Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder / Yu WANG ; Aihua Cao ; Jing WANG ; He Bai ; Tianci Liu ; Chenxi Sun ; Zhuoran Li ; Yuchun Tang ; Feifei Xu ; Shuwei Liu in Autism Research, 18-1 (January 2025)  

Public ISBD [article]  inAutism Research > 18-1 (January 2025) . - p.83-97 Titre : Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder : Autism Research Type de document : Texte imprimé et/ou numérique Auteurs : Yu WANG, Auteur ; Aihua Cao, Auteur ; Jing WANG, Auteur ; He Bai, Auteur ; Tianci Liu, Auteur ; Chenxi Sun, Auteur ; Zhuoran Li, Auteur ; Yuchun Tang, Auteur ; Feifei Xu, Auteur ; Shuwei Liu, Auteur Article en page(s) : p.83-97 Langues : Anglais (eng) Mots-clés : atypical patterns  autism  cerebellar subregions' volume  cerebellocerebral structural covariance  pars opercularis Index. décimale : PER Périodiques Résumé : Abstract The cerebellum plays a crucial role in functions, including sensory-motor coordination, cognition, and emotional processing. Compared to the neocortex, the human cerebellum exhibits a protracted developmental trajectory. This delayed developmental timeline may lead to increased sensitivity of the cerebellum to external influences, potentially extending the vulnerability period for neurological disorders. Abnormal cerebellar development in individuals with autism has been confirmed, and these atypical cerebellar changes may affect the development of the neocortex. However, due to the heterogeneity of autism spectrum disorder (ASD), the regional changes in the cerebellum and cerebellocerebral structural relationship remain unknown. To address these issues, we utilized imaging methods optimized for the cerebellum and cerebrum on 817 individuals aged 5?18?years in the ABIDE II dataset. After FDR correction, significant differences between groups were found in the right crus II/VIIB and vermis VI-VII. Structural covariance analysis revealed enhanced structural covariance in individuals with autism between the cerebellum and parahippocampal gyrus, pars opercularis, and transverse temporal gyrus in the right hemisphere after FDR correction. Furthermore, the structural covariance between the cerebellum and some regions of the cerebrum varied across sexes. A significant increase in structural covariance between the cerebellum and specific subcortical structures was also observed in individuals with ASD. Our study found atypical patterns in the structural covariance between the cerebellum and cerebrum in individuals with autism, which suggested that the underlying pathological processes of ASD might concurrently affect these brain regions. This study provided insight into the potential of cerebellocerebral pathways as therapeutic targets for ASD. En ligne : https://doi.org/10.1002/aur.3287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder : Autism Research [Texte imprimé et/ou numérique] / Yu WANG, Auteur ; Aihua Cao, Auteur ; Jing WANG, Auteur ; He Bai, Auteur ; Tianci Liu, Auteur ; Chenxi Sun, Auteur ; Zhuoran Li, Auteur ; Yuchun Tang, Auteur ; Feifei Xu, Auteur ; Shuwei Liu, Auteur . - p.83-97. Langues : Anglais (eng) in Autism Research > 18-1 (January 2025) . - p.83-97 Mots-clés : atypical patterns  autism  cerebellar subregions' volume  cerebellocerebral structural covariance  pars opercularis Index. décimale : PER Périodiques Résumé : Abstract The cerebellum plays a crucial role in functions, including sensory-motor coordination, cognition, and emotional processing. Compared to the neocortex, the human cerebellum exhibits a protracted developmental trajectory. This delayed developmental timeline may lead to increased sensitivity of the cerebellum to external influences, potentially extending the vulnerability period for neurological disorders. Abnormal cerebellar development in individuals with autism has been confirmed, and these atypical cerebellar changes may affect the development of the neocortex. However, due to the heterogeneity of autism spectrum disorder (ASD), the regional changes in the cerebellum and cerebellocerebral structural relationship remain unknown. To address these issues, we utilized imaging methods optimized for the cerebellum and cerebrum on 817 individuals aged 5?18?years in the ABIDE II dataset. After FDR correction, significant differences between groups were found in the right crus II/VIIB and vermis VI-VII. Structural covariance analysis revealed enhanced structural covariance in individuals with autism between the cerebellum and parahippocampal gyrus, pars opercularis, and transverse temporal gyrus in the right hemisphere after FDR correction. Furthermore, the structural covariance between the cerebellum and some regions of the cerebrum varied across sexes. A significant increase in structural covariance between the cerebellum and specific subcortical structures was also observed in individuals with ASD. Our study found atypical patterns in the structural covariance between the cerebellum and cerebrum in individuals with autism, which suggested that the underlying pathological processes of ASD might concurrently affect these brain regions. This study provided insight into the potential of cerebellocerebral pathways as therapeutic targets for ASD. En ligne : https://doi.org/10.1002/aur.3287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

Attentional biases to faces with direct versus averted gaze in children without and with autism spectrum disorder: A dot-probe paradigm / Wei JING in Research in Autism Spectrum Disorders, 108 (October 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 108 (October 2023) . - p.102233 Titre : Attentional biases to faces with direct versus averted gaze in children without and with autism spectrum disorder: A dot-probe paradigm Type de document : Texte imprimé et/ou numérique Auteurs : Wei JING, Auteur ; Jing WANG, Auteur ; Jinxia FU, Auteur Article en page(s) : p.102233 Mots-clés : Children with ASD  Dot-probe paradigms  Direct gaze  Averted gaze  Facial attention Index. décimale : PER Périodiques Résumé : Previous research utilized a variety of paradigms to demonstrate attentional biases to faces with direct versus averted gaze in typical development (TD) and no such bias in autism spectrum disorder (ASD). However, little is known about whether the biases can be observed during automatic processing stages in TD and whether the lack of such bias in ASD is due to passive neglect or active avoidance of direct gaze. Therefore, we employed a dot-probe paradigm and manipulated stimulus onset asynchrony (SOA) to measure response times to probes replacing faces with direct gaze compared to faces with averted gaze in children without and with ASD. There was no evidence of attentional bias in either group when stimuli were presented during the automatic processing stage (200 ms SOA). However, during the controlled processing stage (1000 ms SOA), an attentional bias to faces with direct versus averted gaze was found in control children but not in those with ASD. The results indicate that the facilitation of direct gaze on facial attention occurs during controlled rather than automatic processing stages in TD individuals. In contrast, children with ASD respond indiscriminately to direct and averted gaze during both stages of cognitive processing, supporting the gaze indifference hypothesis. For TD children but not for children with ASD, direct gaze is an adaptively informative or socially salient signal. En ligne : https://doi.org/10.1016/j.rasd.2023.102233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514 [article] Attentional biases to faces with direct versus averted gaze in children without and with autism spectrum disorder: A dot-probe paradigm [Texte imprimé et/ou numérique] / Wei JING, Auteur ; Jing WANG, Auteur ; Jinxia FU, Auteur . - p.102233. in Research in Autism Spectrum Disorders > 108 (October 2023) . - p.102233 Mots-clés : Children with ASD  Dot-probe paradigms  Direct gaze  Averted gaze  Facial attention Index. décimale : PER Périodiques Résumé : Previous research utilized a variety of paradigms to demonstrate attentional biases to faces with direct versus averted gaze in typical development (TD) and no such bias in autism spectrum disorder (ASD). However, little is known about whether the biases can be observed during automatic processing stages in TD and whether the lack of such bias in ASD is due to passive neglect or active avoidance of direct gaze. Therefore, we employed a dot-probe paradigm and manipulated stimulus onset asynchrony (SOA) to measure response times to probes replacing faces with direct gaze compared to faces with averted gaze in children without and with ASD. There was no evidence of attentional bias in either group when stimuli were presented during the automatic processing stage (200 ms SOA). However, during the controlled processing stage (1000 ms SOA), an attentional bias to faces with direct versus averted gaze was found in control children but not in those with ASD. The results indicate that the facilitation of direct gaze on facial attention occurs during controlled rather than automatic processing stages in TD individuals. In contrast, children with ASD respond indiscriminately to direct and averted gaze during both stages of cognitive processing, supporting the gaze indifference hypothesis. For TD children but not for children with ASD, direct gaze is an adaptively informative or socially salient signal. En ligne : https://doi.org/10.1016/j.rasd.2023.102233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=514

Changes in women's alcoholic, antisocial, and depressive symptomatology over 12 years: A multilevel network of individual, familial, and neighborhood influences / Anne BUU in Development and Psychopathology, 23-1 (January 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-1 (January 2011) . - p.325-337 Titre : Changes in women's alcoholic, antisocial, and depressive symptomatology over 12 years: A multilevel network of individual, familial, and neighborhood influences Type de document : Texte imprimé et/ou numérique Auteurs : Anne BUU, Auteur ; Wei WANG, Auteur ; Jing WANG, Auteur ; Leon I. PUTTLER, Auteur ; Hiram E. FITZGERALD, Auteur ; Robert A. ZUCKER, Auteur Année de publication : 2011 Article en page(s) : p.325-337 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In a sample of 273 adult women and their families, we examined the effects of women's psychopathology history, their social support, their husbands' and children's symptomatology, family stress, and neighborhood environment on their alcohol problems, antisocial behavior, and depression over a 12-year period during their 30s and early 40s. Women's alcohol problems and antisocial behavior decreased but their depression symptoms increased over time. Women's disorder history and their partners' parallel symptomatology were associated with their symptoms. For women's antisocial behavior, their own history of alcoholism and their partners' alcohol problems were also significant risk factors. Higher levels of social support were associated with lower levels of depression in women. Children's externalizing behavior was positively correlated with their mothers' alcohol problems and antisocial behavior, whereas children's internalizing behavior was positively correlated with their mothers' depression. Neighborhood residential instability was associated with higher levels of alcoholic and depressive symptomatology in women. Intervention efforts might target women with young children by improving social support, educational or professional training opportunity, access to family counseling, and neighborhood environment. En ligne : http://dx.doi.org/10.1017/S0954579410000830 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117 [article] Changes in women's alcoholic, antisocial, and depressive symptomatology over 12 years: A multilevel network of individual, familial, and neighborhood influences [Texte imprimé et/ou numérique] / Anne BUU, Auteur ; Wei WANG, Auteur ; Jing WANG, Auteur ; Leon I. PUTTLER, Auteur ; Hiram E. FITZGERALD, Auteur ; Robert A. ZUCKER, Auteur . - 2011 . - p.325-337. Langues : Anglais (eng) in Development and Psychopathology > 23-1 (January 2011) . - p.325-337 Index. décimale : PER Périodiques Résumé : In a sample of 273 adult women and their families, we examined the effects of women's psychopathology history, their social support, their husbands' and children's symptomatology, family stress, and neighborhood environment on their alcohol problems, antisocial behavior, and depression over a 12-year period during their 30s and early 40s. Women's alcohol problems and antisocial behavior decreased but their depression symptoms increased over time. Women's disorder history and their partners' parallel symptomatology were associated with their symptoms. For women's antisocial behavior, their own history of alcoholism and their partners' alcohol problems were also significant risk factors. Higher levels of social support were associated with lower levels of depression in women. Children's externalizing behavior was positively correlated with their mothers' alcohol problems and antisocial behavior, whereas children's internalizing behavior was positively correlated with their mothers' depression. Neighborhood residential instability was associated with higher levels of alcoholic and depressive symptomatology in women. Intervention efforts might target women with young children by improving social support, educational or professional training opportunity, access to family counseling, and neighborhood environment. En ligne : http://dx.doi.org/10.1017/S0954579410000830 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117

Shank3 deficiency elicits autistic-like behaviors by activating p38? in hypothalamic AgRP neurons / Shanshan WU in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 14p. Titre : Shank3 deficiency elicits autistic-like behaviors by activating p38? in hypothalamic AgRP neurons Type de document : Texte imprimé et/ou numérique Auteurs : Shanshan WU, Auteur ; Jing WANG, Auteur ; Zicheng ZHANG, Auteur ; Xinchen JIN, Auteur ; Yang XU, Auteur ; Youwen SI, Auteur ; Yixiao LIANG, Auteur ; Yueping GE, Auteur ; Huidong ZHAN, Auteur ; Li PENG, Auteur ; Wenkai BI, Auteur ; Dandan LUO, Auteur ; Mengzhu LI, Auteur ; Bo MENG, Auteur ; Qingbo GUAN, Auteur ; Jiajun ZHAO, Auteur ; Ling GAO, Auteur ; Zhao HE, Auteur Article en page(s) : 14p. Langues : Anglais (eng) Mots-clés : Animals  Mice  Agouti-Related Protein/genetics/metabolism  Arcuate Nucleus of Hypothalamus/metabolism  Autistic Disorder/genetics/metabolism  Hypothalamus/metabolism  Microfilament Proteins/metabolism  Nerve Tissue Proteins/genetics/metabolism  Neurons/metabolism  Mitogen-Activated Protein Kinase 14/metabolism  AgRP  Autism  Shank3  Sociability  Stereotypic behavior  p38? Index. décimale : PER Périodiques Résumé : BACKGROUND: SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) monogenic mutations or deficiency leads to excessive stereotypic behavior and impaired sociability, which frequently occur in autism cases. To date, the underlying mechanisms by which Shank3 mutation or deletion causes autism and the part of the brain in which Shank3 mutation leads to the autistic phenotypes are understudied. The hypothalamus is associated with stereotypic behavior and sociability. p38?, a mediator of inflammatory responses in the brain, has been postulated as a potential gene for certain cases of autism occurrence. However, it is unclear whether hypothalamus and p38? are involved in the development of autism caused by Shank3 mutations or deficiency. METHODS: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and immunoblotting were used to assess alternated signaling pathways in the hypothalamus of Shank3 knockout (Shank3(-/-)) mice. Home-Cage real-time monitoring test was performed to record stereotypic behavior and three-chamber test was used to monitor the sociability of mice. Adeno-associated viruses 9 (AAV9) were used to express p38? in the arcuate nucleus (ARC) or agouti-related peptide (AgRP) neurons. D176A and F327S mutations expressed constitutively active p38?. T180A and Y182F mutations expressed inactive p38?. RESULTS: We found that Shank3 controls stereotypic behavior and sociability by regulating p38? activity in AgRP neurons. Phosphorylated p38 level in hypothalamus is significantly enhanced in Shank3(-/-) mice. Consistently, overexpression of p38? in ARC or AgRP neurons elicits excessive stereotypic behavior and impairs sociability in wild-type (WT) mice. Notably, activated p38? in AgRP neurons increases stereotypic behavior and impairs sociability. Conversely, inactivated p38? in AgRP neurons significantly ameliorates autistic behaviors of Shank3(-/-) mice. In contrast, activated p38? in pro-opiomelanocortin (POMC) neurons does not affect stereotypic behavior and sociability in mice. LIMITATIONS: We demonstrated that SHANK3 regulates the phosphorylated p38 level in the hypothalamus and inactivated p38? in AgRP neurons significantly ameliorates autistic behaviors of Shank3(-/-) mice. However, we did not clarify the biochemical mechanism of SHANK3 inhibiting p38? in AgRP neurons. CONCLUSIONS: These results demonstrate that the Shank3 deficiency caused autistic-like behaviors by activating p38? signaling in AgRP neurons, suggesting that p38? signaling in AgRP neurons is a potential therapeutic target for Shank3 mutant-related autism. En ligne : https://dx.doi.org/10.1186/s13229-024-00595-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Shank3 deficiency elicits autistic-like behaviors by activating p38? in hypothalamic AgRP neurons [Texte imprimé et/ou numérique] / Shanshan WU, Auteur ; Jing WANG, Auteur ; Zicheng ZHANG, Auteur ; Xinchen JIN, Auteur ; Yang XU, Auteur ; Youwen SI, Auteur ; Yixiao LIANG, Auteur ; Yueping GE, Auteur ; Huidong ZHAN, Auteur ; Li PENG, Auteur ; Wenkai BI, Auteur ; Dandan LUO, Auteur ; Mengzhu LI, Auteur ; Bo MENG, Auteur ; Qingbo GUAN, Auteur ; Jiajun ZHAO, Auteur ; Ling GAO, Auteur ; Zhao HE, Auteur . - 14p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 14p. Mots-clés : Animals  Mice  Agouti-Related Protein/genetics/metabolism  Arcuate Nucleus of Hypothalamus/metabolism  Autistic Disorder/genetics/metabolism  Hypothalamus/metabolism  Microfilament Proteins/metabolism  Nerve Tissue Proteins/genetics/metabolism  Neurons/metabolism  Mitogen-Activated Protein Kinase 14/metabolism  AgRP  Autism  Shank3  Sociability  Stereotypic behavior  p38? Index. décimale : PER Périodiques Résumé : BACKGROUND: SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) monogenic mutations or deficiency leads to excessive stereotypic behavior and impaired sociability, which frequently occur in autism cases. To date, the underlying mechanisms by which Shank3 mutation or deletion causes autism and the part of the brain in which Shank3 mutation leads to the autistic phenotypes are understudied. The hypothalamus is associated with stereotypic behavior and sociability. p38?, a mediator of inflammatory responses in the brain, has been postulated as a potential gene for certain cases of autism occurrence. However, it is unclear whether hypothalamus and p38? are involved in the development of autism caused by Shank3 mutations or deficiency. METHODS: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and immunoblotting were used to assess alternated signaling pathways in the hypothalamus of Shank3 knockout (Shank3(-/-)) mice. Home-Cage real-time monitoring test was performed to record stereotypic behavior and three-chamber test was used to monitor the sociability of mice. Adeno-associated viruses 9 (AAV9) were used to express p38? in the arcuate nucleus (ARC) or agouti-related peptide (AgRP) neurons. D176A and F327S mutations expressed constitutively active p38?. T180A and Y182F mutations expressed inactive p38?. RESULTS: We found that Shank3 controls stereotypic behavior and sociability by regulating p38? activity in AgRP neurons. Phosphorylated p38 level in hypothalamus is significantly enhanced in Shank3(-/-) mice. Consistently, overexpression of p38? in ARC or AgRP neurons elicits excessive stereotypic behavior and impairs sociability in wild-type (WT) mice. Notably, activated p38? in AgRP neurons increases stereotypic behavior and impairs sociability. Conversely, inactivated p38? in AgRP neurons significantly ameliorates autistic behaviors of Shank3(-/-) mice. In contrast, activated p38? in pro-opiomelanocortin (POMC) neurons does not affect stereotypic behavior and sociability in mice. LIMITATIONS: We demonstrated that SHANK3 regulates the phosphorylated p38 level in the hypothalamus and inactivated p38? in AgRP neurons significantly ameliorates autistic behaviors of Shank3(-/-) mice. However, we did not clarify the biochemical mechanism of SHANK3 inhibiting p38? in AgRP neurons. CONCLUSIONS: These results demonstrate that the Shank3 deficiency caused autistic-like behaviors by activating p38? signaling in AgRP neurons, suggesting that p38? signaling in AgRP neurons is a potential therapeutic target for Shank3 mutant-related autism. En ligne : https://dx.doi.org/10.1186/s13229-024-00595-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

The Moderating Effects of Maternal Psychopathology on Children's Adjustment Post-Hurricane Katrina / Annie W. SPELL in Journal of Clinical Child & Adolescent Psychology, 37-3 (July-September 2008)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 37-3 (July-September 2008) . - p.553-563 Titre : The Moderating Effects of Maternal Psychopathology on Children's Adjustment Post-Hurricane Katrina Type de document : Texte imprimé et/ou numérique Auteurs : Annie W. SPELL, Auteur ; Valerie PAASCH, Auteur ; Kara MEYER, Auteur ; Jeannette L. PALCIC, Auteur ; Angie PELLEGRIN, Auteur ; Karen L. DAVIDSON, Auteur ; Shannon SELF-BROWN, Auteur ; Jing WANG, Auteur ; Mary Lou KELLEY, Auteur ; Audrey BAUMEISTER, Auteur Année de publication : 2008 Article en page(s) : p.553-563 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study investigated the role of maternal psychopathology in predicting children's psychological distress in a disaster-exposed sample. Participants consisted of 260 children (ages 8-16) recruited from public schools and their mothers. These families were displaced from New Orleans because of Hurricane Katrina in 2005. Assessment took place 3 to 7 months postdisaster. Hierarchical regression analyses revealed that global maternal psychological distress and maternal posttraumatic stress disorder moderated the relation between child hurricane exposure and mother-reported child internalizing and externalizing symptoms. En ligne : http://dx.doi.org/10.1080/1.5374410802148210 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544 [article] The Moderating Effects of Maternal Psychopathology on Children's Adjustment Post-Hurricane Katrina [Texte imprimé et/ou numérique] / Annie W. SPELL, Auteur ; Valerie PAASCH, Auteur ; Kara MEYER, Auteur ; Jeannette L. PALCIC, Auteur ; Angie PELLEGRIN, Auteur ; Karen L. DAVIDSON, Auteur ; Shannon SELF-BROWN, Auteur ; Jing WANG, Auteur ; Mary Lou KELLEY, Auteur ; Audrey BAUMEISTER, Auteur . - 2008 . - p.553-563. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 37-3 (July-September 2008) . - p.553-563 Index. décimale : PER Périodiques Résumé : This study investigated the role of maternal psychopathology in predicting children's psychological distress in a disaster-exposed sample. Participants consisted of 260 children (ages 8-16) recruited from public schools and their mothers. These families were displaced from New Orleans because of Hurricane Katrina in 2005. Assessment took place 3 to 7 months postdisaster. Hierarchical regression analyses revealed that global maternal psychological distress and maternal posttraumatic stress disorder moderated the relation between child hurricane exposure and mother-reported child internalizing and externalizing symptoms. En ligne : http://dx.doi.org/10.1080/1.5374410802148210 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544

Transcriptomics of Gabra4 knockout mice reveals common NMDAR pathways underlying autism, memory, and epilepsy / Cuixia FAN in Molecular Autism, 11 (2020)  

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