Prenatal depression and risk of child autism-related traits among participants in the Environmental influences on Child Health Outcomes program / Lyndsay A. AVALOS in Autism Research, 16-9 (September 2023)  

Public ISBD [article]  inAutism Research > 16-9 (September 2023) . - p.1825-1835 Titre : Prenatal depression and risk of child autism-related traits among participants in the Environmental influences on Child Health Outcomes program Type de document : texte imprimé Auteurs : Lyndsay A. AVALOS, Auteur ; Aruna CHANDRAN, Auteur ; Marie L. CHURCHILL, Auteur ; Xingyu GAO, Auteur ; Jennifer L. AMES, Auteur ; Sara S. NOZADI, Auteur ; Danielle S. ROUBINOV, Auteur ; Patricia A. BRENNAN, Auteur ; Nicole R. BUSH, Auteur ; Carlos A. CAMARGO, Auteur ; Kecia N. CARROLL, Auteur ; Camille C. CIOFFI, Auteur ; Assiamira FERRARA, Auteur ; Brandon GOLDSON, Auteur ; Monique M. HEDDERSON, Auteur ; Alison E. HIPWELL, Auteur ; Jean M. KERVER, Auteur ; Thomas G. O'CONNOR, Auteur ; Christina A. PORUCZNIK, Auteur ; Lauren C. SHUFFREY, Auteur ; Maria M. TALAVERA-BARBER, Auteur ; Rosalind J. WRIGHT, Auteur ; Yeyi ZHU, Auteur ; Lisa A. CROEN, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur Article en page(s) : p.1825-1835 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract This study evaluated the association between prenatal depression and offspring autism-related traits. The sample comprised 33 prenatal/pediatric cohorts participating in the Environmental influences on Child Health Outcomes program who contributed information on prenatal depression and autism-related traits. Autism-related traits were assessed continuously and at the diagnostic cut-off using the Social Responsiveness Scale for children up to 12 years of age. Main analyses included 3994 parent-child pairs with prenatal depression diagnoses data; secondary analyses included 1730 parent-child pairs with depression severity data. After confounder adjustment, we observed an increase in autism-related traits among children of individuals with prenatal depression compared to those without (adjusted ?=1.31 95% CI: 0.65, 1.98). Analyses stratified by child sex documented a similar significant association among boys (a?=1.34 95%CI: 0.36, 2.32) and girls (a?=1.26 95% CI: 0.37, 2.15). Prenatal depression was also associated with increased odds of moderate to severe autism-related traits (adjusted odds ratio: 1.64, 95%CI: 1.09, 2.46), the screening threshold considered high risk of autism spectrum disorder (ASD) diagnosis. Findings highlight the importance of prenatal depression screening and preventive interventions for children of pregnant individuals with depression to support healthy development. Future research is needed to clarify whether these findings reflect overlap in genetic risk for depression and ASD-related traits or another mechanism. En ligne : https://doi.org/10.1002/aur.2988 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] Prenatal depression and risk of child autism-related traits among participants in the Environmental influences on Child Health Outcomes program [texte imprimé] / Lyndsay A. AVALOS, Auteur ; Aruna CHANDRAN, Auteur ; Marie L. CHURCHILL, Auteur ; Xingyu GAO, Auteur ; Jennifer L. AMES, Auteur ; Sara S. NOZADI, Auteur ; Danielle S. ROUBINOV, Auteur ; Patricia A. BRENNAN, Auteur ; Nicole R. BUSH, Auteur ; Carlos A. CAMARGO, Auteur ; Kecia N. CARROLL, Auteur ; Camille C. CIOFFI, Auteur ; Assiamira FERRARA, Auteur ; Brandon GOLDSON, Auteur ; Monique M. HEDDERSON, Auteur ; Alison E. HIPWELL, Auteur ; Jean M. KERVER, Auteur ; Thomas G. O'CONNOR, Auteur ; Christina A. PORUCZNIK, Auteur ; Lauren C. SHUFFREY, Auteur ; Maria M. TALAVERA-BARBER, Auteur ; Rosalind J. WRIGHT, Auteur ; Yeyi ZHU, Auteur ; Lisa A. CROEN, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur . - p.1825-1835. Langues : Anglais (eng) in Autism Research > 16-9 (September 2023) . - p.1825-1835 Index. décimale : PER Périodiques Résumé : Abstract This study evaluated the association between prenatal depression and offspring autism-related traits. The sample comprised 33 prenatal/pediatric cohorts participating in the Environmental influences on Child Health Outcomes program who contributed information on prenatal depression and autism-related traits. Autism-related traits were assessed continuously and at the diagnostic cut-off using the Social Responsiveness Scale for children up to 12 years of age. Main analyses included 3994 parent-child pairs with prenatal depression diagnoses data; secondary analyses included 1730 parent-child pairs with depression severity data. After confounder adjustment, we observed an increase in autism-related traits among children of individuals with prenatal depression compared to those without (adjusted ?=1.31 95% CI: 0.65, 1.98). Analyses stratified by child sex documented a similar significant association among boys (a?=1.34 95%CI: 0.36, 2.32) and girls (a?=1.26 95% CI: 0.37, 2.15). Prenatal depression was also associated with increased odds of moderate to severe autism-related traits (adjusted odds ratio: 1.64, 95%CI: 1.09, 2.46), the screening threshold considered high risk of autism spectrum disorder (ASD) diagnosis. Findings highlight the importance of prenatal depression screening and preventive interventions for children of pregnant individuals with depression to support healthy development. Future research is needed to clarify whether these findings reflect overlap in genetic risk for depression and ASD-related traits or another mechanism. En ligne : https://doi.org/10.1002/aur.2988 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

Prenatal smoking and child psychopathology associations by age and sex in the ECHO cohort / Kristine MARCEAU in Development and Psychopathology, 38-3 (August 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-3 (August 2026) . - p.1551-1563 Titre : Prenatal smoking and child psychopathology associations by age and sex in the ECHO cohort Type de document : texte imprimé Auteurs : Kristine MARCEAU, Auteur ; Andrew LAW, Auteur ; Karen J. DEREFINKO, Auteur ; Olivia C. ROBERTSON, Auteur ; Sara S. NOZADI, Auteur ; Lijun LI, Auteur ; Chang LIU, Auteur ; Leslie D. LEVE, Auteur ; Jody M. GANIBAN, Auteur ; Nicole BUSH, Auteur ; Cathi PROPPER, Auteur ; Briana MOORE, Auteur ; Amy J. ELLIOTT, Auteur ; Catrina A. CALUB, Auteur ; Theresa M. BASTAIN, Auteur ; Donghai LIANG, Auteur ; Julie B. SCHWEITZER, Auteur ; Ban AL-SAHAB, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Jenae M. NEIDERHISER, Auteur Article en page(s) : p.1551-1563 Langues : Anglais (eng) Mots-clés : Environmental Influences on Child Health Outcomes (ECHO)  Smoking during pregnancy  externalizing  internalizing  severity and directionality Index. décimale : PER Périodiques Résumé : Maternal tobacco smoking during pregnancy (MSDP) is associated with an increased risk of child externalizing problems. It remains unclear whether these associations are externalizing-specific, or better explained by comorbidity between externalizing and internalizing domains, or vary by age and sex. To address comorbidity and differentiation between domains, we leveraged the severity-directional model of psychopathology. Severity reflects the overall level of psychopathology symptoms across both domains (high levels of severity can only be reached by having symptoms of both types simultaneously), whereas directionality captures the balance/differentiation of internalizing vs. externalizing symptoms regardless of number of total symptoms. Participants included 16,335 children aged 1–19 years old (47.78% female, 58.17% White, 75.46% non-Hispanic) from 55 U.S.-based cohorts within the Environmental Influences on Child Health Outcomes (ECHO) consortium. MSDP predicted differentiation toward externalizing problems in 2-year age bins 1–2 through 7–8 and 13–14 years; remaining (non-significant) age bins had similar magnitudes. MSDP predicted higher symptom severity in all age bins. Findings likely reflect a combination of MSDP associations with comorbid symptom severity and specificity toward externalizing problems, with little evidence of age or sex differences. Additional analyses explored e-cigarette use, other prenatal substance use, and postnatal smoke exposure; associations were sparse and unsystematic. En ligne : https://dx.doi.org/10.1017/S095457942610128X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] Prenatal smoking and child psychopathology associations by age and sex in the ECHO cohort [texte imprimé] / Kristine MARCEAU, Auteur ; Andrew LAW, Auteur ; Karen J. DEREFINKO, Auteur ; Olivia C. ROBERTSON, Auteur ; Sara S. NOZADI, Auteur ; Lijun LI, Auteur ; Chang LIU, Auteur ; Leslie D. LEVE, Auteur ; Jody M. GANIBAN, Auteur ; Nicole BUSH, Auteur ; Cathi PROPPER, Auteur ; Briana MOORE, Auteur ; Amy J. ELLIOTT, Auteur ; Catrina A. CALUB, Auteur ; Theresa M. BASTAIN, Auteur ; Donghai LIANG, Auteur ; Julie B. SCHWEITZER, Auteur ; Ban AL-SAHAB, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Jenae M. NEIDERHISER, Auteur . - p.1551-1563. Langues : Anglais (eng) in Development and Psychopathology > 38-3 (August 2026) . - p.1551-1563 Mots-clés : Environmental Influences on Child Health Outcomes (ECHO)  Smoking during pregnancy  externalizing  internalizing  severity and directionality Index. décimale : PER Périodiques Résumé : Maternal tobacco smoking during pregnancy (MSDP) is associated with an increased risk of child externalizing problems. It remains unclear whether these associations are externalizing-specific, or better explained by comorbidity between externalizing and internalizing domains, or vary by age and sex. To address comorbidity and differentiation between domains, we leveraged the severity-directional model of psychopathology. Severity reflects the overall level of psychopathology symptoms across both domains (high levels of severity can only be reached by having symptoms of both types simultaneously), whereas directionality captures the balance/differentiation of internalizing vs. externalizing symptoms regardless of number of total symptoms. Participants included 16,335 children aged 1–19 years old (47.78% female, 58.17% White, 75.46% non-Hispanic) from 55 U.S.-based cohorts within the Environmental Influences on Child Health Outcomes (ECHO) consortium. MSDP predicted differentiation toward externalizing problems in 2-year age bins 1–2 through 7–8 and 13–14 years; remaining (non-significant) age bins had similar magnitudes. MSDP predicted higher symptom severity in all age bins. Findings likely reflect a combination of MSDP associations with comorbid symptom severity and specificity toward externalizing problems, with little evidence of age or sex differences. Additional analyses explored e-cigarette use, other prenatal substance use, and postnatal smoke exposure; associations were sparse and unsystematic. En ligne : https://dx.doi.org/10.1017/S095457942610128X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

The role of negative affectivity in the developmental pathway linking perinatal complications to behavioral and emotional problems in children / Xiaoye XU in Development and Psychopathology, 38-3 (August 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-3 (August 2026) . - p.1322-1332 Titre : The role of negative affectivity in the developmental pathway linking perinatal complications to behavioral and emotional problems in children Type de document : texte imprimé Auteurs : Xiaoye XU, Auteur ; Lauren C. SHUFFREY, Auteur ; Theresa M. BASTAIN, Auteur ; Chang LIU, Auteur ; Rosalind J. WRIGHT, Auteur ; Michelle BOSQUET ENLOW, Auteur ; Alexis HERNANDEZ, Auteur ; Jody GANIBAN, Auteur ; Sara S. NOZADI, Auteur ; Amy E. MARGOLIS, Auteur ; Amy J. ELLIOTT, Auteur ; Santiago MORALES, Auteur Article en page(s) : p.1322-1332 Langues : Anglais (eng) Mots-clés : emotional and behavioral problems  mediation  negative affectivity  perinatal complications Index. décimale : PER Périodiques Résumé : Although temperamental negative affectivity has been identified as a developmental mechanism mediating the link between perinatal risk and internalizing problems in early childhood, its role in predicting broader behavioral and emotional problems across childhood remains understudied. We examined the longitudinal relations among perinatal complications (i.e., prenatal maternal depression and cardiometabolic complications, preterm birth, and low birth weight), children’s negative affectivity (Mage = 2.76; SD = 2.32; range = 0.24–12.46 years), and children’s internalizing, externalizing, and total problems (Mage = 5.12; SD = 2.63; range = 1.50–16.85 years) in the Environmental influences on Child Health Outcomes (ECHO) program (N = 3070; 47% females). Results support child negative affectivity as a mechanism in the developmental pathway linking perinatal maternal depressive symptoms and preterm birth to future emotional and behavioral problems, underscoring the importance of early prevention and intervention efforts to promote psychological well-being of at-risk children. En ligne : https://dx.doi.org/10.1017/S0954579426101175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] The role of negative affectivity in the developmental pathway linking perinatal complications to behavioral and emotional problems in children [texte imprimé] / Xiaoye XU, Auteur ; Lauren C. SHUFFREY, Auteur ; Theresa M. BASTAIN, Auteur ; Chang LIU, Auteur ; Rosalind J. WRIGHT, Auteur ; Michelle BOSQUET ENLOW, Auteur ; Alexis HERNANDEZ, Auteur ; Jody GANIBAN, Auteur ; Sara S. NOZADI, Auteur ; Amy E. MARGOLIS, Auteur ; Amy J. ELLIOTT, Auteur ; Santiago MORALES, Auteur . - p.1322-1332. Langues : Anglais (eng) in Development and Psychopathology > 38-3 (August 2026) . - p.1322-1332 Mots-clés : emotional and behavioral problems  mediation  negative affectivity  perinatal complications Index. décimale : PER Périodiques Résumé : Although temperamental negative affectivity has been identified as a developmental mechanism mediating the link between perinatal risk and internalizing problems in early childhood, its role in predicting broader behavioral and emotional problems across childhood remains understudied. We examined the longitudinal relations among perinatal complications (i.e., prenatal maternal depression and cardiometabolic complications, preterm birth, and low birth weight), children’s negative affectivity (Mage = 2.76; SD = 2.32; range = 0.24–12.46 years), and children’s internalizing, externalizing, and total problems (Mage = 5.12; SD = 2.63; range = 1.50–16.85 years) in the Environmental influences on Child Health Outcomes (ECHO) program (N = 3070; 47% females). Results support child negative affectivity as a mechanism in the developmental pathway linking perinatal maternal depressive symptoms and preterm birth to future emotional and behavioral problems, underscoring the importance of early prevention and intervention efforts to promote psychological well-being of at-risk children. En ligne : https://dx.doi.org/10.1017/S0954579426101175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

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