Dyskinetic Cerebral Palsy in Children: Clinical Perspectives on Common Comorbidities and Health-Related Quality of Life / Arushi Gahlot SAINI in Journal of Autism and Developmental Disorders, 55-10 (October 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-10 (October 2025) . - p.3755-3764 Titre : Dyskinetic Cerebral Palsy in Children: Clinical Perspectives on Common Comorbidities and Health-Related Quality of Life Type de document : texte imprimé Auteurs : Arushi Gahlot SAINI, Auteur ; Naveen SANKHYAN, Auteur ; Prahbhjot MALHI, Auteur ; Chirag AHUJA, Auteur ; Niranjan KHANDELWAL, Auteur ; Pratibha SINGHI, Auteur Article en page(s) : p.3755-3764 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background: The data on specific comorbidities in children with dyskinetic cerebral palsy (DCP) is limited. We evaluated the pattern of comorbidities and health related quality of life (HRQOL) in these children and compared them between etiological and motor impairment subgroups. Methodology: This cross-sectional study was conducted over 18 months in children with DCP of both sex, and age between one and 14 years. Comorbidities were assessed using standardized scales such as gross motor functioning scale (GMFCS), developmental profile-3 (DP-3), developmental behaviour checklist, sleep behaviour questionnaire (SBQ), and caregiver questionnaire. Results: Sixty-five children with DCP were evaluated (hyperbilirubinemia n = 43, 66% and perinatal asphyxia n = 19, 29%). The majority of children were severely affected in gross motor functioning (level IV 29.2% and level V 53.8%). Epilepsy was seen in 21.5% of cases (19% in hyperbilirubinemia and 32% in asphyxia, p = 0.4). The mean age of onset of seizures was 15.4 + 20.6 months (range 2–72). Visual problems were seen in 54% of cases and included upgaze palsy, squint, refractive error, optic atrophy and cortical blindness. A significant proportion of children with hyperbilirubinemia had upgaze palsy as compared to those with perinatal asphyxia (70% vs. 32%, p 0.01). Rest of the visual problems were not significantly different between the two etiological subgroups. Drooling (87.6%), protein-energy malnutrition (66.6%), and reflux (57%) were the most common gastrointestinal problems in children with DCP. Children with DCP showed problems in social relating (33.8%), anxiety (26.2%), and self-absorbed behaviour (7.7%). However, there were no statistically significant differences between the etiological, motor impairment and age-based subgroups. Children with DCP had high scores on SBQ, suggesting sleep problems. Sleep scores were similar in the hyperbilirubinemia and perinatal asphyxia subgroups. Greater sleep problems were noted in children aged < 4y (70.6 + 10.1 vs. 56.5 + 11.3, p < 0.05 as compared to children above 4y of age) and severe motor impairments (68.2 + 11.3 vs. 57.2 + 13.1, p 0.008 as compared to mild-moderate motor impairment). Poor overall developmental scores were seen in 61.5% children and were significantly associated with GMFCS (p 0.04). The majority of children showed impairments in physical (58.5%), adaptive behaviour (58.5%), social-emotional (50.8%), cognitive (60%) and communication (52%) subscales of DP-3. Cognitive impairment was similar in the etiological (hyperbilirubinemia vs. perinatal asphyxia, p = 0.3), and motor impairment (mild-moderate vs. severe, p = 0.9) subgroups. HRQOL was significantly affected by motor impairment in positioning-transfer (p value 0.0001), and interaction-communication domains (p value 0.0001), however, there was no difference based on the etiology of hyperbilirubinemia and asphyxia. Conclusion: Children with DCP demonstrate several comorbidities and impaired quality of life. These are similar in hyperbilirubinemia and perinatal asphyxia cohorts, expect for significant proportion of upgaze palsy in DCP secondary to hyperbilirubinemia. Younger children have more problematic behaviour and impaired sleep quality. Severe motor disability influences the developmental outcomes, cognition, sleep and HRQOL in children with DCP. En ligne : https://doi.org/10.1007/s10803-024-06467-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Dyskinetic Cerebral Palsy in Children: Clinical Perspectives on Common Comorbidities and Health-Related Quality of Life [texte imprimé] / Arushi Gahlot SAINI, Auteur ; Naveen SANKHYAN, Auteur ; Prahbhjot MALHI, Auteur ; Chirag AHUJA, Auteur ; Niranjan KHANDELWAL, Auteur ; Pratibha SINGHI, Auteur . - p.3755-3764. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-10 (October 2025) . - p.3755-3764 Index. décimale : PER Périodiques Résumé : Background: The data on specific comorbidities in children with dyskinetic cerebral palsy (DCP) is limited. We evaluated the pattern of comorbidities and health related quality of life (HRQOL) in these children and compared them between etiological and motor impairment subgroups. Methodology: This cross-sectional study was conducted over 18 months in children with DCP of both sex, and age between one and 14 years. Comorbidities were assessed using standardized scales such as gross motor functioning scale (GMFCS), developmental profile-3 (DP-3), developmental behaviour checklist, sleep behaviour questionnaire (SBQ), and caregiver questionnaire. Results: Sixty-five children with DCP were evaluated (hyperbilirubinemia n = 43, 66% and perinatal asphyxia n = 19, 29%). The majority of children were severely affected in gross motor functioning (level IV 29.2% and level V 53.8%). Epilepsy was seen in 21.5% of cases (19% in hyperbilirubinemia and 32% in asphyxia, p = 0.4). The mean age of onset of seizures was 15.4 + 20.6 months (range 2–72). Visual problems were seen in 54% of cases and included upgaze palsy, squint, refractive error, optic atrophy and cortical blindness. A significant proportion of children with hyperbilirubinemia had upgaze palsy as compared to those with perinatal asphyxia (70% vs. 32%, p 0.01). Rest of the visual problems were not significantly different between the two etiological subgroups. Drooling (87.6%), protein-energy malnutrition (66.6%), and reflux (57%) were the most common gastrointestinal problems in children with DCP. Children with DCP showed problems in social relating (33.8%), anxiety (26.2%), and self-absorbed behaviour (7.7%). However, there were no statistically significant differences between the etiological, motor impairment and age-based subgroups. Children with DCP had high scores on SBQ, suggesting sleep problems. Sleep scores were similar in the hyperbilirubinemia and perinatal asphyxia subgroups. Greater sleep problems were noted in children aged < 4y (70.6 + 10.1 vs. 56.5 + 11.3, p < 0.05 as compared to children above 4y of age) and severe motor impairments (68.2 + 11.3 vs. 57.2 + 13.1, p 0.008 as compared to mild-moderate motor impairment). Poor overall developmental scores were seen in 61.5% children and were significantly associated with GMFCS (p 0.04). The majority of children showed impairments in physical (58.5%), adaptive behaviour (58.5%), social-emotional (50.8%), cognitive (60%) and communication (52%) subscales of DP-3. Cognitive impairment was similar in the etiological (hyperbilirubinemia vs. perinatal asphyxia, p = 0.3), and motor impairment (mild-moderate vs. severe, p = 0.9) subgroups. HRQOL was significantly affected by motor impairment in positioning-transfer (p value 0.0001), and interaction-communication domains (p value 0.0001), however, there was no difference based on the etiology of hyperbilirubinemia and asphyxia. Conclusion: Children with DCP demonstrate several comorbidities and impaired quality of life. These are similar in hyperbilirubinemia and perinatal asphyxia cohorts, expect for significant proportion of upgaze palsy in DCP secondary to hyperbilirubinemia. Younger children have more problematic behaviour and impaired sleep quality. Severe motor disability influences the developmental outcomes, cognition, sleep and HRQOL in children with DCP. En ligne : https://doi.org/10.1007/s10803-024-06467-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Risk clustering and psychopathology from a multi-center cohort of Indian children, adolescents, and young adults / Debasish BASU in Development and Psychopathology, 35-2 (May 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-2 (May 2023) . - p.800-808 Titre : Risk clustering and psychopathology from a multi-center cohort of Indian children, adolescents, and young adults Type de document : texte imprimé Auteurs : Debasish BASU, Auteur ; Abhishek GHOSH, Auteur ; Chandrima NASKAR, Auteur ; Srinivas BALACHANDER, Auteur ; Gwen FERNANDES, Auteur ; Nilakshi VAIDYA, Auteur ; Kalyanaraman KUMARAN, Auteur ; Murali KRISHNA, Auteur ; Gareth J. BARKER, Auteur ; Eesha SHARMA, Auteur ; Pratima MURTHY, Auteur ; Bharath HOLLA, Auteur ; Sanjeev JAIN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Kartik KALYANRAM, Auteur ; Meera PURUSHOTTAM, Auteur ; Rose Dawn BHARATH, Auteur ; Mathew VARGHESE, Auteur ; Kandavel THENNARASU, Auteur ; Amit CHAKRABARTI, Auteur ; Rajkumar Lenin SINGH, Auteur ; Roshan Lourembam SINGH, Auteur ; Subodh Bhagyalakshmi NANJAYYA, Auteur ; Chirag Kamal AHUJA, Auteur ; Kamakshi KARTIK, Auteur ; Ghattu KRISHNAVENI, Auteur ; Rebecca KURIYAN, Auteur ; Sunita Simon KURPAD, Auteur ; Sylvane DESRIVIERES, Auteur ; Udita IYENGAR, Auteur ; Yuning ZHANG, Auteur ; Matthew HICKMAN, Auteur ; Alex SPIERS, Auteur ; Mireille TOLEDANO, Auteur ; Gunter SCHUMANN, Auteur ; Vivek BENEGAL, Auteur Article en page(s) : p.800-808 Langues : Anglais (eng) Mots-clés : childhood experience  India  psychopathology  social deprivation  trauma Index. décimale : PER Périodiques Résumé : Developmental adversities early in life are associated with later psychopathology. Clustering may be a useful approach to group multiple diverse risks together and study their relation with psychopathology. To generate risk clusters of children, adolescents, and young adults, based on adverse environmental exposure and developmental characteristics, and to examine the association of risk clusters with manifest psychopathology. Participants (n = 8300) between 6 and 23 years were recruited from seven sites in India. We administered questionnaires to elicit history of previous exposure to adverse childhood environments, family history of psychiatric disorders in first-degree relatives, and a range of antenatal and postnatal adversities. We used these variables to generate risk clusters. Mini-International Neuropsychiatric Interview-5 was administered to evaluate manifest psychopathology. Two-step cluster analysis revealed two clusters designated as high-risk cluster (HRC) and low-risk cluster (LRC), comprising 4197 (50.5%) and 4103 (49.5%) participants, respectively. HRC had higher frequencies of family history of mental illness, antenatal and neonatal risk factors, developmental delays, history of migration, and exposure to adverse childhood experiences than LRC. There were significantly higher risks of any psychiatric disorder [Relative Risk (RR) = 2.0, 95% CI 1.8-2.3], externalizing (RR = 4.8, 95% CI 3.6-6.4) and internalizing disorders (RR = 2.6, 95% CI 2.2-2.9), and suicidality (2.3, 95% CI 1.8-2.8) in HRC. Social-environmental and developmental factors could classify Indian children, adolescents and young adults into homogeneous clusters at high or low risk of psychopathology. These biopsychosocial determinants of mental health may have practice, policy and research implications for people in low- and middle-income countries. En ligne : http://dx.doi.org/10.1017/S0954579422000050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Risk clustering and psychopathology from a multi-center cohort of Indian children, adolescents, and young adults [texte imprimé] / Debasish BASU, Auteur ; Abhishek GHOSH, Auteur ; Chandrima NASKAR, Auteur ; Srinivas BALACHANDER, Auteur ; Gwen FERNANDES, Auteur ; Nilakshi VAIDYA, Auteur ; Kalyanaraman KUMARAN, Auteur ; Murali KRISHNA, Auteur ; Gareth J. BARKER, Auteur ; Eesha SHARMA, Auteur ; Pratima MURTHY, Auteur ; Bharath HOLLA, Auteur ; Sanjeev JAIN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Kartik KALYANRAM, Auteur ; Meera PURUSHOTTAM, Auteur ; Rose Dawn BHARATH, Auteur ; Mathew VARGHESE, Auteur ; Kandavel THENNARASU, Auteur ; Amit CHAKRABARTI, Auteur ; Rajkumar Lenin SINGH, Auteur ; Roshan Lourembam SINGH, Auteur ; Subodh Bhagyalakshmi NANJAYYA, Auteur ; Chirag Kamal AHUJA, Auteur ; Kamakshi KARTIK, Auteur ; Ghattu KRISHNAVENI, Auteur ; Rebecca KURIYAN, Auteur ; Sunita Simon KURPAD, Auteur ; Sylvane DESRIVIERES, Auteur ; Udita IYENGAR, Auteur ; Yuning ZHANG, Auteur ; Matthew HICKMAN, Auteur ; Alex SPIERS, Auteur ; Mireille TOLEDANO, Auteur ; Gunter SCHUMANN, Auteur ; Vivek BENEGAL, Auteur . - p.800-808. Langues : Anglais (eng) in Development and Psychopathology > 35-2 (May 2023) . - p.800-808 Mots-clés : childhood experience  India  psychopathology  social deprivation  trauma Index. décimale : PER Périodiques Résumé : Developmental adversities early in life are associated with later psychopathology. Clustering may be a useful approach to group multiple diverse risks together and study their relation with psychopathology. To generate risk clusters of children, adolescents, and young adults, based on adverse environmental exposure and developmental characteristics, and to examine the association of risk clusters with manifest psychopathology. Participants (n = 8300) between 6 and 23 years were recruited from seven sites in India. We administered questionnaires to elicit history of previous exposure to adverse childhood environments, family history of psychiatric disorders in first-degree relatives, and a range of antenatal and postnatal adversities. We used these variables to generate risk clusters. Mini-International Neuropsychiatric Interview-5 was administered to evaluate manifest psychopathology. Two-step cluster analysis revealed two clusters designated as high-risk cluster (HRC) and low-risk cluster (LRC), comprising 4197 (50.5%) and 4103 (49.5%) participants, respectively. HRC had higher frequencies of family history of mental illness, antenatal and neonatal risk factors, developmental delays, history of migration, and exposure to adverse childhood experiences than LRC. There were significantly higher risks of any psychiatric disorder [Relative Risk (RR) = 2.0, 95% CI 1.8-2.3], externalizing (RR = 4.8, 95% CI 3.6-6.4) and internalizing disorders (RR = 2.6, 95% CI 2.2-2.9), and suicidality (2.3, 95% CI 1.8-2.8) in HRC. Social-environmental and developmental factors could classify Indian children, adolescents and young adults into homogeneous clusters at high or low risk of psychopathology. These biopsychosocial determinants of mental health may have practice, policy and research implications for people in low- and middle-income countries. En ligne : http://dx.doi.org/10.1017/S0954579422000050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

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