A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder / Julia A. SCOTT in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.246-257 Titre : A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Julia A. SCOTT, Auteur ; David G. AMARAL, Auteur ; Cynthia MILLS-SCHUMANN, Auteur ; Beth GOODLIN-JONES, Auteur Année de publication : 2009 Article en page(s) : p.246-257 Langues : Anglais (eng) Mots-clés : Asperger MRI developmental-delays vermis neurodevelopmental-disorder Index. décimale : PER Périodiques Résumé : Magnetic resonance imaging (MRI) and postmortem neuropathological studies have implicated the cerebellum in the pathophysiology of autism. Controversy remains, however, concerning the nature and the consistency of cerebellar alterations. MRI studies of the cross-sectional area of the vermis have found both decreases and no difference in autism groups. Volumetric analysis of the vermis, which is less prone to plane of section artifacts may provide a more reliable assessment of size differences but few such studies exist in the literature. Here we present the results of a volumetric analysis of the structure of the whole cerebellum and its components in children and adolescents with autism spectrum disorders. Structural MRI's were acquired from 62 male participants (7.5 to 18.5 years-old) who met criteria for the following age-matched diagnostic groups: low functioning autism, high functioning autism (HFA), Asperger syndrome, and typically developing children. When compared to controls, the midsagittal area of the vermis, or of subgroups of lobules, was not reduced in any of the autism groups. However, we did find that total vermis volume was decreased in the combined autism group. When examined separately, the vermis of only the HFA group was significantly reduced compared to typically developing controls. Neither IQ nor age predicted the size of the vermis within the autism groups. There were no differences in the volume of individual vermal lobules or cerebellar hemispheres. These findings are discussed in relation to the pathology of autism and to the fairly common alterations of vermal morphology in various neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.97 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938 [article] A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Julia A. SCOTT, Auteur ; David G. AMARAL, Auteur ; Cynthia MILLS-SCHUMANN, Auteur ; Beth GOODLIN-JONES, Auteur . - 2009 . - p.246-257. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.246-257 Mots-clés : Asperger MRI developmental-delays vermis neurodevelopmental-disorder Index. décimale : PER Périodiques Résumé : Magnetic resonance imaging (MRI) and postmortem neuropathological studies have implicated the cerebellum in the pathophysiology of autism. Controversy remains, however, concerning the nature and the consistency of cerebellar alterations. MRI studies of the cross-sectional area of the vermis have found both decreases and no difference in autism groups. Volumetric analysis of the vermis, which is less prone to plane of section artifacts may provide a more reliable assessment of size differences but few such studies exist in the literature. Here we present the results of a volumetric analysis of the structure of the whole cerebellum and its components in children and adolescents with autism spectrum disorders. Structural MRI's were acquired from 62 male participants (7.5 to 18.5 years-old) who met criteria for the following age-matched diagnostic groups: low functioning autism, high functioning autism (HFA), Asperger syndrome, and typically developing children. When compared to controls, the midsagittal area of the vermis, or of subgroups of lobules, was not reduced in any of the autism groups. However, we did find that total vermis volume was decreased in the combined autism group. When examined separately, the vermis of only the HFA group was significantly reduced compared to typically developing controls. Neither IQ nor age predicted the size of the vermis within the autism groups. There were no differences in the volume of individual vermal lobules or cerebellar hemispheres. These findings are discussed in relation to the pathology of autism and to the fairly common alterations of vermal morphology in various neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.97 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938

Methods for acquiring MRI data in children with autism spectrum disorder and intellectual impairment without the use of sedation / Christine W. NORDAHL in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.20 Titre : Methods for acquiring MRI data in children with autism spectrum disorder and intellectual impairment without the use of sedation Type de document : Texte imprimé et/ou numérique Auteurs : Christine W. NORDAHL, Auteur ; M. MELLO, Auteur ; A. M. SHEN, Auteur ; M. D. SHEN, Auteur ; Laurie A. VISMARA, Auteur ; D. LI, Auteur ; K. HARRINGTON, Auteur ; C. TANASE, Auteur ; Beth GOODLIN-JONES, Auteur ; S. ROGERS, Auteur ; Leonard ABBEDUTO, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.20 Langues : Anglais (eng) Mots-clés : Applied behavior analysis  Brain  Compliance  Intellectual disability  Low-functioning autism  Mri  Neurodevelopment Index. décimale : PER Périodiques Résumé : BACKGROUND: Magnetic resonance imaging (MRI) has been widely used in studies evaluating the neuropathology of autism spectrum disorder (ASD). Studies are often limited, however, to higher functioning individuals with ASD. MRI studies of individuals with ASD and comorbid intellectual disability (ID) are lacking, due in part to the challenges of acquiring images without the use of sedation. METHODS: Utilizing principles of applied behavior analysis (ABA), we developed a protocol for acquiring structural MRI scans in school-aged children with ASD and intellectual impairment. Board certified behavior analysts worked closely with each child and their parent(s), utilizing behavior change techniques such as pairing, shaping, desensitization, and positive reinforcement, through a series of mock scanner visits to prepare the child for the MRI scan. An objective, quantitative assessment of motion artifact in T1- and diffusion-weighted scans was implemented to ensure that high-quality images were acquired. RESULTS: The sample consisted of 17 children with ASD who are participants in the UC Davis Autism Phenome Project, a longitudinal MRI study aimed at evaluating brain developmental trajectories from early to middle childhood. At the time of their initial scan (2-3.5 years), all 17 children had a diagnosis of ASD and development quotient (DQ) <70. At the time of the current scan (9-13 years), 13 participants continued to have IQs in the range of ID (mean IQ = 54.1, sd = 12.1), and four participants had IQs in the normal range (mean = 102.2, sd = 7.5). The success rate in acquiring T1-weighted images that met quality assurance for acceptable motion artifact was 100 %. The success rate for acquiring high-quality diffusion-weighted images was 94 %. CONCLUSIONS: By using principles of ABA in a research MRI setting, it is feasible to acquire high-quality images in school-aged children with ASD and intellectual impairment without the use of sedation. This is especially critical to ensure that ongoing longitudinal studies of brain development can extend from infancy and early childhood into middle childhood in children with ASD at all levels of functioning, including those with comorbid ID. En ligne : http://dx.doi.org/10.1186/s11689-016-9154-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348 [article] Methods for acquiring MRI data in children with autism spectrum disorder and intellectual impairment without the use of sedation [Texte imprimé et/ou numérique] / Christine W. NORDAHL, Auteur ; M. MELLO, Auteur ; A. M. SHEN, Auteur ; M. D. SHEN, Auteur ; Laurie A. VISMARA, Auteur ; D. LI, Auteur ; K. HARRINGTON, Auteur ; C. TANASE, Auteur ; Beth GOODLIN-JONES, Auteur ; S. ROGERS, Auteur ; Leonard ABBEDUTO, Auteur ; David G. AMARAL, Auteur . - p.20. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.20 Mots-clés : Applied behavior analysis  Brain  Compliance  Intellectual disability  Low-functioning autism  Mri  Neurodevelopment Index. décimale : PER Périodiques Résumé : BACKGROUND: Magnetic resonance imaging (MRI) has been widely used in studies evaluating the neuropathology of autism spectrum disorder (ASD). Studies are often limited, however, to higher functioning individuals with ASD. MRI studies of individuals with ASD and comorbid intellectual disability (ID) are lacking, due in part to the challenges of acquiring images without the use of sedation. METHODS: Utilizing principles of applied behavior analysis (ABA), we developed a protocol for acquiring structural MRI scans in school-aged children with ASD and intellectual impairment. Board certified behavior analysts worked closely with each child and their parent(s), utilizing behavior change techniques such as pairing, shaping, desensitization, and positive reinforcement, through a series of mock scanner visits to prepare the child for the MRI scan. An objective, quantitative assessment of motion artifact in T1- and diffusion-weighted scans was implemented to ensure that high-quality images were acquired. RESULTS: The sample consisted of 17 children with ASD who are participants in the UC Davis Autism Phenome Project, a longitudinal MRI study aimed at evaluating brain developmental trajectories from early to middle childhood. At the time of their initial scan (2-3.5 years), all 17 children had a diagnosis of ASD and development quotient (DQ) <70. At the time of the current scan (9-13 years), 13 participants continued to have IQs in the range of ID (mean IQ = 54.1, sd = 12.1), and four participants had IQs in the normal range (mean = 102.2, sd = 7.5). The success rate in acquiring T1-weighted images that met quality assurance for acceptable motion artifact was 100 %. The success rate for acquiring high-quality diffusion-weighted images was 94 %. CONCLUSIONS: By using principles of ABA in a research MRI setting, it is feasible to acquire high-quality images in school-aged children with ASD and intellectual impairment without the use of sedation. This is especially critical to ensure that ongoing longitudinal studies of brain development can extend from infancy and early childhood into middle childhood in children with ASD at all levels of functioning, including those with comorbid ID. En ligne : http://dx.doi.org/10.1186/s11689-016-9154-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348

Sleep problems, sleepiness and daytime behavior in preschool-age children / Beth GOODLIN-JONES in Journal of Child Psychology and Psychiatry, 50-12 (December 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-12 (December 2009) . - p.1532-1540 Titre : Sleep problems, sleepiness and daytime behavior in preschool-age children Type de document : Texte imprimé et/ou numérique Auteurs : Beth GOODLIN-JONES, Auteur ; Karen TANG, Auteur ; Jingyi LIU, Auteur ; Thomas F. ANDERS, Auteur Année de publication : 2009 Article en page(s) : p.1532-1540 Langues : Anglais (eng) Mots-clés : Sleep-disorder sleepiness behavior autism preschoolers developmental-delay Index. décimale : PER Périodiques Résumé : Background: Sleep problems are a common complaint of parents of preschool children. Children with neurodevelopmental disorders have even more disrupted sleep than typically developing children. Although disrupted nighttime sleep has been reported to affect daytime behavior, the pathway from sleep disruption to sleep problems, to impairments in daytime performance or behavior is not clear. This multi-method, preliminary study assessed this path in 68 children with autism, matched to 57 children with developmental delay without autism and 69 children developing typically. Methods: Actigraphy, structured questionnaires, laboratory assessments, and parent reports were obtained in 194 children. Results: Controlling for diagnosis and developmental age of the child, nighttime sleep problems determined by parent reports were significantly associated with decrements in daytime behavior, also measured by parent report instruments. However, actigraph-defined sleep problems and objective measures of daytime sleepiness were not associated with decrements in daytime performance. Conclusions: Parent report measures substantiate relationships between disrupted sleep patterns and waking behavior. Further understanding of the pathway from sleep disorders to daytime sleepiness and decrements in waking performance, however, may require more rigorous methods of assessment such as polysomnography and the multiple sleep latency test. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02110.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=883 [article] Sleep problems, sleepiness and daytime behavior in preschool-age children [Texte imprimé et/ou numérique] / Beth GOODLIN-JONES, Auteur ; Karen TANG, Auteur ; Jingyi LIU, Auteur ; Thomas F. ANDERS, Auteur . - 2009 . - p.1532-1540. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-12 (December 2009) . - p.1532-1540 Mots-clés : Sleep-disorder sleepiness behavior autism preschoolers developmental-delay Index. décimale : PER Périodiques Résumé : Background: Sleep problems are a common complaint of parents of preschool children. Children with neurodevelopmental disorders have even more disrupted sleep than typically developing children. Although disrupted nighttime sleep has been reported to affect daytime behavior, the pathway from sleep disruption to sleep problems, to impairments in daytime performance or behavior is not clear. This multi-method, preliminary study assessed this path in 68 children with autism, matched to 57 children with developmental delay without autism and 69 children developing typically. Methods: Actigraphy, structured questionnaires, laboratory assessments, and parent reports were obtained in 194 children. Results: Controlling for diagnosis and developmental age of the child, nighttime sleep problems determined by parent reports were significantly associated with decrements in daytime behavior, also measured by parent report instruments. However, actigraph-defined sleep problems and objective measures of daytime sleepiness were not associated with decrements in daytime performance. Conclusions: Parent report measures substantiate relationships between disrupted sleep patterns and waking behavior. Further understanding of the pathway from sleep disorders to daytime sleepiness and decrements in waking performance, however, may require more rigorous methods of assessment such as polysomnography and the multiple sleep latency test. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02110.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=883

Social Impairments in Chromosome 22q11.2 Deletion Syndrome (22q11.2DS): Autism Spectrum Disorder or a Different Endophenotype? / Kathleen ANGKUSTSIRI in Journal of Autism and Developmental Disorders, 44-4 (April 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.739-746 Titre : Social Impairments in Chromosome 22q11.2 Deletion Syndrome (22q11.2DS): Autism Spectrum Disorder or a Different Endophenotype? Type de document : Texte imprimé et/ou numérique Auteurs : Kathleen ANGKUSTSIRI, Auteur ; Beth GOODLIN-JONES, Auteur ; Lesley DEPREY, Auteur ; Khyati BRAHMBHATT, Auteur ; Susan HARRIS, Auteur ; Tony J. SIMON, Auteur Année de publication : 2014 Article en page(s) : p.739-746 Langues : Anglais (eng) Mots-clés : Autism  ASD  22q11.2 deletion syndrome  Velocardiofacial syndrome Index. décimale : PER Périodiques Résumé : High prevalence of autism spectrum disorders (ASD) has been reported in 22q11.2DS, although this has been based solely on parent report measures. This study describes the presence of ASD using a procedure more similar to that used in clinical practice by incorporating history (Social Communication Questionnaire) AND a standardized observation measure (Autism Diagnostic Observation Schedule) and suggests that ASD is not as common as previously reported in 22q11.2DS. Differences in methodology, along with comorbid conditions such as anxiety, likely contribute to false elevations in ASD prevalence and information from multiple sources should be included in the evaluation of ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1920-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 [article] Social Impairments in Chromosome 22q11.2 Deletion Syndrome (22q11.2DS): Autism Spectrum Disorder or a Different Endophenotype? [Texte imprimé et/ou numérique] / Kathleen ANGKUSTSIRI, Auteur ; Beth GOODLIN-JONES, Auteur ; Lesley DEPREY, Auteur ; Khyati BRAHMBHATT, Auteur ; Susan HARRIS, Auteur ; Tony J. SIMON, Auteur . - 2014 . - p.739-746. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.739-746 Mots-clés : Autism  ASD  22q11.2 deletion syndrome  Velocardiofacial syndrome Index. décimale : PER Périodiques Résumé : High prevalence of autism spectrum disorders (ASD) has been reported in 22q11.2DS, although this has been based solely on parent report measures. This study describes the presence of ASD using a procedure more similar to that used in clinical practice by incorporating history (Social Communication Questionnaire) AND a standardized observation measure (Autism Diagnostic Observation Schedule) and suggests that ASD is not as common as previously reported in 22q11.2DS. Differences in methodology, along with comorbid conditions such as anxiety, likely contribute to false elevations in ASD prevalence and information from multiple sources should be included in the evaluation of ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1920-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228

The Effectiveness of Parent–Child Interaction Therapy for Families of Children on the Autism Spectrum / Marjorie SOLOMON in Journal of Autism and Developmental Disorders, 38-9 (October 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-9 (October 2008) . - p.1767-1776 Titre : The Effectiveness of Parent–Child Interaction Therapy for Families of Children on the Autism Spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Marjorie SOLOMON, Auteur ; Michele ONO, Auteur ; Beth GOODLIN-JONES, Auteur ; Susan G. TIMMER, Auteur Année de publication : 2008 Article en page(s) : p.1767-1776 Langues : Anglais (eng) Mots-clés : Autism Asperger-Syndrome PDDNOS Intervention Problem-behaviors Index. décimale : PER Périodiques Résumé : We report the results of a pilot trial of an evidence-based treatment—Parent–Child Interaction Therapy (PCIT; Eyberg et al. Psychopharmacology Bulletin, 31(1), 83–91, 1995) for boys aged 5–12 with high functioning autism spectrum disorders and clinically significant behavioral problems. The study also included an investigation of the role of shared positive affect during the course of therapy on child and parent outcomes. The intervention group showed reductions in parent perceptions of child problem behaviors and child atypicality, as well as an increase in child adaptability. Shared positive affect in parent child dyads and parent positive affect increased between the initial and final phases of the therapy. Parent positive affect after the first phase was related to perceptions of improvement in problem behaviors and adaptive functioning. En ligne : http://dx.doi.org/10.1007/s10803-008-0567-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=605 [article] The Effectiveness of Parent–Child Interaction Therapy for Families of Children on the Autism Spectrum [Texte imprimé et/ou numérique] / Marjorie SOLOMON, Auteur ; Michele ONO, Auteur ; Beth GOODLIN-JONES, Auteur ; Susan G. TIMMER, Auteur . - 2008 . - p.1767-1776. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-9 (October 2008) . - p.1767-1776 Mots-clés : Autism Asperger-Syndrome PDDNOS Intervention Problem-behaviors Index. décimale : PER Périodiques Résumé : We report the results of a pilot trial of an evidence-based treatment—Parent–Child Interaction Therapy (PCIT; Eyberg et al. Psychopharmacology Bulletin, 31(1), 83–91, 1995) for boys aged 5–12 with high functioning autism spectrum disorders and clinically significant behavioral problems. The study also included an investigation of the role of shared positive affect during the course of therapy on child and parent outcomes. The intervention group showed reductions in parent perceptions of child problem behaviors and child atypicality, as well as an increase in child adaptability. Shared positive affect in parent child dyads and parent positive affect increased between the initial and final phases of the therapy. Parent positive affect after the first phase was related to perceptions of improvement in problem behaviors and adaptive functioning. En ligne : http://dx.doi.org/10.1007/s10803-008-0567-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=605

---

1 (1 - 5 / 5)