3 recherche sur le mot-clé 'neurocognitive functioning'

Psychopathology as long-term sequelae of maltreatment and socioeconomic disadvantage: Neurocognitive development perspectives / Jungmeen KIM-SPOON ; Alexis BRIEANT ; Ann FOLKER ; Morgan LINDENMUTH ; Jacob LEE ; Brooks CASAS ; Kirby DEATER-DECKARD in Development and Psychopathology, 36-5 (December 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-5 (December 2024) . - p.2421-2432 Titre : Psychopathology as long-term sequelae of maltreatment and socioeconomic disadvantage: Neurocognitive development perspectives : Development and Psychopathology Type de document : texte imprimé Auteurs : Jungmeen KIM-SPOON, Auteur ; Alexis BRIEANT, Auteur ; Ann FOLKER, Auteur ; Morgan LINDENMUTH, Auteur ; Jacob LEE, Auteur ; Brooks CASAS, Auteur ; Kirby DEATER-DECKARD, Auteur Année de publication : 2024 Article en page(s) : p.2421-2432 Langues : Anglais (eng) Mots-clés : adverse experiences  maltreatment  neurocognitive functioning  psychopathology  socioeconomic disadvantage Index. décimale : PER Périodiques Résumé : Neuroscience research underscores the critical impact of adverse experiences on brain development. Yet, there is limited understanding of the specific pathways linking adverse experiences to accelerated or delayed brain development and their ultimate contributions to psychopathology. Here, we present new longitudinal data demonstrating that neurocognitive functioning during adolescence, as affected by adverse experiences, predicts psychopathology during young adulthood. The sample included 167 participants (52% male) assessed in adolescence and young adulthood. Adverse experiences were measured by early maltreatment experiences and low family socioeconomic status. Cognitive control was assessed by neural activation and behavioral performance during the Multi-Source Interference Task. Psychopathology was measured by self-reported internalizing and externalizing symptomatology. Results indicated that higher maltreatment predicted heightened frontoparietal activation during cognitive control, indicating delayed neurodevelopment, which, in turn predicted higher internalizing and externalizing symptomatology. Furthermore, higher maltreatment predicted a steeper decline in frontoparietal activation across adolescence, indicating neural plasticity in cognitive control-related brain development, which was associated with lower internalizing symptomatology. Our results elucidate the crucial role of neurocognitive development in the processes linking adverse experiences and psychopathology. Implications of the findings and directions for future research on the effects of adverse experiences on brain development are discussed. En ligne : https://dx.doi.org/10.1017/S0954579424000531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545 [article] Psychopathology as long-term sequelae of maltreatment and socioeconomic disadvantage: Neurocognitive development perspectives : Development and Psychopathology [texte imprimé] / Jungmeen KIM-SPOON, Auteur ; Alexis BRIEANT, Auteur ; Ann FOLKER, Auteur ; Morgan LINDENMUTH, Auteur ; Jacob LEE, Auteur ; Brooks CASAS, Auteur ; Kirby DEATER-DECKARD, Auteur . - 2024 . - p.2421-2432. Langues : Anglais (eng) in Development and Psychopathology > 36-5 (December 2024) . - p.2421-2432 Mots-clés : adverse experiences  maltreatment  neurocognitive functioning  psychopathology  socioeconomic disadvantage Index. décimale : PER Périodiques Résumé : Neuroscience research underscores the critical impact of adverse experiences on brain development. Yet, there is limited understanding of the specific pathways linking adverse experiences to accelerated or delayed brain development and their ultimate contributions to psychopathology. Here, we present new longitudinal data demonstrating that neurocognitive functioning during adolescence, as affected by adverse experiences, predicts psychopathology during young adulthood. The sample included 167 participants (52% male) assessed in adolescence and young adulthood. Adverse experiences were measured by early maltreatment experiences and low family socioeconomic status. Cognitive control was assessed by neural activation and behavioral performance during the Multi-Source Interference Task. Psychopathology was measured by self-reported internalizing and externalizing symptomatology. Results indicated that higher maltreatment predicted heightened frontoparietal activation during cognitive control, indicating delayed neurodevelopment, which, in turn predicted higher internalizing and externalizing symptomatology. Furthermore, higher maltreatment predicted a steeper decline in frontoparietal activation across adolescence, indicating neural plasticity in cognitive control-related brain development, which was associated with lower internalizing symptomatology. Our results elucidate the crucial role of neurocognitive development in the processes linking adverse experiences and psychopathology. Implications of the findings and directions for future research on the effects of adverse experiences on brain development are discussed. En ligne : https://dx.doi.org/10.1017/S0954579424000531 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545

Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth / Lauren MICALIZZI in Development and Psychopathology, 33-1 (February 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-1 (February 2021) . - p.76-86 Titre : Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth Type de document : texte imprimé Auteurs : Lauren MICALIZZI, Auteur ; Leslie A. BRICK, Auteur ; Marisa E. MARRACCINI, Auteur ; Chelsie E. BENCA-BACHMAN, Auteur ; Rohan H.C. PALMER, Auteur ; Valerie S. KNOPIK, Auteur Article en page(s) : p.76-86 Langues : Anglais (eng) Mots-clés : Gcta  adolescence  genetics  heritability  inattention  neurocognitive functioning Index. décimale : PER Périodiques Résumé : Theoretical models of attention-deficit/hyperactivity disorder implicate neurocognitive dysfunction, yet neurocognitive functioning covers a range of abilities that may not all be linked with inattention. This study (a) investigated the single nucleotide polymorphism (SNP) heritability (h2SNP) of inattention and aspects of neurocognitive efficiency (memory, social cognition, executive function, and complex cognition) based on additive genome-wide effects; (b) examined if there were shared genetic effects among inattention and each aspect of neurocognitive efficiency; and (c) conducted an exploratory genome-wide association study to identify genetic regions associated with inattention. The sample included 3,563 participants of the Philadelphia Neurodevelopmental Cohort, a general population sample aged 8-21 years who completed the Penn Neurocognitive Battery. Data on inattention was obtained with the Kiddie Schedule of Affective Disorders (adapted). Genomic relatedness matrix restricted maximum likelihood was implemented in genome-wide complex trait analysis. Analyses revealed significant h2SNP for inattention (20%, SE = 0.08), social cognition (13%, SE = 0.08), memory (17%, SE = 0.08), executive function (25%, SE = 0.08), and complex cognition (24%, SE = 0.08). There was a positive genetic correlation (0.67, SE = 0.37) and a negative residual covariance (-0.23, SE = 0.06) between inattention and social cognition. No SNPs reached genome-wide significance for inattention. Results suggest specificity in genetic overlap among inattention and different aspects of neurocognitive efficiency. En ligne : http://dx.doi.org/10.1017/s0954579419001573 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 [article] Single nucleotide polymorphism heritability and differential patterns of genetic overlap between inattention and four neurocognitive factors in youth [texte imprimé] / Lauren MICALIZZI, Auteur ; Leslie A. BRICK, Auteur ; Marisa E. MARRACCINI, Auteur ; Chelsie E. BENCA-BACHMAN, Auteur ; Rohan H.C. PALMER, Auteur ; Valerie S. KNOPIK, Auteur . - p.76-86. Langues : Anglais (eng) in Development and Psychopathology > 33-1 (February 2021) . - p.76-86 Mots-clés : Gcta  adolescence  genetics  heritability  inattention  neurocognitive functioning Index. décimale : PER Périodiques Résumé : Theoretical models of attention-deficit/hyperactivity disorder implicate neurocognitive dysfunction, yet neurocognitive functioning covers a range of abilities that may not all be linked with inattention. This study (a) investigated the single nucleotide polymorphism (SNP) heritability (h2SNP) of inattention and aspects of neurocognitive efficiency (memory, social cognition, executive function, and complex cognition) based on additive genome-wide effects; (b) examined if there were shared genetic effects among inattention and each aspect of neurocognitive efficiency; and (c) conducted an exploratory genome-wide association study to identify genetic regions associated with inattention. The sample included 3,563 participants of the Philadelphia Neurodevelopmental Cohort, a general population sample aged 8-21 years who completed the Penn Neurocognitive Battery. Data on inattention was obtained with the Kiddie Schedule of Affective Disorders (adapted). Genomic relatedness matrix restricted maximum likelihood was implemented in genome-wide complex trait analysis. Analyses revealed significant h2SNP for inattention (20%, SE = 0.08), social cognition (13%, SE = 0.08), memory (17%, SE = 0.08), executive function (25%, SE = 0.08), and complex cognition (24%, SE = 0.08). There was a positive genetic correlation (0.67, SE = 0.37) and a negative residual covariance (-0.23, SE = 0.06) between inattention and social cognition. No SNPs reached genome-wide significance for inattention. Results suggest specificity in genetic overlap among inattention and different aspects of neurocognitive efficiency. En ligne : http://dx.doi.org/10.1017/s0954579419001573 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442

Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample / Scott TILLEM in Development and Psychopathology, 34-4 (October 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-4 (October 2022) . - p.1573-1584 Titre : Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample Type de document : texte imprimé Auteurs : Scott TILLEM, Auteur ; May I. CONLEY, Auteur ; Arielle BASKIN-SOMMERS, Auteur Article en page(s) : p.1573-1584 Langues : Anglais (eng) Mots-clés : Adolescent  Brain  Child  Cluster Analysis  Conduct Disorder/diagnostic imaging  Connectome  Humans  Magnetic Resonance Imaging/methods  conduct disorder  graph analysis  neural topology  neurocognitive functioning  subcortical structures Index. décimale : PER Périodiques Résumé : Conduct disorder (CD), characterized by youth antisocial behavior, is associated with a variety of neurocognitive impairments. However, questions remain regarding the neural underpinnings of these impairments. To investigate novel neural mechanisms that may support these neurocognitive abnormalities, the present study applied a graph analysis to resting-state functional magnetic resonance imaging (fMRI) data collected from a national sample of 4,781 youth, ages 9-10, who participated in the baseline session of the Adolescent Brain Cognitive Development(SM) Study (ABCD Study®). Analyses were then conducted to examine the relationships among levels of CD symptomatology, metrics of global topology, node-level metrics for subcortical structures, and performance on neurocognitive assessments. Youth higher on CD displayed higher global clustering (ÃŽ2= .039, 95% CI(corrected) [.0027 .0771]), but lower Degree(subcortical) (ÃŽ2= -.052, 95% CI(corrected) [-.0916 -.0152]). Youth higher on CD had worse performance on a general neurocognitive assessment (ÃŽ2= -.104, 95% CI [-.1328 -.0763]) and an emotion recognition memory assessment (ÃŽ2= -.061, 95% CI [-.0919 -.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect ÃŽ2= -.002, 95% CI [-.0044 -.0002]), and Degree(subcortical) mediated the relationship between CD and emotion recognition memory performance (indirect ÃŽ2= -.002, 95% CI [-.0046 -.0005]). CD appears associated with neuro-topological abnormalities and these abnormalities may represent neural mechanisms supporting CD-related neurocognitive disruptions. En ligne : http://dx.doi.org/10.1017/s0954579421000237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample [texte imprimé] / Scott TILLEM, Auteur ; May I. CONLEY, Auteur ; Arielle BASKIN-SOMMERS, Auteur . - p.1573-1584. Langues : Anglais (eng) in Development and Psychopathology > 34-4 (October 2022) . - p.1573-1584 Mots-clés : Adolescent  Brain  Child  Cluster Analysis  Conduct Disorder/diagnostic imaging  Connectome  Humans  Magnetic Resonance Imaging/methods  conduct disorder  graph analysis  neural topology  neurocognitive functioning  subcortical structures Index. décimale : PER Périodiques Résumé : Conduct disorder (CD), characterized by youth antisocial behavior, is associated with a variety of neurocognitive impairments. However, questions remain regarding the neural underpinnings of these impairments. To investigate novel neural mechanisms that may support these neurocognitive abnormalities, the present study applied a graph analysis to resting-state functional magnetic resonance imaging (fMRI) data collected from a national sample of 4,781 youth, ages 9-10, who participated in the baseline session of the Adolescent Brain Cognitive Development(SM) Study (ABCD Study®). Analyses were then conducted to examine the relationships among levels of CD symptomatology, metrics of global topology, node-level metrics for subcortical structures, and performance on neurocognitive assessments. Youth higher on CD displayed higher global clustering (ÃŽ2= .039, 95% CI(corrected) [.0027 .0771]), but lower Degree(subcortical) (ÃŽ2= -.052, 95% CI(corrected) [-.0916 -.0152]). Youth higher on CD had worse performance on a general neurocognitive assessment (ÃŽ2= -.104, 95% CI [-.1328 -.0763]) and an emotion recognition memory assessment (ÃŽ2= -.061, 95% CI [-.0919 -.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect ÃŽ2= -.002, 95% CI [-.0044 -.0002]), and Degree(subcortical) mediated the relationship between CD and emotion recognition memory performance (indirect ÃŽ2= -.002, 95% CI [-.0046 -.0005]). CD appears associated with neuro-topological abnormalities and these abnormalities may represent neural mechanisms supporting CD-related neurocognitive disruptions. En ligne : http://dx.doi.org/10.1017/s0954579421000237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489