Defining clusters of young autistic and typically developing children based on loudness-dependent auditory electrophysiological responses / Patrick DWYER in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 48 p. Titre : Defining clusters of young autistic and typically developing children based on loudness-dependent auditory electrophysiological responses Type de document : Texte imprimé et/ou numérique Auteurs : Patrick DWYER, Auteur ; Xiaodong WANG, Auteur ; Rosanna DE MEO-MONTEIL, Auteur ; Fushing HSIEH, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur Article en page(s) : 48 p. Langues : Anglais (eng) Mots-clés : Autism  Event-related potentials (ERPs)  Heterogeneity  Hierarchical clustering  Sensory processing  Subgroups  study. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic individuals exhibit atypical patterns of sensory processing that are known to be related to quality of life, but which are also highly heterogeneous. Previous investigations of this heterogeneity have ordinarily used questionnaires and have rarely investigated sensory processing in typical development (TD) alongside autism spectrum development (ASD). METHODS: The present study used hierarchical clustering in a large sample to identify subgroups of young autistic and typically developing children based on the normalized global field power (GFP) of their event-related potentials (ERPs) to auditory stimuli of four different loudness intensities (50, 60, 70, 80?dB SPL): that is, based on an index of the relative strengths of their neural responses across these loudness conditions. RESULTS: Four clusters of participants were defined. Normalized GFP responses to sounds of different intensities differed strongly across clusters. There was considerable overlap in cluster assignments of autistic and typically developing participants, but autistic participants were more likely to display a pattern of relatively linear increases in response strength accompanied by a disproportionately strong response to 70?dB stimuli. Autistic participants displaying this pattern trended towards obtaining higher scores on assessments of cognitive abilities. There was also a trend for typically developing participants to disproportionately fall into a cluster characterized by disproportionately/nonlinearly strong 60?dB responses. Greater auditory distractibility was reported among autistic participants in a cluster characterized by disproportionately strong responses to the loudest (80?dB) sounds, and furthermore, relatively strong responses to loud sounds were correlated with auditory distractibility. This appears to provide evidence of coinciding behavioral and neural sensory atypicalities. LIMITATIONS: Replication may be needed to verify exploratory results. This analysis does not address variability related to classical ERP latencies and topographies. The sensory questionnaire employed was not specifically designed for use in autism. Hearing acuity was not measured. Variability in sensory responses unrelated to loudness is not addressed, leaving room for additional research. CONCLUSIONS: Taken together, these data demonstrate the broader benefits of using electrophysiology to explore individual differences. They illuminate different neural response patterns and suggest relationships between sensory neural responses and sensory behaviors, cognitive abilities, and autism diagnostic status. En ligne : http://dx.doi.org/10.1186/s13229-020-00352-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Defining clusters of young autistic and typically developing children based on loudness-dependent auditory electrophysiological responses [Texte imprimé et/ou numérique] / Patrick DWYER, Auteur ; Xiaodong WANG, Auteur ; Rosanna DE MEO-MONTEIL, Auteur ; Fushing HSIEH, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur . - 48 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 48 p. Mots-clés : Autism  Event-related potentials (ERPs)  Heterogeneity  Hierarchical clustering  Sensory processing  Subgroups  study. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic individuals exhibit atypical patterns of sensory processing that are known to be related to quality of life, but which are also highly heterogeneous. Previous investigations of this heterogeneity have ordinarily used questionnaires and have rarely investigated sensory processing in typical development (TD) alongside autism spectrum development (ASD). METHODS: The present study used hierarchical clustering in a large sample to identify subgroups of young autistic and typically developing children based on the normalized global field power (GFP) of their event-related potentials (ERPs) to auditory stimuli of four different loudness intensities (50, 60, 70, 80?dB SPL): that is, based on an index of the relative strengths of their neural responses across these loudness conditions. RESULTS: Four clusters of participants were defined. Normalized GFP responses to sounds of different intensities differed strongly across clusters. There was considerable overlap in cluster assignments of autistic and typically developing participants, but autistic participants were more likely to display a pattern of relatively linear increases in response strength accompanied by a disproportionately strong response to 70?dB stimuli. Autistic participants displaying this pattern trended towards obtaining higher scores on assessments of cognitive abilities. There was also a trend for typically developing participants to disproportionately fall into a cluster characterized by disproportionately/nonlinearly strong 60?dB responses. Greater auditory distractibility was reported among autistic participants in a cluster characterized by disproportionately strong responses to the loudest (80?dB) sounds, and furthermore, relatively strong responses to loud sounds were correlated with auditory distractibility. This appears to provide evidence of coinciding behavioral and neural sensory atypicalities. LIMITATIONS: Replication may be needed to verify exploratory results. This analysis does not address variability related to classical ERP latencies and topographies. The sensory questionnaire employed was not specifically designed for use in autism. Hearing acuity was not measured. Variability in sensory responses unrelated to loudness is not addressed, leaving room for additional research. CONCLUSIONS: Taken together, these data demonstrate the broader benefits of using electrophysiology to explore individual differences. They illuminate different neural response patterns and suggest relationships between sensory neural responses and sensory behaviors, cognitive abilities, and autism diagnostic status. En ligne : http://dx.doi.org/10.1186/s13229-020-00352-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Exploring Sensory Subgroups in Typical Development and Autism Spectrum Development Using Factor Mixture Modelling / Patrick DWYER in Journal of Autism and Developmental Disorders, 52-9 (September 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3840-3860 Titre : Exploring Sensory Subgroups in Typical Development and Autism Spectrum Development Using Factor Mixture Modelling Type de document : Texte imprimé et/ou numérique Auteurs : Patrick DWYER, Auteur ; Emilio FERRER, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur Article en page(s) : p.3840-3860 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Child Development Disorders, Pervasive  Humans  Auditory P1  Auditory event-related potentials (ERPs)  Autism  Factor mixture modelling  Heterogeneity  Sensory processing Index. décimale : PER Périodiques Résumé : This study uses factor mixture modelling of the Short Sensory Profile (SSP) at two time points to describe subgroups of young autistic and typically-developing children. This approach allows separate SSP subscales to influence overall SSP performance differentially across subgroups. Three subgroups were described, one including almost all typically-developing participants plus many autistic participants. SSP performance of a second, largely-autistic subgroup was predominantly shaped by a subscale indexing behaviours of low energy/weakness. Finally, the third subgroup, again largely autistic, contained participants with low (or more "atypical") SSP scores across most subscales. In this subgroup, autistic participants exhibited large P1 amplitudes to loud sounds. Autistic participants in subgroups with more atypical SSP scores had higher anxiety and more sleep disturbances. En ligne : http://dx.doi.org/10.1007/s10803-021-05256-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Exploring Sensory Subgroups in Typical Development and Autism Spectrum Development Using Factor Mixture Modelling [Texte imprimé et/ou numérique] / Patrick DWYER, Auteur ; Emilio FERRER, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur . - p.3840-3860. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3840-3860 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Child Development Disorders, Pervasive  Humans  Auditory P1  Auditory event-related potentials (ERPs)  Autism  Factor mixture modelling  Heterogeneity  Sensory processing Index. décimale : PER Périodiques Résumé : This study uses factor mixture modelling of the Short Sensory Profile (SSP) at two time points to describe subgroups of young autistic and typically-developing children. This approach allows separate SSP subscales to influence overall SSP performance differentially across subgroups. Three subgroups were described, one including almost all typically-developing participants plus many autistic participants. SSP performance of a second, largely-autistic subgroup was predominantly shaped by a subscale indexing behaviours of low energy/weakness. Finally, the third subgroup, again largely autistic, contained participants with low (or more "atypical") SSP scores across most subscales. In this subgroup, autistic participants exhibited large P1 amplitudes to loud sounds. Autistic participants in subgroups with more atypical SSP scores had higher anxiety and more sleep disturbances. En ligne : http://dx.doi.org/10.1007/s10803-021-05256-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

Habituation of auditory responses in young autistic and neurotypical children / Patrick DWYER in Autism Research, 16-10 (October 2023)  

Public ISBD [article]  inAutism Research > 16-10 (October 2023) . - p.1903-1923 Titre : Habituation of auditory responses in young autistic and neurotypical children Type de document : Texte imprimé et/ou numérique Auteurs : Patrick DWYER, Auteur ; Zachary J. WILLIAMS, Auteur ; Svjetlana VUKUSIC, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur Article en page(s) : p.1903-1923 Index. décimale : PER Périodiques Résumé : Abstract Prior studies suggest that habituation of sensory responses is reduced in autism and that diminished habituation could be related to atypical autistic sensory experiences, for example, by causing brain responses to aversive stimuli to remain strong over time instead of being suppressed. While many prior studies exploring habituation in autism have repeatedly presented identical stimuli, other studies suggest group differences can still be observed in habituation to intermittent stimuli. The present study explored habituation of electrophysiological responses to auditory complex tones of varying intensities (50-80?dB SPL), presented passively in an interleaved manner, in a well-characterized sample of 127 autistic (MDQ?=?65.41, SD?=?20.54) and 79 typically developing (MDQ?=?106.02, SD?=?11.50) children between 2 and 5?years old. Habituation was quantified as changes in the amplitudes of single-trial responses to tones of each intensity over the course of the experiment. Habituation of the auditory N2 response was substantially reduced in autistic participants as compared to typically developing controls, although diagnostic groups did not clearly differ in habituation of the P1 response. Interestingly, the P1 habituated less to loud 80?dB sounds than softer sounds, whereas the N2 habituated less to soft 50?dB sounds than louder sounds. No associations were found between electrophysiological habituation and cognitive ability or participants' caregiver-reported sound tolerance (Sensory Profile Hyperacusis Index). The results present study results extend prior research suggesting habituation of certain sensory responses is reduced in autism; however, they also suggest that habituation differences observed using this study's paradigm might not be a primary driver of autistic participants' real-world sound intolerance. En ligne : https://doi.org/10.1002/aur.3022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Habituation of auditory responses in young autistic and neurotypical children [Texte imprimé et/ou numérique] / Patrick DWYER, Auteur ; Zachary J. WILLIAMS, Auteur ; Svjetlana VUKUSIC, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur . - p.1903-1923. in Autism Research > 16-10 (October 2023) . - p.1903-1923 Index. décimale : PER Périodiques Résumé : Abstract Prior studies suggest that habituation of sensory responses is reduced in autism and that diminished habituation could be related to atypical autistic sensory experiences, for example, by causing brain responses to aversive stimuli to remain strong over time instead of being suppressed. While many prior studies exploring habituation in autism have repeatedly presented identical stimuli, other studies suggest group differences can still be observed in habituation to intermittent stimuli. The present study explored habituation of electrophysiological responses to auditory complex tones of varying intensities (50-80?dB SPL), presented passively in an interleaved manner, in a well-characterized sample of 127 autistic (MDQ?=?65.41, SD?=?20.54) and 79 typically developing (MDQ?=?106.02, SD?=?11.50) children between 2 and 5?years old. Habituation was quantified as changes in the amplitudes of single-trial responses to tones of each intensity over the course of the experiment. Habituation of the auditory N2 response was substantially reduced in autistic participants as compared to typically developing controls, although diagnostic groups did not clearly differ in habituation of the P1 response. Interestingly, the P1 habituated less to loud 80?dB sounds than softer sounds, whereas the N2 habituated less to soft 50?dB sounds than louder sounds. No associations were found between electrophysiological habituation and cognitive ability or participants' caregiver-reported sound tolerance (Sensory Profile Hyperacusis Index). The results present study results extend prior research suggesting habituation of certain sensory responses is reduced in autism; however, they also suggest that habituation differences observed using this study's paradigm might not be a primary driver of autistic participants' real-world sound intolerance. En ligne : https://doi.org/10.1002/aur.3022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

?Neural Noise? in Auditory Responses in Young Autistic and Neurotypical Children / Svjetlana VUKUSIC ; Zachary J. WILLIAMS ; Clifford D. SARON ; Susan M. RIVERA in Journal of Autism and Developmental Disorders, 54-2 (February 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-2 (February 2024) . - p.642-661 Titre : ?Neural Noise? in Auditory Responses in Young Autistic and Neurotypical Children Type de document : Texte imprimé et/ou numérique Auteurs : Svjetlana VUKUSIC, Auteur ; Zachary J. WILLIAMS, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur Article en page(s) : p.642-661 Index. décimale : PER Périodiques Résumé : Elevated ?neural noise? has been advanced as an explanation of autism and autistic sensory experiences. However, functional neuroimaging measures of neural noise may be vulnerable to contamination by recording noise. This study explored variability of electrophysiological responses to tones of different intensities in 127 autistic and 79 typically-developing children aged 2?5 years old. A rigorous data processing pipeline, including advanced visualizations of different signal sources that were maximally independent across different time lags, was used to identify and eliminate putative recording noise. Inter-trial variability was measured using median absolute deviations (MADs) of EEG amplitudes across trials and inter-trial phase coherence (ITPC). ITPC was elevated in autism in the 50 and 60 dB intensity conditions, suggesting diminished (rather than elevated) neural noise in autism, although reduced ITPC to soft 50 dB sounds was associated with increased loudness discomfort. Autistic and non-autistic participants did not differ in MADs, and indeed, the vast majority of the statistical tests examined in this study yielded no significant effects. These results appear inconsistent with the neural noise account. En ligne : https://doi.org/10.1007/s10803-022-05797-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 [article] ?Neural Noise? in Auditory Responses in Young Autistic and Neurotypical Children [Texte imprimé et/ou numérique] / Svjetlana VUKUSIC, Auteur ; Zachary J. WILLIAMS, Auteur ; Clifford D. SARON, Auteur ; Susan M. RIVERA, Auteur . - p.642-661. in Journal of Autism and Developmental Disorders > 54-2 (February 2024) . - p.642-661 Index. décimale : PER Périodiques Résumé : Elevated ?neural noise? has been advanced as an explanation of autism and autistic sensory experiences. However, functional neuroimaging measures of neural noise may be vulnerable to contamination by recording noise. This study explored variability of electrophysiological responses to tones of different intensities in 127 autistic and 79 typically-developing children aged 2?5 years old. A rigorous data processing pipeline, including advanced visualizations of different signal sources that were maximally independent across different time lags, was used to identify and eliminate putative recording noise. Inter-trial variability was measured using median absolute deviations (MADs) of EEG amplitudes across trials and inter-trial phase coherence (ITPC). ITPC was elevated in autism in the 50 and 60 dB intensity conditions, suggesting diminished (rather than elevated) neural noise in autism, although reduced ITPC to soft 50 dB sounds was associated with increased loudness discomfort. Autistic and non-autistic participants did not differ in MADs, and indeed, the vast majority of the statistical tests examined in this study yielded no significant effects. These results appear inconsistent with the neural noise account. En ligne : https://doi.org/10.1007/s10803-022-05797-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520

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