were performed by the Adolescent Brain Cognitive Development Study's data analysis core. Anterior cingulate cortex (ACC) thickness, area, white matter fractional anisotropy, amygdala volume, and cingulo-opercular network-amygdala resting-state functional connectivity were assessed. For ACC cortical thickness and ACC fractional anisotropy, significant indirect effects indicated that a stressful family environment relates to more advanced pubertal stage and more mature brain structure. For cingulo-opercular network-amygdala functional connectivity, results indicated a trend in the expected direction. For ACC area, evidence for quadratic mediation by pubertal stage was found. Sex-stratified analyses suggest stronger results for girls. Despite small effect sizes, structural measures of circuits important for emotional behavior are associated with family environment and show initial evidence of accelerated pubertal development. En ligne : http://dx.doi.org/10.1017/s0954579419000580 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Pubertal development mediates the association between family environment and brain structure and function in childhood [Texte imprimé et/ou numérique] / Sandra THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; Monica LUCIANA, Auteur . - p.687-702. Langues : Anglais (eng) in Development and Psychopathology > 32-2 (May 2020) . - p.687-702 Mots-clés : accelerated development  amygdala–medial prefrontal cortex circuit  family environment  psychosocial acceleration theory  pubertal development Index. décimale : PER Périodiques Résumé : Psychosocial acceleration theory suggests that pubertal maturation is accelerated in response to adversity. In addition, suboptimal caregiving accelerates development of the amygdala-medial prefrontal cortex circuit. These findings may be related. Here, we assess whether associations between family environment and measures of the amygdala-medial prefrontal cortex circuit are mediated by pubertal development in more than 2000 9- and 10-year-old children from the Adolescent Brain Cognitive Development Study (http://dx.doi.org/10.15154/1412097). Using structural equation modeling, demographic, child-reported, and parent-reported data on family dynamics were compiled into a higher level family environment latent variable. Magnetic resonance imaging preprocessing and compilations were performed by the Adolescent Brain Cognitive Development Study's data analysis core. Anterior cingulate cortex (ACC) thickness, area, white matter fractional anisotropy, amygdala volume, and cingulo-opercular network-amygdala resting-state functional connectivity were assessed. For ACC cortical thickness and ACC fractional anisotropy, significant indirect effects indicated that a stressful family environment relates to more advanced pubertal stage and more mature brain structure. For cingulo-opercular network-amygdala functional connectivity, results indicated a trend in the expected direction. For ACC area, evidence for quadratic mediation by pubertal stage was found. Sex-stratified analyses suggest stronger results for girls. Despite small effect sizes, structural measures of circuits important for emotional behavior are associated with family environment and show initial evidence of accelerated pubertal development. En ligne : http://dx.doi.org/10.1017/s0954579419000580 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Pubertal development mediates the association between family environment and brain structure and function in childhood – ADDENDUM / Sandra THIJSSEN in Development and Psychopathology, 33-1 (February 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-1 (February 2021) . - p.372-375 Titre : Pubertal development mediates the association between family environment and brain structure and function in childhood – ADDENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Sandra THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; Monica LUCIANA, Auteur Article en page(s) : p.372-375 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579420000322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Pubertal development mediates the association between family environment and brain structure and function in childhood – ADDENDUM [Texte imprimé et/ou numérique] / Sandra THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; Monica LUCIANA, Auteur . - p.372-375. Langues : Anglais (eng) in Development and Psychopathology > 33-1 (February 2021) . - p.372-375 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579420000322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

The longitudinal association between externalizing behavior and frontoamygdalar resting-state functional connectivity in late adolescence and young adulthood / S. THIJSSEN in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.857-867 Titre : The longitudinal association between externalizing behavior and frontoamygdalar resting-state functional connectivity in late adolescence and young adulthood Type de document : Texte imprimé et/ou numérique Auteurs : S. THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; H. WEISS, Auteur ; M. LUCIANA, Auteur Article en page(s) : p.857-867 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Amygdala/diagnostic imaging  Gyrus Cinguli  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  Prefrontal Cortex/diagnostic imaging  Young Adult  Externalizing behavior  amygdala  anterior cingulate cortex  functional connectivity  orbitofrontal cortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Externalizing behavior has been attributed, in part, to decreased frontolimbic control over amygdala activation. However, little is known about developmental trajectories of frontoamygdalar functional connectivity and its relation to externalizing behavior. The present study addresses this gap by examining longitudinal associations between adolescent and adult externalizing behavior and amygdala-anterior cingulate cortex (ACC) and amygdala-orbitofrontal cortex (OFC) resting-state functional connectivity in a sample of 111 typically developing participants aged 11-23 at baseline. METHODS: Participants completed two-to-four data waves spaced approximately two years apart, resulting in a total of 309 data points. At each data wave, externalizing behavior was measured using the Externalizing Behavior Broadband Scale from the Achenbach Youth/Adult Self-Report questionnaire. Resting-state fMRI preprocessing was performed using FSL. Amygdala functional connectivity was examined using AFNI. The longitudinal association between externalizing behavior and amygdala-ACC/OFC functional connectivity was examined using linear mixed effect models in R. RESULTS: Externalizing behavior was associated with increased amygdala-ACC and amygdala-OFC resting-state functional connectivity across adolescence and young adulthood. For amygdala-ACC connectivity, externalizing behavior at baseline primarily drove this association, whereas for amygdala-OFC functional connectivity, change in externalizing behavior relative to baseline drove the main effect of externalizing behavior on amygdala-OFC functional connectivity. No evidence was found for differential developmental trajectories of frontoamygdalar connectivity for different levels of externalizing behavior (i.e., age-by-externalizing behavior interaction effect). CONCLUSIONS: Higher externalizing behavior is associated with increased resting-state attunement between the amygdala and ACC/OFC, perhaps indicating a generally more vigilant state for neural networks important for emotional processing and control. En ligne : http://dx.doi.org/10.1111/jcpp.13330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] The longitudinal association between externalizing behavior and frontoamygdalar resting-state functional connectivity in late adolescence and young adulthood [Texte imprimé et/ou numérique] / S. THIJSSEN, Auteur ; Paul F. COLLINS, Auteur ; H. WEISS, Auteur ; M. LUCIANA, Auteur . - p.857-867. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.857-867 Mots-clés : Adolescent  Adult  Amygdala/diagnostic imaging  Gyrus Cinguli  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  Prefrontal Cortex/diagnostic imaging  Young Adult  Externalizing behavior  amygdala  anterior cingulate cortex  functional connectivity  orbitofrontal cortex Index. décimale : PER Périodiques Résumé : BACKGROUND: Externalizing behavior has been attributed, in part, to decreased frontolimbic control over amygdala activation. However, little is known about developmental trajectories of frontoamygdalar functional connectivity and its relation to externalizing behavior. The present study addresses this gap by examining longitudinal associations between adolescent and adult externalizing behavior and amygdala-anterior cingulate cortex (ACC) and amygdala-orbitofrontal cortex (OFC) resting-state functional connectivity in a sample of 111 typically developing participants aged 11-23 at baseline. METHODS: Participants completed two-to-four data waves spaced approximately two years apart, resulting in a total of 309 data points. At each data wave, externalizing behavior was measured using the Externalizing Behavior Broadband Scale from the Achenbach Youth/Adult Self-Report questionnaire. Resting-state fMRI preprocessing was performed using FSL. Amygdala functional connectivity was examined using AFNI. The longitudinal association between externalizing behavior and amygdala-ACC/OFC functional connectivity was examined using linear mixed effect models in R. RESULTS: Externalizing behavior was associated with increased amygdala-ACC and amygdala-OFC resting-state functional connectivity across adolescence and young adulthood. For amygdala-ACC connectivity, externalizing behavior at baseline primarily drove this association, whereas for amygdala-OFC functional connectivity, change in externalizing behavior relative to baseline drove the main effect of externalizing behavior on amygdala-OFC functional connectivity. No evidence was found for differential developmental trajectories of frontoamygdalar connectivity for different levels of externalizing behavior (i.e., age-by-externalizing behavior interaction effect). CONCLUSIONS: Higher externalizing behavior is associated with increased resting-state attunement between the amygdala and ACC/OFC, perhaps indicating a generally more vigilant state for neural networks important for emotional processing and control. En ligne : http://dx.doi.org/10.1111/jcpp.13330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

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