Cognitive processes predicting advanced theory of mind in the broader autism phenotype / Cherie C. GREEN in Autism Research, 13-6 (June 2020)  

Public ISBD [article]  inAutism Research > 13-6 (June 2020) . - p.921-934 Titre : Cognitive processes predicting advanced theory of mind in the broader autism phenotype Type de document : texte imprimé Auteurs : Cherie C. GREEN, Auteur ; Natasha J. BROWN, Auteur ; Valerie M. Z. YAP, Auteur ; Ingrid E. SCHEFFER, Auteur ; Sarah J. WILSON, Auteur Article en page(s) : p.921-934 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  broader autism phenotype  developmental psychology  executive function  faux pas  social skills  theory of mind Index. décimale : PER Périodiques Résumé : Little is known about executive functions (EFs) associated with advanced theory of mind (ToM) abilities. We aimed to determine if advanced ToM abilities were reduced in individuals with subclinical traits of autism spectrum disorder (ASD), known as the "Broader Autism Phenotype" (BAP), and identify the EFs that predicted unimpaired performance on an advanced ToM task, the faux pas test. We assessed 29 participants (13 males) with the BAP who were relatives of children with ASD. Thirteen participants showed reduced ability to understand a faux pas. A discriminant function analysis correctly classified 79% of cases as impaired or unimpaired, with high sensitivity (80%) and specificity (77%), which was best predicted by language-mediated EFs, including verbal generativity, working memory, cognitive inhibition, and flexibility. Autism Res 2020, 13: 921-934. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Little is known about the complex cognitive processes that enable accurate interpretation of another person's thoughts and emotions, known as "theory of mind." In relatives of individuals with autism, who had mild traits of autism themselves, approximately half had difficulty interpreting situations involving a social faux pas. Cognitive inhibition and flexibility, working memory, and verbal generativity were related to, and appeared to be protective for, unimpaired understanding of a faux pas. En ligne : http://dx.doi.org/10.1002/aur.2209 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Cognitive processes predicting advanced theory of mind in the broader autism phenotype [texte imprimé] / Cherie C. GREEN, Auteur ; Natasha J. BROWN, Auteur ; Valerie M. Z. YAP, Auteur ; Ingrid E. SCHEFFER, Auteur ; Sarah J. WILSON, Auteur . - p.921-934. Langues : Anglais (eng) in Autism Research > 13-6 (June 2020) . - p.921-934 Mots-clés : autism spectrum disorder  broader autism phenotype  developmental psychology  executive function  faux pas  social skills  theory of mind Index. décimale : PER Périodiques Résumé : Little is known about executive functions (EFs) associated with advanced theory of mind (ToM) abilities. We aimed to determine if advanced ToM abilities were reduced in individuals with subclinical traits of autism spectrum disorder (ASD), known as the "Broader Autism Phenotype" (BAP), and identify the EFs that predicted unimpaired performance on an advanced ToM task, the faux pas test. We assessed 29 participants (13 males) with the BAP who were relatives of children with ASD. Thirteen participants showed reduced ability to understand a faux pas. A discriminant function analysis correctly classified 79% of cases as impaired or unimpaired, with high sensitivity (80%) and specificity (77%), which was best predicted by language-mediated EFs, including verbal generativity, working memory, cognitive inhibition, and flexibility. Autism Res 2020, 13: 921-934. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Little is known about the complex cognitive processes that enable accurate interpretation of another person's thoughts and emotions, known as "theory of mind." In relatives of individuals with autism, who had mild traits of autism themselves, approximately half had difficulty interpreting situations involving a social faux pas. Cognitive inhibition and flexibility, working memory, and verbal generativity were related to, and appeared to be protective for, unimpaired understanding of a faux pas. En ligne : http://dx.doi.org/10.1002/aur.2209 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Endophenotyping social cognition in the broader autism phenotype / Tarishi DESAI ; Cherie GREEN ; Krysta TREVIS ; Natasha J. BROWN ; Martin DELATYCKI ; Ingrid SCHEFFER ; Sarah WILSON in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1365-1380 Titre : Endophenotyping social cognition in the broader autism phenotype Type de document : texte imprimé Auteurs : Tarishi DESAI, Auteur ; Cherie GREEN, Auteur ; Krysta TREVIS, Auteur ; Natasha J. BROWN, Auteur ; Martin DELATYCKI, Auteur ; Ingrid SCHEFFER, Auteur ; Sarah WILSON, Auteur Article en page(s) : p.1365-1380 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Relatives of individuals with autism spectrum disorder (ASD) may display milder social traits of the broader autism phenotype (BAP) providing potential endophenotypic markers of genetic risk for ASD. We performed a case-control comparison to quantify social cognition and pragmatic language difficulties in the BAP (n = 25 cases; n = 33 controls) using the Faux Pas test (FPT) and the Goldman-Eisler Cartoon task. Using deep phenotyping we then examined patterns of inheritance of social cognition in two large multiplex families and the spectrum of performance in 32 additional families (159 members; n = 51 ASD, n = 87 BAP, n = 21 unaffected). BAP individuals showed significantly poorer FPT performance and reduced verbal fluency with the absence of a compression effect in social discourse compared to controls. In multiplex families, we observed reduced FPT performance in 89% of autistic family members, 63% of BAP relatives and 50% of unaffected relatives. Across all affected families, there was a graded spectrum of difficulties, with ASD individuals showing the most severe FPT difficulties, followed by the BAP and unaffected relatives compared to community controls. We conclude that relatives of probands show an inherited pattern of graded difficulties in social cognition with atypical faux pas detection in social discourse providing a novel candidate endophenotype for ASD. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Endophenotyping social cognition in the broader autism phenotype [texte imprimé] / Tarishi DESAI, Auteur ; Cherie GREEN, Auteur ; Krysta TREVIS, Auteur ; Natasha J. BROWN, Auteur ; Martin DELATYCKI, Auteur ; Ingrid SCHEFFER, Auteur ; Sarah WILSON, Auteur . - p.1365-1380. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1365-1380 Index. décimale : PER Périodiques Résumé : Abstract Relatives of individuals with autism spectrum disorder (ASD) may display milder social traits of the broader autism phenotype (BAP) providing potential endophenotypic markers of genetic risk for ASD. We performed a case-control comparison to quantify social cognition and pragmatic language difficulties in the BAP (n = 25 cases; n = 33 controls) using the Faux Pas test (FPT) and the Goldman-Eisler Cartoon task. Using deep phenotyping we then examined patterns of inheritance of social cognition in two large multiplex families and the spectrum of performance in 32 additional families (159 members; n = 51 ASD, n = 87 BAP, n = 21 unaffected). BAP individuals showed significantly poorer FPT performance and reduced verbal fluency with the absence of a compression effect in social discourse compared to controls. In multiplex families, we observed reduced FPT performance in 89% of autistic family members, 63% of BAP relatives and 50% of unaffected relatives. Across all affected families, there was a graded spectrum of difficulties, with ASD individuals showing the most severe FPT difficulties, followed by the BAP and unaffected relatives compared to community controls. We conclude that relatives of probands show an inherited pattern of graded difficulties in social cognition with atypical faux pas detection in social discourse providing a novel candidate endophenotype for ASD. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

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