Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample / Scott TILLEM in Development and Psychopathology, 34-4 (October 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-4 (October 2022) . - p.1573-1584 Titre : Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample Type de document : Texte imprimé et/ou numérique Auteurs : Scott TILLEM, Auteur ; May I. CONLEY, Auteur ; Arielle BASKIN-SOMMERS, Auteur Article en page(s) : p.1573-1584 Langues : Anglais (eng) Mots-clés : Adolescent  Brain  Child  Cluster Analysis  Conduct Disorder/diagnostic imaging  Connectome  Humans  Magnetic Resonance Imaging/methods  conduct disorder  graph analysis  neural topology  neurocognitive functioning  subcortical structures Index. décimale : PER Périodiques Résumé : Conduct disorder (CD), characterized by youth antisocial behavior, is associated with a variety of neurocognitive impairments. However, questions remain regarding the neural underpinnings of these impairments. To investigate novel neural mechanisms that may support these neurocognitive abnormalities, the present study applied a graph analysis to resting-state functional magnetic resonance imaging (fMRI) data collected from a national sample of 4,781 youth, ages 9-10, who participated in the baseline session of the Adolescent Brain Cognitive Development(SM) Study (ABCD Study®). Analyses were then conducted to examine the relationships among levels of CD symptomatology, metrics of global topology, node-level metrics for subcortical structures, and performance on neurocognitive assessments. Youth higher on CD displayed higher global clustering (Î2= .039, 95% CI(corrected) [.0027 .0771]), but lower Degree(subcortical) (Î2= -.052, 95% CI(corrected) [-.0916 -.0152]). Youth higher on CD had worse performance on a general neurocognitive assessment (Î2= -.104, 95% CI [-.1328 -.0763]) and an emotion recognition memory assessment (Î2= -.061, 95% CI [-.0919 -.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect Î2= -.002, 95% CI [-.0044 -.0002]), and Degree(subcortical) mediated the relationship between CD and emotion recognition memory performance (indirect Î2= -.002, 95% CI [-.0046 -.0005]). CD appears associated with neuro-topological abnormalities and these abnormalities may represent neural mechanisms supporting CD-related neurocognitive disruptions. En ligne : http://dx.doi.org/10.1017/s0954579421000237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample [Texte imprimé et/ou numérique] / Scott TILLEM, Auteur ; May I. CONLEY, Auteur ; Arielle BASKIN-SOMMERS, Auteur . - p.1573-1584. Langues : Anglais (eng) in Development and Psychopathology > 34-4 (October 2022) . - p.1573-1584 Mots-clés : Adolescent  Brain  Child  Cluster Analysis  Conduct Disorder/diagnostic imaging  Connectome  Humans  Magnetic Resonance Imaging/methods  conduct disorder  graph analysis  neural topology  neurocognitive functioning  subcortical structures Index. décimale : PER Périodiques Résumé : Conduct disorder (CD), characterized by youth antisocial behavior, is associated with a variety of neurocognitive impairments. However, questions remain regarding the neural underpinnings of these impairments. To investigate novel neural mechanisms that may support these neurocognitive abnormalities, the present study applied a graph analysis to resting-state functional magnetic resonance imaging (fMRI) data collected from a national sample of 4,781 youth, ages 9-10, who participated in the baseline session of the Adolescent Brain Cognitive Development(SM) Study (ABCD Study®). Analyses were then conducted to examine the relationships among levels of CD symptomatology, metrics of global topology, node-level metrics for subcortical structures, and performance on neurocognitive assessments. Youth higher on CD displayed higher global clustering (Î2= .039, 95% CI(corrected) [.0027 .0771]), but lower Degree(subcortical) (Î2= -.052, 95% CI(corrected) [-.0916 -.0152]). Youth higher on CD had worse performance on a general neurocognitive assessment (Î2= -.104, 95% CI [-.1328 -.0763]) and an emotion recognition memory assessment (Î2= -.061, 95% CI [-.0919 -.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect Î2= -.002, 95% CI [-.0044 -.0002]), and Degree(subcortical) mediated the relationship between CD and emotion recognition memory performance (indirect Î2= -.002, 95% CI [-.0046 -.0005]). CD appears associated with neuro-topological abnormalities and these abnormalities may represent neural mechanisms supporting CD-related neurocognitive disruptions. En ligne : http://dx.doi.org/10.1017/s0954579421000237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

The role of perceived threats on mental health, social, and neurocognitive youth outcomes: A multicontextual, person-centered approach / May I. CONLEY in Development and Psychopathology, 35-2 (May 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-2 (May 2023) . - p.689-710 Titre : The role of perceived threats on mental health, social, and neurocognitive youth outcomes: A multicontextual, person-centered approach Type de document : Texte imprimé et/ou numérique Auteurs : May I. CONLEY, Auteur ; Jasmine HERNANDEZ, Auteur ; Joeann M. SALVATI, Auteur ; Dylan G. GEE, Auteur ; Arielle BASKIN-SOMMERS, Auteur Article en page(s) : p.689-710 Langues : Anglais (eng) Mots-clés : mental health  neurocognition  perceived threat  social functioning  youth environments Index. décimale : PER Périodiques Résumé : Perceived threat in youth?s environments can elevate risk for mental health, social, and neurocognitive difficulties throughout the lifespan. However, few studies examine variability in youth?s perceptions of threat across multiple contexts or evaluate outcomes across multiple domains, ultimately limiting our understanding of specific risks associated with perceived threats in different contexts. This study examined associations between perceived threat in youth?s neighborhood, school, and family contexts at ages 9-10 and mental health, social, and neurocognitive outcomes at ages 11-12 within a large US cohort (N = 5525) enrolled in the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®). Latent profile analysis revealed four distinct profiles: Low Threat in all contexts, Elevated Family Threat, Elevated Neighborhood Threat, and Elevated Threat in all contexts. Mixed-effect models and post hoc pairwise comparisons showed that youth in Elevated Threat profile had poorer mental health and social outcomes 2 years later. Youth in the Elevated Family Threat profile uniquely showed increased disruptive behavior symptoms, whereas youth in the Elevated Neighborhood Threat profile predominantly displayed increased sleep problems and worse neurocognitive outcomes 2 years later. Together, findings highlight the importance of considering perceptions of threat across multiple contexts to achieve a more nuanced developmental picture. En ligne : http://dx.doi.org/10.1017/S095457942100184X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] The role of perceived threats on mental health, social, and neurocognitive youth outcomes: A multicontextual, person-centered approach [Texte imprimé et/ou numérique] / May I. CONLEY, Auteur ; Jasmine HERNANDEZ, Auteur ; Joeann M. SALVATI, Auteur ; Dylan G. GEE, Auteur ; Arielle BASKIN-SOMMERS, Auteur . - p.689-710. Langues : Anglais (eng) in Development and Psychopathology > 35-2 (May 2023) . - p.689-710 Mots-clés : mental health  neurocognition  perceived threat  social functioning  youth environments Index. décimale : PER Périodiques Résumé : Perceived threat in youth?s environments can elevate risk for mental health, social, and neurocognitive difficulties throughout the lifespan. However, few studies examine variability in youth?s perceptions of threat across multiple contexts or evaluate outcomes across multiple domains, ultimately limiting our understanding of specific risks associated with perceived threats in different contexts. This study examined associations between perceived threat in youth?s neighborhood, school, and family contexts at ages 9-10 and mental health, social, and neurocognitive outcomes at ages 11-12 within a large US cohort (N = 5525) enrolled in the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®). Latent profile analysis revealed four distinct profiles: Low Threat in all contexts, Elevated Family Threat, Elevated Neighborhood Threat, and Elevated Threat in all contexts. Mixed-effect models and post hoc pairwise comparisons showed that youth in Elevated Threat profile had poorer mental health and social outcomes 2 years later. Youth in the Elevated Family Threat profile uniquely showed increased disruptive behavior symptoms, whereas youth in the Elevated Neighborhood Threat profile predominantly displayed increased sleep problems and worse neurocognitive outcomes 2 years later. Together, findings highlight the importance of considering perceptions of threat across multiple contexts to achieve a more nuanced developmental picture. En ligne : http://dx.doi.org/10.1017/S095457942100184X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

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