Identifying structural brain markers of resilience to adversity in young people using voxel-based morphometry / Stephane A. DE BRITO ; Graeme FAIRCHILD ; Christine M. FREITAG ; Karen GONZALEZ-MADRUGA ; Catherine HAMILTON-GIACHRITSIS ; Gregor KOHLS ; Kerstin KONRAD ; Anne MARTINELLI ; Nora RASCHLE ; Jack C. ROGERS ; Areti SMARAGDI ; Christina STADLER ; Marlene STAGINNUS ; Nicola TOSCHI in Development and Psychopathology, 35-5 (December 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-5 (December 2023) . - p.2302-2314 Titre : Identifying structural brain markers of resilience to adversity in young people using voxel-based morphometry Type de document : texte imprimé Auteurs : Stephane A. DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur ; Christine M. FREITAG, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Catherine HAMILTON-GIACHRITSIS, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Anne MARTINELLI, Auteur ; Nora RASCHLE, Auteur ; Jack C. ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Christina STADLER, Auteur ; Marlene STAGINNUS, Auteur ; Nicola TOSCHI, Auteur Article en page(s) : p.2302-2314 Mots-clés : Resilience  adversity  brain structure  voxel-based morphometry  youth Index. décimale : PER Périodiques Résumé : There is increasing evidence that resilience in youth may have a neurobiological basis. However, the existing literature lacks a consistent way of operationalizing resilience, often relying on arbitrary judgments or narrow definitions (e.g., not developing PTSD) to classify individuals as resilient. Therefore, this study used data-driven, continuous resilience scores based on adversity and psychopathology to investigate associations between resilience and brain structure in youth. Structural MRI data from 298 youth aged 9 18 years (Mage = 13.51; 51% female) who participated in the European multisite FemNAT-CD study were preprocessed using SPM12 and analyzed using voxel-based morphometry. Resilience scores were derived by regressing data on adversity exposure against current/lifetime psychopathology and quantifying each individual?s distance from the regression line. General linear models tested for associations between resilience and gray matter volume (GMV) and examined whether associations between resilience and GMV differed by sex. Resilience was positively correlated with GMV in the right inferior frontal and medial frontal gyri. Sex-by-resilience interactions were observed in the middle temporal and middle frontal gyri. These findings demonstrate that resilience in youth is associated with volume in brain regions implicated in executive functioning, emotion regulation, and attention. Our results also provide evidence for sex differences in the neurobiology of resilience. En ligne : https://dx.doi.org/10.1017/S0954579423000718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Identifying structural brain markers of resilience to adversity in young people using voxel-based morphometry [texte imprimé] / Stephane A. DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur ; Christine M. FREITAG, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Catherine HAMILTON-GIACHRITSIS, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Anne MARTINELLI, Auteur ; Nora RASCHLE, Auteur ; Jack C. ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Christina STADLER, Auteur ; Marlene STAGINNUS, Auteur ; Nicola TOSCHI, Auteur . - p.2302-2314. in Development and Psychopathology > 35-5 (December 2023) . - p.2302-2314 Mots-clés : Resilience  adversity  brain structure  voxel-based morphometry  youth Index. décimale : PER Périodiques Résumé : There is increasing evidence that resilience in youth may have a neurobiological basis. However, the existing literature lacks a consistent way of operationalizing resilience, often relying on arbitrary judgments or narrow definitions (e.g., not developing PTSD) to classify individuals as resilient. Therefore, this study used data-driven, continuous resilience scores based on adversity and psychopathology to investigate associations between resilience and brain structure in youth. Structural MRI data from 298 youth aged 9 18 years (Mage = 13.51; 51% female) who participated in the European multisite FemNAT-CD study were preprocessed using SPM12 and analyzed using voxel-based morphometry. Resilience scores were derived by regressing data on adversity exposure against current/lifetime psychopathology and quantifying each individual?s distance from the regression line. General linear models tested for associations between resilience and gray matter volume (GMV) and examined whether associations between resilience and GMV differed by sex. Resilience was positively correlated with GMV in the right inferior frontal and medial frontal gyri. Sex-by-resilience interactions were observed in the middle temporal and middle frontal gyri. These findings demonstrate that resilience in youth is associated with volume in brain regions implicated in executive functioning, emotion regulation, and attention. Our results also provide evidence for sex differences in the neurobiology of resilience. En ligne : https://dx.doi.org/10.1017/S0954579423000718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Positive and negative parenting in conduct disorder with high versus low levels of callous–unemotional traits / Ruth PAULI in Development and Psychopathology, 33-3 (August 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-3 (August 2021) . - p.980-991 Titre : Positive and negative parenting in conduct disorder with high versus low levels of callous–unemotional traits Type de document : texte imprimé Auteurs : Ruth PAULI, Auteur ; Peter TINO, Auteur ; Jack C. ROGERS, Auteur ; Rosalind BAKER, Auteur ; Roberta CLANTON, Auteur ; Philippa BIRCH, Auteur ; Abigail BROWN, Auteur ; Gemma DANIEL, Auteur ; Lisandra FERREIRA, Auteur ; Liam GRISLEY, Auteur ; Gregor KOHLS, Auteur ; Sarah BAUMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Katharina ACKERMANN, Auteur ; Helen LAZARATOU, Auteur ; Foteini TSIAKOULIA, Auteur ; Panagiota BALI, Auteur ; Helena OLDENHOF, Auteur ; Lucres M.C. JANSEN, Auteur ; Areti SMARAGDI, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Miguel Angel GONZALEZ-TORRES, Auteur ; Maider GONZALEZ DE ARTAZA-LAVESA, Auteur ; Martin STEPPAN, Auteur ; Noortje VRIENDS, Auteur ; Aitana BIGORRA, Auteur ; Reka SIKLOSI, Auteur ; Sreejita GHOSH, Auteur ; Kerstin BUNTE, Auteur ; Roberta DOCHNAL, Auteur ; Amaia HERVAS, Auteur ; Christina STADLER, Auteur ; Aranzazu FERNANDEZ-RIVAS, Auteur ; Graeme FAIRCHILD, Auteur ; Arne POPMA, Auteur ; Dimitris DIKEOS, Auteur ; Kerstin KONRAD, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Christine M. FREITAG, Auteur ; Pia ROTSHTEIN, Auteur ; Stephane A. DE BRITO, Auteur Article en page(s) : p.980-991 Langues : Anglais (eng) Mots-clés : angle-based generalized matrix learning vector quantization  callous–unemotional traits  conduct disorder  machine learning  parenting Index. décimale : PER Périodiques Résumé : Less is known about the relationship between conduct disorder (CD), callous–unemotional (CU) traits, and positive and negative parenting in youth compared to early childhood. We combined traditional univariate analyses with a novel machine learning classifier (Angle-based Generalized Matrix Learning Vector Quantization) to classify youth (N = 756; 9–18 years) into typically developing (TD) or CD groups with or without elevated CU traits (CD/HCU, CD/LCU, respectively) using youth- and parent-reports of parenting behavior. At the group level, both CD/HCU and CD/LCU were associated with high negative and low positive parenting relative to TD. However, only positive parenting differed between the CD/HCU and CD/LCU groups. In classification analyses, performance was best when distinguishing CD/HCU from TD groups and poorest when distinguishing CD/HCU from CD/LCU groups. Positive and negative parenting were both relevant when distinguishing CD/HCU from TD, negative parenting was most relevant when distinguishing between CD/LCU and TD, and positive parenting was most relevant when distinguishing CD/HCU from CD/LCU groups. These findings suggest that while positive parenting distinguishes between CD/HCU and CD/LCU, negative parenting is associated with both CD subtypes. These results highlight the importance of considering multiple parenting behaviors in CD with varying levels of CU traits in late childhood/adolescence. En ligne : http://dx.doi.org/10.1017/S0954579420000279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Positive and negative parenting in conduct disorder with high versus low levels of callous–unemotional traits [texte imprimé] / Ruth PAULI, Auteur ; Peter TINO, Auteur ; Jack C. ROGERS, Auteur ; Rosalind BAKER, Auteur ; Roberta CLANTON, Auteur ; Philippa BIRCH, Auteur ; Abigail BROWN, Auteur ; Gemma DANIEL, Auteur ; Lisandra FERREIRA, Auteur ; Liam GRISLEY, Auteur ; Gregor KOHLS, Auteur ; Sarah BAUMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Katharina ACKERMANN, Auteur ; Helen LAZARATOU, Auteur ; Foteini TSIAKOULIA, Auteur ; Panagiota BALI, Auteur ; Helena OLDENHOF, Auteur ; Lucres M.C. JANSEN, Auteur ; Areti SMARAGDI, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Miguel Angel GONZALEZ-TORRES, Auteur ; Maider GONZALEZ DE ARTAZA-LAVESA, Auteur ; Martin STEPPAN, Auteur ; Noortje VRIENDS, Auteur ; Aitana BIGORRA, Auteur ; Reka SIKLOSI, Auteur ; Sreejita GHOSH, Auteur ; Kerstin BUNTE, Auteur ; Roberta DOCHNAL, Auteur ; Amaia HERVAS, Auteur ; Christina STADLER, Auteur ; Aranzazu FERNANDEZ-RIVAS, Auteur ; Graeme FAIRCHILD, Auteur ; Arne POPMA, Auteur ; Dimitris DIKEOS, Auteur ; Kerstin KONRAD, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Christine M. FREITAG, Auteur ; Pia ROTSHTEIN, Auteur ; Stephane A. DE BRITO, Auteur . - p.980-991. Langues : Anglais (eng) in Development and Psychopathology > 33-3 (August 2021) . - p.980-991 Mots-clés : angle-based generalized matrix learning vector quantization  callous–unemotional traits  conduct disorder  machine learning  parenting Index. décimale : PER Périodiques Résumé : Less is known about the relationship between conduct disorder (CD), callous–unemotional (CU) traits, and positive and negative parenting in youth compared to early childhood. We combined traditional univariate analyses with a novel machine learning classifier (Angle-based Generalized Matrix Learning Vector Quantization) to classify youth (N = 756; 9–18 years) into typically developing (TD) or CD groups with or without elevated CU traits (CD/HCU, CD/LCU, respectively) using youth- and parent-reports of parenting behavior. At the group level, both CD/HCU and CD/LCU were associated with high negative and low positive parenting relative to TD. However, only positive parenting differed between the CD/HCU and CD/LCU groups. In classification analyses, performance was best when distinguishing CD/HCU from TD groups and poorest when distinguishing CD/HCU from CD/LCU groups. Positive and negative parenting were both relevant when distinguishing CD/HCU from TD, negative parenting was most relevant when distinguishing between CD/LCU and TD, and positive parenting was most relevant when distinguishing CD/HCU from CD/LCU groups. These findings suggest that while positive parenting distinguishes between CD/HCU and CD/LCU, negative parenting is associated with both CD subtypes. These results highlight the importance of considering multiple parenting behaviors in CD with varying levels of CU traits in late childhood/adolescence. En ligne : http://dx.doi.org/10.1017/S0954579420000279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder / Kerstin KONRAD in Journal of Child Psychology and Psychiatry, 63-2 (February 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.218-228 Titre : Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder Type de document : texte imprimé Auteurs : Kerstin KONRAD, Auteur ; Gregor KOHLS, Auteur ; Stephanie BAUMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Katharina ACKERMANN, Auteur ; Areti SMARAGDI, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Amy WELLS, Auteur ; Jack C. ROGERS, Auteur ; Ruth PAULI, Auteur ; Roberta CLANTON, Auteur ; Rosalind BAKER, Auteur ; Linda KERSTEN, Auteur ; Martin PRÄTZLICH, Auteur ; Helena OLDENHOF, Auteur ; Lucres M.C. JANSEN, Auteur ; Anneke KLEEVEN, Auteur ; Aitana BIGORRA, Auteur ; Amaia HERVAS, Auteur ; Iñaki KEREXETA-LIZEAGA, Auteur ; Eva SESMA-PARDO, Auteur ; Miguel Angel GONZALEZ-TORRES, Auteur ; Reka SIKLOSI, Auteur ; Roberta DOCHNAL, Auteur ; Zacharias KALOGERAKIS, Auteur ; Mara PIRLYMPOU, Auteur ; Leonidas PAPADAKOS, Auteur ; Harriet CORNWELL, Auteur ; Wolfgang SCHARKE, Auteur ; Dimitris DIKEOS, Auteur ; Aranzazu FERNANDEZ-RIVAS, Auteur ; Arne POPMA, Auteur ; Christina STADLER, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Stephane A. DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.218-228 Langues : Anglais (eng) Mots-clés : Conduct disorder  callous-unemotional traits  psychiatric comorbidity  sex differences Index. décimale : PER Périodiques Résumé : BACKGROUND: Conduct disorder (CD) rarely occurs alone but is typically accompanied by comorbid psychiatric disorders, which complicates the clinical presentation and treatment of affected youths. The aim of this study was to investigate sex differences in comorbidity pattern in CD and to systematically explore the 'gender paradox' and 'delayed-onset pathway' hypotheses of female CD. METHODS: As part of the FemNAT-CD multisite study, semistructured clinical interviews and rating scales were used to perform a comprehensive phenotypic characterization of 454 girls and 295 boys with CD (9-18 years), compared to 864 sex- and age-matched typically developing controls. RESULTS: Girls with CD exhibited higher rates of current major depression, anxiety disorders, post-traumatic stress disorder and borderline personality disorder, whereas boys with CD had higher rates of current attention-deficit/hyperactivity disorder. In line with the 'gender paradox' hypothesis, relative to boys, girls with CD showed significantly more lifetime psychiatric comorbidities (incl. Alcohol Use Disorder), which were accompanied by more severe CD symptoms. Female and male youths with CD also differed significantly in their CD symptom profiles and distribution of age-of-onset subtypes of CD (i.e. fewer girls with childhood-onset CD). In line with the 'delayed-onset pathway' hypothesis, girls with adolescent-onset CD showed similar levels of dimensional psychopathology like boys with childhood-onset CD, while boys with adolescent-onset CD had the lowest levels of internalizing psychopathology. CONCLUSIONS: Within the largest study of CD in girls performed to date, we found compelling evidence for sex differences in comorbidity patterns and clinical presentation of CD. Our findings further support aspects of the 'gender paradox' and 'delayed-onset pathway' hypotheses by showing that girls with CD had higher rates of comorbid lifetime mental disorders and functional impairments, and they usually developed CD during adolescence. These novel data on sex-specific clinical profiles of CD will be critical in informing intervention and prevention programmes. En ligne : http://dx.doi.org/10.1111/jcpp.13428 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder [texte imprimé] / Kerstin KONRAD, Auteur ; Gregor KOHLS, Auteur ; Stephanie BAUMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Katharina ACKERMANN, Auteur ; Areti SMARAGDI, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Amy WELLS, Auteur ; Jack C. ROGERS, Auteur ; Ruth PAULI, Auteur ; Roberta CLANTON, Auteur ; Rosalind BAKER, Auteur ; Linda KERSTEN, Auteur ; Martin PRÄTZLICH, Auteur ; Helena OLDENHOF, Auteur ; Lucres M.C. JANSEN, Auteur ; Anneke KLEEVEN, Auteur ; Aitana BIGORRA, Auteur ; Amaia HERVAS, Auteur ; Iñaki KEREXETA-LIZEAGA, Auteur ; Eva SESMA-PARDO, Auteur ; Miguel Angel GONZALEZ-TORRES, Auteur ; Reka SIKLOSI, Auteur ; Roberta DOCHNAL, Auteur ; Zacharias KALOGERAKIS, Auteur ; Mara PIRLYMPOU, Auteur ; Leonidas PAPADAKOS, Auteur ; Harriet CORNWELL, Auteur ; Wolfgang SCHARKE, Auteur ; Dimitris DIKEOS, Auteur ; Aranzazu FERNANDEZ-RIVAS, Auteur ; Arne POPMA, Auteur ; Christina STADLER, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Stephane A. DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur ; Christine M. FREITAG, Auteur . - p.218-228. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.218-228 Mots-clés : Conduct disorder  callous-unemotional traits  psychiatric comorbidity  sex differences Index. décimale : PER Périodiques Résumé : BACKGROUND: Conduct disorder (CD) rarely occurs alone but is typically accompanied by comorbid psychiatric disorders, which complicates the clinical presentation and treatment of affected youths. The aim of this study was to investigate sex differences in comorbidity pattern in CD and to systematically explore the 'gender paradox' and 'delayed-onset pathway' hypotheses of female CD. METHODS: As part of the FemNAT-CD multisite study, semistructured clinical interviews and rating scales were used to perform a comprehensive phenotypic characterization of 454 girls and 295 boys with CD (9-18 years), compared to 864 sex- and age-matched typically developing controls. RESULTS: Girls with CD exhibited higher rates of current major depression, anxiety disorders, post-traumatic stress disorder and borderline personality disorder, whereas boys with CD had higher rates of current attention-deficit/hyperactivity disorder. In line with the 'gender paradox' hypothesis, relative to boys, girls with CD showed significantly more lifetime psychiatric comorbidities (incl. Alcohol Use Disorder), which were accompanied by more severe CD symptoms. Female and male youths with CD also differed significantly in their CD symptom profiles and distribution of age-of-onset subtypes of CD (i.e. fewer girls with childhood-onset CD). In line with the 'delayed-onset pathway' hypothesis, girls with adolescent-onset CD showed similar levels of dimensional psychopathology like boys with childhood-onset CD, while boys with adolescent-onset CD had the lowest levels of internalizing psychopathology. CONCLUSIONS: Within the largest study of CD in girls performed to date, we found compelling evidence for sex differences in comorbidity patterns and clinical presentation of CD. Our findings further support aspects of the 'gender paradox' and 'delayed-onset pathway' hypotheses by showing that girls with CD had higher rates of comorbid lifetime mental disorders and functional impairments, and they usually developed CD during adolescence. These novel data on sex-specific clinical profiles of CD will be critical in informing intervention and prevention programmes. En ligne : http://dx.doi.org/10.1111/jcpp.13428 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Testing the ecophenotype hypothesis: Differences in white matter microstructure in youth with conduct disorder with versus without a history of childhood abuse / Sophie TOWNEND in Development and Psychopathology, 38-1 (February 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-1 (February 2026) . - p.211-225 Titre : Testing the ecophenotype hypothesis: Differences in white matter microstructure in youth with conduct disorder with versus without a history of childhood abuse Type de document : texte imprimé Auteurs : Sophie TOWNEND, Auteur ; Marlene STAGINNUS, Auteur ; Jack ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Anne MARTINELLI, Auteur ; Anka BERNHARD, Auteur ; Nora Maria RASCHLE, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Christina STADLER, Auteur ; Christine M. FREITAG, Auteur ; Esther WALTON, Auteur ; Stephane A. DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur Article en page(s) : p.211-225 Langues : Anglais (eng) Mots-clés : antisocial behavior child abuse childhood maltreatment conduct disorder diffusion tensor imaging sex differences Index. décimale : PER Périodiques Résumé : Childhood maltreatment is a key risk factor for conduct disorder (CD), and the “ecophenotype hypothesis” suggests that maltreatment-related versus non-maltreatment-related CD are neurobiologically distinct. This may explain inconsistent findings in previous structural connectivity studies of CD. We tested this hypothesis by comparing youth with CD with (CD/+) versus without (CD/−) childhood physical or sexual abuse in white-matter microstructure. Diffusion tensor imaging data were collected from 100 CD and 169 control participants aged 9–18 years. Using Tract-Based Spatial Statistics, we compared the CD and control groups in fractional anisotropy, and axial, radial and mean diffusivity, then compared the CD/+ (n = 39) and CD/− (n = 61) subgroups and controls. The combined CD group had higher fractional anisotropy in the corpus callosum than controls. When divided by abuse history, only the CD/− subgroup exhibited higher corpus callosum fractional anisotropy than controls; the CD/+ subgroup did not differ from controls. Comparing the CD subgroups, the CD/+ subgroup displayed higher superior longitudinal fasciculus axial diffusivity than the CD/− subgroup. Notably, sex-stratified analyses yielded different findings in all-male and all-female samples. Findings support the ecophenotype hypothesis, demonstrating microstructural differences between the CD/+ and CD/− subgroups and emphasizing the importance of considering abuse/maltreatment (and sex) in future studies. En ligne : https://dx.doi.org/10.1017/S0954579425000367 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Testing the ecophenotype hypothesis: Differences in white matter microstructure in youth with conduct disorder with versus without a history of childhood abuse [texte imprimé] / Sophie TOWNEND, Auteur ; Marlene STAGINNUS, Auteur ; Jack ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Anne MARTINELLI, Auteur ; Anka BERNHARD, Auteur ; Nora Maria RASCHLE, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Christina STADLER, Auteur ; Christine M. FREITAG, Auteur ; Esther WALTON, Auteur ; Stephane A. DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur . - p.211-225. Langues : Anglais (eng) in Development and Psychopathology > 38-1 (February 2026) . - p.211-225 Mots-clés : antisocial behavior child abuse childhood maltreatment conduct disorder diffusion tensor imaging sex differences Index. décimale : PER Périodiques Résumé : Childhood maltreatment is a key risk factor for conduct disorder (CD), and the “ecophenotype hypothesis” suggests that maltreatment-related versus non-maltreatment-related CD are neurobiologically distinct. This may explain inconsistent findings in previous structural connectivity studies of CD. We tested this hypothesis by comparing youth with CD with (CD/+) versus without (CD/−) childhood physical or sexual abuse in white-matter microstructure. Diffusion tensor imaging data were collected from 100 CD and 169 control participants aged 9–18 years. Using Tract-Based Spatial Statistics, we compared the CD and control groups in fractional anisotropy, and axial, radial and mean diffusivity, then compared the CD/+ (n = 39) and CD/− (n = 61) subgroups and controls. The combined CD group had higher fractional anisotropy in the corpus callosum than controls. When divided by abuse history, only the CD/− subgroup exhibited higher corpus callosum fractional anisotropy than controls; the CD/+ subgroup did not differ from controls. Comparing the CD subgroups, the CD/+ subgroup displayed higher superior longitudinal fasciculus axial diffusivity than the CD/− subgroup. Notably, sex-stratified analyses yielded different findings in all-male and all-female samples. Findings support the ecophenotype hypothesis, demonstrating microstructural differences between the CD/+ and CD/− subgroups and emphasizing the importance of considering abuse/maltreatment (and sex) in future studies. En ligne : https://dx.doi.org/10.1017/S0954579425000367 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

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