Atypical gaze patterns in autistic adults are heterogeneous across but reliable within individuals / Umit KELES in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 39 p. Titre : Atypical gaze patterns in autistic adults are heterogeneous across but reliable within individuals Type de document : texte imprimé Auteurs : Umit KELES, Auteur ; Dorit KLIEMANN, Auteur ; Lisa BYRGE, Auteur ; Heini SAARIMAKI, Auteur ; Lynn K. PAUL, Auteur ; Daniel P. KENNEDY, Auteur ; Ralph ADOLPHS, Auteur Article en page(s) : 39 p. Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Fixation, Ocular  Humans  Autism  Eye tracking  Heterogeneity  Individual differences  Videos Index. décimale : PER Périodiques Résumé : BACKGROUND: Across behavioral studies, autistic individuals show greater variability than typically developing individuals. However, it remains unknown to what extent this variability arises from heterogeneity across individuals, or from unreliability within individuals. Here, we focus on eye tracking, which provides rich dependent measures that have been used extensively in studies of autism. Autistic individuals have an atypical gaze onto both static visual images and dynamic videos that could be leveraged for diagnostic purposes if the above open question could be addressed. METHODS: We tested three competing hypotheses: (1) that gaze patterns of autistic individuals are less reliable or noisier than those of controls, (2) that atypical gaze patterns are individually reliable but heterogeneous across autistic individuals, or (3) that atypical gaze patterns are individually reliable and also homogeneous among autistic individuals. We collected desktop-based eye tracking data from two different full-length television sitcom episodes, at two independent sites (Caltech and Indiana University), in a total of over 150 adult participants (N=48 autistic individuals with IQ in the normal range, 105 controls) and quantified gaze onto features of the videos using automated computer vision-based feature extraction. RESULTS: We found support for the second of these hypotheses. Autistic people and controls showed equivalently reliable gaze onto specific features of videos, such as faces, so much so that individuals could be identified significantly above chance using a fingerprinting approach from video epochs as short as 2 min. However, classification of participants into diagnostic groups based on their eye tracking data failed to produce clear group classifications, due to heterogeneity in the autistic group. LIMITATIONS: Three limitations are the relatively small sample size, assessment across only two videos (from the same television series), and the absence of other dependent measures (e.g., neuroimaging or genetics) that might have revealed individual-level variability that was not evident with eye tracking. Future studies should expand to larger samples across longer longitudinal epochs, an aim that is now becoming feasible with Internet- and phone-based eye tracking. CONCLUSIONS: These findings pave the way for the investigation of autism subtypes, and for elucidating the specific visual features that best discriminate gaze patterns-directions that will also combine with and inform neuroimaging and genetic studies of this complex disorder. En ligne : http://dx.doi.org/10.1186/s13229-022-00517-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Atypical gaze patterns in autistic adults are heterogeneous across but reliable within individuals [texte imprimé] / Umit KELES, Auteur ; Dorit KLIEMANN, Auteur ; Lisa BYRGE, Auteur ; Heini SAARIMAKI, Auteur ; Lynn K. PAUL, Auteur ; Daniel P. KENNEDY, Auteur ; Ralph ADOLPHS, Auteur . - 39 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 39 p. Mots-clés : Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Fixation, Ocular  Humans  Autism  Eye tracking  Heterogeneity  Individual differences  Videos Index. décimale : PER Périodiques Résumé : BACKGROUND: Across behavioral studies, autistic individuals show greater variability than typically developing individuals. However, it remains unknown to what extent this variability arises from heterogeneity across individuals, or from unreliability within individuals. Here, we focus on eye tracking, which provides rich dependent measures that have been used extensively in studies of autism. Autistic individuals have an atypical gaze onto both static visual images and dynamic videos that could be leveraged for diagnostic purposes if the above open question could be addressed. METHODS: We tested three competing hypotheses: (1) that gaze patterns of autistic individuals are less reliable or noisier than those of controls, (2) that atypical gaze patterns are individually reliable but heterogeneous across autistic individuals, or (3) that atypical gaze patterns are individually reliable and also homogeneous among autistic individuals. We collected desktop-based eye tracking data from two different full-length television sitcom episodes, at two independent sites (Caltech and Indiana University), in a total of over 150 adult participants (N=48 autistic individuals with IQ in the normal range, 105 controls) and quantified gaze onto features of the videos using automated computer vision-based feature extraction. RESULTS: We found support for the second of these hypotheses. Autistic people and controls showed equivalently reliable gaze onto specific features of videos, such as faces, so much so that individuals could be identified significantly above chance using a fingerprinting approach from video epochs as short as 2 min. However, classification of participants into diagnostic groups based on their eye tracking data failed to produce clear group classifications, due to heterogeneity in the autistic group. LIMITATIONS: Three limitations are the relatively small sample size, assessment across only two videos (from the same television series), and the absence of other dependent measures (e.g., neuroimaging or genetics) that might have revealed individual-level variability that was not evident with eye tracking. Future studies should expand to larger samples across longer longitudinal epochs, an aim that is now becoming feasible with Internet- and phone-based eye tracking. CONCLUSIONS: These findings pave the way for the investigation of autism subtypes, and for elucidating the specific visual features that best discriminate gaze patterns-directions that will also combine with and inform neuroimaging and genetic studies of this complex disorder. En ligne : http://dx.doi.org/10.1186/s13229-022-00517-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement / Lynn K. PAUL in Journal of Neurodevelopmental Disorders, 3-1 (March 2011)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 3-1 (March 2011) . - p.3-27 Titre : Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement Type de document : texte imprimé Auteurs : Lynn K. PAUL, Auteur Article en page(s) : p.3-27 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This review provides an overview of the involvement of the corpus callosum (CC) in a variety of developmental disorders that are currently defined exclusively by genetics, developmental insult, and/or behavior. I begin with a general review of CC development, connectivity, and function, followed by discussion of the research methods typically utilized to study the callosum. The bulk of the review concentrates on specific developmental disorders, beginning with agenesis of the corpus callosum (AgCC)-the only condition diagnosed exclusively by callosal anatomy. This is followed by a review of several genetic disorders that commonly result in social impairments and/or psychopathology similar to AgCC (neurofibromatosis-1, Turner syndrome, 22q11.2 deletion syndrome, Williams yndrome, and fragile X) and two forms of prenatal injury (premature birth, fetal alcohol syndrome) known to impact callosal development. Finally, I examine callosal involvement in several common developmental disorders defined exclusively by behavioral patterns (developmental language delay, dyslexia, attention-deficit hyperactive disorder, autism spectrum disorders, and Tourette syndrome). En ligne : http://dx.doi.org/10.1007/s11689-010-9059-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342 [article] Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement [texte imprimé] / Lynn K. PAUL, Auteur . - p.3-27. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 3-1 (March 2011) . - p.3-27 Index. décimale : PER Périodiques Résumé : This review provides an overview of the involvement of the corpus callosum (CC) in a variety of developmental disorders that are currently defined exclusively by genetics, developmental insult, and/or behavior. I begin with a general review of CC development, connectivity, and function, followed by discussion of the research methods typically utilized to study the callosum. The bulk of the review concentrates on specific developmental disorders, beginning with agenesis of the corpus callosum (AgCC)-the only condition diagnosed exclusively by callosal anatomy. This is followed by a review of several genetic disorders that commonly result in social impairments and/or psychopathology similar to AgCC (neurofibromatosis-1, Turner syndrome, 22q11.2 deletion syndrome, Williams yndrome, and fragile X) and two forms of prenatal injury (premature birth, fetal alcohol syndrome) known to impact callosal development. Finally, I examine callosal involvement in several common developmental disorders defined exclusively by behavioral patterns (developmental language delay, dyslexia, attention-deficit hyperactive disorder, autism spectrum disorders, and Tourette syndrome). En ligne : http://dx.doi.org/10.1007/s11689-010-9059-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342

Does bilateral damage to the human amygdala produce autistic symptoms? / Lynn K. PAUL in Journal of Neurodevelopmental Disorders, 2-3 (September 2010)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 2-3 (September 2010) . - p.165-173 Titre : Does bilateral damage to the human amygdala produce autistic symptoms? Type de document : texte imprimé Auteurs : Lynn K. PAUL, Auteur ; Christina M. CORSELLO, Auteur ; Daniel TRANEL, Auteur ; Ralph ADOLPHS, Auteur Article en page(s) : p.165-173 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A leading neurological hypothesis for autism postulates amygdala dysfunction. This hypothesis has considerable support from anatomical and neuroimaging studies. Individuals with bilateral amygdala lesions show impairments in some aspects of social cognition. These impairments bear intriguing similarity to those reported in people with autism, such as impaired recognition of emotion in faces, impaired theory of mind abilities, failure to fixate eyes in faces, and difficulties in regulating personal space distance to others. Yet such neurological cases have never before been assessed directly to see if they meet criteria for autism spectrum disorders (ASD). Here we undertook such an investigation in two rare participants with developmental-onset bilateral amygdala lesions. We administered a comprehensive clinical examination, as well as the Autism Diagnostic Observation Schedule (ADOS), the Social Responsiveness Scale (SRS), together with several other standardized questionnaires. Results from the two individuals with amygdala lesions were compared with published norms from both healthy populations as well as from people with ASD. Neither participant with amygdala lesions showed any evidence of autism across the array of different measures. The findings demonstrate that amygdala lesions in isolation are not sufficient for producing autistic symptoms. We suggest instead that it may be abnormal connectivity between the amygdala and other structures that contributes to autistic symptoms at a network level. En ligne : http://dx.doi.org/10.1007/s11689-010-9056-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342 [article] Does bilateral damage to the human amygdala produce autistic symptoms? [texte imprimé] / Lynn K. PAUL, Auteur ; Christina M. CORSELLO, Auteur ; Daniel TRANEL, Auteur ; Ralph ADOLPHS, Auteur . - p.165-173. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 2-3 (September 2010) . - p.165-173 Index. décimale : PER Périodiques Résumé : A leading neurological hypothesis for autism postulates amygdala dysfunction. This hypothesis has considerable support from anatomical and neuroimaging studies. Individuals with bilateral amygdala lesions show impairments in some aspects of social cognition. These impairments bear intriguing similarity to those reported in people with autism, such as impaired recognition of emotion in faces, impaired theory of mind abilities, failure to fixate eyes in faces, and difficulties in regulating personal space distance to others. Yet such neurological cases have never before been assessed directly to see if they meet criteria for autism spectrum disorders (ASD). Here we undertook such an investigation in two rare participants with developmental-onset bilateral amygdala lesions. We administered a comprehensive clinical examination, as well as the Autism Diagnostic Observation Schedule (ADOS), the Social Responsiveness Scale (SRS), together with several other standardized questionnaires. Results from the two individuals with amygdala lesions were compared with published norms from both healthy populations as well as from people with ASD. Neither participant with amygdala lesions showed any evidence of autism across the array of different measures. The findings demonstrate that amygdala lesions in isolation are not sufficient for producing autistic symptoms. We suggest instead that it may be abnormal connectivity between the amygdala and other structures that contributes to autistic symptoms at a network level. En ligne : http://dx.doi.org/10.1007/s11689-010-9056-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342

Facial emotion recognition in agenesis of the corpus callosum / Matthew W. BRIDGMAN in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.32 Titre : Facial emotion recognition in agenesis of the corpus callosum Type de document : texte imprimé Auteurs : Matthew W. BRIDGMAN, Auteur ; Warren S. BROWN, Auteur ; Michael L. SPEZIO, Auteur ; Matthew K. LEONARD, Auteur ; Ralph ADOLPHS, Auteur ; Lynn K. PAUL, Auteur Article en page(s) : p.32 Langues : Anglais (eng) Mots-clés : Corpus callosum  Corpus callosum agenesis  Facial emotion Index. décimale : PER Périodiques Résumé : BACKGROUND: Impaired social functioning is a common symptom of individuals with developmental disruptions in callosal connectivity. Among these developmental conditions, agenesis of the corpus callosum provides the most extreme and clearly identifiable example of callosal disconnection. To date, deficits in nonliteral language comprehension, humor, theory of mind, and social reasoning have been documented in agenesis of the corpus callosum. Here, we examined a basic social ability as yet not investigated in this population: recognition of facial emotion and its association with social gaze. METHODS: Nine individuals with callosal agenesis and nine matched controls completed four tasks involving emotional faces: emotion recognition from upright and inverted faces, gender recognition, and passive viewing. Eye-tracking data were collected concurrently on all four tasks and analyzed according to designated facial regions of interest. RESULTS: Individuals with callosal agenesis exhibited impairments in recognizing emotions from upright faces, in particular lower accuracy for fear and anger, and these impairments were directly associated with diminished attention to the eye region. The callosal agenesis group exhibited greater consistency in emotion recognition across conditions (upright vs. inverted), with poorest performance for fear identification in both conditions. The callosal agenesis group also had atypical facial scanning (lower fractional dwell time in the eye region) during gender naming and passive viewing of faces, but they did not differ from controls on gender naming performance. The pattern of results did not differ when taking into account full-scale intelligence quotient or presence of autism spectrum symptoms. CONCLUSIONS: Agenesis of the corpus callosum results in a pattern of atypical facial scanning characterized by diminished attention to the eyes. This pattern suggests that reduced callosal connectivity may contribute to the development and maintenance of emotion processing deficits involving reduced attention to others' eyes. En ligne : http://dx.doi.org/10.1186/1866-1955-6-32 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346 [article] Facial emotion recognition in agenesis of the corpus callosum [texte imprimé] / Matthew W. BRIDGMAN, Auteur ; Warren S. BROWN, Auteur ; Michael L. SPEZIO, Auteur ; Matthew K. LEONARD, Auteur ; Ralph ADOLPHS, Auteur ; Lynn K. PAUL, Auteur . - p.32. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.32 Mots-clés : Corpus callosum  Corpus callosum agenesis  Facial emotion Index. décimale : PER Périodiques Résumé : BACKGROUND: Impaired social functioning is a common symptom of individuals with developmental disruptions in callosal connectivity. Among these developmental conditions, agenesis of the corpus callosum provides the most extreme and clearly identifiable example of callosal disconnection. To date, deficits in nonliteral language comprehension, humor, theory of mind, and social reasoning have been documented in agenesis of the corpus callosum. Here, we examined a basic social ability as yet not investigated in this population: recognition of facial emotion and its association with social gaze. METHODS: Nine individuals with callosal agenesis and nine matched controls completed four tasks involving emotional faces: emotion recognition from upright and inverted faces, gender recognition, and passive viewing. Eye-tracking data were collected concurrently on all four tasks and analyzed according to designated facial regions of interest. RESULTS: Individuals with callosal agenesis exhibited impairments in recognizing emotions from upright faces, in particular lower accuracy for fear and anger, and these impairments were directly associated with diminished attention to the eye region. The callosal agenesis group exhibited greater consistency in emotion recognition across conditions (upright vs. inverted), with poorest performance for fear identification in both conditions. The callosal agenesis group also had atypical facial scanning (lower fractional dwell time in the eye region) during gender naming and passive viewing of faces, but they did not differ from controls on gender naming performance. The pattern of results did not differ when taking into account full-scale intelligence quotient or presence of autism spectrum symptoms. CONCLUSIONS: Agenesis of the corpus callosum results in a pattern of atypical facial scanning characterized by diminished attention to the eyes. This pattern suggests that reduced callosal connectivity may contribute to the development and maintenance of emotion processing deficits involving reduced attention to others' eyes. En ligne : http://dx.doi.org/10.1186/1866-1955-6-32 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346

Smartphone-based gaze estimation for in-home autism research / Junfeng HE ; Qianying WU ; Na DAI ; Kai KOHLHOFF ; Jasmin M. TURNER ; Lynn K. PAUL ; Daniel P. KENNEDY ; Ralph ADOLPHS ; Vidhya NAVALPAKKAM in Autism Research, 17-6 (June 2024)  

Public ISBD [article]  inAutism Research > 17-6 (June 2024) . - p.1140-1148 Titre : Smartphone-based gaze estimation for in-home autism research Type de document : texte imprimé Auteurs : Junfeng HE, Auteur ; Qianying WU, Auteur ; Na DAI, Auteur ; Kai KOHLHOFF, Auteur ; Jasmin M. TURNER, Auteur ; Lynn K. PAUL, Auteur ; Daniel P. KENNEDY, Auteur ; Ralph ADOLPHS, Auteur ; Vidhya NAVALPAKKAM, Auteur Article en page(s) : p.1140-1148 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Atypical gaze patterns are a promising biomarker of autism spectrum disorder. To measure gaze accurately, however, it typically requires highly controlled studies in the laboratory using specialized equipment that is often expensive, thereby limiting the scalability of these approaches. Here we test whether a recently developed smartphone-based gaze estimation method could overcome such limitations and take advantage of the ubiquity of smartphones. As a proof-of-principle, we measured gaze while a small sample of well-assessed autistic participants and controls watched videos on a smartphone, both in the laboratory (with lab personnel) and in remote home settings (alone). We demonstrate that gaze data can be efficiently collected, in-home and longitudinally by participants themselves, with sufficiently high accuracy (gaze estimation error below 1° visual angle on average) for quantitative, feature-based analysis. Using this approach, we show that autistic individuals have reduced gaze time on human faces and longer gaze time on non-social features in the background, thereby reproducing established findings in autism using just smartphones and no additional hardware. Our approach provides a foundation for scaling future research with larger and more representative participant groups at vastly reduced cost, also enabling better inclusion of underserved communities. En ligne : https://doi.org/10.1002/aur.3140 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=531 [article] Smartphone-based gaze estimation for in-home autism research [texte imprimé] / Junfeng HE, Auteur ; Qianying WU, Auteur ; Na DAI, Auteur ; Kai KOHLHOFF, Auteur ; Jasmin M. TURNER, Auteur ; Lynn K. PAUL, Auteur ; Daniel P. KENNEDY, Auteur ; Ralph ADOLPHS, Auteur ; Vidhya NAVALPAKKAM, Auteur . - p.1140-1148. Langues : Anglais (eng) in Autism Research > 17-6 (June 2024) . - p.1140-1148 Index. décimale : PER Périodiques Résumé : Abstract Atypical gaze patterns are a promising biomarker of autism spectrum disorder. To measure gaze accurately, however, it typically requires highly controlled studies in the laboratory using specialized equipment that is often expensive, thereby limiting the scalability of these approaches. Here we test whether a recently developed smartphone-based gaze estimation method could overcome such limitations and take advantage of the ubiquity of smartphones. As a proof-of-principle, we measured gaze while a small sample of well-assessed autistic participants and controls watched videos on a smartphone, both in the laboratory (with lab personnel) and in remote home settings (alone). We demonstrate that gaze data can be efficiently collected, in-home and longitudinally by participants themselves, with sufficiently high accuracy (gaze estimation error below 1° visual angle on average) for quantitative, feature-based analysis. Using this approach, we show that autistic individuals have reduced gaze time on human faces and longer gaze time on non-social features in the background, thereby reproducing established findings in autism using just smartphones and no additional hardware. Our approach provides a foundation for scaling future research with larger and more representative participant groups at vastly reduced cost, also enabling better inclusion of underserved communities. En ligne : https://doi.org/10.1002/aur.3140 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=531

Social Inferences in Agenesis of the Corpus Callosum and Autism: Semantic Analysis and Topic Modeling / Tiffany RENTERIA-VAZQUEZ in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

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