[article]
| Titre : |
Exposure to General Anesthesia May Contribute to the Association between Cesarean Delivery and Autism Spectrum Disorder |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
M. HUBERMAN SAMUEL, Auteur ; G. MEIRI, Auteur ; I. DINSTEIN, Auteur ; H. FLUSSER, Auteur ; A. MICHAELOVSKI, Auteur ; Asher BASHIRI, Auteur ; I. MENASHE, Auteur |
| Article en page(s) : |
p.3127-3135 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism spectrum disorder Cesarean section General anesthesia |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Cesarean section (CS) has been consistently associated with susceptibility to autism spectrum disorder (ASD), however, the underlying mechanism for this association remains vague. Here, we studied various pre-peri-and-neonatal factors among 347 children with ASD, 117 children with other developmental delays (DD), and 2226 age, sex and ethnicity matched controls. We found that CS is significantly associated with an increased risk of ASD but not DD (p = 0.019 and p = 0.540 respectively). Furthermore, we show that only CS performed with general anesthesia (GA) elevated the risk of ASD with no significant difference between indicated and non-indicated surgeries (aOR = 1.537; 95% CI 1.026-2.302, and aOR = 1.692; 95% CI 1.057-2.709, pdiff = 0.865). We therefore suggest that exposure to GA during CS may explain the association between CS and ASD. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-019-04034-9 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 |
in Journal of Autism and Developmental Disorders > 49-8 (August 2019) . - p.3127-3135
[article] Exposure to General Anesthesia May Contribute to the Association between Cesarean Delivery and Autism Spectrum Disorder [Texte imprimé et/ou numérique] / M. HUBERMAN SAMUEL, Auteur ; G. MEIRI, Auteur ; I. DINSTEIN, Auteur ; H. FLUSSER, Auteur ; A. MICHAELOVSKI, Auteur ; Asher BASHIRI, Auteur ; I. MENASHE, Auteur . - p.3127-3135. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 49-8 (August 2019) . - p.3127-3135
| Mots-clés : |
Autism spectrum disorder Cesarean section General anesthesia |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Cesarean section (CS) has been consistently associated with susceptibility to autism spectrum disorder (ASD), however, the underlying mechanism for this association remains vague. Here, we studied various pre-peri-and-neonatal factors among 347 children with ASD, 117 children with other developmental delays (DD), and 2226 age, sex and ethnicity matched controls. We found that CS is significantly associated with an increased risk of ASD but not DD (p = 0.019 and p = 0.540 respectively). Furthermore, we show that only CS performed with general anesthesia (GA) elevated the risk of ASD with no significant difference between indicated and non-indicated surgeries (aOR = 1.537; 95% CI 1.026-2.302, and aOR = 1.692; 95% CI 1.057-2.709, pdiff = 0.865). We therefore suggest that exposure to GA during CS may explain the association between CS and ASD. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-019-04034-9 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 |
|
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