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A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism / Lucia BILLECI in Autism, 27-1 (January 2023)
[article]
Titre : A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism Type de document : Texte imprimé et/ou numérique Auteurs : Lucia BILLECI, Auteur ; Alejandro Luis CALLARA, Auteur ; Letizia GUIDUCCI, Auteur ; Margherita PROSPERI, Auteur ; Maria Aurora MORALES, Auteur ; Sara CALDERONI, Auteur ; Filippo MURATORI, Auteur ; Elisa SANTOCCHI, Auteur Article en page(s) : p.117-132 Langues : Anglais (eng) Mots-clés : autism spectrum disorder clinical trial EEG preschoolers probiotics Index. décimale : PER Périodiques Résumé : Previous studies suggest that autism spectrum disorders are characterized by alterations in the microbiota-gut-brain axis. Probiotics may modify the composition and the functionality of the gut microbiota of autism spectrum disorder individuals, with possible cascading effects on brain function. In this study, we analyzed possible brain modifications induced by the administration of probiotics in 46 children with autism spectrum disorder using electroencephalography. A randomized 6-month controlled trial was performed. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. Lay abstract This study investigates the effects of a probiotic on preschoolers’ brain electrical activity with autism spectrum disorder. Autism is a disorder with an increasing prevalence characterized by an enormous individual, family, and social cost. Although the etiology of autism spectrum disorder is unknown, an interaction between genetic and environmental factors is implicated, converging in altered brain synaptogenesis and, therefore, connectivity. Besides deepening the knowledge on the resting brain electrical activity that characterizes this disorder, this study allows analyzing the positive central effects of a 6-month therapy with a probiotic through a randomized, double-blind placebo-controlled study and the correlations between electroencephalography activity and biochemical and clinical parameters. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. En ligne : http://dx.doi.org/10.1177/13623613221082710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491
in Autism > 27-1 (January 2023) . - p.117-132[article] A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism [Texte imprimé et/ou numérique] / Lucia BILLECI, Auteur ; Alejandro Luis CALLARA, Auteur ; Letizia GUIDUCCI, Auteur ; Margherita PROSPERI, Auteur ; Maria Aurora MORALES, Auteur ; Sara CALDERONI, Auteur ; Filippo MURATORI, Auteur ; Elisa SANTOCCHI, Auteur . - p.117-132.
Langues : Anglais (eng)
in Autism > 27-1 (January 2023) . - p.117-132
Mots-clés : autism spectrum disorder clinical trial EEG preschoolers probiotics Index. décimale : PER Périodiques Résumé : Previous studies suggest that autism spectrum disorders are characterized by alterations in the microbiota-gut-brain axis. Probiotics may modify the composition and the functionality of the gut microbiota of autism spectrum disorder individuals, with possible cascading effects on brain function. In this study, we analyzed possible brain modifications induced by the administration of probiotics in 46 children with autism spectrum disorder using electroencephalography. A randomized 6-month controlled trial was performed. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. Lay abstract This study investigates the effects of a probiotic on preschoolers’ brain electrical activity with autism spectrum disorder. Autism is a disorder with an increasing prevalence characterized by an enormous individual, family, and social cost. Although the etiology of autism spectrum disorder is unknown, an interaction between genetic and environmental factors is implicated, converging in altered brain synaptogenesis and, therefore, connectivity. Besides deepening the knowledge on the resting brain electrical activity that characterizes this disorder, this study allows analyzing the positive central effects of a 6-month therapy with a probiotic through a randomized, double-blind placebo-controlled study and the correlations between electroencephalography activity and biochemical and clinical parameters. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. En ligne : http://dx.doi.org/10.1177/13623613221082710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice / X. WANG in Autism Research, 12-4 (April 2019)
[article]
Titre : Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice Type de document : Texte imprimé et/ou numérique Auteurs : X. WANG, Auteur ; J. YANG, Auteur ; H. ZHANG, Auteur ; J. YU, Auteur ; Z. YAO, Auteur Article en page(s) : p.576-588 Langues : Anglais (eng) Mots-clés : anti-inflammation autism spectrum disorders interleukin 17a interleukin 6 maternal immune activation probiotics Index. décimale : PER Périodiques Résumé : Maternal immune activation (MIA) is associated with an increased risk for autism spectrum disorders (ASD) in offspring. Animal experiments have found that interleukin 6 (IL-6) and IL-17a are key cytokines in the induction of ASD by MIA. Moreover, probiotics were verified to inhibit the production of proinflammatory cytokines. Therefore, we investigated whether the administration of oral probiotics during pregnancy might protect the offspring that have suffered MIA from developing ASD. Probiotics were orally administered to pregnant mice with/without the simultaneous administration of Poly(I:C). We found that oral probiotics prevented the ASD-like behaviors induced by MIA in offspring. Furthermore, oral probiotics prevented the MIA-induced increases in the IL-6 and IL-17a levels in both maternal serum and fetal brains, parvalbumin positive (PV(+) ) neuron loss, and the decrease in the gamma-aminobutyric acid levels in the prefrontal cortex of adult offspring. This work suggests that administering oral probiotics during pregnancy may help decrease the risk of ASD following MIA during pregnancy. Autism Res 2019, 12: 576-588. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Interleukin 6 (IL-6) and IL-17a are key cytokines in the maternal immune activation (MIA)-induced autism spectrum disorders (ASD). Based on emerging evidence that probiotics can inhibit the production of proinflammatory cytokines, we found that oral probiotics prevented MIA-induced ASD-like behaviors in offspring. This work suggested that oral probiotics during pregnancy may be an effective means for decreasing the incidence of ASD in offspring. En ligne : https://dx.doi.org/10.1002/aur.2079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388
in Autism Research > 12-4 (April 2019) . - p.576-588[article] Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice [Texte imprimé et/ou numérique] / X. WANG, Auteur ; J. YANG, Auteur ; H. ZHANG, Auteur ; J. YU, Auteur ; Z. YAO, Auteur . - p.576-588.
Langues : Anglais (eng)
in Autism Research > 12-4 (April 2019) . - p.576-588
Mots-clés : anti-inflammation autism spectrum disorders interleukin 17a interleukin 6 maternal immune activation probiotics Index. décimale : PER Périodiques Résumé : Maternal immune activation (MIA) is associated with an increased risk for autism spectrum disorders (ASD) in offspring. Animal experiments have found that interleukin 6 (IL-6) and IL-17a are key cytokines in the induction of ASD by MIA. Moreover, probiotics were verified to inhibit the production of proinflammatory cytokines. Therefore, we investigated whether the administration of oral probiotics during pregnancy might protect the offspring that have suffered MIA from developing ASD. Probiotics were orally administered to pregnant mice with/without the simultaneous administration of Poly(I:C). We found that oral probiotics prevented the ASD-like behaviors induced by MIA in offspring. Furthermore, oral probiotics prevented the MIA-induced increases in the IL-6 and IL-17a levels in both maternal serum and fetal brains, parvalbumin positive (PV(+) ) neuron loss, and the decrease in the gamma-aminobutyric acid levels in the prefrontal cortex of adult offspring. This work suggests that administering oral probiotics during pregnancy may help decrease the risk of ASD following MIA during pregnancy. Autism Res 2019, 12: 576-588. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Interleukin 6 (IL-6) and IL-17a are key cytokines in the maternal immune activation (MIA)-induced autism spectrum disorders (ASD). Based on emerging evidence that probiotics can inhibit the production of proinflammatory cytokines, we found that oral probiotics prevented MIA-induced ASD-like behaviors in offspring. This work suggested that oral probiotics during pregnancy may be an effective means for decreasing the incidence of ASD in offspring. En ligne : https://dx.doi.org/10.1002/aur.2079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 Therapeutic diets and supplementation: exploring their impact on autism spectrum disorders in childhood - A narrative review of recent clinical trials / Ruzha PANCHEVA in Research in Autism Spectrum Disorders, 112 (April 2024)
[article]
Titre : Therapeutic diets and supplementation: exploring their impact on autism spectrum disorders in childhood - A narrative review of recent clinical trials Type de document : Texte imprimé et/ou numérique Auteurs : Ruzha PANCHEVA, Auteur ; Rositsa CHAMOVA, Auteur ; Dimitar MARINOV, Auteur ; Albena TONEVA, Auteur ; Mariya DZHOGOVA, Auteur ; Sevdzhihan EYUBOVA, Auteur ; Natalya USHEVA, Auteur Article en page(s) : p.102352 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Nutritional interventions Clinical trials Gluten-free diet Omega-3 fatty acids Vitamins Probiotics Developmental disabilities Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits, restricted interests, and repetitive behaviors. Nutritional interventions have gained attention as potential therapeutic strategies for individuals with ASD. This review aims to provide a comprehensive summary of recent clinical trials investigating the effects of various nutritional interventions on ASD symptoms. Methods A systematic search was conducted in multiple databases to identify clinical trials published between 2018 and 2023. Studies focusing on children with ASD and evaluating the impact of nutritional interventions were included. The selected articles were analyzed for study design, intervention type, outcome measures, and results. Results A total of 26 studies were included in the review, covering a range of nutritional interventions including gluten-free and casein-free diets, omega-3 fatty acid supplementation, vitamin and mineral supplementation, probiotics, prebiotics, and others. The studies varied in design, sample size, and outcome measures. Overall, the findings revealed some positive effects of specific nutritional interventions on ASD symptoms, such as improvements in social responsiveness, communication, hyperactivity, and stereotypical behaviors. However, discrepancies and limitations were noted across the studies, highlighting the need for further research. Conclusion This comprehensive review provides insights into the potential therapeutic effects of nutritional interventions for individuals with ASD. While some interventions showed promising results, further research with larger sample sizes, standardized methodologies, and longer-term follow-ups is needed to establish their efficacy. Personalized approaches, considering the heterogeneity of ASD, and strategies to enhance adherence to dietary interventions are also crucial in developing effective treatment plans. Overall, nutritional interventions hold promise as adjunctive therapies for individuals with ASD, warranting continued investigation in this field of research. En ligne : https://doi.org/10.1016/j.rasd.2024.102352 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524
in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102352[article] Therapeutic diets and supplementation: exploring their impact on autism spectrum disorders in childhood - A narrative review of recent clinical trials [Texte imprimé et/ou numérique] / Ruzha PANCHEVA, Auteur ; Rositsa CHAMOVA, Auteur ; Dimitar MARINOV, Auteur ; Albena TONEVA, Auteur ; Mariya DZHOGOVA, Auteur ; Sevdzhihan EYUBOVA, Auteur ; Natalya USHEVA, Auteur . - p.102352.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102352
Mots-clés : Autism Spectrum Disorder Nutritional interventions Clinical trials Gluten-free diet Omega-3 fatty acids Vitamins Probiotics Developmental disabilities Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits, restricted interests, and repetitive behaviors. Nutritional interventions have gained attention as potential therapeutic strategies for individuals with ASD. This review aims to provide a comprehensive summary of recent clinical trials investigating the effects of various nutritional interventions on ASD symptoms. Methods A systematic search was conducted in multiple databases to identify clinical trials published between 2018 and 2023. Studies focusing on children with ASD and evaluating the impact of nutritional interventions were included. The selected articles were analyzed for study design, intervention type, outcome measures, and results. Results A total of 26 studies were included in the review, covering a range of nutritional interventions including gluten-free and casein-free diets, omega-3 fatty acid supplementation, vitamin and mineral supplementation, probiotics, prebiotics, and others. The studies varied in design, sample size, and outcome measures. Overall, the findings revealed some positive effects of specific nutritional interventions on ASD symptoms, such as improvements in social responsiveness, communication, hyperactivity, and stereotypical behaviors. However, discrepancies and limitations were noted across the studies, highlighting the need for further research. Conclusion This comprehensive review provides insights into the potential therapeutic effects of nutritional interventions for individuals with ASD. While some interventions showed promising results, further research with larger sample sizes, standardized methodologies, and longer-term follow-ups is needed to establish their efficacy. Personalized approaches, considering the heterogeneity of ASD, and strategies to enhance adherence to dietary interventions are also crucial in developing effective treatment plans. Overall, nutritional interventions hold promise as adjunctive therapies for individuals with ASD, warranting continued investigation in this field of research. En ligne : https://doi.org/10.1016/j.rasd.2024.102352 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524