Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? / Roseriet BEIJERS ; Kieran J. O?DONNELL ; Carolina DE WEERTH ; Marieke S. TOLLENAAR in Development and Psychopathology, 36-2 (May 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-2 (May 2024) . - p.967-978 Titre : Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? Type de document : Texte imprimé et/ou numérique Auteurs : Roseriet BEIJERS, Auteur ; Kieran J. O?DONNELL, Auteur ; Carolina DE WEERTH, Auteur ; Marieke S. TOLLENAAR, Auteur Article en page(s) : p.967-978 Langues : Anglais (eng) Mots-clés : NR3C1  externalizing  internalizing  maternal sensitivity  methylation Index. décimale : PER Périodiques Résumé : The early caregiving environment can have lasting effects on child mental health. Animal models suggest that glucocorticoid receptor gene (NR3C1) DNA methylation plays a mediating role in linking more responsive caregiving to improved behavioral outcomes by its impact on the stress regulatory system. In this longitudinal study, we examined whether children?s NR3C1 methylation levels mediate an effect of maternal sensitivity in infancy on levels of child internalizing and externalizing behavior in a community sample. Maternal sensitivity of 145 mothers was rated at infant age 5 weeks, 12 months, and 30 months by observing mother-infant interactions. Buccal DNA methylation was assessed in the same children at age 6 years and maternal-reported internalizing and externalizing behavior was assessed at age 6 and 10 years. Higher sensitivity at age 5 weeks significantly predicted lower DNA methylation levels at two NR3C1 CpG loci, although methylation levels at these loci did not mediate an effect of maternal sensitivity on levels of child internalizing and externalizing behavior. Overall, the study provides evidence that maternal sensitivity in early infancy is associated with DNA methylation levels at loci involved in stress regulation, but the significance of this finding for child mental health remains unclear. En ligne : https://dx.doi.org/10.1017/S0954579423000226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528 [article] Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? [Texte imprimé et/ou numérique] / Roseriet BEIJERS, Auteur ; Kieran J. O?DONNELL, Auteur ; Carolina DE WEERTH, Auteur ; Marieke S. TOLLENAAR, Auteur . - p.967-978. Langues : Anglais (eng) in Development and Psychopathology > 36-2 (May 2024) . - p.967-978 Mots-clés : NR3C1  externalizing  internalizing  maternal sensitivity  methylation Index. décimale : PER Périodiques Résumé : The early caregiving environment can have lasting effects on child mental health. Animal models suggest that glucocorticoid receptor gene (NR3C1) DNA methylation plays a mediating role in linking more responsive caregiving to improved behavioral outcomes by its impact on the stress regulatory system. In this longitudinal study, we examined whether children?s NR3C1 methylation levels mediate an effect of maternal sensitivity in infancy on levels of child internalizing and externalizing behavior in a community sample. Maternal sensitivity of 145 mothers was rated at infant age 5 weeks, 12 months, and 30 months by observing mother-infant interactions. Buccal DNA methylation was assessed in the same children at age 6 years and maternal-reported internalizing and externalizing behavior was assessed at age 6 and 10 years. Higher sensitivity at age 5 weeks significantly predicted lower DNA methylation levels at two NR3C1 CpG loci, although methylation levels at these loci did not mediate an effect of maternal sensitivity on levels of child internalizing and externalizing behavior. Overall, the study provides evidence that maternal sensitivity in early infancy is associated with DNA methylation levels at loci involved in stress regulation, but the significance of this finding for child mental health remains unclear. En ligne : https://dx.doi.org/10.1017/S0954579423000226 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528

To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort / Muzi LI in Development and Psychopathology, 36-1 (February 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-1 (February 2024) . - p.50-61 Titre : To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort Type de document : Texte imprimé et/ou numérique Auteurs : Muzi LI, Auteur ; Kieran J. O?DONNELL, Auteur ; Jean CARON, Auteur ; Michael J. MEANEY, Auteur ; Michael KOBOR, Auteur ; Carl D?ARCY, Auteur ; Yingying SU, Auteur ; Aihua LIU, Auteur ; Xiangfei MENG, Auteur Article en page(s) : p.50-61 Langues : Anglais (eng) Mots-clés : childhood maltreatment  coping strategies  depression  resilience  social support Index. décimale : PER Périodiques Résumé : This study aimed to articulate the roles of social support and coping strategies in the relation between childhood maltreatment (CM) and subsequent major depressive disorder (MDD) with a comprehensive exploration of potential factors in a longitudinal community-based cohort. Parallel and serial mediation analyses were applied to estimate the direct effect (DE) (from CM to MDD) and indirect effects (from CM to MDD through social support and coping strategies, simultaneously and sequentially). Sociodemographic characteristics and genetic predispositions of MDD were considered in the modeling process. A total of 902 participants were included in the analyses. CM was significantly associated with MDD (DE coefficient (?) = 0.015, 95% confidence interval (CI) = 0.002?0.028). This relation was partially mediated by social support (indirect ? = 0.004, 95% CI = 0.0001?0.008) and negative coping (indirect ? = 0.013, 95% CI = 0.008?0.020), respectively. Social support, positive coping, and negative coping also influenced each other and collectively mediated the association between CM and MDD. This study provides robust evidence that although CM has a detrimental effect on later-on MDD, social support and coping strategies could be viable solutions to minimize the risk of MDD. Intervention and prevention programs should primarily focus on weakening negative coping strategies, then strengthening social support and positive coping strategies. En ligne : https://dx.doi.org/10.1017/S0954579422000918 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort [Texte imprimé et/ou numérique] / Muzi LI, Auteur ; Kieran J. O?DONNELL, Auteur ; Jean CARON, Auteur ; Michael J. MEANEY, Auteur ; Michael KOBOR, Auteur ; Carl D?ARCY, Auteur ; Yingying SU, Auteur ; Aihua LIU, Auteur ; Xiangfei MENG, Auteur . - p.50-61. Langues : Anglais (eng) in Development and Psychopathology > 36-1 (February 2024) . - p.50-61 Mots-clés : childhood maltreatment  coping strategies  depression  resilience  social support Index. décimale : PER Périodiques Résumé : This study aimed to articulate the roles of social support and coping strategies in the relation between childhood maltreatment (CM) and subsequent major depressive disorder (MDD) with a comprehensive exploration of potential factors in a longitudinal community-based cohort. Parallel and serial mediation analyses were applied to estimate the direct effect (DE) (from CM to MDD) and indirect effects (from CM to MDD through social support and coping strategies, simultaneously and sequentially). Sociodemographic characteristics and genetic predispositions of MDD were considered in the modeling process. A total of 902 participants were included in the analyses. CM was significantly associated with MDD (DE coefficient (?) = 0.015, 95% confidence interval (CI) = 0.002?0.028). This relation was partially mediated by social support (indirect ? = 0.004, 95% CI = 0.0001?0.008) and negative coping (indirect ? = 0.013, 95% CI = 0.008?0.020), respectively. Social support, positive coping, and negative coping also influenced each other and collectively mediated the association between CM and MDD. This study provides robust evidence that although CM has a detrimental effect on later-on MDD, social support and coping strategies could be viable solutions to minimize the risk of MDD. Intervention and prevention programs should primarily focus on weakening negative coping strategies, then strengthening social support and positive coping strategies. En ligne : https://dx.doi.org/10.1017/S0954579422000918 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

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