Action execution and observation in autistic adults: A systematic review of fMRI studies / Sara Stillesjö ; Hanna Hjärtström ; Anna-Maria Johansson ; Thomas Rudolfsson ; Daniel Säfström ; Erik DOMELLÖF in Autism Research, 18-2 (February 2025)  

Public ISBD [article]  inAutism Research > 18-2 (February 2025) . - p.238-260 Titre : Action execution and observation in autistic adults: A systematic review of fMRI studies : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Sara Stillesjö, Auteur ; Hanna Hjärtström, Auteur ; Anna-Maria Johansson, Auteur ; Thomas Rudolfsson, Auteur ; Daniel Säfström, Auteur ; Erik DOMELLÖF, Auteur Article en page(s) : p.238-260 Langues : Anglais (eng) Mots-clés : action execution action imitation action observation autism autism spectrum disorder fMRI motor Index. décimale : PER Périodiques Résumé : Abstract Motor impairments are common in individuals with autism spectrum disorder (ASD) although less is known about the neural mechanisms related to such difficulties. This review provides an outline of functional magnetic resonance imaging (fMRI) findings associated with execution and observation of naturalistic actions in autistic adults. Summarized outcomes revealed that adults with ASD recruit similar brain regions as neurotypical adults during action execution and during action observation, although with a difference in direction and/or magnitude. For action execution, this included higher and lower activity bilaterally in the precentral cortex, the parietal cortex, the inferior frontal gyrus (IFG), the middle temporal gyrus (MTG), the occipital cortex, and the cerebellum. For action observation, differences mainly concerned both higher and lower activity in bilateral IFG and right precentral gyrus, and lower activity in MTG. Activity overlaps between action execution and observation highlight atypical recruitment of IFG, MTG, precentral, and parieto-occipital regions in ASD. The results show atypical recruitment of brain regions subserving motor planning and/or predictive control in ASD. Atypical brain activations during action observation, and the pattern of activity overlaps, indicate an association with difficulties in understanding others' actions and intentions. En ligne : https://doi.org/10.1002/aur.3291 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Action execution and observation in autistic adults: A systematic review of fMRI studies : Autism Research [Texte imprimé et/ou numérique] / Sara Stillesjö, Auteur ; Hanna Hjärtström, Auteur ; Anna-Maria Johansson, Auteur ; Thomas Rudolfsson, Auteur ; Daniel Säfström, Auteur ; Erik DOMELLÖF, Auteur . - p.238-260. Langues : Anglais (eng) in Autism Research > 18-2 (February 2025) . - p.238-260 Mots-clés : action execution action imitation action observation autism autism spectrum disorder fMRI motor Index. décimale : PER Périodiques Résumé : Abstract Motor impairments are common in individuals with autism spectrum disorder (ASD) although less is known about the neural mechanisms related to such difficulties. This review provides an outline of functional magnetic resonance imaging (fMRI) findings associated with execution and observation of naturalistic actions in autistic adults. Summarized outcomes revealed that adults with ASD recruit similar brain regions as neurotypical adults during action execution and during action observation, although with a difference in direction and/or magnitude. For action execution, this included higher and lower activity bilaterally in the precentral cortex, the parietal cortex, the inferior frontal gyrus (IFG), the middle temporal gyrus (MTG), the occipital cortex, and the cerebellum. For action observation, differences mainly concerned both higher and lower activity in bilateral IFG and right precentral gyrus, and lower activity in MTG. Activity overlaps between action execution and observation highlight atypical recruitment of IFG, MTG, precentral, and parieto-occipital regions in ASD. The results show atypical recruitment of brain regions subserving motor planning and/or predictive control in ASD. Atypical brain activations during action observation, and the pattern of activity overlaps, indicate an association with difficulties in understanding others' actions and intentions. En ligne : https://doi.org/10.1002/aur.3291 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Atypical development of sequential manual motor planning and visuomotor integration in children with autism at early school-age: A longitudinal kinematic study / Anna-Maria Johansson ; Thomas Rudolfsson ; Louise RONNQVIST ; Claes VON HOFSTEN ; Kerstin ROSANDER ; Erik DOMELLÖF in Autism, 29-6 (June 2025)  

Public ISBD [article]  inAutism > 29-6 (June 2025) . - p.1510-1523 Titre : Atypical development of sequential manual motor planning and visuomotor integration in children with autism at early school-age: A longitudinal kinematic study Type de document : Texte imprimé et/ou numérique Auteurs : Anna-Maria Johansson, Auteur ; Thomas Rudolfsson, Auteur ; Louise RONNQVIST, Auteur ; Claes VON HOFSTEN, Auteur ; Kerstin ROSANDER, Auteur ; Erik DOMELLÖF, Auteur Article en page(s) : p.1510-1523 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  development  kinematics  longitudinal  motor planning  school-age children  visuomotor integration Index. décimale : PER Périodiques Résumé : Sensorimotor difficulties are common in children with autism spectrum disorder, and it has been suggested that motor planning problems underlie their atypical movements. At early school-age, motor planning development typically involves changes in visuomotor integration, a function known to be affected in autism spectrum disorder. However, there is a lack of detailed characterization of typical motor planning development during this stage, and how motor planning develops in children with autism spectrum disorder is largely unknown. This longitudinal kinematic study examined goal-directed sequential manual movements in children with autism spectrum disorder and in typically developing children across ages 7, 8, and 9?years. We manipulated goal-difficulty and availability of initial visual information to investigate visuomotor integration and chaining of subparts during movement performance. The results revealed emerging group differences at older age, suggesting atypical motor planning development in children with autism spectrum disorder. Notably, unlike the typically developing group, availability of initial visual information did not facilitate motor planning for the autism spectrum disorder group. The results show that motor planning differences in autism spectrum disorder appear related to atypical visuomotor integration and global processing of sensorimotor information. The findings also emphasize the importance of considering developmental aspects in research and practice related to motor problems in children with autism spectrum disorder.Lay abstract Many children with autism struggle with movement difficulties, yet the causes of these difficulties remain unclear. One possible explanation is atypical motor planning and integration of visual and motoric information. Before performing a goal-directed movement, the brain creates a prediction of the movement based on visual and sensory information and previous experience, forming a "blueprint" of the motor steps needed to achieve the goal. This process is called motor planning. During movement, adjustments to the plan can be made through feedback mechanisms. This longitudinal study aimed to examine the development of motor planning in children with autism and typically developing children over early school-age (7-9?years). The children performed a sequential manual peg-rotation task, which involved grasping, rotating, and placing a peg, while detailed measures of movement were collected. Task end-goal difficulty varied, and the goal was either initially occluded or fully visible. The results revealed that children with autism showed atypical motor planning development compared with typically developing peers, and these differences became more pronounced as the children grew older. As the typically developing children matured, they appeared to rely more on initial visual information, which assisted them in motor planning. However, this facilitation did not occur for children with autism. These findings suggest that the differences in motor planning seen in children with autism may be linked to atypical visuomotor integration, highlighting the need for individualized interventions. Furthermore, it is crucial to consider developmental aspects to fully understand motor planning in children with autism. En ligne : https://dx.doi.org/10.1177/13623613241311333 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Atypical development of sequential manual motor planning and visuomotor integration in children with autism at early school-age: A longitudinal kinematic study [Texte imprimé et/ou numérique] / Anna-Maria Johansson, Auteur ; Thomas Rudolfsson, Auteur ; Louise RONNQVIST, Auteur ; Claes VON HOFSTEN, Auteur ; Kerstin ROSANDER, Auteur ; Erik DOMELLÖF, Auteur . - p.1510-1523. Langues : Anglais (eng) in Autism > 29-6 (June 2025) . - p.1510-1523 Mots-clés : autism spectrum disorders  development  kinematics  longitudinal  motor planning  school-age children  visuomotor integration Index. décimale : PER Périodiques Résumé : Sensorimotor difficulties are common in children with autism spectrum disorder, and it has been suggested that motor planning problems underlie their atypical movements. At early school-age, motor planning development typically involves changes in visuomotor integration, a function known to be affected in autism spectrum disorder. However, there is a lack of detailed characterization of typical motor planning development during this stage, and how motor planning develops in children with autism spectrum disorder is largely unknown. This longitudinal kinematic study examined goal-directed sequential manual movements in children with autism spectrum disorder and in typically developing children across ages 7, 8, and 9?years. We manipulated goal-difficulty and availability of initial visual information to investigate visuomotor integration and chaining of subparts during movement performance. The results revealed emerging group differences at older age, suggesting atypical motor planning development in children with autism spectrum disorder. Notably, unlike the typically developing group, availability of initial visual information did not facilitate motor planning for the autism spectrum disorder group. The results show that motor planning differences in autism spectrum disorder appear related to atypical visuomotor integration and global processing of sensorimotor information. The findings also emphasize the importance of considering developmental aspects in research and practice related to motor problems in children with autism spectrum disorder.Lay abstract Many children with autism struggle with movement difficulties, yet the causes of these difficulties remain unclear. One possible explanation is atypical motor planning and integration of visual and motoric information. Before performing a goal-directed movement, the brain creates a prediction of the movement based on visual and sensory information and previous experience, forming a "blueprint" of the motor steps needed to achieve the goal. This process is called motor planning. During movement, adjustments to the plan can be made through feedback mechanisms. This longitudinal study aimed to examine the development of motor planning in children with autism and typically developing children over early school-age (7-9?years). The children performed a sequential manual peg-rotation task, which involved grasping, rotating, and placing a peg, while detailed measures of movement were collected. Task end-goal difficulty varied, and the goal was either initially occluded or fully visible. The results revealed that children with autism showed atypical motor planning development compared with typically developing peers, and these differences became more pronounced as the children grew older. As the typically developing children matured, they appeared to rely more on initial visual information, which assisted them in motor planning. However, this facilitation did not occur for children with autism. These findings suggest that the differences in motor planning seen in children with autism may be linked to atypical visuomotor integration, highlighting the need for individualized interventions. Furthermore, it is crucial to consider developmental aspects to fully understand motor planning in children with autism. En ligne : https://dx.doi.org/10.1177/13623613241311333 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers / Olga EGOROVA in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 7 p. Titre : Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers Type de document : Texte imprimé et/ou numérique Auteurs : Olga EGOROVA, Auteur ; Robin MYTE, Auteur ; Jörn SCHNEEDE, Auteur ; Bruno HAGGLOF, Auteur ; Sven BÖLTE, Auteur ; Erik DOMELLÖF, Auteur ; Barbro IVARS A'ROCH, Auteur ; Fredrik ELGH, Auteur ; Per Magne UELAND, Auteur ; Sven-Arne SILFVERDAL, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : Autism  Folate  Inflammation  One-carbon metabolism  Pregnancy  Vitamin A  Vitamin B  Vitamin D  that he has in the last 5 years acted as an author, consultant, or lecturer for  Shire, Medice, Roche, Eli Lilly, Prima Psychiatry, GLGroup, System Analytic,  Kompetento, Expo Medica, and Prophase. He receives royalties for text books and  diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Erik Domellöf is supported  by a grant from the Knut and Alice Wallenberg Foundation (KAW 2015.0192). There are  no other financial disclosures or conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) evolves from an interplay between genetic and environmental factors during prenatal development. Since identifying maternal biomarkers associated with ASD risk in offspring during early pregnancy might result in new strategies for intervention, we investigated maternal metabolic biomarkers in relation to occurrence of ASD in offspring using both univariate logistic regression and multivariate network analysis. METHODS: Serum samples from 100 women with an offspring diagnosed with ASD and 100 matched control women with typically developing offspring were collected at week 14 of pregnancy. Concentrations of 62 metabolic biomarkers were determined, including amino acids, vitamins (A, B, D, E, and K), and biomarkers related to folate (vitamin B(9)) metabolism, lifestyle factors, as well as C-reactive protein (CRP), the kynurenine-tryptophan ratio (KTR), and neopterin as markers of inflammation and immune activation. RESULTS: We found weak evidence for a positive association between higher maternal serum concentrations of folate and increased occurrence of ASD (OR per 1 SD increase: 1.70, 95% CI 1.22-2.37, FDR adjusted P = 0.07). Multivariate network analysis confirmed expected internal biochemical relations between the biomarkers. Neither inflammation markers nor vitamin D(3) levels, all hypothesized to be involved in ASD etiology, displayed associations with ASD occurrence in the offspring. CONCLUSIONS: Our findings suggest that high maternal serum folate status during early pregnancy may be associated with the occurrence of ASD in offspring. No inference about physiological mechanisms behind this observation can be made at the present time because blood folate levels may have complex relations with nutritional intake, the cellular folate status and status of other B-vitamins. Therefore, further investigations, which may clarify the potential role and mechanisms of maternal blood folate status in ASD risk and the interplay with other potential risk factors, in larger materials are warranted. En ligne : http://dx.doi.org/10.1186/s13229-020-0315-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers [Texte imprimé et/ou numérique] / Olga EGOROVA, Auteur ; Robin MYTE, Auteur ; Jörn SCHNEEDE, Auteur ; Bruno HAGGLOF, Auteur ; Sven BÖLTE, Auteur ; Erik DOMELLÖF, Auteur ; Barbro IVARS A'ROCH, Auteur ; Fredrik ELGH, Auteur ; Per Magne UELAND, Auteur ; Sven-Arne SILFVERDAL, Auteur . - 7 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 7 p. Mots-clés : Autism  Folate  Inflammation  One-carbon metabolism  Pregnancy  Vitamin A  Vitamin B  Vitamin D  that he has in the last 5 years acted as an author, consultant, or lecturer for  Shire, Medice, Roche, Eli Lilly, Prima Psychiatry, GLGroup, System Analytic,  Kompetento, Expo Medica, and Prophase. He receives royalties for text books and  diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Erik Domellöf is supported  by a grant from the Knut and Alice Wallenberg Foundation (KAW 2015.0192). There are  no other financial disclosures or conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) evolves from an interplay between genetic and environmental factors during prenatal development. Since identifying maternal biomarkers associated with ASD risk in offspring during early pregnancy might result in new strategies for intervention, we investigated maternal metabolic biomarkers in relation to occurrence of ASD in offspring using both univariate logistic regression and multivariate network analysis. METHODS: Serum samples from 100 women with an offspring diagnosed with ASD and 100 matched control women with typically developing offspring were collected at week 14 of pregnancy. Concentrations of 62 metabolic biomarkers were determined, including amino acids, vitamins (A, B, D, E, and K), and biomarkers related to folate (vitamin B(9)) metabolism, lifestyle factors, as well as C-reactive protein (CRP), the kynurenine-tryptophan ratio (KTR), and neopterin as markers of inflammation and immune activation. RESULTS: We found weak evidence for a positive association between higher maternal serum concentrations of folate and increased occurrence of ASD (OR per 1 SD increase: 1.70, 95% CI 1.22-2.37, FDR adjusted P = 0.07). Multivariate network analysis confirmed expected internal biochemical relations between the biomarkers. Neither inflammation markers nor vitamin D(3) levels, all hypothesized to be involved in ASD etiology, displayed associations with ASD occurrence in the offspring. CONCLUSIONS: Our findings suggest that high maternal serum folate status during early pregnancy may be associated with the occurrence of ASD in offspring. No inference about physiological mechanisms behind this observation can be made at the present time because blood folate levels may have complex relations with nutritional intake, the cellular folate status and status of other B-vitamins. Therefore, further investigations, which may clarify the potential role and mechanisms of maternal blood folate status in ASD risk and the interplay with other potential risk factors, in larger materials are warranted. En ligne : http://dx.doi.org/10.1186/s13229-020-0315-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

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