Early trauma exposure moderates associations between cortisol reactivity and youth anxiety and externalizing symptoms / Gretchen R. PERHAMUS in Development and Psychopathology, 38-4 (October 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-4 (October 2026) . - p.2000-2011 Titre : Early trauma exposure moderates associations between cortisol reactivity and youth anxiety and externalizing symptoms Type de document : texte imprimé Auteurs : Gretchen R. PERHAMUS, Auteur ; Rachel E. SICILIANO, Auteur ; Tiffany PHU, Auteur ; Christopher T. SEGE, Auteur ; Zachary W. ADAMS, Auteur ; Jane E. JOSEPH, Auteur ; Jason E. CHAPMAN, Auteur ; Colleen A. HALLIDAY, Auteur ; Colin BOWYER, Auteur ; Donte L. BERNARD, Auteur ; Benjamin L. HANKIN, Auteur ; Lisa M. MCTEAGUE, Auteur ; Carla KMETT DANIELSON, Auteur Article en page(s) : p.2000-2011 Langues : Anglais (eng) Mots-clés : adolescence  anxiety  cortisol  externalizing  trauma Index. décimale : PER Périodiques Résumé : Early (before age 6) potentially traumatic events (PTEs) may interact with hypothalamic–pituitary–adrenal (HPA) axis functioning to shape outcomes involving externalizing problems and anxiety. However, directions of effects remain unclear. This study examined associations between aspects of HPA axis reactivity, anxiety, and externalizing problems over two years by early PTE exposure history, while statistically capturing the co-occurrence of symptom domains. Youth (N = 189; Mage = 10.96 years, SD = 2.51, Range = 8–15; 52.4% female, 47.1% male; 50.3% White, 35.4% Black/African American, 6.4% Other; 7.4% Hispanic/Latine) were included if they had early PTE exposure (n = 107) or had never experienced a PTE (n = 82). HPA axis reactivity to social stress was calculated using area under the curve with respect to ground (AUCg) and increase (AUCi). For youth with early PTE exposure, higher AUCg was concurrently associated with more externalizing symptoms and greater predominance of externalizing over anxiety. Blunted AUCi predicted increasing predominance of externalizing for the early PTE group, but elevated AUCi predicted increases in anxiety for the no PTE group. Findings highlight distinct roles of overall and reactive HPA axis functioning in shaping outcomes following early trauma. En ligne : https://dx.doi.org/10.1017/S0954579426101771 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Early trauma exposure moderates associations between cortisol reactivity and youth anxiety and externalizing symptoms [texte imprimé] / Gretchen R. PERHAMUS, Auteur ; Rachel E. SICILIANO, Auteur ; Tiffany PHU, Auteur ; Christopher T. SEGE, Auteur ; Zachary W. ADAMS, Auteur ; Jane E. JOSEPH, Auteur ; Jason E. CHAPMAN, Auteur ; Colleen A. HALLIDAY, Auteur ; Colin BOWYER, Auteur ; Donte L. BERNARD, Auteur ; Benjamin L. HANKIN, Auteur ; Lisa M. MCTEAGUE, Auteur ; Carla KMETT DANIELSON, Auteur . - p.2000-2011. Langues : Anglais (eng) in Development and Psychopathology > 38-4 (October 2026) . - p.2000-2011 Mots-clés : adolescence  anxiety  cortisol  externalizing  trauma Index. décimale : PER Périodiques Résumé : Early (before age 6) potentially traumatic events (PTEs) may interact with hypothalamic–pituitary–adrenal (HPA) axis functioning to shape outcomes involving externalizing problems and anxiety. However, directions of effects remain unclear. This study examined associations between aspects of HPA axis reactivity, anxiety, and externalizing problems over two years by early PTE exposure history, while statistically capturing the co-occurrence of symptom domains. Youth (N = 189; Mage = 10.96 years, SD = 2.51, Range = 8–15; 52.4% female, 47.1% male; 50.3% White, 35.4% Black/African American, 6.4% Other; 7.4% Hispanic/Latine) were included if they had early PTE exposure (n = 107) or had never experienced a PTE (n = 82). HPA axis reactivity to social stress was calculated using area under the curve with respect to ground (AUCg) and increase (AUCi). For youth with early PTE exposure, higher AUCg was concurrently associated with more externalizing symptoms and greater predominance of externalizing over anxiety. Blunted AUCi predicted increasing predominance of externalizing for the early PTE group, but elevated AUCi predicted increases in anxiety for the no PTE group. Findings highlight distinct roles of overall and reactive HPA axis functioning in shaping outcomes following early trauma. En ligne : https://dx.doi.org/10.1017/S0954579426101771 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Interpersonal violence moderates sustained-transient threat co-activation in the vmPFC and amygdala in a community sample of youth / Jane E. JOSEPH ; Zachary W. ADAMS ; Kathleen I. CRUM ; Christopher T. SEGE ; Lisa M. MCTEAGUE ; Greg HAJCAK ; Colleen A. HALLIDAY ; Carla Kmett DANIELSON in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.2151-2160 Titre : Interpersonal violence moderates sustained-transient threat co-activation in the vmPFC and amygdala in a community sample of youth Type de document : texte imprimé Auteurs : Jane E. JOSEPH, Auteur ; Zachary W. ADAMS, Auteur ; Kathleen I. CRUM, Auteur ; Christopher T. SEGE, Auteur ; Lisa M. MCTEAGUE, Auteur ; Greg HAJCAK, Auteur ; Colleen A. HALLIDAY, Auteur ; Carla Kmett DANIELSON, Auteur Article en page(s) : p.2151-2160 Langues : Anglais (eng) Mots-clés : Childhood adversity  RdoC  threat processing Index. décimale : PER Périodiques Résumé : The increased risk for psychopathology associated with interpersonal violence exposure (IPV, e.g., physical abuse, sexual assault) is partially mediated by neurobiological alterations in threat-related processes. Evidence supports parsing neural circuitry related to transient and sustained threat, as they appear to be separable processes with distinct neurobiological underpinnings. Although childhood is a sensitive period for neurodevelopment, most prior work has been conducted in adult samples. Further, it is unknown how IPV exposure may impact transient-sustained threat neural interactions. The current study tested the moderating role of IPV exposure on sustained vmPFC-transient amygdala co-activation during an fMRI task during which threat and neutral cues were predictably or unpredictably presented. Analyses were conducted in a sample of 212 community-recruited youth (M/SDage = 11.77/2.44 years old; 51.9% male; 56.1% White/Caucasian). IPV-exposed youth evidenced a positive sustained vmPFC-transient amygdala co-activation, while youth with no IPV exposure did not show this association. Consistent with theoretical models, effects were specific to unpredictable, negative trials and to exposure to IPV (i.e., unrelated to non-IPV traumatic experiences). Although preliminary, these findings provide novel insight into how childhood IPV exposure may alter neural circuity involved in specific facets of threat processing. En ligne : https://dx.doi.org/10.1017/S0954579424001743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Interpersonal violence moderates sustained-transient threat co-activation in the vmPFC and amygdala in a community sample of youth [texte imprimé] / Jane E. JOSEPH, Auteur ; Zachary W. ADAMS, Auteur ; Kathleen I. CRUM, Auteur ; Christopher T. SEGE, Auteur ; Lisa M. MCTEAGUE, Auteur ; Greg HAJCAK, Auteur ; Colleen A. HALLIDAY, Auteur ; Carla Kmett DANIELSON, Auteur . - p.2151-2160. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.2151-2160 Mots-clés : Childhood adversity  RdoC  threat processing Index. décimale : PER Périodiques Résumé : The increased risk for psychopathology associated with interpersonal violence exposure (IPV, e.g., physical abuse, sexual assault) is partially mediated by neurobiological alterations in threat-related processes. Evidence supports parsing neural circuitry related to transient and sustained threat, as they appear to be separable processes with distinct neurobiological underpinnings. Although childhood is a sensitive period for neurodevelopment, most prior work has been conducted in adult samples. Further, it is unknown how IPV exposure may impact transient-sustained threat neural interactions. The current study tested the moderating role of IPV exposure on sustained vmPFC-transient amygdala co-activation during an fMRI task during which threat and neutral cues were predictably or unpredictably presented. Analyses were conducted in a sample of 212 community-recruited youth (M/SDage = 11.77/2.44 years old; 51.9% male; 56.1% White/Caucasian). IPV-exposed youth evidenced a positive sustained vmPFC-transient amygdala co-activation, while youth with no IPV exposure did not show this association. Consistent with theoretical models, effects were specific to unpredictable, negative trials and to exposure to IPV (i.e., unrelated to non-IPV traumatic experiences). Although preliminary, these findings provide novel insight into how childhood IPV exposure may alter neural circuity involved in specific facets of threat processing. En ligne : https://dx.doi.org/10.1017/S0954579424001743 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

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