Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia / Katherine H. KARLSGODT in Development and Psychopathology, 20-4 (Fall 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-4 (Fall 2008) . - p.1297-1327 Titre : Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia Type de document : texte imprimé Auteurs : Katherine H. KARLSGODT, Auteur ; Tyrone D. CANNON, Auteur ; Daqiang SUN, Auteur ; Amy M. JIMENEZ, Auteur ; Evan S. LUTKENHOFF, Auteur ; Rachael WILLHITE, Auteur ; Theo G.M. VAN ERP, Auteur Année de publication : 2008 Article en page(s) : p.1297-1327 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Schizophrenia has been thought of as a disorder of reduced functional and structural connectivity. Recent advances in neuroimaging techniques such as functional magnetic resonance imaging, structural magnetic resonance imaging, diffusion tensor imaging, and small animal imaging have advanced our ability to investigate this hypothesis. Moreover, the power of longitudinal designs possible with these noninvasive techniques enable the study of not just how connectivity is disrupted in schizophrenia, but when this disruption emerges during development. This article reviews genetic and neurodevelopmental influences on structural and functional connectivity in human populations with or at risk for schizophrenia and in animal models of the disorder. We conclude that the weight of evidence across these diverse lines of inquiry points to a developmental disruption of neural connectivity in schizophrenia and that this disrupted connectivity likely involves susceptibility genes that affect processes involved in establishing intra- and interregional connectivity. En ligne : http://dx.doi.org/10.1017/s095457940800062x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=603 [article] Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia [texte imprimé] / Katherine H. KARLSGODT, Auteur ; Tyrone D. CANNON, Auteur ; Daqiang SUN, Auteur ; Amy M. JIMENEZ, Auteur ; Evan S. LUTKENHOFF, Auteur ; Rachael WILLHITE, Auteur ; Theo G.M. VAN ERP, Auteur . - 2008 . - p.1297-1327. Langues : Anglais (eng) in Development and Psychopathology > 20-4 (Fall 2008) . - p.1297-1327 Index. décimale : PER Périodiques Résumé : Schizophrenia has been thought of as a disorder of reduced functional and structural connectivity. Recent advances in neuroimaging techniques such as functional magnetic resonance imaging, structural magnetic resonance imaging, diffusion tensor imaging, and small animal imaging have advanced our ability to investigate this hypothesis. Moreover, the power of longitudinal designs possible with these noninvasive techniques enable the study of not just how connectivity is disrupted in schizophrenia, but when this disruption emerges during development. This article reviews genetic and neurodevelopmental influences on structural and functional connectivity in human populations with or at risk for schizophrenia and in animal models of the disorder. We conclude that the weight of evidence across these diverse lines of inquiry points to a developmental disruption of neural connectivity in schizophrenia and that this disrupted connectivity likely involves susceptibility genes that affect processes involved in establishing intra- and interregional connectivity. En ligne : http://dx.doi.org/10.1017/s095457940800062x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=603

Social cognition in 22q11.2 deletion syndrome and idiopathic developmental neuropsychiatric disorders / Rhideeta JALAL in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Social cognition in 22q11.2 deletion syndrome and idiopathic developmental neuropsychiatric disorders Type de document : texte imprimé Auteurs : Rhideeta JALAL, Auteur ; Aarti NAIR, Auteur ; Amy LIN, Auteur ; Ariel ECKFELD, Auteur ; Leila KUSHAN, Auteur ; Jamie ZINBERG, Auteur ; Katherine H. KARLSGODT, Auteur ; Tyrone D. CANNON, Auteur ; Carrie E. BEARDEN, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Child  Cognition  DiGeorge Syndrome  Female  Humans  Male  Psychotic Disorders  Social Cognition  Young Adult  22q11.2 deletion  Neurocognition  Psychosis  Social cognition Index. décimale : PER Périodiques Résumé : BACKGROUND: 22q11.2 deletion syndrome (22q11DS) is a common recurrent neurogenetic condition associated with elevated risk for developmental neuropsychiatric disorders and intellectual disability. Children and adults with 22q11DS often exhibit marked social impairment as well as neurocognitive deficits, and have elevated rates of both autism spectrum disorder (ASD) and psychosis. However, the relationship between the basic processes of social cognition and cognitive ability has not been well studied in 22q11DS. Here, we examined differences in social cognition in 22q11DS, relative to multiple groups of idiopathic neuropsychiatric disorders, and typically developing healthy controls (HC). Additionally, we examined differences in intellectual functioning and its relationship to social cognitive abilities. Finally, we examined the relationship between social cognitive abilities and real-world social behavior. METHODS: We examined social cognition and intellectual functioning in 273 participants (mean age = 17.74 ± 5.18% female = 44.3%): 50 with 22q11DS, 49 youth with first episode psychosis (FEP), 48 at clinical high-risk (CHR) for psychosis, 24 participants with ASD, and 102 HC. Social cognition was assessed using The Awareness of Social Inference Test (TASIT), while reciprocal social behavior was assessed via parent/caregiver ratings on the Social Responsiveness Scale (SRS). Participants were also administered the Wechsler Abbreviated Scale of Intelligence, 2nd edition (WASI-II) to assess intellectual functioning. RESULTS: The 22q11DS group exhibited significantly lower social cognitive abilities compared to CHR, FEP, and HC groups after controlling for intellectual functioning, but not in comparison to the ASD group. Significant positive correlations were found between social cognition, as measured by the TASIT and IQ across groups. In contrast, no significant relationships were found between TASIT and real-world social behavior (SRS) for any group. CONCLUSIONS: Our findings indicate social cognitive deficits are more prominent in 22q11DS than idiopathic neuropsychiatric conditions across the age range, even after adjusting for global intellectual function. These results contribute to our understanding of the intellectual and social vulnerabilities of 22q11DS in comparison to idiopathic neuropsychiatric disorders. Our findings of robust associations between intellectual ability and social cognition emphasizes the importance of accounting for neurocognitive deficits in social skills interventions and tailoring these existing treatment models for 22q11DS and other populations with intellectual impairment. En ligne : https://dx.doi.org/10.1186/s11689-021-09363-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Social cognition in 22q11.2 deletion syndrome and idiopathic developmental neuropsychiatric disorders [texte imprimé] / Rhideeta JALAL, Auteur ; Aarti NAIR, Auteur ; Amy LIN, Auteur ; Ariel ECKFELD, Auteur ; Leila KUSHAN, Auteur ; Jamie ZINBERG, Auteur ; Katherine H. KARLSGODT, Auteur ; Tyrone D. CANNON, Auteur ; Carrie E. BEARDEN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Adolescent  Autism Spectrum Disorder  Child  Cognition  DiGeorge Syndrome  Female  Humans  Male  Psychotic Disorders  Social Cognition  Young Adult  22q11.2 deletion  Neurocognition  Psychosis  Social cognition Index. décimale : PER Périodiques Résumé : BACKGROUND: 22q11.2 deletion syndrome (22q11DS) is a common recurrent neurogenetic condition associated with elevated risk for developmental neuropsychiatric disorders and intellectual disability. Children and adults with 22q11DS often exhibit marked social impairment as well as neurocognitive deficits, and have elevated rates of both autism spectrum disorder (ASD) and psychosis. However, the relationship between the basic processes of social cognition and cognitive ability has not been well studied in 22q11DS. Here, we examined differences in social cognition in 22q11DS, relative to multiple groups of idiopathic neuropsychiatric disorders, and typically developing healthy controls (HC). Additionally, we examined differences in intellectual functioning and its relationship to social cognitive abilities. Finally, we examined the relationship between social cognitive abilities and real-world social behavior. METHODS: We examined social cognition and intellectual functioning in 273 participants (mean age = 17.74 ± 5.18% female = 44.3%): 50 with 22q11DS, 49 youth with first episode psychosis (FEP), 48 at clinical high-risk (CHR) for psychosis, 24 participants with ASD, and 102 HC. Social cognition was assessed using The Awareness of Social Inference Test (TASIT), while reciprocal social behavior was assessed via parent/caregiver ratings on the Social Responsiveness Scale (SRS). Participants were also administered the Wechsler Abbreviated Scale of Intelligence, 2nd edition (WASI-II) to assess intellectual functioning. RESULTS: The 22q11DS group exhibited significantly lower social cognitive abilities compared to CHR, FEP, and HC groups after controlling for intellectual functioning, but not in comparison to the ASD group. Significant positive correlations were found between social cognition, as measured by the TASIT and IQ across groups. In contrast, no significant relationships were found between TASIT and real-world social behavior (SRS) for any group. CONCLUSIONS: Our findings indicate social cognitive deficits are more prominent in 22q11DS than idiopathic neuropsychiatric conditions across the age range, even after adjusting for global intellectual function. These results contribute to our understanding of the intellectual and social vulnerabilities of 22q11DS in comparison to idiopathic neuropsychiatric disorders. Our findings of robust associations between intellectual ability and social cognition emphasizes the importance of accounting for neurocognitive deficits in social skills interventions and tailoring these existing treatment models for 22q11DS and other populations with intellectual impairment. En ligne : https://dx.doi.org/10.1186/s11689-021-09363-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis / Aarti NAIR in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70163 Titre : Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis Type de document : texte imprimé Auteurs : Aarti NAIR, Auteur ; Rhideeta JALAL, Auteur ; Katherine E. LAWRENCE, Auteur ; Niharika VERMA, Auteur ; Hector GUTIERREZ, Auteur ; Kristen LAULETTE, Auteur ; Katherine H. KARLSGODT, Auteur ; Carrie E. BEARDEN, Auteur Article en page(s) : e70163 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  early-onset psychosis  functional connectivity  resting-state  social cognition Index. décimale : PER Périodiques Résumé : ABSTRACT Both autism spectrum disorder (ASD) and psychosis are associated with challenges in social cognition. The triple-network model posits that dysfunction within and between the default mode network (DMN), central executive network (CEN), and salience network (SN) contributes to these deficits. However, the relationship between triple-network connectivity and social cognition has not been systematically compared across these groups during adolescence. We examined whole-brain functional connectivity of the triple-network in a sample of youth with ASD (N?=?24), youth with early-onset psychosis (EOP; N?=?25), and age-matched typically developing (TD) controls (N?=?26, overall mean age?=?16.39?±?2.36, % female?=?41%). Additionally, we examined relationships between connectivity patterns of the triple-network and behavioral measures of social cognition and emotion recognition in each group. ASD youth showed mixed over- and under-connectivity in the DMN, CEN overconnectivity, and SN underconnectivity, while EOP youth showed DMN and CEN overconnectivity, with relatively intact SN connectivity, compared to TD controls. Compared to EOP, ASD participants had reduced SN connectivity and mixed disruptions in DMN connectivity. Across groups, connectivity patterns were linked to social behaviors: in EOP, DMN overconnectivity was associated with poorer social cognition; in ASD, SN underconnectivity was associated with poorer social cognition. These findings highlight both shared and distinct patterns of triple-network dysconnectivity in ASD and EOP, supporting transdiagnostic models of social cognitive dysfunction, and reinforcing adolescence as a key developmental window for network-based brain changes. En ligne : https://doi.org/10.1002/aur.70163 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Triple-Network Functional Connectivity in Adolescents With Autism Spectrum Disorder Compared to Early-Onset Psychosis [texte imprimé] / Aarti NAIR, Auteur ; Rhideeta JALAL, Auteur ; Katherine E. LAWRENCE, Auteur ; Niharika VERMA, Auteur ; Hector GUTIERREZ, Auteur ; Kristen LAULETTE, Auteur ; Katherine H. KARLSGODT, Auteur ; Carrie E. BEARDEN, Auteur . - e70163. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70163 Mots-clés : autism spectrum disorder  early-onset psychosis  functional connectivity  resting-state  social cognition Index. décimale : PER Périodiques Résumé : ABSTRACT Both autism spectrum disorder (ASD) and psychosis are associated with challenges in social cognition. The triple-network model posits that dysfunction within and between the default mode network (DMN), central executive network (CEN), and salience network (SN) contributes to these deficits. However, the relationship between triple-network connectivity and social cognition has not been systematically compared across these groups during adolescence. We examined whole-brain functional connectivity of the triple-network in a sample of youth with ASD (N?=?24), youth with early-onset psychosis (EOP; N?=?25), and age-matched typically developing (TD) controls (N?=?26, overall mean age?=?16.39?±?2.36, % female?=?41%). Additionally, we examined relationships between connectivity patterns of the triple-network and behavioral measures of social cognition and emotion recognition in each group. ASD youth showed mixed over- and under-connectivity in the DMN, CEN overconnectivity, and SN underconnectivity, while EOP youth showed DMN and CEN overconnectivity, with relatively intact SN connectivity, compared to TD controls. Compared to EOP, ASD participants had reduced SN connectivity and mixed disruptions in DMN connectivity. Across groups, connectivity patterns were linked to social behaviors: in EOP, DMN overconnectivity was associated with poorer social cognition; in ASD, SN underconnectivity was associated with poorer social cognition. These findings highlight both shared and distinct patterns of triple-network dysconnectivity in ASD and EOP, supporting transdiagnostic models of social cognitive dysfunction, and reinforcing adolescence as a key developmental window for network-based brain changes. En ligne : https://doi.org/10.1002/aur.70163 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

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