Genetic Advances in Autism / A. THAPAR in Journal of Autism and Developmental Disorders, 51-12 (December 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4321-4332 Titre : Genetic Advances in Autism Type de document : Texte imprimé et/ou numérique Auteurs : A. THAPAR, Auteur ; M. RUTTER, Auteur Article en page(s) : p.4321-4332 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/genetics  Autistic Disorder/diagnosis/genetics  Genetic Predisposition to Disease  Humans Index. décimale : PER Périodiques Résumé : In the last 40 years, there has been a huge increase in autism genetics research and a rapidly growing number of discoveries. We now know autism is one of the most highly heritable disorders with negligible shared environmental contributions. Recent discoveries also show that rare variants of large effect size as well as small effect common gene variants all contribute to autism risk. These discoveries challenge traditional diagnostic boundaries and highlight huge heterogeneity in autism. In this review, we consider some of the key findings that are shaping current understanding of autism and what these discoveries mean for clinicians. En ligne : http://dx.doi.org/10.1007/s10803-020-04685-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Genetic Advances in Autism [Texte imprimé et/ou numérique] / A. THAPAR, Auteur ; M. RUTTER, Auteur . - p.4321-4332. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4321-4332 Mots-clés : Autism Spectrum Disorder/diagnosis/genetics  Autistic Disorder/diagnosis/genetics  Genetic Predisposition to Disease  Humans Index. décimale : PER Périodiques Résumé : In the last 40 years, there has been a huge increase in autism genetics research and a rapidly growing number of discoveries. We now know autism is one of the most highly heritable disorders with negligible shared environmental contributions. Recent discoveries also show that rare variants of large effect size as well as small effect common gene variants all contribute to autism risk. These discoveries challenge traditional diagnostic boundaries and highlight huge heterogeneity in autism. In this review, we consider some of the key findings that are shaping current understanding of autism and what these discoveries mean for clinicians. En ligne : http://dx.doi.org/10.1007/s10803-020-04685-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

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