An examination of maternal prenatal BMI and human fetal brain development / Megan E. NORR in Journal of Child Psychology and Psychiatry, 62-4 (April 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.458-469 Titre : An examination of maternal prenatal BMI and human fetal brain development Type de document : texte imprimé Auteurs : Megan E. NORR, Auteur ; Jasmine L. HECT, Auteur ; Carly J. LENNIGER, Auteur ; Martijn P. VAN DEN HEUVEL, Auteur ; Moriah E. THOMASON, Auteur Article en page(s) : p.458-469 Langues : Anglais (eng) Mots-clés : Functional connectivity  fMRI  obesity  prenatal  resting-state Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal development is a time when the brain is acutely vulnerable to insult and alteration by environmental factors (e.g., toxins, maternal health). One important risk factor is maternal obesity (Body Mass Index > 30). Recent research indicates that high maternal BMI during pregnancy is associated with increased risk for numerous physical health, cognitive, and mental health problems in offspring across the lifespan. It is possible that heightened maternal prenatal BMI influences the developing brain even before birth. METHODS: The present study examines this possibility at the level of macrocircuitry in the human fetal brain. Using a data-driven strategy for parcellating the brain into subnetworks, we test whether MRI functional connectivity within or between fetal neural subnetworks varies with maternal prenatal BMI in 109 fetuses between the ages of 26 and 39weeks. RESULTS: We discovered that strength of connectivity between two subnetworks, left anterior insula/inferior frontal gyrus (aIN/IFG) and bilateral prefrontal cortex (PFC), varied with maternal BMI. At the level of individual aIN/IFG-PFC connections, we observed both increased and decreased between-network connectivity with a tendency for increased within-hemisphere connectivity and reduced cross-hemisphere connectivity in higher BMI pregnancies. Maternal BMI was not associated with global differences in network topography based on network-based statistical analyses. CONCLUSIONS: Overall effects were localized in regions that will later support behavioral regulation and integrative processes, regions commonly associated with obesity-related deficits. By establishing onset in neural differences prior to birth, this study supports a model in which maternal BMI-related risk is associated with fetal connectome-level brain organization with implications for offspring long-term cognitive development and mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13301 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 [article] An examination of maternal prenatal BMI and human fetal brain development [texte imprimé] / Megan E. NORR, Auteur ; Jasmine L. HECT, Auteur ; Carly J. LENNIGER, Auteur ; Martijn P. VAN DEN HEUVEL, Auteur ; Moriah E. THOMASON, Auteur . - p.458-469. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.458-469 Mots-clés : Functional connectivity  fMRI  obesity  prenatal  resting-state Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal development is a time when the brain is acutely vulnerable to insult and alteration by environmental factors (e.g., toxins, maternal health). One important risk factor is maternal obesity (Body Mass Index > 30). Recent research indicates that high maternal BMI during pregnancy is associated with increased risk for numerous physical health, cognitive, and mental health problems in offspring across the lifespan. It is possible that heightened maternal prenatal BMI influences the developing brain even before birth. METHODS: The present study examines this possibility at the level of macrocircuitry in the human fetal brain. Using a data-driven strategy for parcellating the brain into subnetworks, we test whether MRI functional connectivity within or between fetal neural subnetworks varies with maternal prenatal BMI in 109 fetuses between the ages of 26 and 39weeks. RESULTS: We discovered that strength of connectivity between two subnetworks, left anterior insula/inferior frontal gyrus (aIN/IFG) and bilateral prefrontal cortex (PFC), varied with maternal BMI. At the level of individual aIN/IFG-PFC connections, we observed both increased and decreased between-network connectivity with a tendency for increased within-hemisphere connectivity and reduced cross-hemisphere connectivity in higher BMI pregnancies. Maternal BMI was not associated with global differences in network topography based on network-based statistical analyses. CONCLUSIONS: Overall effects were localized in regions that will later support behavioral regulation and integrative processes, regions commonly associated with obesity-related deficits. By establishing onset in neural differences prior to birth, this study supports a model in which maternal BMI-related risk is associated with fetal connectome-level brain organization with implications for offspring long-term cognitive development and mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13301 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445

Prenatal neural origins of infant motor development: Associations between fetal brain and infant motor development / Moriah E. THOMASON in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.763-772 Titre : Prenatal neural origins of infant motor development: Associations between fetal brain and infant motor development Type de document : texte imprimé Auteurs : Moriah E. THOMASON, Auteur ; Jasmine HECT, Auteur ; Rebecca WALLER, Auteur ; Janessa MANNING, Auteur ; Ann M. STACKS, Auteur ; Marjorie BEEGHLY, Auteur ; Jordan L. BOEVE, Auteur ; Kingsley WONG, Auteur ; Marion I. VAN DEN HEUVEL, Auteur ; Edgar HERNANDEZ-ANDRADE, Auteur ; Sonia S. HASSAN, Auteur ; Roberto ROMERO, Auteur Article en page(s) : p.763-772 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Functional circuits of the human brain emerge and change dramatically over the second half of gestation. It is possible that variation in neural functional system connectivity in utero predicts individual differences in infant behavioral development, but this possibility has yet to be examined. The current study examines the association between fetal sensorimotor brain system functional connectivity and infant postnatal motor ability. Resting-state functional connectivity data was obtained in 96 healthy human fetuses during the second and third trimesters of pregnancy. Infant motor ability was measured 7 months after birth using the Bayley Scales of Infant Development. Increased connectivity between the emerging motor network and regions of the prefrontal cortex, temporal lobes, posterior cingulate, and supplementary motor regions was observed in infants that showed more mature motor functions. In addition, females demonstrated stronger fetal-brain to infant-behavior associations. These observations extend prior longitudinal research back into prenatal brain development and raise exciting new ideas about the advent of risk and the ontogeny of early sex differences. En ligne : http://dx.doi.org/10.1017/s095457941800072x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] Prenatal neural origins of infant motor development: Associations between fetal brain and infant motor development [texte imprimé] / Moriah E. THOMASON, Auteur ; Jasmine HECT, Auteur ; Rebecca WALLER, Auteur ; Janessa MANNING, Auteur ; Ann M. STACKS, Auteur ; Marjorie BEEGHLY, Auteur ; Jordan L. BOEVE, Auteur ; Kingsley WONG, Auteur ; Marion I. VAN DEN HEUVEL, Auteur ; Edgar HERNANDEZ-ANDRADE, Auteur ; Sonia S. HASSAN, Auteur ; Roberto ROMERO, Auteur . - p.763-772. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.763-772 Index. décimale : PER Périodiques Résumé : Functional circuits of the human brain emerge and change dramatically over the second half of gestation. It is possible that variation in neural functional system connectivity in utero predicts individual differences in infant behavioral development, but this possibility has yet to be examined. The current study examines the association between fetal sensorimotor brain system functional connectivity and infant postnatal motor ability. Resting-state functional connectivity data was obtained in 96 healthy human fetuses during the second and third trimesters of pregnancy. Infant motor ability was measured 7 months after birth using the Bayley Scales of Infant Development. Increased connectivity between the emerging motor network and regions of the prefrontal cortex, temporal lobes, posterior cingulate, and supplementary motor regions was observed in infants that showed more mature motor functions. In addition, females demonstrated stronger fetal-brain to infant-behavior associations. These observations extend prior longitudinal research back into prenatal brain development and raise exciting new ideas about the advent of risk and the ontogeny of early sex differences. En ligne : http://dx.doi.org/10.1017/s095457941800072x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

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