Defining clusters of young autistic and typically developing children based on loudness-dependent auditory electrophysiological responses / Patrick DWYER in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 48 p. Titre : Defining clusters of young autistic and typically developing children based on loudness-dependent auditory electrophysiological responses Type de document : texte imprimé Auteurs : Patrick DWYER, Auteur ; Xiaodong WANG, Auteur ; Rosanna DE MEO-MONTEIL, Auteur ; Fushing HSIEH, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur Article en page(s) : 48 p. Langues : Anglais (eng) Mots-clés : Autism  Event-related potentials (ERPs)  Heterogeneity  Hierarchical clustering  Sensory processing  Subgroups  study. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic individuals exhibit atypical patterns of sensory processing that are known to be related to quality of life, but which are also highly heterogeneous. Previous investigations of this heterogeneity have ordinarily used questionnaires and have rarely investigated sensory processing in typical development (TD) alongside autism spectrum development (ASD). METHODS: The present study used hierarchical clustering in a large sample to identify subgroups of young autistic and typically developing children based on the normalized global field power (GFP) of their event-related potentials (ERPs) to auditory stimuli of four different loudness intensities (50, 60, 70, 80 dB SPL): that is, based on an index of the relative strengths of their neural responses across these loudness conditions. RESULTS: Four clusters of participants were defined. Normalized GFP responses to sounds of different intensities differed strongly across clusters. There was considerable overlap in cluster assignments of autistic and typically developing participants, but autistic participants were more likely to display a pattern of relatively linear increases in response strength accompanied by a disproportionately strong response to 70 dB stimuli. Autistic participants displaying this pattern trended towards obtaining higher scores on assessments of cognitive abilities. There was also a trend for typically developing participants to disproportionately fall into a cluster characterized by disproportionately/nonlinearly strong 60 dB responses. Greater auditory distractibility was reported among autistic participants in a cluster characterized by disproportionately strong responses to the loudest (80 dB) sounds, and furthermore, relatively strong responses to loud sounds were correlated with auditory distractibility. This appears to provide evidence of coinciding behavioral and neural sensory atypicalities. LIMITATIONS: Replication may be needed to verify exploratory results. This analysis does not address variability related to classical ERP latencies and topographies. The sensory questionnaire employed was not specifically designed for use in autism. Hearing acuity was not measured. Variability in sensory responses unrelated to loudness is not addressed, leaving room for additional research. CONCLUSIONS: Taken together, these data demonstrate the broader benefits of using electrophysiology to explore individual differences. They illuminate different neural response patterns and suggest relationships between sensory neural responses and sensory behaviors, cognitive abilities, and autism diagnostic status. En ligne : http://dx.doi.org/10.1186/s13229-020-00352-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Defining clusters of young autistic and typically developing children based on loudness-dependent auditory electrophysiological responses [texte imprimé] / Patrick DWYER, Auteur ; Xiaodong WANG, Auteur ; Rosanna DE MEO-MONTEIL, Auteur ; Fushing HSIEH, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur . - 48 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 48 p. Mots-clés : Autism  Event-related potentials (ERPs)  Heterogeneity  Hierarchical clustering  Sensory processing  Subgroups  study. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic individuals exhibit atypical patterns of sensory processing that are known to be related to quality of life, but which are also highly heterogeneous. Previous investigations of this heterogeneity have ordinarily used questionnaires and have rarely investigated sensory processing in typical development (TD) alongside autism spectrum development (ASD). METHODS: The present study used hierarchical clustering in a large sample to identify subgroups of young autistic and typically developing children based on the normalized global field power (GFP) of their event-related potentials (ERPs) to auditory stimuli of four different loudness intensities (50, 60, 70, 80 dB SPL): that is, based on an index of the relative strengths of their neural responses across these loudness conditions. RESULTS: Four clusters of participants were defined. Normalized GFP responses to sounds of different intensities differed strongly across clusters. There was considerable overlap in cluster assignments of autistic and typically developing participants, but autistic participants were more likely to display a pattern of relatively linear increases in response strength accompanied by a disproportionately strong response to 70 dB stimuli. Autistic participants displaying this pattern trended towards obtaining higher scores on assessments of cognitive abilities. There was also a trend for typically developing participants to disproportionately fall into a cluster characterized by disproportionately/nonlinearly strong 60 dB responses. Greater auditory distractibility was reported among autistic participants in a cluster characterized by disproportionately strong responses to the loudest (80 dB) sounds, and furthermore, relatively strong responses to loud sounds were correlated with auditory distractibility. This appears to provide evidence of coinciding behavioral and neural sensory atypicalities. LIMITATIONS: Replication may be needed to verify exploratory results. This analysis does not address variability related to classical ERP latencies and topographies. The sensory questionnaire employed was not specifically designed for use in autism. Hearing acuity was not measured. Variability in sensory responses unrelated to loudness is not addressed, leaving room for additional research. CONCLUSIONS: Taken together, these data demonstrate the broader benefits of using electrophysiology to explore individual differences. They illuminate different neural response patterns and suggest relationships between sensory neural responses and sensory behaviors, cognitive abilities, and autism diagnostic status. En ligne : http://dx.doi.org/10.1186/s13229-020-00352-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Differential Altered Auditory Event-Related Potential Responses in Young Boys on the Autism Spectrum With and Without Disproportionate Megalencephaly / Rosanna DE MEO-MONTEIL in Autism Research, 12-8 (August 2019)  

Public ISBD [article]  inAutism Research > 12-8 (August 2019) . - p.1236-1250 Titre : Differential Altered Auditory Event-Related Potential Responses in Young Boys on the Autism Spectrum With and Without Disproportionate Megalencephaly Type de document : texte imprimé Auteurs : Rosanna DE MEO-MONTEIL, Auteur ; Christine W. NORDAHL, Auteur ; David G. AMARAL, Auteur ; Sally J. ROGERS, Auteur ; Sevan K. HAROOTONIAN, Auteur ; Joanna MARTIN, Auteur ; Susan M. RIVERA, Auteur ; Clifford D. SARON, Auteur Article en page(s) : p.1236-1250 Langues : Anglais (eng) Mots-clés : Eeg  auditory processing  autism spectrum disorder  disproportionate megalencephaly  toddlers Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD), characterized by impairments in social communication and repetitive behaviors, often includes altered responses to sensory inputs as part of its phenotype. The neurobiological basis for altered sensory processing is not well understood. The UC Davis Medical Investigation of Neurodevelopmental Disorders Institute Autism Phenome Project is a longitudinal, multidisciplinary study of young children with ASD and age-matched typically developing (TD) controls. Previous analyses of the magnetic resonance imaging data from this cohort have shown that approximately 15% of boys with ASD have disproportionate megalencephaly (DM) or brain size to height ratio, that is 1.5 standard deviations above the TD mean. Here, we investigated electrophysiological responses to auditory stimuli of increasing intensity (50-80 dB) in young toddlers (27-48 months old). Analyses included data from 36 age-matched boys, of which 24 were diagnosed with ASD (12 with and 12 without DM; ASD-DM and ASD-N) and 12 TD controls. We found that the two ASD subgroups differed in their electrophysiological response patterns to sounds of increasing intensity. At early latencies (55-115 ms), ASD-N does not show a loudness-dependent response like TD and ASD-DM, but tends to group intensities by soft vs. loud sounds, suggesting differences in sensory sensitivity in this group. At later latencies (145-195 ms), only the ASD-DM group shows significantly higher amplitudes for loud sounds. Because no similar effects were found in ASD-N and TD groups, this may be related to their altered neuroanatomy. These results contribute to the effort to delineate ASD subgroups and further characterize physiological responses associated with observable phenotypes. Autism Res 2019, 12: 1236-1250. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Approximately 15% of boys with ASD have much bigger brains when compared to individuals with typical development. By recording brain waves (electroencephalography) we compared how autistic children, with or without big brains, react to sounds compared to typically developing controls. We found that brain responses in the big-brained group are different from the two other groups, suggesting that they represent a specific autism subgroup. En ligne : http://dx.doi.org/10.1002/aur.2137 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Differential Altered Auditory Event-Related Potential Responses in Young Boys on the Autism Spectrum With and Without Disproportionate Megalencephaly [texte imprimé] / Rosanna DE MEO-MONTEIL, Auteur ; Christine W. NORDAHL, Auteur ; David G. AMARAL, Auteur ; Sally J. ROGERS, Auteur ; Sevan K. HAROOTONIAN, Auteur ; Joanna MARTIN, Auteur ; Susan M. RIVERA, Auteur ; Clifford D. SARON, Auteur . - p.1236-1250. Langues : Anglais (eng) in Autism Research > 12-8 (August 2019) . - p.1236-1250 Mots-clés : Eeg  auditory processing  autism spectrum disorder  disproportionate megalencephaly  toddlers Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD), characterized by impairments in social communication and repetitive behaviors, often includes altered responses to sensory inputs as part of its phenotype. The neurobiological basis for altered sensory processing is not well understood. The UC Davis Medical Investigation of Neurodevelopmental Disorders Institute Autism Phenome Project is a longitudinal, multidisciplinary study of young children with ASD and age-matched typically developing (TD) controls. Previous analyses of the magnetic resonance imaging data from this cohort have shown that approximately 15% of boys with ASD have disproportionate megalencephaly (DM) or brain size to height ratio, that is 1.5 standard deviations above the TD mean. Here, we investigated electrophysiological responses to auditory stimuli of increasing intensity (50-80 dB) in young toddlers (27-48 months old). Analyses included data from 36 age-matched boys, of which 24 were diagnosed with ASD (12 with and 12 without DM; ASD-DM and ASD-N) and 12 TD controls. We found that the two ASD subgroups differed in their electrophysiological response patterns to sounds of increasing intensity. At early latencies (55-115 ms), ASD-N does not show a loudness-dependent response like TD and ASD-DM, but tends to group intensities by soft vs. loud sounds, suggesting differences in sensory sensitivity in this group. At later latencies (145-195 ms), only the ASD-DM group shows significantly higher amplitudes for loud sounds. Because no similar effects were found in ASD-N and TD groups, this may be related to their altered neuroanatomy. These results contribute to the effort to delineate ASD subgroups and further characterize physiological responses associated with observable phenotypes. Autism Res 2019, 12: 1236-1250. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Approximately 15% of boys with ASD have much bigger brains when compared to individuals with typical development. By recording brain waves (electroencephalography) we compared how autistic children, with or without big brains, react to sounds compared to typically developing controls. We found that brain responses in the big-brained group are different from the two other groups, suggesting that they represent a specific autism subgroup. En ligne : http://dx.doi.org/10.1002/aur.2137 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Exploring Sensory Subgroups in Typical Development and Autism Spectrum Development Using Factor Mixture Modelling / Patrick DWYER in Journal of Autism and Developmental Disorders, 52-9 (September 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3840-3860 Titre : Exploring Sensory Subgroups in Typical Development and Autism Spectrum Development Using Factor Mixture Modelling Type de document : texte imprimé Auteurs : Patrick DWYER, Auteur ; Emilio FERRER, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur Article en page(s) : p.3840-3860 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Child Development Disorders, Pervasive  Humans  Auditory P1  Auditory event-related potentials (ERPs)  Autism  Factor mixture modelling  Heterogeneity  Sensory processing Index. décimale : PER Périodiques Résumé : This study uses factor mixture modelling of the Short Sensory Profile (SSP) at two time points to describe subgroups of young autistic and typically-developing children. This approach allows separate SSP subscales to influence overall SSP performance differentially across subgroups. Three subgroups were described, one including almost all typically-developing participants plus many autistic participants. SSP performance of a second, largely-autistic subgroup was predominantly shaped by a subscale indexing behaviours of low energy/weakness. Finally, the third subgroup, again largely autistic, contained participants with low (or more "atypical") SSP scores across most subscales. In this subgroup, autistic participants exhibited large P1 amplitudes to loud sounds. Autistic participants in subgroups with more atypical SSP scores had higher anxiety and more sleep disturbances. En ligne : http://dx.doi.org/10.1007/s10803-021-05256-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Exploring Sensory Subgroups in Typical Development and Autism Spectrum Development Using Factor Mixture Modelling [texte imprimé] / Patrick DWYER, Auteur ; Emilio FERRER, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur . - p.3840-3860. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3840-3860 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Child Development Disorders, Pervasive  Humans  Auditory P1  Auditory event-related potentials (ERPs)  Autism  Factor mixture modelling  Heterogeneity  Sensory processing Index. décimale : PER Périodiques Résumé : This study uses factor mixture modelling of the Short Sensory Profile (SSP) at two time points to describe subgroups of young autistic and typically-developing children. This approach allows separate SSP subscales to influence overall SSP performance differentially across subgroups. Three subgroups were described, one including almost all typically-developing participants plus many autistic participants. SSP performance of a second, largely-autistic subgroup was predominantly shaped by a subscale indexing behaviours of low energy/weakness. Finally, the third subgroup, again largely autistic, contained participants with low (or more "atypical") SSP scores across most subscales. In this subgroup, autistic participants exhibited large P1 amplitudes to loud sounds. Autistic participants in subgroups with more atypical SSP scores had higher anxiety and more sleep disturbances. En ligne : http://dx.doi.org/10.1007/s10803-021-05256-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

Habituation of auditory responses in young autistic and neurotypical children / Patrick DWYER in Autism Research, 16-10 (October 2023)  

Public ISBD [article]  inAutism Research > 16-10 (October 2023) . - p.1903-1923 Titre : Habituation of auditory responses in young autistic and neurotypical children Type de document : texte imprimé Auteurs : Patrick DWYER, Auteur ; Zachary J. WILLIAMS, Auteur ; Svjetlana VUKUSIC, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur Article en page(s) : p.1903-1923 Index. décimale : PER Périodiques Résumé : Abstract Prior studies suggest that habituation of sensory responses is reduced in autism and that diminished habituation could be related to atypical autistic sensory experiences, for example, by causing brain responses to aversive stimuli to remain strong over time instead of being suppressed. While many prior studies exploring habituation in autism have repeatedly presented identical stimuli, other studies suggest group differences can still be observed in habituation to intermittent stimuli. The present study explored habituation of electrophysiological responses to auditory complex tones of varying intensities (50-80 dB SPL), presented passively in an interleaved manner, in a well-characterized sample of 127 autistic (MDQ 65.41, SD 20.54) and 79 typically developing (MDQ 106.02, SD 11.50) children between 2 and 5 years old. Habituation was quantified as changes in the amplitudes of single-trial responses to tones of each intensity over the course of the experiment. Habituation of the auditory N2 response was substantially reduced in autistic participants as compared to typically developing controls, although diagnostic groups did not clearly differ in habituation of the P1 response. Interestingly, the P1 habituated less to loud 80 dB sounds than softer sounds, whereas the N2 habituated less to soft 50 dB sounds than louder sounds. No associations were found between electrophysiological habituation and cognitive ability or participants' caregiver-reported sound tolerance (Sensory Profile Hyperacusis Index). The results present study results extend prior research suggesting habituation of certain sensory responses is reduced in autism; however, they also suggest that habituation differences observed using this study's paradigm might not be a primary driver of autistic participants' real-world sound intolerance. En ligne : https://doi.org/10.1002/aur.3022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Habituation of auditory responses in young autistic and neurotypical children [texte imprimé] / Patrick DWYER, Auteur ; Zachary J. WILLIAMS, Auteur ; Svjetlana VUKUSIC, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur . - p.1903-1923. in Autism Research > 16-10 (October 2023) . - p.1903-1923 Index. décimale : PER Périodiques Résumé : Abstract Prior studies suggest that habituation of sensory responses is reduced in autism and that diminished habituation could be related to atypical autistic sensory experiences, for example, by causing brain responses to aversive stimuli to remain strong over time instead of being suppressed. While many prior studies exploring habituation in autism have repeatedly presented identical stimuli, other studies suggest group differences can still be observed in habituation to intermittent stimuli. The present study explored habituation of electrophysiological responses to auditory complex tones of varying intensities (50-80 dB SPL), presented passively in an interleaved manner, in a well-characterized sample of 127 autistic (MDQ 65.41, SD 20.54) and 79 typically developing (MDQ 106.02, SD 11.50) children between 2 and 5 years old. Habituation was quantified as changes in the amplitudes of single-trial responses to tones of each intensity over the course of the experiment. Habituation of the auditory N2 response was substantially reduced in autistic participants as compared to typically developing controls, although diagnostic groups did not clearly differ in habituation of the P1 response. Interestingly, the P1 habituated less to loud 80 dB sounds than softer sounds, whereas the N2 habituated less to soft 50 dB sounds than louder sounds. No associations were found between electrophysiological habituation and cognitive ability or participants' caregiver-reported sound tolerance (Sensory Profile Hyperacusis Index). The results present study results extend prior research suggesting habituation of certain sensory responses is reduced in autism; however, they also suggest that habituation differences observed using this study's paradigm might not be a primary driver of autistic participants' real-world sound intolerance. En ligne : https://doi.org/10.1002/aur.3022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Identification of Longitudinal Sensory Subtypes in Typical Development and Autism Spectrum Development Using Growth Mixture Modelling / Patrick DWYER in Research in Autism Spectrum Disorders, 78 (October 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 78 (October 2020) . - 101645 Titre : Identification of Longitudinal Sensory Subtypes in Typical Development and Autism Spectrum Development Using Growth Mixture Modelling Type de document : texte imprimé Auteurs : Patrick DWYER, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur Article en page(s) : 101645 Langues : Anglais (eng) Mots-clés : Autism  sensory processing  heterogeneity  subgroups  growth mixture model  subtypes Index. décimale : PER Périodiques Résumé : Background Prior longitudinal investigations of trajectories of sensory features in Autism Spectrum Development (ASD) have not explored heterogeneity. The present study explores initial levels and trajectories of sensory features in ASD as well as, for comparison, typical development. Method Growth mixture modelling was used to explore classes of autistic and typically-developing participants based on caregiver-reported total sensory behaviours on the Short Sensory Profile (SSP) at two time points, when children were aged 2-5 and 4-10 years of age, respectively. Results Three classes are described: a mixed class of autistic and typically-developing participants with few problematic sensory behaviours (“Stable Mild”), a mostly-autistic class with more problematic sensory features (“Stable Intense”), and a small class of autistic participants whose sensory features reportedly worsened (“Increasingly Intense”). Autistic participants in the Stable Intense class exhibited high anxiety, while autistic participants in the Increasingly Intense class appeared to obtain high scores on cognitive assessments. Conclusions The heterogeneity of sensory features and challenges found in the present study may suggest that practitioners should conduct individualized assessments of sensory features in ASD. Furthermore, practitioners should be aware of links between sensory features and anxiety in ASD, which may imply that sensory accommodations and supports could protect against anxiety. Finally, the worsening of sensory features over time in the Increasingly Intense subgroup may indicate a need for continued monitoring of changes in sensory features, perhaps especially as sensory environments change during periods of transition. En ligne : https://doi.org/10.1016/j.rasd.2020.101645 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Identification of Longitudinal Sensory Subtypes in Typical Development and Autism Spectrum Development Using Growth Mixture Modelling [texte imprimé] / Patrick DWYER, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur . - 101645. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 78 (October 2020) . - 101645 Mots-clés : Autism  sensory processing  heterogeneity  subgroups  growth mixture model  subtypes Index. décimale : PER Périodiques Résumé : Background Prior longitudinal investigations of trajectories of sensory features in Autism Spectrum Development (ASD) have not explored heterogeneity. The present study explores initial levels and trajectories of sensory features in ASD as well as, for comparison, typical development. Method Growth mixture modelling was used to explore classes of autistic and typically-developing participants based on caregiver-reported total sensory behaviours on the Short Sensory Profile (SSP) at two time points, when children were aged 2-5 and 4-10 years of age, respectively. Results Three classes are described: a mixed class of autistic and typically-developing participants with few problematic sensory behaviours (“Stable Mild”), a mostly-autistic class with more problematic sensory features (“Stable Intense”), and a small class of autistic participants whose sensory features reportedly worsened (“Increasingly Intense”). Autistic participants in the Stable Intense class exhibited high anxiety, while autistic participants in the Increasingly Intense class appeared to obtain high scores on cognitive assessments. Conclusions The heterogeneity of sensory features and challenges found in the present study may suggest that practitioners should conduct individualized assessments of sensory features in ASD. Furthermore, practitioners should be aware of links between sensory features and anxiety in ASD, which may imply that sensory accommodations and supports could protect against anxiety. Finally, the worsening of sensory features over time in the Increasingly Intense subgroup may indicate a need for continued monitoring of changes in sensory features, perhaps especially as sensory environments change during periods of transition. En ligne : https://doi.org/10.1016/j.rasd.2020.101645 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Investigating autistic hyperfocus and monotropism: Limited convergence of event-related potentials, laboratory tasks, and questionnaire responses / Andre SILLAS ; Clifford D. SARON ; Susan M. RIVERA in Research in Autism, 127 (September 2025)  

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?Neural Noise? in Auditory Responses in Young Autistic and Neurotypical Children / Svjetlana VUKUSIC ; Zachary J. WILLIAMS ; Clifford D. SARON ; Susan M. RIVERA in Journal of Autism and Developmental Disorders, 54-2 (February 2024)  

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