Childhood cognitive control as a predictor of long-term clinical and functional outcomes in Tourette syndrome / Kathryn E. BARBER in Journal of Child Psychology and Psychiatry, 67-9 (September 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-9 (September 2026) . - p.1525-1536 Titre : Childhood cognitive control as a predictor of long-term clinical and functional outcomes in Tourette syndrome Type de document : texte imprimé Auteurs : Kathryn E. BARBER, Auteur ; Emily J. RICKETTS, Auteur ; Douglas W. WOODS, Auteur ; John PIACENTINI, Auteur ; Flint M. ESPIL, Auteur ; Matthew SPECHT, Auteur ; Shannon M. BENNETT, Auteur ; John T. WALKUP, Auteur ; Susanna CHANG, Auteur ; Alan L. PETERSON, Auteur ; Lawrence SCAHILL, Auteur ; Sabine WILHELM, Auteur ; Joseph F. MCGUIRE, Auteur Article en page(s) : p.1525-1536 Langues : Anglais (eng) Mots-clés : Executive function  inhibition  working memory  set-shifting  longitudinal  neurocognitive Index. décimale : PER Périodiques Résumé : Background Tourette syndrome (TS) is a childhood-onset neuropsychiatric condition characterized by motor and vocal tics. Many individuals with TS continue to experience tics and functional difficulties into adulthood, yet the factors influencing these long-term trajectories remain poorly understood. Cognitive control processes, implicated in the etiology and treatment of TS, may serve as indicators of later clinical and functional outcomes. Methods This study tested whether childhood cognitive control predicted outcomes in early adulthood. Participants were 80 individuals with TS (Mage?=?22.8?years, SD?=?2.7) who had entered a randomized clinical trial of behavioral therapy as children and completed a follow-up evaluation an average of 11.7?years (SD?=?1.3) later. Childhood assessments measured tic severity and neurocognitive domains, including processing speed, inhibition, set-shifting, and working memory. Follow-up assessments evaluated clinical, functional, and quality of life outcomes. Results Results showed that greater inhibition, set-shifting, and processing speed in childhood predicted lower tic severity and impairment, greater odds of tic remission, and higher quality of life in early adulthood. Greater working memory and response flexibility predicted higher educational attainment and income. These relationships remained significant after accounting for treatment conditions and comorbid attention-deficit/hyperactivity disorder and obsessive-compulsive disorder. Conclusions Findings highlight childhood cognitive control as an important predictor of clinical and functional outcomes in TS and a viable target for intervention. En ligne : https://doi.org/10.1111/jcpp.70155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592 [article] Childhood cognitive control as a predictor of long-term clinical and functional outcomes in Tourette syndrome [texte imprimé] / Kathryn E. BARBER, Auteur ; Emily J. RICKETTS, Auteur ; Douglas W. WOODS, Auteur ; John PIACENTINI, Auteur ; Flint M. ESPIL, Auteur ; Matthew SPECHT, Auteur ; Shannon M. BENNETT, Auteur ; John T. WALKUP, Auteur ; Susanna CHANG, Auteur ; Alan L. PETERSON, Auteur ; Lawrence SCAHILL, Auteur ; Sabine WILHELM, Auteur ; Joseph F. MCGUIRE, Auteur . - p.1525-1536. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-9 (September 2026) . - p.1525-1536 Mots-clés : Executive function  inhibition  working memory  set-shifting  longitudinal  neurocognitive Index. décimale : PER Périodiques Résumé : Background Tourette syndrome (TS) is a childhood-onset neuropsychiatric condition characterized by motor and vocal tics. Many individuals with TS continue to experience tics and functional difficulties into adulthood, yet the factors influencing these long-term trajectories remain poorly understood. Cognitive control processes, implicated in the etiology and treatment of TS, may serve as indicators of later clinical and functional outcomes. Methods This study tested whether childhood cognitive control predicted outcomes in early adulthood. Participants were 80 individuals with TS (Mage?=?22.8?years, SD?=?2.7) who had entered a randomized clinical trial of behavioral therapy as children and completed a follow-up evaluation an average of 11.7?years (SD?=?1.3) later. Childhood assessments measured tic severity and neurocognitive domains, including processing speed, inhibition, set-shifting, and working memory. Follow-up assessments evaluated clinical, functional, and quality of life outcomes. Results Results showed that greater inhibition, set-shifting, and processing speed in childhood predicted lower tic severity and impairment, greater odds of tic remission, and higher quality of life in early adulthood. Greater working memory and response flexibility predicted higher educational attainment and income. These relationships remained significant after accounting for treatment conditions and comorbid attention-deficit/hyperactivity disorder and obsessive-compulsive disorder. Conclusions Findings highlight childhood cognitive control as an important predictor of clinical and functional outcomes in TS and a viable target for intervention. En ligne : https://doi.org/10.1111/jcpp.70155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=592

Cognitive control processes in behavior therapy for youth with Tourette's disorder / Joseph F. MCGUIRE in Journal of Child Psychology and Psychiatry, 63-3 (March 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.296-304 Titre : Cognitive control processes in behavior therapy for youth with Tourette's disorder Type de document : texte imprimé Auteurs : Joseph F. MCGUIRE, Auteur ; Alexandra STURM, Auteur ; Emily J. RICKETTS, Auteur ; Gabrielle E. MONTALBANO, Auteur ; Susanna CHANG, Auteur ; Sandra K. LOO, Auteur ; Douglas W. WOODS, Auteur ; James T. MCCRACKEN, Auteur ; John PIACENTINI, Auteur Article en page(s) : p.296-304 Langues : Anglais (eng) Mots-clés : Cognitive control  behavior therapy  inhibition  inhibitory control  tic suppression Index. décimale : PER Périodiques Résumé : BACKGROUND: Cognitive control processes are implicated in the behavioral treatment of Tourette's disorder (TD). However, the influence of these processes on treatment outcomes has received minimal attention. This study examined whether cognitive control processes and/or tic suppression predicted reductions in tic severity and treatment response to behavior therapy. METHOD: Fifty-three youth with TD or a pervasive tic disorder participated in a randomized wait list-controlled trial of behavior therapy. Following a baseline assessment to evaluate psychiatric diagnoses, tic severity, and cognitive control processes (e.g., response selection, inhibition, and suppression), youth were randomly assigned to receive eight sessions of behavior therapy (n = 23) or a wait list of equal duration (n = 28). Youth receiving immediate treatment completed a post-treatment assessment to determine improvement in tic severity. Meanwhile, youth in the wait list condition completed another assessment to re-evaluate tic severity and cognitive control processes, and subsequently received 8 sessions of behavior therapy followed by a post-treatment assessment to determine improvement. RESULTS: A multiple linear regression model found that pretreatment inhibition/switching on the Delis-Kaplan Executive Function System Color-Word Interference Test predicted reductions in tic severity after behavior therapy (β = -.36, t = -2.35, p = .025, Æž(2)  = .15). However, other cognitive control processes and tic suppression did not predict treatment response and/or reductions in tic severity. Small nonsignificant effects were observed in cognitive control processes after behavior therapy. CONCLUSION: Cognitive control processes may influence tic severity reductions in behavior therapy. Notably, even when other cognitive control processes are impaired and youth are initially unable to voluntarily suppress their tics, youth with TD can still benefit from behavior therapy. Findings offer implications for clinical practice and research for TD. En ligne : http://dx.doi.org/10.1111/jcpp.13470 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Cognitive control processes in behavior therapy for youth with Tourette's disorder [texte imprimé] / Joseph F. MCGUIRE, Auteur ; Alexandra STURM, Auteur ; Emily J. RICKETTS, Auteur ; Gabrielle E. MONTALBANO, Auteur ; Susanna CHANG, Auteur ; Sandra K. LOO, Auteur ; Douglas W. WOODS, Auteur ; James T. MCCRACKEN, Auteur ; John PIACENTINI, Auteur . - p.296-304. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.296-304 Mots-clés : Cognitive control  behavior therapy  inhibition  inhibitory control  tic suppression Index. décimale : PER Périodiques Résumé : BACKGROUND: Cognitive control processes are implicated in the behavioral treatment of Tourette's disorder (TD). However, the influence of these processes on treatment outcomes has received minimal attention. This study examined whether cognitive control processes and/or tic suppression predicted reductions in tic severity and treatment response to behavior therapy. METHOD: Fifty-three youth with TD or a pervasive tic disorder participated in a randomized wait list-controlled trial of behavior therapy. Following a baseline assessment to evaluate psychiatric diagnoses, tic severity, and cognitive control processes (e.g., response selection, inhibition, and suppression), youth were randomly assigned to receive eight sessions of behavior therapy (n = 23) or a wait list of equal duration (n = 28). Youth receiving immediate treatment completed a post-treatment assessment to determine improvement in tic severity. Meanwhile, youth in the wait list condition completed another assessment to re-evaluate tic severity and cognitive control processes, and subsequently received 8 sessions of behavior therapy followed by a post-treatment assessment to determine improvement. RESULTS: A multiple linear regression model found that pretreatment inhibition/switching on the Delis-Kaplan Executive Function System Color-Word Interference Test predicted reductions in tic severity after behavior therapy (β = -.36, t = -2.35, p = .025, Æž(2)  = .15). However, other cognitive control processes and tic suppression did not predict treatment response and/or reductions in tic severity. Small nonsignificant effects were observed in cognitive control processes after behavior therapy. CONCLUSION: Cognitive control processes may influence tic severity reductions in behavior therapy. Notably, even when other cognitive control processes are impaired and youth are initially unable to voluntarily suppress their tics, youth with TD can still benefit from behavior therapy. Findings offer implications for clinical practice and research for TD. En ligne : http://dx.doi.org/10.1111/jcpp.13470 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

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