Cognitive mechanisms of inhibitory control deficits in autism spectrum disorder / Lauren M. SCHMITT in Journal of Child Psychology and Psychiatry, 59-5 (May 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-5 (May 2018) . - p.586-595 Titre : Cognitive mechanisms of inhibitory control deficits in autism spectrum disorder Type de document : texte imprimé Auteurs : Lauren M. SCHMITT, Auteur ; Stormi P. WHITE, Auteur ; Edwin H.Jr COOK, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur Article en page(s) : p.586-595 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  cognitive development  inhibition Index. décimale : PER Périodiques Résumé : BACKGROUND: Inhibitory control deficits are common in autism spectrum disorder (ASD) and associated with more severe repetitive behaviors. Inhibitory control deficits may reflect slower execution of stopping processes, or a reduced ability to delay the onset of behavioral responses in contexts of uncertainty. Previous studies have documented relatively spared stopping processes in ASD, but whether inhibitory control deficits in ASD reflect failures to delay response onset has not been systematically assessed. Further, while improvements in stopping abilities and response slowing are seen through adolescence/early adulthood in health, their development in ASD is less clear. METHODS: A stop-signal test (SST) was administered to 121 individuals with ASD and 76 age and IQ-matched healthy controls (ages 5-28). This test included 'GO trials' in which participants pressed a button when a peripheral target appeared and interleaved 'STOP trials' in which they were cued to inhibit button-presses when a stop-signal appeared at variable times following the GO cue. STOP trial accuracy, RT of the stopping process (SSRT), and reaction time (RT) slowing during GO trials were examined. RESULTS: Relative to controls, individuals with ASD had reduced accuracy on STOP trials. SSRTs were similar across control and ASD participants, but RT slowing was reduced in patients compared to controls. Age-related increases in stopping ability and RT slowing were attenuated in ASD. Reduced stopping accuracy and RT slowing were associated with more severe repetitive behaviors in ASD. DISCUSSION: Our findings show that inhibitory control deficits in ASD involve failures to strategically delay behavioral response onset. These results suggest that reduced preparatory behavioral control may underpin inhibitory control deficits as well as repetitive behaviors in ASD. Typical age-related improvements in inhibitory control during late childhood/early adolescence are reduced in ASD, highlighting an important developmental window during which treatments may mitigate cognitive alterations contributing to repetitive behaviors. En ligne : http://dx.doi.org/10.1111/jcpp.12837 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359 [article] Cognitive mechanisms of inhibitory control deficits in autism spectrum disorder [texte imprimé] / Lauren M. SCHMITT, Auteur ; Stormi P. WHITE, Auteur ; Edwin H.Jr COOK, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur . - p.586-595. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-5 (May 2018) . - p.586-595 Mots-clés : Autism spectrum disorders  cognitive development  inhibition Index. décimale : PER Périodiques Résumé : BACKGROUND: Inhibitory control deficits are common in autism spectrum disorder (ASD) and associated with more severe repetitive behaviors. Inhibitory control deficits may reflect slower execution of stopping processes, or a reduced ability to delay the onset of behavioral responses in contexts of uncertainty. Previous studies have documented relatively spared stopping processes in ASD, but whether inhibitory control deficits in ASD reflect failures to delay response onset has not been systematically assessed. Further, while improvements in stopping abilities and response slowing are seen through adolescence/early adulthood in health, their development in ASD is less clear. METHODS: A stop-signal test (SST) was administered to 121 individuals with ASD and 76 age and IQ-matched healthy controls (ages 5-28). This test included 'GO trials' in which participants pressed a button when a peripheral target appeared and interleaved 'STOP trials' in which they were cued to inhibit button-presses when a stop-signal appeared at variable times following the GO cue. STOP trial accuracy, RT of the stopping process (SSRT), and reaction time (RT) slowing during GO trials were examined. RESULTS: Relative to controls, individuals with ASD had reduced accuracy on STOP trials. SSRTs were similar across control and ASD participants, but RT slowing was reduced in patients compared to controls. Age-related increases in stopping ability and RT slowing were attenuated in ASD. Reduced stopping accuracy and RT slowing were associated with more severe repetitive behaviors in ASD. DISCUSSION: Our findings show that inhibitory control deficits in ASD involve failures to strategically delay behavioral response onset. These results suggest that reduced preparatory behavioral control may underpin inhibitory control deficits as well as repetitive behaviors in ASD. Typical age-related improvements in inhibitory control during late childhood/early adolescence are reduced in ASD, highlighting an important developmental window during which treatments may mitigate cognitive alterations contributing to repetitive behaviors. En ligne : http://dx.doi.org/10.1111/jcpp.12837 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359

Cognitive Set Shifting Deficits and Their Relationship to Repetitive Behaviors in Autism Spectrum Disorder / Haylie L. MILLER in Journal of Autism and Developmental Disorders, 45-3 (March 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.805-815 Titre : Cognitive Set Shifting Deficits and Their Relationship to Repetitive Behaviors in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Haylie L. MILLER, Auteur ; Michael E. RAGOZZINO, Auteur ; Edwin H.Jr COOK, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur Article en page(s) : p.805-815 Langues : Anglais (eng) Mots-clés : Cognitive flexibility  Insistence on sameness  Repetitive behavior Index. décimale : PER Périodiques Résumé : The neurocognitive impairments associated with restricted and repetitive behaviors (RRBs) in autism spectrum disorder (ASD) are not yet clear. Prior studies indicate that individuals with ASD show reduced cognitive flexibility, which could reflect difficulty shifting from a previously learned response pattern or a failure to maintain a new response set. We examined different error types on a test of set-shifting completed by 60 individuals with ASD and 55 age- and nonverbal IQ-matched controls. Individuals with ASD were able to initially shift sets, but they exhibited difficulty maintaining new response sets. Difficulty with set maintenance was related to increased severity of RRBs. General difficulty maintaining new response sets and a heightened tendency to revert to old preferences may contribute to RRBs. En ligne : http://dx.doi.org/10.1007/s10803-014-2244-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Cognitive Set Shifting Deficits and Their Relationship to Repetitive Behaviors in Autism Spectrum Disorder [texte imprimé] / Haylie L. MILLER, Auteur ; Michael E. RAGOZZINO, Auteur ; Edwin H.Jr COOK, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur . - p.805-815. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.805-815 Mots-clés : Cognitive flexibility  Insistence on sameness  Repetitive behavior Index. décimale : PER Périodiques Résumé : The neurocognitive impairments associated with restricted and repetitive behaviors (RRBs) in autism spectrum disorder (ASD) are not yet clear. Prior studies indicate that individuals with ASD show reduced cognitive flexibility, which could reflect difficulty shifting from a previously learned response pattern or a failure to maintain a new response set. We examined different error types on a test of set-shifting completed by 60 individuals with ASD and 55 age- and nonverbal IQ-matched controls. Individuals with ASD were able to initially shift sets, but they exhibited difficulty maintaining new response sets. Difficulty with set maintenance was related to increased severity of RRBs. General difficulty maintaining new response sets and a heightened tendency to revert to old preferences may contribute to RRBs. En ligne : http://dx.doi.org/10.1007/s10803-014-2244-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Commentary: Making the brain matter in assessing and treating adolescent substance use – a commentary on Conrod and Nikolaou (2016) / Matthew W. MOSCONI in Journal of Child Psychology and Psychiatry, 57-3 (March 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.395-397 Titre : Commentary: Making the brain matter in assessing and treating adolescent substance use – a commentary on Conrod and Nikolaou (2016) Type de document : texte imprimé Auteurs : Matthew W. MOSCONI, Auteur ; Carl W. LEJUEZ, Auteur Article en page(s) : p.395-397 Langues : Anglais (eng) Mots-clés : Substance use Index. décimale : PER Périodiques Résumé : Adolescence represents a period of vulnerability to psychiatric problems due to a range of factors, including advances in social and cognitive abilities, increased levels of autonomy in decision-making and behavioral governance, and greater exposure to opportunities for risk-taking behavior. Adding to these psychological and social challenges, adolescence also is marked by robust maturational changes affecting both the microcircuitry and connectivity between widely distributed brain systems. These changes alter the communication among parallel, distributed brain networks, have implications for one's vulnerability to engage in risk behavior and make the brain particularly susceptible to external perturbations, such as exposure to neurotoxic substances. En ligne : http://dx.doi.org/10.1111/jcpp.12532 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Commentary: Making the brain matter in assessing and treating adolescent substance use – a commentary on Conrod and Nikolaou (2016) [texte imprimé] / Matthew W. MOSCONI, Auteur ; Carl W. LEJUEZ, Auteur . - p.395-397. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.395-397 Mots-clés : Substance use Index. décimale : PER Périodiques Résumé : Adolescence represents a period of vulnerability to psychiatric problems due to a range of factors, including advances in social and cognitive abilities, increased levels of autonomy in decision-making and behavioral governance, and greater exposure to opportunities for risk-taking behavior. Adding to these psychological and social challenges, adolescence also is marked by robust maturational changes affecting both the microcircuitry and connectivity between widely distributed brain systems. These changes alter the communication among parallel, distributed brain networks, have implications for one's vulnerability to engage in risk behavior and make the brain particularly susceptible to external perturbations, such as exposure to neurotoxic substances. En ligne : http://dx.doi.org/10.1111/jcpp.12532 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Erratum to: Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome / L.E. ETHRIDGE in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 38p. Titre : Erratum to: Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome Type de document : texte imprimé Auteurs : L.E. ETHRIDGE, Auteur ; Stormi P. WHITE, Auteur ; Matthew W. MOSCONI, Auteur ; Jing WANG, Auteur ; Ernest V. PEDAPATI, Auteur ; Craig ERICKSON, Auteur ; M.J. BYERLY, Auteur ; John A. SWEENEY, Auteur Article en page(s) : 38p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : [This corrects the article DOI: 10.1186/s13229-017-0140-1.]. En ligne : http://dx.doi.org/10.1186/s13229-017-0150-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Erratum to: Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome [texte imprimé] / L.E. ETHRIDGE, Auteur ; Stormi P. WHITE, Auteur ; Matthew W. MOSCONI, Auteur ; Jing WANG, Auteur ; Ernest V. PEDAPATI, Auteur ; Craig ERICKSON, Auteur ; M.J. BYERLY, Auteur ; John A. SWEENEY, Auteur . - 38p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 38p. Index. décimale : PER Périodiques Résumé : [This corrects the article DOI: 10.1186/s13229-017-0140-1.]. En ligne : http://dx.doi.org/10.1186/s13229-017-0150-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Familiality of behavioral flexibility and response inhibition deficits in autism spectrum disorder (ASD) / Lauren M. SCHMITT in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 47 p. Titre : Familiality of behavioral flexibility and response inhibition deficits in autism spectrum disorder (ASD) Type de document : texte imprimé Auteurs : Lauren M. SCHMITT, Auteur ; E.K. BOJANEK, Auteur ; Stormi P. WHITE, Auteur ; M.E. RAGOZZINO, Auteur ; Edwin H.Jr COOK, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur Article en page(s) : 47 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background: Diminished cognitive control, including reduced behavioral flexibility and behavioral response inhibition, has been repeatedly documented in autism spectrum disorder (ASD). We evaluated behavioral flexibility and response inhibition in probands and their parents using a family trio design to determine the extent to which these cognitive control impairments represent familial traits associated with ASD. Methods: We examined 66 individuals with ASD (probands), 135 unaffected biological parents, and 76 typically developing controls. Participants completed a probabilistic reversal learning task (PRL) and a stop-signal task (SST) to assess behavioral flexibility and response inhibition respectively. Rates of PRL and SST errors were examined across groups, within families, and in relation to clinical and subclinical traits of ASD. Based on prior findings that subclinical broader autism phenotypic (BAP) traits may co-segregate within families and reflect heritable risk factors, we also examined whether cognitive control deficits were more prominent in families in which parents showed BAP features (BAP+). Results: Probands and parents each showed increased rates of PRL and SST errors relative to controls. Error rates across tasks were not related. SST error rates inter-correlated among probands and their parents. PRL errors were more severe in BAP+ parents and their children relative to BAP- parents and their children. For probands of BAP+ parents, PRL and SST error rates were associated with more severe social-communication abnormalities and repetitive behaviors, respectively. Conclusion: Reduced behavioral flexibility and response inhibition are present among probands and their unaffected parents, but represent unique familial deficits associated with ASD that track with separate clinical issues. Specifically, behavioral response inhibition impairments are familial in ASD and manifest independently from parental subclinical features. In contrast, behavioral flexibility deficits are selectively present in families with BAP characteristics, suggesting they co-segregate in families with parental subclinical social, communication, and rigid personality traits. Together, these findings provide evidence that behavioral flexibility and response inhibition impairments track differentially with ASD risk mechanisms and related behavioral traits. En ligne : http://dx.doi.org/10.1186/s13229-019-0296-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414 [article] Familiality of behavioral flexibility and response inhibition deficits in autism spectrum disorder (ASD) [texte imprimé] / Lauren M. SCHMITT, Auteur ; E.K. BOJANEK, Auteur ; Stormi P. WHITE, Auteur ; M.E. RAGOZZINO, Auteur ; Edwin H.Jr COOK, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur . - 47 p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 47 p. Index. décimale : PER Périodiques Résumé : Background: Diminished cognitive control, including reduced behavioral flexibility and behavioral response inhibition, has been repeatedly documented in autism spectrum disorder (ASD). We evaluated behavioral flexibility and response inhibition in probands and their parents using a family trio design to determine the extent to which these cognitive control impairments represent familial traits associated with ASD. Methods: We examined 66 individuals with ASD (probands), 135 unaffected biological parents, and 76 typically developing controls. Participants completed a probabilistic reversal learning task (PRL) and a stop-signal task (SST) to assess behavioral flexibility and response inhibition respectively. Rates of PRL and SST errors were examined across groups, within families, and in relation to clinical and subclinical traits of ASD. Based on prior findings that subclinical broader autism phenotypic (BAP) traits may co-segregate within families and reflect heritable risk factors, we also examined whether cognitive control deficits were more prominent in families in which parents showed BAP features (BAP+). Results: Probands and parents each showed increased rates of PRL and SST errors relative to controls. Error rates across tasks were not related. SST error rates inter-correlated among probands and their parents. PRL errors were more severe in BAP+ parents and their children relative to BAP- parents and their children. For probands of BAP+ parents, PRL and SST error rates were associated with more severe social-communication abnormalities and repetitive behaviors, respectively. Conclusion: Reduced behavioral flexibility and response inhibition are present among probands and their unaffected parents, but represent unique familial deficits associated with ASD that track with separate clinical issues. Specifically, behavioral response inhibition impairments are familial in ASD and manifest independently from parental subclinical features. In contrast, behavioral flexibility deficits are selectively present in families with BAP characteristics, suggesting they co-segregate in families with parental subclinical social, communication, and rigid personality traits. Together, these findings provide evidence that behavioral flexibility and response inhibition impairments track differentially with ASD risk mechanisms and related behavioral traits. En ligne : http://dx.doi.org/10.1186/s13229-019-0296-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414

Functional brain abnormalities associated with comorbid anxiety in autism spectrum disorder / James BARTOLOTTI in Development and Psychopathology, 32-4 (October 2020)  

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Initial action output and feedback-guided motor behaviors in autism spectrum disorder / Kathryn E. UNRUH in Molecular Autism, 12 (2021)  

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Motor Functioning and Dyspraxia in Autism Spectrum Disorders / Matthew W. MOSCONI

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Motor Memory Deficits Contribute to Motor Impairments in Autism Spectrum Disorder / Kristina A. NEELY in Journal of Autism and Developmental Disorders, 49-7 (July 2019)  

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Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome / L.E. ETHRIDGE in Molecular Autism, 8 (2017)  

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Postural orientation and equilibrium processes associated with increased postural sway in autism spectrum disorder (ASD) / Ziqi WANG in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

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Reduced Proactive Control Processes Associated With Behavioral Response Inhibition Deficits in Autism Spectrum Disorder / Shannon E. KELLY in Autism Research, 14-2 (February 2021)  

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A resting EEG study of neocortical hyperexcitability and altered functional connectivity in fragile X syndrome / Jing WANG in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

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Resting state EEG abnormalities in autism spectrum disorders / Jing WANG in Journal of Neurodevelopmental Disorders, 5-1 (December 2013)  

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Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in cerebellum and brainstem / Lauren M. SCHMITT in Molecular Autism, (September 2014)  

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