The effect of probiotic intervention on behavioral and gastrointestinal symptoms in children with autism: A systematic review and meta-analysis / Tingting WANG ; Yongting LI ; Wanlin ZOU ; Xiaolong CHEN ; Zhigang LI in Research in Autism, 126 (August 2025)  

Public ISBD [article]  inResearch in Autism > 126 (August 2025) . - p.202630 Titre : The effect of probiotic intervention on behavioral and gastrointestinal symptoms in children with autism: A systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Tingting WANG, Auteur ; Yongting LI, Auteur ; Wanlin ZOU, Auteur ; Xiaolong CHEN, Auteur ; Zhigang LI, Auteur Article en page(s) : p.202630 Langues : Anglais (eng) Mots-clés : Autism  Children  Probiotics  Gastrointestinal symptoms Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition affecting children's physical and psychological well-being. Recent research highlights the gut microbiota's role in autism, with probiotic interventions gaining attention as a potential treatment. Objective This meta-analysis evaluates the impact of probiotics on behavioral and gastrointestinal (GI) symptoms in children with autism, focusing on clinical and crossover randomized controlled trials (RCTs). Methods We systematically searched PubMed, Embase, Web of Science, and EBSCOhost for relevant studies published in the past decade. Meta-analysis was performed using R software (version 4.4.1). Results A total of 8 studies were included in the Meta-analysis, and we found a significant overall effect size of the probiotic intervention on the severity of behavioral symptoms in children with autism (SMD = ?0.251, 95 % CI:?0.466-?0.037,P = 0.04). Only three of the studies reported data related to gastrointestinal symptoms, and the analysis showed a non-significant intervention effect of probiotics in this area (SMD = ?0.048, 95 % CI: ?0.399 to 0.303, P = 0.41). Additional subgroup analyses showed no significant effect of region, duration of intervention, or probiotic type on the intervention effect. Conclusion Probiotic intervention reduced autism symptoms but had minimal effect on GI symptoms. Limitations include small sample sizes, short intervention durations, and variability in probiotics and measurement scales. Further high-quality RCTs are needed to confirm these findings. En ligne : https://doi.org/10.1016/j.reia.2025.202630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] The effect of probiotic intervention on behavioral and gastrointestinal symptoms in children with autism: A systematic review and meta-analysis [Texte imprimé et/ou numérique] / Tingting WANG, Auteur ; Yongting LI, Auteur ; Wanlin ZOU, Auteur ; Xiaolong CHEN, Auteur ; Zhigang LI, Auteur . - p.202630. Langues : Anglais (eng) in Research in Autism > 126 (August 2025) . - p.202630 Mots-clés : Autism  Children  Probiotics  Gastrointestinal symptoms Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition affecting children's physical and psychological well-being. Recent research highlights the gut microbiota's role in autism, with probiotic interventions gaining attention as a potential treatment. Objective This meta-analysis evaluates the impact of probiotics on behavioral and gastrointestinal (GI) symptoms in children with autism, focusing on clinical and crossover randomized controlled trials (RCTs). Methods We systematically searched PubMed, Embase, Web of Science, and EBSCOhost for relevant studies published in the past decade. Meta-analysis was performed using R software (version 4.4.1). Results A total of 8 studies were included in the Meta-analysis, and we found a significant overall effect size of the probiotic intervention on the severity of behavioral symptoms in children with autism (SMD = ?0.251, 95 % CI:?0.466-?0.037,P = 0.04). Only three of the studies reported data related to gastrointestinal symptoms, and the analysis showed a non-significant intervention effect of probiotics in this area (SMD = ?0.048, 95 % CI: ?0.399 to 0.303, P = 0.41). Additional subgroup analyses showed no significant effect of region, duration of intervention, or probiotic type on the intervention effect. Conclusion Probiotic intervention reduced autism symptoms but had minimal effect on GI symptoms. Limitations include small sample sizes, short intervention durations, and variability in probiotics and measurement scales. Further high-quality RCTs are needed to confirm these findings. En ligne : https://doi.org/10.1016/j.reia.2025.202630 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

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