Altered ventral striatal–medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care / Dominic S. FARERI in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1865-1876 Titre : Altered ventral striatal–medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care Type de document : Texte imprimé et/ou numérique Auteurs : Dominic S. FARERI, Auteur ; Laurel GABARD-DURNAM, Auteur ; Bonnie GOFF, Auteur ; Jessica FLANNERY, Auteur ; Dylan G. GEE, Auteur ; Daniel S. LUMIAN, Auteur ; Christina CALDERA, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : p.1865-1876 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early caregiving adversity is associated with increased risk for social difficulties. The ventral striatum and associated corticostriatal circuitry, which have demonstrated vulnerability to early exposures to adversity, are implicated in many aspects of social behavior, including social play, aggression, and valuation of social stimuli across development. Here, we used resting-state functional magnetic resonance imaging to assess the degree to which early caregiving adversity was associated with altered coritocostriatal resting connectivity in previously institutionalized youth (n = 41) relative to youth who were raised with their biological families from birth (n = 47), and the degree to which this connectivity was associated with parent-reported social problems. Using a seed-based approach, we observed increased positive coupling between the ventral striatum and anterior regions of medial prefrontal cortex (mPFC) in previously institutionalized youth. Stronger ventral striatum–mPFC coupling was associated with parent reports of social problems. A moderated-mediation analysis showed that ventral striatal–mPFC connectivity mediated group differences in social problems, and more so with increasing age. These findings show that early institutional care is associated with differences in resting-state connectivity between the ventral striatum and the mPFC, and this connectivity seems to play an increasingly important role in social behaviors as youth enter adolescence. En ligne : http://dx.doi.org/10.1017/S0954579417001456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Altered ventral striatal–medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care [Texte imprimé et/ou numérique] / Dominic S. FARERI, Auteur ; Laurel GABARD-DURNAM, Auteur ; Bonnie GOFF, Auteur ; Jessica FLANNERY, Auteur ; Dylan G. GEE, Auteur ; Daniel S. LUMIAN, Auteur ; Christina CALDERA, Auteur ; Nim TOTTENHAM, Auteur . - p.1865-1876. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1865-1876 Index. décimale : PER Périodiques Résumé : Early caregiving adversity is associated with increased risk for social difficulties. The ventral striatum and associated corticostriatal circuitry, which have demonstrated vulnerability to early exposures to adversity, are implicated in many aspects of social behavior, including social play, aggression, and valuation of social stimuli across development. Here, we used resting-state functional magnetic resonance imaging to assess the degree to which early caregiving adversity was associated with altered coritocostriatal resting connectivity in previously institutionalized youth (n = 41) relative to youth who were raised with their biological families from birth (n = 47), and the degree to which this connectivity was associated with parent-reported social problems. Using a seed-based approach, we observed increased positive coupling between the ventral striatum and anterior regions of medial prefrontal cortex (mPFC) in previously institutionalized youth. Stronger ventral striatum–mPFC coupling was associated with parent reports of social problems. A moderated-mediation analysis showed that ventral striatal–mPFC connectivity mediated group differences in social problems, and more so with increasing age. These findings show that early institutional care is associated with differences in resting-state connectivity between the ventral striatum and the mPFC, and this connectivity seems to play an increasingly important role in social behaviors as youth enter adolescence. En ligne : http://dx.doi.org/10.1017/S0954579417001456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Amygdala responses to threat in violence-exposed children depend on trauma context and maternal caregiving / Jennifer S. STEVENS in Development and Psychopathology, 35-3 (August 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-3 (August 2023) . - p.1159-1170 Titre : Amygdala responses to threat in violence-exposed children depend on trauma context and maternal caregiving Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer S. STEVENS, Auteur ; Sanne J. H. VAN ROOIJ, Auteur ; Anais F. STENSON, Auteur ; Timothy D. ELY, Auteur ; Abigail POWERS, Auteur ; Aimee CLIFFORD, Auteur ; Ye Ji KIM, Auteur ; Rebecca HINRICHS, Auteur ; Nim TOTTENHAM, Auteur ; Tanja JOVANOVIC, Auteur Article en page(s) : p.1159-1170 Langues : Anglais (eng) Mots-clés : amygdala  habituation  maternal buffering  resilience  violence exposure Index. décimale : PER Périodiques Résumé : Early life adversity (ELA) has been linked with increased arousal responses to threat, including increased amygdala reactivity. Effects of ELA on brain function are well recognized, and emerging evidence suggests that caregivers may influence how environmental stressors impact children?s brain function. We investigated the hypothesis that positive interaction between mother and child can buffer against ELA effects on children?s neural responses to threat, and related symptoms. N = 53 mother-child pairs (children ages 8-14 years) were recruited from an urban population at high risk for violence exposure. Maternal caregiving was measured using the Parenting Questionnaire and in a cooperation challenge task. Children viewed fearful and neutral face stimuli during functional magnetic resonance imaging. Children who experienced greater violence at home showed amygdala sensitization, whereas children experiencing more school and community violence showed amygdala habituation. Sensitization was in turn linked with externalizing symptoms. However, maternal warmth was associated with a normalization of amygdala sensitization in children, and fewer externalizing behaviors prospectively up to 1 year later. Findings suggested that the effects of violence exposure on threat-related neural circuitry depend on trauma context (inside or outside the home) and that primary caregivers can increase resilience. En ligne : http://dx.doi.org/10.1017/S0954579421001085 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] Amygdala responses to threat in violence-exposed children depend on trauma context and maternal caregiving [Texte imprimé et/ou numérique] / Jennifer S. STEVENS, Auteur ; Sanne J. H. VAN ROOIJ, Auteur ; Anais F. STENSON, Auteur ; Timothy D. ELY, Auteur ; Abigail POWERS, Auteur ; Aimee CLIFFORD, Auteur ; Ye Ji KIM, Auteur ; Rebecca HINRICHS, Auteur ; Nim TOTTENHAM, Auteur ; Tanja JOVANOVIC, Auteur . - p.1159-1170. Langues : Anglais (eng) in Development and Psychopathology > 35-3 (August 2023) . - p.1159-1170 Mots-clés : amygdala  habituation  maternal buffering  resilience  violence exposure Index. décimale : PER Périodiques Résumé : Early life adversity (ELA) has been linked with increased arousal responses to threat, including increased amygdala reactivity. Effects of ELA on brain function are well recognized, and emerging evidence suggests that caregivers may influence how environmental stressors impact children?s brain function. We investigated the hypothesis that positive interaction between mother and child can buffer against ELA effects on children?s neural responses to threat, and related symptoms. N = 53 mother-child pairs (children ages 8-14 years) were recruited from an urban population at high risk for violence exposure. Maternal caregiving was measured using the Parenting Questionnaire and in a cooperation challenge task. Children viewed fearful and neutral face stimuli during functional magnetic resonance imaging. Children who experienced greater violence at home showed amygdala sensitization, whereas children experiencing more school and community violence showed amygdala habituation. Sensitization was in turn linked with externalizing symptoms. However, maternal warmth was associated with a normalization of amygdala sensitization in children, and fewer externalizing behaviors prospectively up to 1 year later. Findings suggested that the effects of violence exposure on threat-related neural circuitry depend on trauma context (inside or outside the home) and that primary caregivers can increase resilience. En ligne : http://dx.doi.org/10.1017/S0954579421001085 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

Associations between cortical thickness and anxious/depressive symptoms differ by the quality of early care / Marta KOROM in Development and Psychopathology, 35-1 (February 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-1 (February 2023) . - p.73-84 Titre : Associations between cortical thickness and anxious/depressive symptoms differ by the quality of early care Type de document : Texte imprimé et/ou numérique Auteurs : Marta KOROM, Auteur ; Nim TOTTENHAM, Auteur ; Emilio A. VALADEZ, Auteur ; Mary DOZIER, Auteur Article en page(s) : p.73-84 Langues : Anglais (eng) Mots-clés : anxious/depressive symptoms  caregiving quality  cortical thickness  early adversity  pial surface area Index. décimale : PER Périodiques Résumé : A variety of childhood experiences can lead to anxious/depressed (A/D) symptoms. The aim of the present study was to explore the brain morphological (cortical thickness and surface area) correlates of A/D symptoms and the extent to which these phenotypes vary depending on the quality of the parenting context in which children develop. Structural magnetic resonance imaging (MRI) scans were acquired on 45 children with Child Protective Services (CPS) involvement due to risk of not receiving adequate care (high-risk group) and 25 children without CPS involvement (low-risk group) (rangeage = 8.08-12.14; Mage = 10.05) to assess cortical thickness (CT) and cortical surface area (SA). A/D symptoms were measured using the Child Behavioral Checklist. The association between A/D symptoms and CT, but not SA, differed by risk status such that high-risk children showed decreasing CT as A/D scores increased, whereas low-risk children showed increasing CT as A/D scores increased. This interaction was specific to CT in prefrontal, frontal, temporal, and parietal cortical regions. The groups had marginally different A/D scores, in the direction of higher risk being associated with lower A/D scores. Results suggest that CT correlates of A/D symptoms are differentially shaped by the quality of early caregiving experiences and should be distinguished between high- and low-risk children. En ligne : https://doi.org/10.1017/S0954579421000845 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Associations between cortical thickness and anxious/depressive symptoms differ by the quality of early care [Texte imprimé et/ou numérique] / Marta KOROM, Auteur ; Nim TOTTENHAM, Auteur ; Emilio A. VALADEZ, Auteur ; Mary DOZIER, Auteur . - p.73-84. Langues : Anglais (eng) in Development and Psychopathology > 35-1 (February 2023) . - p.73-84 Mots-clés : anxious/depressive symptoms  caregiving quality  cortical thickness  early adversity  pial surface area Index. décimale : PER Périodiques Résumé : A variety of childhood experiences can lead to anxious/depressed (A/D) symptoms. The aim of the present study was to explore the brain morphological (cortical thickness and surface area) correlates of A/D symptoms and the extent to which these phenotypes vary depending on the quality of the parenting context in which children develop. Structural magnetic resonance imaging (MRI) scans were acquired on 45 children with Child Protective Services (CPS) involvement due to risk of not receiving adequate care (high-risk group) and 25 children without CPS involvement (low-risk group) (rangeage = 8.08-12.14; Mage = 10.05) to assess cortical thickness (CT) and cortical surface area (SA). A/D symptoms were measured using the Child Behavioral Checklist. The association between A/D symptoms and CT, but not SA, differed by risk status such that high-risk children showed decreasing CT as A/D scores increased, whereas low-risk children showed increasing CT as A/D scores increased. This interaction was specific to CT in prefrontal, frontal, temporal, and parietal cortical regions. The groups had marginally different A/D scores, in the direction of higher risk being associated with lower A/D scores. Results suggest that CT correlates of A/D symptoms are differentially shaped by the quality of early caregiving experiences and should be distinguished between high- and low-risk children. En ligne : https://doi.org/10.1017/S0954579421000845 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Callous-unemotional traits and reduced default mode network connectivity within a community sample of children / Rebecca H. UMBACH in Development and Psychopathology, 33-4 (October 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-4 (October 2021) . - p.1170-1183 Titre : Callous-unemotional traits and reduced default mode network connectivity within a community sample of children Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca H. UMBACH, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : p.1170-1183 Langues : Anglais (eng) Mots-clés : brain imaging developmental  callous-unemotional  resting state Index. décimale : PER Périodiques Résumé : Callous-unemotional (CU) traits characterize a subset of youth at risk for persistent and serious antisocial behavior. Differences in resting state connectivity in the default mode network (DMN) have been associated with CU traits in forensic and clinical samples of adolescents and with deficient interpersonal/affective traits (often operationalized as Factor 1 psychopathy traits) in adults. It is unclear whether these brain-behavior associations extend to community-based children. Using mixed model analyses, we tested the associations between CU traits and within-network resting-state connectivity of seven task-activated networks and the DMN using data from 9,636 9–11-year-olds in the Adolescent Brain Cognitive Development (ABCD) study. Even after accounting for comorbid externalizing problems, higher levels of CU traits were associated with reduced connectivity within the DMN. This finding is consistent with prior literature surrounding psychopathy and CU traits in clinically and forensically based populations, suggesting the correlation likely exists on a spectrum, can be detected in childhood, and is not restricted to children with significant antisocial behavior. En ligne : http://dx.doi.org/10.1017/S0954579420000401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Callous-unemotional traits and reduced default mode network connectivity within a community sample of children [Texte imprimé et/ou numérique] / Rebecca H. UMBACH, Auteur ; Nim TOTTENHAM, Auteur . - p.1170-1183. Langues : Anglais (eng) in Development and Psychopathology > 33-4 (October 2021) . - p.1170-1183 Mots-clés : brain imaging developmental  callous-unemotional  resting state Index. décimale : PER Périodiques Résumé : Callous-unemotional (CU) traits characterize a subset of youth at risk for persistent and serious antisocial behavior. Differences in resting state connectivity in the default mode network (DMN) have been associated with CU traits in forensic and clinical samples of adolescents and with deficient interpersonal/affective traits (often operationalized as Factor 1 psychopathy traits) in adults. It is unclear whether these brain-behavior associations extend to community-based children. Using mixed model analyses, we tested the associations between CU traits and within-network resting-state connectivity of seven task-activated networks and the DMN using data from 9,636 9–11-year-olds in the Adolescent Brain Cognitive Development (ABCD) study. Even after accounting for comorbid externalizing problems, higher levels of CU traits were associated with reduced connectivity within the DMN. This finding is consistent with prior literature surrounding psychopathy and CU traits in clinically and forensically based populations, suggesting the correlation likely exists on a spectrum, can be detected in childhood, and is not restricted to children with significant antisocial behavior. En ligne : http://dx.doi.org/10.1017/S0954579420000401 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Discrimination of amygdala response predicts future separation anxiety in youth with early deprivation / Shulamite A. GREEN in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1135-1144 Titre : Discrimination of amygdala response predicts future separation anxiety in youth with early deprivation Type de document : Texte imprimé et/ou numérique Auteurs : Shulamite A. GREEN, Auteur ; Bonnie GOFF, Auteur ; Dylan G. GEE, Auteur ; Laurel GABARD-DURNAM, Auteur ; Jessica FLANNERY, Auteur ; Eva H. TELZER, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Jennifer LOUIE, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : p.1135-1144 Langues : Anglais (eng) Mots-clés : Amygdala development  parents  stress  institutional rearing  separation anxiety  social Index. décimale : PER Périodiques Résumé : Background Significant disruption in caregiving is associated with increased internalizing symptoms, most notably heightened separation anxiety symptoms during childhood. It is also associated with altered functional development of the amygdala, a neurobiological correlate of anxious behavior. However, much less is known about how functional alterations of amygdala predict individual differences in anxiety. Here, we probed amygdala function following institutional caregiving using very subtle social-affective stimuli (trustworthy and untrustworthy faces), which typically result in large differences in amygdala signal, and change in separation anxiety behaviors over a 2-year period. We hypothesized that the degree of differentiation of amygdala signal to trustworthy versus untrustworthy face stimuli would predict separation anxiety symptoms. Methods Seventy-four youths mean (SD) age = 9.7 years (2.64) with and without previous institutional care, who were all living in families at the time of testing, participated in an fMRI task designed to examine differential amygdala response to trustworthy versus untrustworthy faces. Parents reported on their children's separation anxiety symptoms at the time of scan and again 2 years later. Results Previous institutional care was associated with diminished amygdala signal differences and behavioral differences to the contrast of untrustworthy and trustworthy faces. Diminished differentiation of these stimuli types predicted more severe separation anxiety symptoms 2 years later. Older age at adoption was associated with diminished differentiation of amygdala responses. Conclusions A history of institutional care is associated with reduced differential amygdala responses to social-affective cues of trustworthiness that are typically exhibited by comparison samples. Individual differences in the degree of amygdala differential responding to these cues predict the severity of separation anxiety symptoms over a 2-year period. These findings provide a biological mechanism to explain the associations between early caregiving adversity and individual differences in internalizing symptomology during development, thereby contributing to individualized predictions of future clinical outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Discrimination of amygdala response predicts future separation anxiety in youth with early deprivation [Texte imprimé et/ou numérique] / Shulamite A. GREEN, Auteur ; Bonnie GOFF, Auteur ; Dylan G. GEE, Auteur ; Laurel GABARD-DURNAM, Auteur ; Jessica FLANNERY, Auteur ; Eva H. TELZER, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Jennifer LOUIE, Auteur ; Nim TOTTENHAM, Auteur . - p.1135-1144. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1135-1144 Mots-clés : Amygdala development  parents  stress  institutional rearing  separation anxiety  social Index. décimale : PER Périodiques Résumé : Background Significant disruption in caregiving is associated with increased internalizing symptoms, most notably heightened separation anxiety symptoms during childhood. It is also associated with altered functional development of the amygdala, a neurobiological correlate of anxious behavior. However, much less is known about how functional alterations of amygdala predict individual differences in anxiety. Here, we probed amygdala function following institutional caregiving using very subtle social-affective stimuli (trustworthy and untrustworthy faces), which typically result in large differences in amygdala signal, and change in separation anxiety behaviors over a 2-year period. We hypothesized that the degree of differentiation of amygdala signal to trustworthy versus untrustworthy face stimuli would predict separation anxiety symptoms. Methods Seventy-four youths mean (SD) age = 9.7 years (2.64) with and without previous institutional care, who were all living in families at the time of testing, participated in an fMRI task designed to examine differential amygdala response to trustworthy versus untrustworthy faces. Parents reported on their children's separation anxiety symptoms at the time of scan and again 2 years later. Results Previous institutional care was associated with diminished amygdala signal differences and behavioral differences to the contrast of untrustworthy and trustworthy faces. Diminished differentiation of these stimuli types predicted more severe separation anxiety symptoms 2 years later. Older age at adoption was associated with diminished differentiation of amygdala responses. Conclusions A history of institutional care is associated with reduced differential amygdala responses to social-affective cues of trustworthiness that are typically exhibited by comparison samples. Individual differences in the degree of amygdala differential responding to these cues predict the severity of separation anxiety symptoms over a 2-year period. These findings provide a biological mechanism to explain the associations between early caregiving adversity and individual differences in internalizing symptomology during development, thereby contributing to individualized predictions of future clinical outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes / Aki NIKOLAIDIS in Development and Psychopathology, 34-2 (May 2022)  

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Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes - CORRIGENDUM / Aki NIKOLAIDIS in Development and Psychopathology, 35-3 (August 2023)  

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Hidden talents in harsh environments / Bruce J. ELLIS in Development and Psychopathology, 34-1 (February 2022)  

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Measuring early life adversity: A dimensional approach / Ilana S. BERMAN in Development and Psychopathology, 34-2 (May 2022)  

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Mind and gut: Associations between mood and gastrointestinal distress in children exposed to adversity / Bridget L. CALLAGHAN in Development and Psychopathology, 32-1 (February 2020)  

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Neural and behavioral correlates of expectancy violations in attention-deficit hyperactivity disorder / Sarah DURSTON in Journal of Child Psychology and Psychiatry, 48-9 (September 2007)  

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Neural meaning making, prediction, and prefrontal-subcortical development following early adverse caregiving / Nim TOTTENHAM in Development and Psychopathology, 32-5 (December 2020)  

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Positive valence bias and parent–child relationship security moderate the association between early institutional caregiving and internalizing symptoms / Michelle R. VANTIEGHEM in Development and Psychopathology, 29-2 (May 2017)  

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Sensory processing challenges as a novel link between early caregiving experiences and mental health / Laura A. ALBA ; Kaitlin K. CUMMINGS ; Jiwon JUNG ; Yael H. WAIZMAN ; João F. GUASSI MOREIRA ; Natalie M. SARAGOSA-HARRIS ; Emilia NINOVA ; Jill M. WATERMAN ; Audra K. LANGLEY ; Nim TOTTENHAM ; Jennifer A. SILVERS ; Shulamite A. GREEN in Development and Psychopathology, 35-4 (October 2023)  

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Stress and the healthy adolescent brain: Evidence for the neural embedding of life events / Barbara L. GANZEL in Development and Psychopathology, 25-4 (November 2013)  

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