Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression / Meghan E. Carey in Journal of Autism and Developmental Disorders, 53-8 (August 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2975-2985 Titre : Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression Type de document : texte imprimé Auteurs : Meghan E. Carey, Auteur ; Juliette RANDO, Auteur ; Stepan MELNYK, Auteur ; S. Jill JAMES, Auteur ; Nathaniel SNYDER, Auteur ; Carolyn SALAFIA, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Heather VOLK, Auteur ; Craig NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.2975-2985 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling?s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile ?: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. En ligne : https://doi.org/10.1007/s10803-022-05625-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression [texte imprimé] / Meghan E. Carey, Auteur ; Juliette RANDO, Auteur ; Stepan MELNYK, Auteur ; S. Jill JAMES, Auteur ; Nathaniel SNYDER, Auteur ; Carolyn SALAFIA, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Heather VOLK, Auteur ; Craig NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur . - p.2975-2985. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2975-2985 Index. décimale : PER Périodiques Résumé : We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling?s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile ?: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. En ligne : https://doi.org/10.1007/s10803-022-05625-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

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