Brief Report: Genetic Links Between Autism and Suicidal Behavior-A Preliminary Investigation / Emily DIBLASI in Journal of Autism and Developmental Disorders, 50-10 (October 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3525-3530 Titre : Brief Report: Genetic Links Between Autism and Suicidal Behavior-A Preliminary Investigation Type de document : texte imprimé Auteurs : Emily DIBLASI, Auteur ; Anne V. KIRBY, Auteur ; Eoin GAJ, Auteur ; Anna R. DOCHERTY, Auteur ; Brooks R. KEESHIN, Auteur ; Amanda V. BAKIAN, Auteur ; Hilary H. COON, Auteur Article en page(s) : p.3525-3530 Langues : Anglais (eng) Mots-clés : Autism  Gene set enrichment  Genetic  Suicide  publicly-available databases and existing published literature  no direct research  was conducted with human participants nor animals. No informed consent procedures  were used. Index. décimale : PER Périodiques Résumé : Evidence suggests there may be increased risk for suicidal behavior among individuals with autism spectrum disorder (ASD). An emerging body of research explores social factors that may contribute to increased risk, however little is known about the potential role of biological factors. The current project addresses this knowledge gap through a preliminary study of genes associated with both ASD and suicidal behavior. Gene set enrichment tests of eight genes strongly associated with both ASD and suicidal behavior revealed overrepresentation of nine biological processes, including cognition and synapse function, and 14 cellular components, including the neuron, the synapse, and the synaptic and postsynaptic membrane. These results can be used to inform future investigations of the biological underpinnings of suicidal behavior and ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04419-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Brief Report: Genetic Links Between Autism and Suicidal Behavior-A Preliminary Investigation [texte imprimé] / Emily DIBLASI, Auteur ; Anne V. KIRBY, Auteur ; Eoin GAJ, Auteur ; Anna R. DOCHERTY, Auteur ; Brooks R. KEESHIN, Auteur ; Amanda V. BAKIAN, Auteur ; Hilary H. COON, Auteur . - p.3525-3530. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3525-3530 Mots-clés : Autism  Gene set enrichment  Genetic  Suicide  publicly-available databases and existing published literature  no direct research  was conducted with human participants nor animals. No informed consent procedures  were used. Index. décimale : PER Périodiques Résumé : Evidence suggests there may be increased risk for suicidal behavior among individuals with autism spectrum disorder (ASD). An emerging body of research explores social factors that may contribute to increased risk, however little is known about the potential role of biological factors. The current project addresses this knowledge gap through a preliminary study of genes associated with both ASD and suicidal behavior. Gene set enrichment tests of eight genes strongly associated with both ASD and suicidal behavior revealed overrepresentation of nine biological processes, including cognition and synapse function, and 14 cellular components, including the neuron, the synapse, and the synaptic and postsynaptic membrane. These results can be used to inform future investigations of the biological underpinnings of suicidal behavior and ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04419-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

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