Caregiver-Mediated Early Support Program Delivered Online Versus Care-as-Usual for Infants at Elevated Familial Likelihood for Autism: A Parallel, Assessor Masked, Feasibility Randomized Controlled Trial in India / Shoba S. MEERA in Autism Research, 18-11 (November 2025)  

Public ISBD [article]  inAutism Research > 18-11 (November 2025) . - p.2345-2355 Titre : Caregiver-Mediated Early Support Program Delivered Online Versus Care-as-Usual for Infants at Elevated Familial Likelihood for Autism: A Parallel, Assessor Masked, Feasibility Randomized Controlled Trial in India Type de document : texte imprimé Auteurs : Shoba S. MEERA, Auteur ; Prathyusha VASUKI, Auteur ; Malavi SRIKAR, Auteur ; Reny RAJU, Auteur ; Divya SWAMINATHAN, Auteur ; Shree VOLME, Auteur ; Rachel Elizabeth JOHNSON, Auteur ; Linda R. WATSON, Auteur ; Andrew WHITEHOUSE, Auteur ; Mirko ULJAREVIĆ, Auteur ; Ming Wai WAN, Auteur ; John Vijay SAGAR, Auteur ; Deepa Bhat NAIR, Auteur Article en page(s) : p.2345-2355 Langues : Anglais (eng) Mots-clés : autism  caregiver responsiveness  early intervention  India  infant siblings  LiL' STEPS  online intervention Index. décimale : PER Périodiques Résumé : ABSTRACT LiL' STEPS (Language development n?=?12) using fixed block randomization. While families in the former group received the LiL' STEPS early support program, those in the latter did not avail themselves of any early supports. Assessors were masked to group status. The primary outcome was caregiver sensitive responsiveness, assessed using the Manchester Assessment for Caregiver-Infant Interaction (MACI). Secondary outcomes included caregiver-reported measures of social communication and language. Outcomes were measured at three time points: baseline (T1), 12?weeks post-baseline (T2), and 12?weeks after program completion (T3). Intention-to-treat analyses were performed using linear mixed models. No significant treatment effects were found between baseline (T1) and endpoint (T3) on the primary or secondary outcomes. However, significant, large, positive treatment effects were observed for caregiver sensitive responsiveness (??=?1.48; 95% CI?=?0.51?2.34; d?=?1.15) and dyadic mutuality (??=?1.22; 95% CI?=?0.03?2.15; d?=?1.01) between baseline (T1) and T2, highlighting the need for ongoing support between T2 and T3?a key direction for future large scale efficacy trials. En ligne : https://doi.org/10.1002/aur.70116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Caregiver-Mediated Early Support Program Delivered Online Versus Care-as-Usual for Infants at Elevated Familial Likelihood for Autism: A Parallel, Assessor Masked, Feasibility Randomized Controlled Trial in India [texte imprimé] / Shoba S. MEERA, Auteur ; Prathyusha VASUKI, Auteur ; Malavi SRIKAR, Auteur ; Reny RAJU, Auteur ; Divya SWAMINATHAN, Auteur ; Shree VOLME, Auteur ; Rachel Elizabeth JOHNSON, Auteur ; Linda R. WATSON, Auteur ; Andrew WHITEHOUSE, Auteur ; Mirko ULJAREVIĆ, Auteur ; Ming Wai WAN, Auteur ; John Vijay SAGAR, Auteur ; Deepa Bhat NAIR, Auteur . - p.2345-2355. Langues : Anglais (eng) in Autism Research > 18-11 (November 2025) . - p.2345-2355 Mots-clés : autism  caregiver responsiveness  early intervention  India  infant siblings  LiL' STEPS  online intervention Index. décimale : PER Périodiques Résumé : ABSTRACT LiL' STEPS (Language development n?=?12) using fixed block randomization. While families in the former group received the LiL' STEPS early support program, those in the latter did not avail themselves of any early supports. Assessors were masked to group status. The primary outcome was caregiver sensitive responsiveness, assessed using the Manchester Assessment for Caregiver-Infant Interaction (MACI). Secondary outcomes included caregiver-reported measures of social communication and language. Outcomes were measured at three time points: baseline (T1), 12?weeks post-baseline (T2), and 12?weeks after program completion (T3). Intention-to-treat analyses were performed using linear mixed models. No significant treatment effects were found between baseline (T1) and endpoint (T3) on the primary or secondary outcomes. However, significant, large, positive treatment effects were observed for caregiver sensitive responsiveness (??=?1.48; 95% CI?=?0.51?2.34; d?=?1.15) and dyadic mutuality (??=?1.22; 95% CI?=?0.03?2.15; d?=?1.01) between baseline (T1) and T2, highlighting the need for ongoing support between T2 and T3?a key direction for future large scale efficacy trials. En ligne : https://doi.org/10.1002/aur.70116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

Feasibility and acceptability of a caregiver-mediated early support program, delivered online, for infants at elevated familial likelihood for autism: A feasibility randomized controlled trial / Malavi SRIKAR ; Reny RAJU ; Divya SWAMINATHAN ; Rachel Elizabeth JOHNSON ; Linda R. WATSON ; Deepa Bhat NAIR ; John Vijay Sagar KOMMU ; Jo CHOPRA-MCGOWAN ; Prathyusha P. VASUKI in Autism Research, 17-9 (September 2024)  

Public ISBD [article]  inAutism Research > 17-9 (September 2024) . - p.1853-1866 Titre : Feasibility and acceptability of a caregiver-mediated early support program, delivered online, for infants at elevated familial likelihood for autism: A feasibility randomized controlled trial Type de document : texte imprimé Auteurs : Malavi SRIKAR, Auteur ; Reny RAJU, Auteur ; Divya SWAMINATHAN, Auteur ; Rachel Elizabeth JOHNSON, Auteur ; Linda R. WATSON, Auteur ; Deepa Bhat NAIR, Auteur ; John Vijay Sagar KOMMU, Auteur ; Jo CHOPRA-MCGOWAN, Auteur ; Prathyusha P. VASUKI, Auteur Article en page(s) : p.1853-1866 Langues : Anglais (eng) Mots-clés : acceptability  caregiver perspectives  caregiver-mediated intervention  elevated likelihood for autism  feasibility  LiL' STEPS  randomized controlled trial Index. décimale : PER Périodiques Résumé : Abstract Preliminary evidence indicates potential benefit of providing caregiver-mediated intervention, prior to diagnosis, for infants at elevated familial likelihood for autism and related developmental delays including language delay (EL-A). However, delivering such interventions online and in low-resource settings like India has not been reported. This study aimed to evaluate the feasibility and acceptability of delivering a novel manualized caregiver-mediated early support program, the ?LiL' STEPS,? online in India, for EL-A infants. LiL' STEPS stands for Language development & Intervention Lab's (LiL') Supporting Early social-communication and language by Promoting caregiver Sensitive responsiveness (STEPS). The program comprised 14 sessions with a focus on social-communication and language, conducted over 12-weeks using demonstration and video feedback. Families of 36 EL-A infants aged 9 to 15-months participated in this feasibility randomized controlled trial (RCT). Families were randomized in a 2:1 ratio (n 24 LiL' STEPS and n 12 care as usual groups). Information on feasibility and acceptability was collated following a mixed methods approach from caregiver interviews, fidelity forms, session notes, and study register. Findings indicated the LiL' STEPS study trial as feasible and acceptable with recruitment rate of 4 per month, 100% willingness for randomization, 8.3% attrition, and 3.03% loss of blinding. Interventionist and caregiver fidelity was maintained above 80%. Despite challenges like interruptions during sessions, 100% families found the program acceptable and satisfactory, 86% said they would recommend the program to others, and 71% preferred online modality. Caregivers' perspectives on beneficial components and experience attending the program have been described. Accordingly, recommendations for future definitive RCTs have been presented. En ligne : https://doi.org/10.1002/aur.3217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] Feasibility and acceptability of a caregiver-mediated early support program, delivered online, for infants at elevated familial likelihood for autism: A feasibility randomized controlled trial [texte imprimé] / Malavi SRIKAR, Auteur ; Reny RAJU, Auteur ; Divya SWAMINATHAN, Auteur ; Rachel Elizabeth JOHNSON, Auteur ; Linda R. WATSON, Auteur ; Deepa Bhat NAIR, Auteur ; John Vijay Sagar KOMMU, Auteur ; Jo CHOPRA-MCGOWAN, Auteur ; Prathyusha P. VASUKI, Auteur . - p.1853-1866. Langues : Anglais (eng) in Autism Research > 17-9 (September 2024) . - p.1853-1866 Mots-clés : acceptability  caregiver perspectives  caregiver-mediated intervention  elevated likelihood for autism  feasibility  LiL' STEPS  randomized controlled trial Index. décimale : PER Périodiques Résumé : Abstract Preliminary evidence indicates potential benefit of providing caregiver-mediated intervention, prior to diagnosis, for infants at elevated familial likelihood for autism and related developmental delays including language delay (EL-A). However, delivering such interventions online and in low-resource settings like India has not been reported. This study aimed to evaluate the feasibility and acceptability of delivering a novel manualized caregiver-mediated early support program, the ?LiL' STEPS,? online in India, for EL-A infants. LiL' STEPS stands for Language development & Intervention Lab's (LiL') Supporting Early social-communication and language by Promoting caregiver Sensitive responsiveness (STEPS). The program comprised 14 sessions with a focus on social-communication and language, conducted over 12-weeks using demonstration and video feedback. Families of 36 EL-A infants aged 9 to 15-months participated in this feasibility randomized controlled trial (RCT). Families were randomized in a 2:1 ratio (n 24 LiL' STEPS and n 12 care as usual groups). Information on feasibility and acceptability was collated following a mixed methods approach from caregiver interviews, fidelity forms, session notes, and study register. Findings indicated the LiL' STEPS study trial as feasible and acceptable with recruitment rate of 4 per month, 100% willingness for randomization, 8.3% attrition, and 3.03% loss of blinding. Interventionist and caregiver fidelity was maintained above 80%. Despite challenges like interruptions during sessions, 100% families found the program acceptable and satisfactory, 86% said they would recommend the program to others, and 71% preferred online modality. Caregivers' perspectives on beneficial components and experience attending the program have been described. Accordingly, recommendations for future definitive RCTs have been presented. En ligne : https://doi.org/10.1002/aur.3217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

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