Characterizing self-reported physical activity before and during a subsequent pregnancy among parents in a familial autism cohort / Megan G BRAGG in Autism, 29-1 (January 2025)  

Public ISBD [article]  inAutism > 29-1 (January 2025) . - p.143-154 Titre : Characterizing self-reported physical activity before and during a subsequent pregnancy among parents in a familial autism cohort Type de document : Texte imprimé et/ou numérique Auteurs : Megan G BRAGG, Auteur ; Olivia VESEY, Auteur ; Jorge E CHAVARRO, Auteur ; Jaime E HART, Auteur ; Loni Philip TABB, Auteur ; Marc G WEISSKOPF, Auteur ; Lisa A CROEN, Auteur ; Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig NEWSCHAFFER, Auteur ; Rebecca J SCHMIDT, Auteur ; Heather VOLK, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.143-154 Langues : Anglais (eng) Mots-clés : family functioning and support  quality of life  risk factor epidemiology Index. décimale : PER Périodiques Résumé : Parents of autistic children report barriers to engaging in physical activity, which may be exacerbated during subsequent pregnancies. We aimed to describe physical activity of parents caring for an autistic child, before and during a subsequent pregnancy, and to explore whether physical activity was associated with the autistic child?s Social Responsiveness Scale score, a measure of autism-related traits. We used data from the Early Autism Risk Longitudinal Investigation, in which families with an autistic child were followed through a subsequent pregnancy. Mothers (n = 245) self-reported physical activity in the 3?months before conception and during pregnancy; fathers (n = 130) reported on the 6?months prior to enrollment. Approximately 40% of nonpregnant mothers and fathers and 9.3% of pregnant mothers met Physical Activity Guidelines for Americans recommendations. Most (83.5%) pregnant mothers reported no vigorous activity; after adjustment for covariates, this was more common among mothers of children with Social Responsiveness Scale T-scores >75 compared with mothers of children with lower T-scores (adjusted odds ratio (95% confidence interval) = 2.94 (1.11, 7.78)). Among parents caring for an autistic child before and during a subsequent pregnancy, physical activity was lower than recommended. Family-based interventions may be necessary to help support physical activity levels.Lay AbstractParents of autistic children may have limited time and resources to participate in physical activity, a key aspect of health. Previous studies have been small and included mostly mothers, rather than fathers. No studies have examined physical activity in these parents during another pregnancy, when physical activity is especially important for maternal and fetal health. We aimed to fill this gap by examining physical activity levels among mothers and fathers caring for an autistic child before and during a subsequent pregnancy. We used data from a study which followed pregnant individuals who already had a child with autism. We asked mothers and fathers to report their levels of moderate and vigorous physical activity. We found that mothers and fathers of autistic children reported lower physical activity levels than the national average and were unlikely to meet Physical Activity Guidelines for Americans. Pregnant mothers were the least likely to participate in physical activity, particularly if their autistic child scored highly on a measure of autistic traits. Given that parental physical activity has benefits for parents and children, family-based interventions may be needed to help support parents' physical activity levels. En ligne : https://dx.doi.org/10.1177/13623613241273034 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544 [article] Characterizing self-reported physical activity before and during a subsequent pregnancy among parents in a familial autism cohort [Texte imprimé et/ou numérique] / Megan G BRAGG, Auteur ; Olivia VESEY, Auteur ; Jorge E CHAVARRO, Auteur ; Jaime E HART, Auteur ; Loni Philip TABB, Auteur ; Marc G WEISSKOPF, Auteur ; Lisa A CROEN, Auteur ; Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Craig NEWSCHAFFER, Auteur ; Rebecca J SCHMIDT, Auteur ; Heather VOLK, Auteur ; Kristen LYALL, Auteur . - p.143-154. Langues : Anglais (eng) in Autism > 29-1 (January 2025) . - p.143-154 Mots-clés : family functioning and support  quality of life  risk factor epidemiology Index. décimale : PER Périodiques Résumé : Parents of autistic children report barriers to engaging in physical activity, which may be exacerbated during subsequent pregnancies. We aimed to describe physical activity of parents caring for an autistic child, before and during a subsequent pregnancy, and to explore whether physical activity was associated with the autistic child?s Social Responsiveness Scale score, a measure of autism-related traits. We used data from the Early Autism Risk Longitudinal Investigation, in which families with an autistic child were followed through a subsequent pregnancy. Mothers (n = 245) self-reported physical activity in the 3?months before conception and during pregnancy; fathers (n = 130) reported on the 6?months prior to enrollment. Approximately 40% of nonpregnant mothers and fathers and 9.3% of pregnant mothers met Physical Activity Guidelines for Americans recommendations. Most (83.5%) pregnant mothers reported no vigorous activity; after adjustment for covariates, this was more common among mothers of children with Social Responsiveness Scale T-scores >75 compared with mothers of children with lower T-scores (adjusted odds ratio (95% confidence interval) = 2.94 (1.11, 7.78)). Among parents caring for an autistic child before and during a subsequent pregnancy, physical activity was lower than recommended. Family-based interventions may be necessary to help support physical activity levels.Lay AbstractParents of autistic children may have limited time and resources to participate in physical activity, a key aspect of health. Previous studies have been small and included mostly mothers, rather than fathers. No studies have examined physical activity in these parents during another pregnancy, when physical activity is especially important for maternal and fetal health. We aimed to fill this gap by examining physical activity levels among mothers and fathers caring for an autistic child before and during a subsequent pregnancy. We used data from a study which followed pregnant individuals who already had a child with autism. We asked mothers and fathers to report their levels of moderate and vigorous physical activity. We found that mothers and fathers of autistic children reported lower physical activity levels than the national average and were unlikely to meet Physical Activity Guidelines for Americans. Pregnant mothers were the least likely to participate in physical activity, particularly if their autistic child scored highly on a measure of autistic traits. Given that parental physical activity has benefits for parents and children, family-based interventions may be needed to help support parents' physical activity levels. En ligne : https://dx.doi.org/10.1177/13623613241273034 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544

Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression / Meghan E. Carey in Journal of Autism and Developmental Disorders, 53-8 (August 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2975-2985 Titre : Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression Type de document : Texte imprimé et/ou numérique Auteurs : Meghan E. Carey, Auteur ; Juliette RANDO, Auteur ; Stepan MELNYK, Auteur ; S. Jill JAMES, Auteur ; Nathaniel SNYDER, Auteur ; Carolyn SALAFIA, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Heather VOLK, Auteur ; Craig NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur Article en page(s) : p.2975-2985 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling?s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile ?: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. En ligne : https://doi.org/10.1007/s10803-022-05625-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression [Texte imprimé et/ou numérique] / Meghan E. Carey, Auteur ; Juliette RANDO, Auteur ; Stepan MELNYK, Auteur ; S. Jill JAMES, Auteur ; Nathaniel SNYDER, Auteur ; Carolyn SALAFIA, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Heather VOLK, Auteur ; Craig NEWSCHAFFER, Auteur ; Kristen LYALL, Auteur . - p.2975-2985. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.2975-2985 Index. décimale : PER Périodiques Résumé : We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling?s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile ?: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. En ligne : https://doi.org/10.1007/s10803-022-05625-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Maternal Mediterranean-Style Diet During Pregnancy and Child Social Impairment as Measured by the Social Responsiveness Scale / Xiaoyu CHE in Autism Research, 18-8 (August 2025)  

Public ISBD [article]  inAutism Research > 18-8 (August 2025) . - p.1693-1703 Titre : Maternal Mediterranean-Style Diet During Pregnancy and Child Social Impairment as Measured by the Social Responsiveness Scale Type de document : Texte imprimé et/ou numérique Auteurs : Xiaoyu CHE, Auteur ; Xueqi QU, Auteur ; Ramkripa RAGHAVEN, Auteur ; Colleen PEARSON, Auteur ; William ADAMS, Auteur ; Heather VOLK, Auteur ; Marilyn AUGUSTYN, Auteur ; Xiaobin WANG, Auteur Article en page(s) : p.1693-1703 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  children  dietary pattern  mediterranean-style diet  nutrition  pregnancy  social responsiveness scale Index. décimale : PER Périodiques Résumé : ABSTRACT While previous studies have examined the role of individual micronutrients in autism spectrum disorder (ASD), limited evidence exists on how maternal dietary patterns during pregnancy relate to broader social and communication outcomes. This study aimed to assess the association between adherence to a Mediterranean-style diet during pregnancy and measures of social impairment in a racially diverse, prospective birth cohort. We analyzed 821 mother?child pairs from the Boston Birth Cohort, including 52 children with an ASD diagnosis. Maternal Mediterranean-style Diet Scores (MSDS) during pregnancy were calculated using food frequency questionnaires administered 24?72?h after delivery. Child social impairment was assessed using Social Responsiveness Scale (SRS). Restricted cubic spline models were used to explore potential non-linear relationships between MSDS and SRS total scores. Linear regression models were used to quantify associations between MSDS tertiles and children's SRS total scores and scores across five SRS subdomains. An L-shape association was observed between maternal MSDS and SRS total scores. Compared to the children of mothers in the lowest MSDS tertiles, those in the middle (beta (95% CI)?=??4.95 (?9.59, ?0.31)) and highest tertiles (?5.13 (?9.48, ?0.79)) had significantly lower SRS total scores, indicating reduced social impairment. Associations were particularly pronounced in the social cognition and social communication subdomains. Greater maternal adherence to a Mediterranean-style diet during pregnancy was associated with better social interaction and communication development in children. These findings underscore the critical role of maternal nutrition in child neurodevelopment, highlighting potential targets for early risk assessment and prevention efforts. En ligne : https://doi.org/10.1002/aur.70077 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566 [article] Maternal Mediterranean-Style Diet During Pregnancy and Child Social Impairment as Measured by the Social Responsiveness Scale [Texte imprimé et/ou numérique] / Xiaoyu CHE, Auteur ; Xueqi QU, Auteur ; Ramkripa RAGHAVEN, Auteur ; Colleen PEARSON, Auteur ; William ADAMS, Auteur ; Heather VOLK, Auteur ; Marilyn AUGUSTYN, Auteur ; Xiaobin WANG, Auteur . - p.1693-1703. Langues : Anglais (eng) in Autism Research > 18-8 (August 2025) . - p.1693-1703 Mots-clés : autism spectrum disorder  children  dietary pattern  mediterranean-style diet  nutrition  pregnancy  social responsiveness scale Index. décimale : PER Périodiques Résumé : ABSTRACT While previous studies have examined the role of individual micronutrients in autism spectrum disorder (ASD), limited evidence exists on how maternal dietary patterns during pregnancy relate to broader social and communication outcomes. This study aimed to assess the association between adherence to a Mediterranean-style diet during pregnancy and measures of social impairment in a racially diverse, prospective birth cohort. We analyzed 821 mother?child pairs from the Boston Birth Cohort, including 52 children with an ASD diagnosis. Maternal Mediterranean-style Diet Scores (MSDS) during pregnancy were calculated using food frequency questionnaires administered 24?72?h after delivery. Child social impairment was assessed using Social Responsiveness Scale (SRS). Restricted cubic spline models were used to explore potential non-linear relationships between MSDS and SRS total scores. Linear regression models were used to quantify associations between MSDS tertiles and children's SRS total scores and scores across five SRS subdomains. An L-shape association was observed between maternal MSDS and SRS total scores. Compared to the children of mothers in the lowest MSDS tertiles, those in the middle (beta (95% CI)?=??4.95 (?9.59, ?0.31)) and highest tertiles (?5.13 (?9.48, ?0.79)) had significantly lower SRS total scores, indicating reduced social impairment. Associations were particularly pronounced in the social cognition and social communication subdomains. Greater maternal adherence to a Mediterranean-style diet during pregnancy was associated with better social interaction and communication development in children. These findings underscore the critical role of maternal nutrition in child neurodevelopment, highlighting potential targets for early risk assessment and prevention efforts. En ligne : https://doi.org/10.1002/aur.70077 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566

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