EEG frontal alpha asymmetry mediates the association between maternal and child internalizing symptoms in childhood / Dashiell SACKS in Journal of Child Psychology and Psychiatry, 66-8 (August 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1129-1140 Titre : EEG frontal alpha asymmetry mediates the association between maternal and child internalizing symptoms in childhood Type de document : texte imprimé Auteurs : Dashiell SACKS, Auteur ; Yiyi WANG, Auteur ; Asja ABRON, Auteur ; Kaitlin M. MULLIGAN, Auteur ; Caroline M. KELSEY, Auteur ; Wanze XIE, Auteur ; Charles A. NELSON, Auteur ; Michelle BOSQUET ENLOW, Auteur Article en page(s) : p.1129-1140 Langues : Anglais (eng) Mots-clés : Maternal depression  maternal anxiety  frontal alpha asymmetry  internalizing symptoms  EEG Index. décimale : PER Périodiques Résumé : Background Anxiety and depression are highly prevalent in youth and can cause significant distress and functional impairment. The presence of maternal anxiety and depression are well-established risk factors for child internalizing psychopathology, yet the responsible mechanisms linking the two remain unclear. Methods We examined the potential mediating and moderating roles of EEG frontal alpha asymmetry (FAA) in the intergenerational transmission of internalizing symptoms in a longitudinal sample of N 323 mother?child dyads. Self-report maternal internalizing symptoms were evaluated at child age 3 years and 5 years, child EEG at 5 years, and parent-report child internalizing symptoms at age 7 years. Mediation was evaluated via bootstrapped (N 5,000) confidence intervals. Results We found significant associations among maternal internalizing (anxiety, depressive) symptoms when their children were ages 3 and 5 years, child FAA at age 5 years, and child internalizing symptoms at age 7 years. There was a significant mediation effect, whereby greater maternal anxiety and depressive symptoms at age 3 years were significantly associated with FAA (greater relative right cortical activation) in children at age 5 years, which, in turn, was significantly associated with greater child internalizing symptoms at age 7 years (ps < .001). There was no moderating effect of FAA on the association between maternal internalizing symptoms at age 5 years and child internalizing symptoms at age 7 years. Conclusions Greater right frontal asymmetry may be a neurophysiological mechanism that mediates the intergenerational transmission of internalizing symptoms. En ligne : https://doi.org/10.1111/jcpp.14129 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] EEG frontal alpha asymmetry mediates the association between maternal and child internalizing symptoms in childhood [texte imprimé] / Dashiell SACKS, Auteur ; Yiyi WANG, Auteur ; Asja ABRON, Auteur ; Kaitlin M. MULLIGAN, Auteur ; Caroline M. KELSEY, Auteur ; Wanze XIE, Auteur ; Charles A. NELSON, Auteur ; Michelle BOSQUET ENLOW, Auteur . - p.1129-1140. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1129-1140 Mots-clés : Maternal depression  maternal anxiety  frontal alpha asymmetry  internalizing symptoms  EEG Index. décimale : PER Périodiques Résumé : Background Anxiety and depression are highly prevalent in youth and can cause significant distress and functional impairment. The presence of maternal anxiety and depression are well-established risk factors for child internalizing psychopathology, yet the responsible mechanisms linking the two remain unclear. Methods We examined the potential mediating and moderating roles of EEG frontal alpha asymmetry (FAA) in the intergenerational transmission of internalizing symptoms in a longitudinal sample of N 323 mother?child dyads. Self-report maternal internalizing symptoms were evaluated at child age 3 years and 5 years, child EEG at 5 years, and parent-report child internalizing symptoms at age 7 years. Mediation was evaluated via bootstrapped (N 5,000) confidence intervals. Results We found significant associations among maternal internalizing (anxiety, depressive) symptoms when their children were ages 3 and 5 years, child FAA at age 5 years, and child internalizing symptoms at age 7 years. There was a significant mediation effect, whereby greater maternal anxiety and depressive symptoms at age 3 years were significantly associated with FAA (greater relative right cortical activation) in children at age 5 years, which, in turn, was significantly associated with greater child internalizing symptoms at age 7 years (ps < .001). There was no moderating effect of FAA on the association between maternal internalizing symptoms at age 5 years and child internalizing symptoms at age 7 years. Conclusions Greater right frontal asymmetry may be a neurophysiological mechanism that mediates the intergenerational transmission of internalizing symptoms. En ligne : https://doi.org/10.1111/jcpp.14129 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Neural correlates of child temperament: The role of brain network connectivity in psychopathology risk / Wanze XIE in Journal of Child Psychology and Psychiatry, 67-7 (July 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-7 (July 2026) . - p.1203-1217 Titre : Neural correlates of child temperament: The role of brain network connectivity in psychopathology risk Type de document : texte imprimé Auteurs : Wanze XIE, Auteur ; Yiyi WANG, Auteur ; Dashiell D. SACKS, Auteur ; Charles A. NELSON, Auteur ; Michelle BOSQUET ENLOW, Auteur Article en page(s) : p.1203-1217 Langues : Anglais (eng) Mots-clés : Temperament  developmental psychopathology  internalizing disorder  electroencephalography  neural networks Index. décimale : PER Périodiques Résumé : Background Early temperament has been shown to predict socioemotional outcomes, but its neural correlates are not yet fully understood. In the current study, we investigated the relationship between early temperament and neuronal network functional connectivity (FC), and how these factors contribute to the risk of psychopathology. Methods Using a longitudinal cohort followed from infancy to age 7 (N?=?749 collected at infancy), we assessed temperament through two approaches: data-driven profiles extracted from parent-reported questionnaires collected from infancy to age 3 and lab-based assessments of behavioral inhibition (BI) at age 3. Symptoms of psychopathology were measured at age 7 with the parent-reported Child Behavior Checklist (CBCL). Resting-state EEG data collected at ages 3, 5, and 7, along with source-space connectivity methods, were used to examine FC within brain networks. Results Children with an emotionally and behaviorally dysregulated (EBD) profile, an identified risk factor for psychopathology, exhibited reduced FC in the frontoparietal network compared to their emotionally and behaviorally regulated (EBR) peers. BI at age 3 was also negatively correlated with FC in the ventral attention network at age 3 and the frontoparietal network at age 7. Additionally, frontoparietal FC moderated the relationship between early temperament and later attention-deficit symptoms: EBD children showed higher levels of attention problems than their EBR peers, but only when frontoparietal FC was low. Conclusions These findings underscore the importance of network connectivity in understanding early temperament and its socioemotional outcomes. Specifically, they highlight the role of attention and control networks in the development of psychopathology, suggesting potential targets for early interventions aimed at at-risk children. En ligne : https://doi.org/10.1111/jcpp.70095 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588 [article] Neural correlates of child temperament: The role of brain network connectivity in psychopathology risk [texte imprimé] / Wanze XIE, Auteur ; Yiyi WANG, Auteur ; Dashiell D. SACKS, Auteur ; Charles A. NELSON, Auteur ; Michelle BOSQUET ENLOW, Auteur . - p.1203-1217. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-7 (July 2026) . - p.1203-1217 Mots-clés : Temperament  developmental psychopathology  internalizing disorder  electroencephalography  neural networks Index. décimale : PER Périodiques Résumé : Background Early temperament has been shown to predict socioemotional outcomes, but its neural correlates are not yet fully understood. In the current study, we investigated the relationship between early temperament and neuronal network functional connectivity (FC), and how these factors contribute to the risk of psychopathology. Methods Using a longitudinal cohort followed from infancy to age 7 (N?=?749 collected at infancy), we assessed temperament through two approaches: data-driven profiles extracted from parent-reported questionnaires collected from infancy to age 3 and lab-based assessments of behavioral inhibition (BI) at age 3. Symptoms of psychopathology were measured at age 7 with the parent-reported Child Behavior Checklist (CBCL). Resting-state EEG data collected at ages 3, 5, and 7, along with source-space connectivity methods, were used to examine FC within brain networks. Results Children with an emotionally and behaviorally dysregulated (EBD) profile, an identified risk factor for psychopathology, exhibited reduced FC in the frontoparietal network compared to their emotionally and behaviorally regulated (EBR) peers. BI at age 3 was also negatively correlated with FC in the ventral attention network at age 3 and the frontoparietal network at age 7. Additionally, frontoparietal FC moderated the relationship between early temperament and later attention-deficit symptoms: EBD children showed higher levels of attention problems than their EBR peers, but only when frontoparietal FC was low. Conclusions These findings underscore the importance of network connectivity in understanding early temperament and its socioemotional outcomes. Specifically, they highlight the role of attention and control networks in the development of psychopathology, suggesting potential targets for early interventions aimed at at-risk children. En ligne : https://doi.org/10.1111/jcpp.70095 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588

The role of children?s neural responses to emotional faces in the intergenerational transmission of anxiety symptomatology / Finola KANE-GRADE in Development and Psychopathology, 37-3 (August 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-3 (August 2025) . - p.1659-1675 Titre : The role of children?s neural responses to emotional faces in the intergenerational transmission of anxiety symptomatology Type de document : texte imprimé Auteurs : Finola KANE-GRADE, Auteur ; Dashiell SACKS, Auteur ; Carter R. PETTY, Auteur ; Wanze XIE, Auteur ; Charles A. NELSON, Auteur ; Michelle BOSQUET ENLOW, Auteur Article en page(s) : p.1659-1675 Langues : Anglais (eng) Mots-clés : Child internalizing symptoms  EEG  emotion processing  event-related potential (ERP)  maternal anxiety Index. décimale : PER Périodiques Résumé : Children s neural responses to emotions may play a role in the intergenerational transmission of anxiety. In a prospective longitudinal study of a community sample of N = 464 mother-child dyads, we examined relations among maternal anxiety symptoms when children were infants and age 5 years, child neural responses to emotional faces (angry, fearful, happy) at age 3 years, and child internalizing symptoms at age 5 years. Path analyses tested whether amplitudes of event-related potential (ERP) components selected a priori (N290, Nc, P400) (a) mediated associations between maternal anxiety symptoms in infancy and child internalizing symptoms at 5 years and/or (b) moderated associations between maternal anxiety symptoms at 5 years and child internalizing symptoms at 5 years. Mediating effects were not observed for any of the ERP measures. Nc and P400 amplitudes to angry faces and Nc amplitude to happy faces moderated the effect of maternal anxiety at 5 years on child internalizing symptoms at 5 years. Effects were not related to maternal depressive symptoms. Differential sex effects were not observed. The findings suggest that larger neural responses to emotional faces may represent a biological risk factor that amplifies vulnerability to the development of internalizing symptomatology in young children exposed to maternal anxiety. En ligne : https://www.cambridge.org/core/product/8E3B49EEBF6C8E6D40171A735D025DCE Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] The role of children?s neural responses to emotional faces in the intergenerational transmission of anxiety symptomatology [texte imprimé] / Finola KANE-GRADE, Auteur ; Dashiell SACKS, Auteur ; Carter R. PETTY, Auteur ; Wanze XIE, Auteur ; Charles A. NELSON, Auteur ; Michelle BOSQUET ENLOW, Auteur . - p.1659-1675. Langues : Anglais (eng) in Development and Psychopathology > 37-3 (August 2025) . - p.1659-1675 Mots-clés : Child internalizing symptoms  EEG  emotion processing  event-related potential (ERP)  maternal anxiety Index. décimale : PER Périodiques Résumé : Children s neural responses to emotions may play a role in the intergenerational transmission of anxiety. In a prospective longitudinal study of a community sample of N = 464 mother-child dyads, we examined relations among maternal anxiety symptoms when children were infants and age 5 years, child neural responses to emotional faces (angry, fearful, happy) at age 3 years, and child internalizing symptoms at age 5 years. Path analyses tested whether amplitudes of event-related potential (ERP) components selected a priori (N290, Nc, P400) (a) mediated associations between maternal anxiety symptoms in infancy and child internalizing symptoms at 5 years and/or (b) moderated associations between maternal anxiety symptoms at 5 years and child internalizing symptoms at 5 years. Mediating effects were not observed for any of the ERP measures. Nc and P400 amplitudes to angry faces and Nc amplitude to happy faces moderated the effect of maternal anxiety at 5 years on child internalizing symptoms at 5 years. Effects were not related to maternal depressive symptoms. Differential sex effects were not observed. The findings suggest that larger neural responses to emotional faces may represent a biological risk factor that amplifies vulnerability to the development of internalizing symptomatology in young children exposed to maternal anxiety. En ligne : https://www.cambridge.org/core/product/8E3B49EEBF6C8E6D40171A735D025DCE Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

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