Markers related to oxidative stress in peripheral blood in children with autism spectrum disorder / Xiaoping LIN in Research in Autism Spectrum Disorders, 99 (November)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 99 (November) . - 102067 Titre : Markers related to oxidative stress in peripheral blood in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Xiaoping LIN, Auteur ; Yingyu ZHOU, Auteur ; Shaowen LI, Auteur ; Haohan ZHOU, Auteur ; Binjie MA, Auteur ; Zheqing ZHANG, Auteur ; Jingjing LIANG, Auteur Article en page(s) : 102067 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Oxidative stress  Vitamin A  Vitamin E  Mitochondrial DNA copy number  Telomere length Index. décimale : PER Périodiques Résumé : Background Oxidative stress in the brain contributes to neuronal damage in genetically susceptible children, which might be involved in the pathophysiology of autism spectrum disorder(ASD). However, clinical data were inconsistent. The goal of this study was to investigate whether oxidative stress markers (vitamin A and vitamin E concentrations and leukocyte mitochondrial DNA copy number and telomere length) in peripheral blood are related to ASD in Chinese children aged 6-9 years. Method Sixty seven individuals with ASD and 134 sex- and age-matched neurotypical controls participated. The relative mitochondrial DNA copy number (mtDNAcn) and telomere length of leukocytes in peripheral blood were measured using quantitative real-time polymerase chain reaction. The vitamin A and vitamin E concentrations in plasma were determined using reversed-phase high-performance liquid chromatography. Results ASD group had a higher leukocyte mtDNAcn (1.36 Â+ 0.49 vs. 1.03 Â+ 0.24, p < 0.001) and vitamin E concentration (5.79 Â+ 1.70 ng/ml vs. 5.30 Â+ 0.96 ng/ml, p = 0.044) than the control group, but no significant differences in vitamin A concentration and leukocyte telomere length were detected between groups. Leukocyte mtDNAcn in the highest tertile increased the risk of ASD by 4.259 times (odds ratio:4.259, 95% confidence interval: 1.427-12.707, p = 0.009) compared with the lowest tertile after adjustment for confounders, and a significant dose-response relationship between mtDNAcn and ASD risk was observed (p-trend = 0.032). Conclusions Children with ASD had higher levels of leukocyte mtDNAcn. En ligne : https://doi.org/10.1016/j.rasd.2022.102067 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Markers related to oxidative stress in peripheral blood in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Xiaoping LIN, Auteur ; Yingyu ZHOU, Auteur ; Shaowen LI, Auteur ; Haohan ZHOU, Auteur ; Binjie MA, Auteur ; Zheqing ZHANG, Auteur ; Jingjing LIANG, Auteur . - 102067. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 99 (November) . - 102067 Mots-clés : Autism spectrum disorders  Oxidative stress  Vitamin A  Vitamin E  Mitochondrial DNA copy number  Telomere length Index. décimale : PER Périodiques Résumé : Background Oxidative stress in the brain contributes to neuronal damage in genetically susceptible children, which might be involved in the pathophysiology of autism spectrum disorder(ASD). However, clinical data were inconsistent. The goal of this study was to investigate whether oxidative stress markers (vitamin A and vitamin E concentrations and leukocyte mitochondrial DNA copy number and telomere length) in peripheral blood are related to ASD in Chinese children aged 6-9 years. Method Sixty seven individuals with ASD and 134 sex- and age-matched neurotypical controls participated. The relative mitochondrial DNA copy number (mtDNAcn) and telomere length of leukocytes in peripheral blood were measured using quantitative real-time polymerase chain reaction. The vitamin A and vitamin E concentrations in plasma were determined using reversed-phase high-performance liquid chromatography. Results ASD group had a higher leukocyte mtDNAcn (1.36 Â+ 0.49 vs. 1.03 Â+ 0.24, p < 0.001) and vitamin E concentration (5.79 Â+ 1.70 ng/ml vs. 5.30 Â+ 0.96 ng/ml, p = 0.044) than the control group, but no significant differences in vitamin A concentration and leukocyte telomere length were detected between groups. Leukocyte mtDNAcn in the highest tertile increased the risk of ASD by 4.259 times (odds ratio:4.259, 95% confidence interval: 1.427-12.707, p = 0.009) compared with the lowest tertile after adjustment for confounders, and a significant dose-response relationship between mtDNAcn and ASD risk was observed (p-trend = 0.032). Conclusions Children with ASD had higher levels of leukocyte mtDNAcn. En ligne : https://doi.org/10.1016/j.rasd.2022.102067 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

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