Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology / João F. Guassi MOREIRA ; Adriana S. Méndez LEAL ; Natalie M. SARAGOSA-HARRIS ; Elizabeth GAINES ; Wesley J. MEREDITH ; Yael WAIZMAN ; Emilia NINOVA ; Jennifer A. SILVERS in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.1833-1845 Titre : Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology Type de document : texte imprimé Auteurs : João F. Guassi MOREIRA, Auteur ; Adriana S. Méndez LEAL, Auteur ; Natalie M. SARAGOSA-HARRIS, Auteur ; Elizabeth GAINES, Auteur ; Wesley J. MEREDITH, Auteur ; Yael WAIZMAN, Auteur ; Emilia NINOVA, Auteur ; Jennifer A. SILVERS, Auteur Article en page(s) : p.1833-1845 Langues : Anglais (eng) Mots-clés : Adolescence  anxiety  depression  functional connectivity  threat learning Index. décimale : PER Périodiques Résumé : Background:Reward and threat processes work together to support adaptive learning during development. Adolescence is associated with increasing approach behavior (e.g., novelty-seeking, risk-taking) but often also coincides with emerging internalizing symptoms, which are characterized by heightened avoidance behavior. Peaking engagement of the nucleus accumbens (NAcc) during adolescence, often studied in reward paradigms, may also relate to threat mechanisms of adolescent psychopathology.Methods:47 typically developing adolescents (9.9-22.9 years) completed an aversive learning task during functional magnetic resonance imaging, wherein visual cues were paired with an aversive sound or no sound. Task blocks involved an escapable aversively reinforced stimulus (CS+r), the same stimulus without reinforcement (CS+nr), or a stimulus that was never reinforced (CS?). Parent-reported internalizing symptoms were measured using Revised Child Anxiety and Depression Scales.Results:Functional connectivity between the NAcc and amygdala differentiated the stimuli, such that connectivity increased for the CS+r (p = .023) but not for the CS+nr and CS?. Adolescents with greater internalizing symptoms demonstrated greater positive functional connectivity for the CS? (p = .041).Conclusions:Adolescents show heightened NAcc-amygdala functional connectivity during escape from threat. Higher anxiety and depression symptoms are associated with elevated NAcc-amygdala connectivity during safety, which may reflect poor safety versus threat discrimination. En ligne : https://dx.doi.org/10.1017/S095457942400141X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology [texte imprimé] / João F. Guassi MOREIRA, Auteur ; Adriana S. Méndez LEAL, Auteur ; Natalie M. SARAGOSA-HARRIS, Auteur ; Elizabeth GAINES, Auteur ; Wesley J. MEREDITH, Auteur ; Yael WAIZMAN, Auteur ; Emilia NINOVA, Auteur ; Jennifer A. SILVERS, Auteur . - p.1833-1845. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.1833-1845 Mots-clés : Adolescence  anxiety  depression  functional connectivity  threat learning Index. décimale : PER Périodiques Résumé : Background:Reward and threat processes work together to support adaptive learning during development. Adolescence is associated with increasing approach behavior (e.g., novelty-seeking, risk-taking) but often also coincides with emerging internalizing symptoms, which are characterized by heightened avoidance behavior. Peaking engagement of the nucleus accumbens (NAcc) during adolescence, often studied in reward paradigms, may also relate to threat mechanisms of adolescent psychopathology.Methods:47 typically developing adolescents (9.9-22.9 years) completed an aversive learning task during functional magnetic resonance imaging, wherein visual cues were paired with an aversive sound or no sound. Task blocks involved an escapable aversively reinforced stimulus (CS+r), the same stimulus without reinforcement (CS+nr), or a stimulus that was never reinforced (CS?). Parent-reported internalizing symptoms were measured using Revised Child Anxiety and Depression Scales.Results:Functional connectivity between the NAcc and amygdala differentiated the stimuli, such that connectivity increased for the CS+r (p = .023) but not for the CS+nr and CS?. Adolescents with greater internalizing symptoms demonstrated greater positive functional connectivity for the CS? (p = .041).Conclusions:Adolescents show heightened NAcc-amygdala functional connectivity during escape from threat. Higher anxiety and depression symptoms are associated with elevated NAcc-amygdala connectivity during safety, which may reflect poor safety versus threat discrimination. En ligne : https://dx.doi.org/10.1017/S095457942400141X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

Sensory processing challenges as a novel link between early caregiving experiences and mental health / Laura Alicia ALBA ; Kaitlin K. CUMMINGS ; Jiwon JUNG ; Yael H. WAIZMAN ; João F. GUASSI MOREIRA ; Natalie M. SARAGOSA-HARRIS ; Emilia NINOVA ; Jill M. WATERMAN ; Audra K. LANGLEY ; Nim TOTTENHAM ; Jennifer A. SILVERS ; Shulamite A. GREEN in Development and Psychopathology, 35-4 (October 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-4 (October 2023) . - p.1968-1981 Titre : Sensory processing challenges as a novel link between early caregiving experiences and mental health Type de document : texte imprimé Auteurs : Laura Alicia ALBA, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Jiwon JUNG, Auteur ; Yael H. WAIZMAN, Auteur ; João F. GUASSI MOREIRA, Auteur ; Natalie M. SARAGOSA-HARRIS, Auteur ; Emilia NINOVA, Auteur ; Jill M. WATERMAN, Auteur ; Audra K. LANGLEY, Auteur ; Nim TOTTENHAM, Auteur ; Jennifer A. SILVERS, Auteur ; Shulamite A. GREEN, Auteur Article en page(s) : p.1968-1981 Langues : Anglais (eng) Mots-clés : adolescence  early caregiving adversity  mental health  sensory over-responsivity  sensory processing Index. décimale : PER Périodiques Résumé : Early caregiving adversity (ECA) is associated with elevated psychological symptomatology. While neurobehavioral ECA research has focused on socioemotional and cognitive development, ECA may also increase risk for ?low-level? sensory processing challenges. However, no prior work has compared how diverse ECA exposures differentially relate to sensory processing, or, critically, how this might influence psychological outcomes. We examined sensory processing challenges in 183 8-17-year-old youth with and without histories of institutional (orphanage) or foster caregiving, with a particular focus on sensory over-responsivity (SOR), a pattern of intensified responses to sensory stimuli that may negatively impact mental health. We further tested whether sensory processing challenges are linked to elevated internalizing and externalizing symptoms common in ECA-exposed youth. Relative to nonadopted comparison youth, both groups of ECA-exposed youth had elevated sensory processing challenges, including SOR, and also had heightened internalizing and externalizing symptoms. Additionally, we found significant indirect effects of ECA on internalizing and externalizing symptoms through both general sensory processing challenges and SOR, covarying for age and sex assigned at birth. These findings suggest multiple forms of ECA confer risk for sensory processing challenges that may contribute to mental health outcomes, and motivate continuing examination of these symptoms, with possible long-term implications for screening and treatment following ECA. En ligne : https://dx.doi.org/10.1017/S0954579422000633 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515 [article] Sensory processing challenges as a novel link between early caregiving experiences and mental health [texte imprimé] / Laura Alicia ALBA, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Jiwon JUNG, Auteur ; Yael H. WAIZMAN, Auteur ; João F. GUASSI MOREIRA, Auteur ; Natalie M. SARAGOSA-HARRIS, Auteur ; Emilia NINOVA, Auteur ; Jill M. WATERMAN, Auteur ; Audra K. LANGLEY, Auteur ; Nim TOTTENHAM, Auteur ; Jennifer A. SILVERS, Auteur ; Shulamite A. GREEN, Auteur . - p.1968-1981. Langues : Anglais (eng) in Development and Psychopathology > 35-4 (October 2023) . - p.1968-1981 Mots-clés : adolescence  early caregiving adversity  mental health  sensory over-responsivity  sensory processing Index. décimale : PER Périodiques Résumé : Early caregiving adversity (ECA) is associated with elevated psychological symptomatology. While neurobehavioral ECA research has focused on socioemotional and cognitive development, ECA may also increase risk for ?low-level? sensory processing challenges. However, no prior work has compared how diverse ECA exposures differentially relate to sensory processing, or, critically, how this might influence psychological outcomes. We examined sensory processing challenges in 183 8-17-year-old youth with and without histories of institutional (orphanage) or foster caregiving, with a particular focus on sensory over-responsivity (SOR), a pattern of intensified responses to sensory stimuli that may negatively impact mental health. We further tested whether sensory processing challenges are linked to elevated internalizing and externalizing symptoms common in ECA-exposed youth. Relative to nonadopted comparison youth, both groups of ECA-exposed youth had elevated sensory processing challenges, including SOR, and also had heightened internalizing and externalizing symptoms. Additionally, we found significant indirect effects of ECA on internalizing and externalizing symptoms through both general sensory processing challenges and SOR, covarying for age and sex assigned at birth. These findings suggest multiple forms of ECA confer risk for sensory processing challenges that may contribute to mental health outcomes, and motivate continuing examination of these symptoms, with possible long-term implications for screening and treatment following ECA. En ligne : https://dx.doi.org/10.1017/S0954579422000633 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515

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