Age-variant and age-invariant features of functional brain organization in middle-aged and older autistic adults / Joe BATHELT in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 9 p. Titre : Age-variant and age-invariant features of functional brain organization in middle-aged and older autistic adults Type de document : texte imprimé Auteurs : Joe BATHELT, Auteur ; P. Cédric KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur Article en page(s) : 9 p. Langues : Anglais (eng) Mots-clés : Aging  Autism spectrum disorder  Functional connectivity  Graph theory  perceived as posing a conflict or bias. The authors confirm that the funder had no  influence on the study design, preparation of the manuscript, or decision to  publish. Index. décimale : PER Périodiques Résumé : BACKGROUND: The majority of research effort into autism has been dedicated to understanding mechanisms during early development. As a consequence, research on the broader life course of an autism spectrum condition (ASC) has largely been neglected and almost nothing is known about ASC beyond middle age. Differences in brain connectivity that arise during early development may be maintained across the lifespan and may play protective or detrimental roles in older age. METHOD: This study explored age-related differences in functional connectivity across middle and older age in clinically diagnosed autistic adults (n = 44, 30-73 years) and in an age-matched typical comparison group (n = 45). RESULTS: The results indicated parallel age-related associations in ASC and typical aging for the local efficiency and connection strength of the default mode network and for the segregation of the frontoparietal control network. In contrast, group differences in visual network connectivity are compatible with a safeguarding interpretation of less age-related decline in brain function in ASC. This divergence was mirrored in different associations between visual network connectivity and reaction time variability in the ASC and comparison group. LIMITATIONS: The study is cross-sectional and may be affected by cohort effects. As all participants received their autism diagnosis in adulthood, this might hinder generalizability. CONCLUSION: These results highlight the complexity of aging in ASC with both parallel and divergent trajectories across different aspects of functional network organization. En ligne : http://dx.doi.org/10.1186/s13229-020-0316-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Age-variant and age-invariant features of functional brain organization in middle-aged and older autistic adults [texte imprimé] / Joe BATHELT, Auteur ; P. Cédric KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur . - 9 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 9 p. Mots-clés : Aging  Autism spectrum disorder  Functional connectivity  Graph theory  perceived as posing a conflict or bias. The authors confirm that the funder had no  influence on the study design, preparation of the manuscript, or decision to  publish. Index. décimale : PER Périodiques Résumé : BACKGROUND: The majority of research effort into autism has been dedicated to understanding mechanisms during early development. As a consequence, research on the broader life course of an autism spectrum condition (ASC) has largely been neglected and almost nothing is known about ASC beyond middle age. Differences in brain connectivity that arise during early development may be maintained across the lifespan and may play protective or detrimental roles in older age. METHOD: This study explored age-related differences in functional connectivity across middle and older age in clinically diagnosed autistic adults (n = 44, 30-73 years) and in an age-matched typical comparison group (n = 45). RESULTS: The results indicated parallel age-related associations in ASC and typical aging for the local efficiency and connection strength of the default mode network and for the segregation of the frontoparietal control network. In contrast, group differences in visual network connectivity are compatible with a safeguarding interpretation of less age-related decline in brain function in ASC. This divergence was mirrored in different associations between visual network connectivity and reaction time variability in the ASC and comparison group. LIMITATIONS: The study is cross-sectional and may be affected by cohort effects. As all participants received their autism diagnosis in adulthood, this might hinder generalizability. CONCLUSION: These results highlight the complexity of aging in ASC with both parallel and divergent trajectories across different aspects of functional network organization. En ligne : http://dx.doi.org/10.1186/s13229-020-0316-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Are Autistic Traits in the General Population Related to Global and Regional Brain Differences? / P. Cédric KOOLSCHIJN in Journal of Autism and Developmental Disorders, 45-9 (September 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.2779-2791 Titre : Are Autistic Traits in the General Population Related to Global and Regional Brain Differences? Type de document : texte imprimé Auteurs : P. Cédric KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur ; Andries R. VAN DER LEIJ, Auteur ; H. Steven SCHOLTE, Auteur Article en page(s) : p.2779-2791 Langues : Anglais (eng) Mots-clés : Autistic traits  Gray matter volume  Cortical thickness  Surface area  Diffusion tensor imaging  Autism Index. décimale : PER Périodiques Résumé : There is accumulating evidence that autistic-related traits in the general population lie on a continuum, with autism spectrum disorders representing the extreme end of this distribution. Here, we tested the hypothesis of a possible relationship between autistic traits and brain morphometry in the general population. Participants completed the short autism-spectrum quotient-questionnaire (AQ); T1-anatomical and DWI-scans were acquired. Associations between autistic traits and gray matter, and white matter microstructural-integrity were performed on the exploration-group (N = 204; 105 males, M-age = 22.85), and validated in the validation-group (N = 304; 155 males, M-age = 22.82). No significant associations were found between AQ-scores and brain morphometry in the exploration-group, or after pooling the data. This questions the assumption that autistic traits and their morphological associations do lie on a continuum in the general population. En ligne : http://dx.doi.org/10.1007/s10803-015-2441-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] Are Autistic Traits in the General Population Related to Global and Regional Brain Differences? [texte imprimé] / P. Cédric KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur ; Andries R. VAN DER LEIJ, Auteur ; H. Steven SCHOLTE, Auteur . - p.2779-2791. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.2779-2791 Mots-clés : Autistic traits  Gray matter volume  Cortical thickness  Surface area  Diffusion tensor imaging  Autism Index. décimale : PER Périodiques Résumé : There is accumulating evidence that autistic-related traits in the general population lie on a continuum, with autism spectrum disorders representing the extreme end of this distribution. Here, we tested the hypothesis of a possible relationship between autistic traits and brain morphometry in the general population. Participants completed the short autism-spectrum quotient-questionnaire (AQ); T1-anatomical and DWI-scans were acquired. Associations between autistic traits and gray matter, and white matter microstructural-integrity were performed on the exploration-group (N = 204; 105 males, M-age = 22.85), and validated in the validation-group (N = 304; 155 males, M-age = 22.82). No significant associations were found between AQ-scores and brain morphometry in the exploration-group, or after pooling the data. This questions the assumption that autistic traits and their morphological associations do lie on a continuum in the general population. En ligne : http://dx.doi.org/10.1007/s10803-015-2441-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

Brief Report: Using Cognitive Screeners in Autistic Adults / I. Z. GROOT in Journal of Autism and Developmental Disorders, 51-9 (September 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3374-3379 Titre : Brief Report: Using Cognitive Screeners in Autistic Adults Type de document : texte imprimé Auteurs : I. Z. GROOT, Auteur ; A. G. LEVER, Auteur ; P. Cédric KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur Article en page(s) : p.3374-3379 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder/diagnosis  Cognition  Cognitive Dysfunction/diagnosis  Humans  Infant, Newborn  Mental Status and Dementia Tests  Neuropsychological Tests  Ageing  Autism spectrum condition  Cognitive screening  Mmse  MoCA  Older adults Index. décimale : PER Périodiques Résumé : By comparing 51 autistic adults and 49 age-matched controls (aged 30-73 years) we tested if (1) the Montreal Cognitive Assessment (MoCA) is more sensitive in measuring cognitive impairments than the Mini Mental State Examination (MMSE) and (2) if we can replicate the MoCA-findings of Powell et al. (2017) with the Dutch MoCA(-NL). Results showed that: (1) The MoCA-NL is more sensitive, and (2) like Powell, no group differences were observed on the MoCA-NL. However, in contrast to Powell, we did not observe that older autistic adults show more impairment than controls on the MoCA-NL. Nonetheless, as the MoCA-NL is more sensitive to cognitive impairment, it is the recommended screener for older autistic adults. En ligne : http://dx.doi.org/10.1007/s10803-020-04782-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Brief Report: Using Cognitive Screeners in Autistic Adults [texte imprimé] / I. Z. GROOT, Auteur ; A. G. LEVER, Auteur ; P. Cédric KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur . - p.3374-3379. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3374-3379 Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder/diagnosis  Cognition  Cognitive Dysfunction/diagnosis  Humans  Infant, Newborn  Mental Status and Dementia Tests  Neuropsychological Tests  Ageing  Autism spectrum condition  Cognitive screening  Mmse  MoCA  Older adults Index. décimale : PER Périodiques Résumé : By comparing 51 autistic adults and 49 age-matched controls (aged 30-73 years) we tested if (1) the Montreal Cognitive Assessment (MoCA) is more sensitive in measuring cognitive impairments than the Mini Mental State Examination (MMSE) and (2) if we can replicate the MoCA-findings of Powell et al. (2017) with the Dutch MoCA(-NL). Results showed that: (1) The MoCA-NL is more sensitive, and (2) like Powell, no group differences were observed on the MoCA-NL. However, in contrast to Powell, we did not observe that older autistic adults show more impairment than controls on the MoCA-NL. Nonetheless, as the MoCA-NL is more sensitive to cognitive impairment, it is the recommended screener for older autistic adults. En ligne : http://dx.doi.org/10.1007/s10803-020-04782-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Gray Matter Characteristics in Mid and Old Aged Adults with ASD / P. Cédric KOOLSCHIJN in Journal of Autism and Developmental Disorders, 46-8 (August 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2666-2678 Titre : Gray Matter Characteristics in Mid and Old Aged Adults with ASD Type de document : texte imprimé Auteurs : P. Cédric KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur Article en page(s) : p.2666-2678 Langues : Anglais (eng) Mots-clés : Autism  Gray matter volume  Cortical thickness  Surface area  Gyrification  Adults Index. décimale : PER Périodiques Résumé : It is widely acknowledged that the brain anatomy of children and adolescents with autism spectrum disorder (ASD) shows a different developmental pattern then typical age-matched peers. There is however, a paucity of studies examining gray matter in mid and late adulthood in ASD. In this cross-sectional neuroimaging study, we, performed vertex-wise whole-brain and region-of-interest analyses of cortical volume, thickness, surface area, and gyrification index in 51 adults with and 49 without ASD, between 30 and 75 years. There was significant age-related volume loss and cortical thinning, but there were no group differences. The lack of significant anatomical differences between intellectual able individuals with and without ASD, suggests that ASD is not (strongly) related to gray matter morphology in mid and late adulthood. En ligne : http://dx.doi.org/10.1007/s10803-016-2810-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 [article] Gray Matter Characteristics in Mid and Old Aged Adults with ASD [texte imprimé] / P. Cédric KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur . - p.2666-2678. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-8 (August 2016) . - p.2666-2678 Mots-clés : Autism  Gray matter volume  Cortical thickness  Surface area  Gyrification  Adults Index. décimale : PER Périodiques Résumé : It is widely acknowledged that the brain anatomy of children and adolescents with autism spectrum disorder (ASD) shows a different developmental pattern then typical age-matched peers. There is however, a paucity of studies examining gray matter in mid and late adulthood in ASD. In this cross-sectional neuroimaging study, we, performed vertex-wise whole-brain and region-of-interest analyses of cortical volume, thickness, surface area, and gyrification index in 51 adults with and 49 without ASD, between 30 and 75 years. There was significant age-related volume loss and cortical thinning, but there were no group differences. The lack of significant anatomical differences between intellectual able individuals with and without ASD, suggests that ASD is not (strongly) related to gray matter morphology in mid and late adulthood. En ligne : http://dx.doi.org/10.1007/s10803-016-2810-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290

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