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Détail de l'auteur
Auteur Joe BATHELT |
Documents disponibles écrits par cet auteur (2)
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Age-variant and age-invariant features of functional brain organization in middle-aged and older autistic adults / Joe BATHELT in Molecular Autism, 11 (2020)
[article]
Titre : Age-variant and age-invariant features of functional brain organization in middle-aged and older autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : Joe BATHELT, Auteur ; P. Cédric KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur Article en page(s) : 9 p. Langues : Anglais (eng) Mots-clés : Aging Autism spectrum disorder Functional connectivity Graph theory perceived as posing a conflict or bias. The authors confirm that the funder had no influence on the study design, preparation of the manuscript, or decision to publish. Index. décimale : PER Périodiques Résumé : BACKGROUND: The majority of research effort into autism has been dedicated to understanding mechanisms during early development. As a consequence, research on the broader life course of an autism spectrum condition (ASC) has largely been neglected and almost nothing is known about ASC beyond middle age. Differences in brain connectivity that arise during early development may be maintained across the lifespan and may play protective or detrimental roles in older age. METHOD: This study explored age-related differences in functional connectivity across middle and older age in clinically diagnosed autistic adults (n?=?44, 30-73 years) and in an age-matched typical comparison group (n?=?45). RESULTS: The results indicated parallel age-related associations in ASC and typical aging for the local efficiency and connection strength of the default mode network and for the segregation of the frontoparietal control network. In contrast, group differences in visual network connectivity are compatible with a safeguarding interpretation of less age-related decline in brain function in ASC. This divergence was mirrored in different associations between visual network connectivity and reaction time variability in the ASC and comparison group. LIMITATIONS: The study is cross-sectional and may be affected by cohort effects. As all participants received their autism diagnosis in adulthood, this might hinder generalizability. CONCLUSION: These results highlight the complexity of aging in ASC with both parallel and divergent trajectories across different aspects of functional network organization. En ligne : http://dx.doi.org/10.1186/s13229-020-0316-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 9 p.[article] Age-variant and age-invariant features of functional brain organization in middle-aged and older autistic adults [Texte imprimé et/ou numérique] / Joe BATHELT, Auteur ; P. Cédric KOOLSCHIJN, Auteur ; Hilde M. GEURTS, Auteur . - 9 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 9 p.
Mots-clés : Aging Autism spectrum disorder Functional connectivity Graph theory perceived as posing a conflict or bias. The authors confirm that the funder had no influence on the study design, preparation of the manuscript, or decision to publish. Index. décimale : PER Périodiques Résumé : BACKGROUND: The majority of research effort into autism has been dedicated to understanding mechanisms during early development. As a consequence, research on the broader life course of an autism spectrum condition (ASC) has largely been neglected and almost nothing is known about ASC beyond middle age. Differences in brain connectivity that arise during early development may be maintained across the lifespan and may play protective or detrimental roles in older age. METHOD: This study explored age-related differences in functional connectivity across middle and older age in clinically diagnosed autistic adults (n?=?44, 30-73 years) and in an age-matched typical comparison group (n?=?45). RESULTS: The results indicated parallel age-related associations in ASC and typical aging for the local efficiency and connection strength of the default mode network and for the segregation of the frontoparietal control network. In contrast, group differences in visual network connectivity are compatible with a safeguarding interpretation of less age-related decline in brain function in ASC. This divergence was mirrored in different associations between visual network connectivity and reaction time variability in the ASC and comparison group. LIMITATIONS: The study is cross-sectional and may be affected by cohort effects. As all participants received their autism diagnosis in adulthood, this might hinder generalizability. CONCLUSION: These results highlight the complexity of aging in ASC with both parallel and divergent trajectories across different aspects of functional network organization. En ligne : http://dx.doi.org/10.1186/s13229-020-0316-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Difference in default mode network subsystems in autism across childhood and adolescence / Joe BATHELT in Autism, 25-2 (February 2021)
[article]
Titre : Difference in default mode network subsystems in autism across childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Joe BATHELT, Auteur ; Hilde M. GEURTS, Auteur Article en page(s) : p.556-565 Langues : Anglais (eng) Mots-clés : autism spectrum disorders brain development default mode network functional connectivity modularity Index. décimale : PER Périodiques Résumé : Neuroimaging research has identified a network of brain regions that are more active when we daydream compared to when we are engaged in a task. This network has been named the default mode network. Furthermore, differences in the default mode network are the most consistent findings in neuroimaging research in autism. Recent studies suggest that the default mode network is composed of subnetworks that are tied to different functions, namely memory and understanding others' minds. In this study, we investigated if default mode network differences in autism are related to specific subnetworks of the default mode network and if these differences change across childhood and adolescence. Our results suggest that the subnetworks of the default mode network are less differentiated in autism in middle childhood compared to neurotypicals. By late adolescence, the default mode network subnetwork organisation was similar in the autistic and neurotypical groups. These findings provide a foundation for future studies to investigate if this developmental pattern relates to improvements in the integration of memory and social understanding as autistic children grow up. En ligne : http://dx.doi.org/10.1177/1362361320969258 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442
in Autism > 25-2 (February 2021) . - p.556-565[article] Difference in default mode network subsystems in autism across childhood and adolescence [Texte imprimé et/ou numérique] / Joe BATHELT, Auteur ; Hilde M. GEURTS, Auteur . - p.556-565.
Langues : Anglais (eng)
in Autism > 25-2 (February 2021) . - p.556-565
Mots-clés : autism spectrum disorders brain development default mode network functional connectivity modularity Index. décimale : PER Périodiques Résumé : Neuroimaging research has identified a network of brain regions that are more active when we daydream compared to when we are engaged in a task. This network has been named the default mode network. Furthermore, differences in the default mode network are the most consistent findings in neuroimaging research in autism. Recent studies suggest that the default mode network is composed of subnetworks that are tied to different functions, namely memory and understanding others' minds. In this study, we investigated if default mode network differences in autism are related to specific subnetworks of the default mode network and if these differences change across childhood and adolescence. Our results suggest that the subnetworks of the default mode network are less differentiated in autism in middle childhood compared to neurotypicals. By late adolescence, the default mode network subnetwork organisation was similar in the autistic and neurotypical groups. These findings provide a foundation for future studies to investigate if this developmental pattern relates to improvements in the integration of memory and social understanding as autistic children grow up. En ligne : http://dx.doi.org/10.1177/1362361320969258 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442