Broader autism phenotype as a risk factor for postpartum depression: Hamamatsu Birth Cohort (HBC) Study / Ryosuke ASANO in Research in Autism Spectrum Disorders, 8-12 (December 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-12 (December 2014) . - p.1672-1678 Titre : Broader autism phenotype as a risk factor for postpartum depression: Hamamatsu Birth Cohort (HBC) Study Type de document : Texte imprimé et/ou numérique Auteurs : Ryosuke ASANO, Auteur ; Kenji J. TSUCHIYA, Auteur ; Nori TAKEI, Auteur ; Taeko HARADA, Auteur ; Yumeno KUGIZAKI, Auteur ; Ryuji NAKAHARA, Auteur ; Chikako NAKAYASU, Auteur ; Akemi OKUMURA, Auteur ; Yukiko SUZUKI, Auteur ; Shu TAKAGAI, Auteur ; Norio MORI, Auteur Article en page(s) : p.1672-1678 Langues : Anglais (eng) Mots-clés : Postpartum depression  Broader autism phenotype  Epidemiology  Birth cohort  Pregnant women  Japan. Index. décimale : PER Périodiques Résumé : Abstract The broader autism phenotype (BAP), which refers to the expression of behavioral and cognitive propensities that are milder but qualitatively similar to those defining autism spectrum disorder, can play a crucial role in postpartum depression (PPD). We investigated whether pregnant women's BAP would increase the risk for PPD, using a representative birth cohort in Japan. Pregnant women were enrolled in the Hamamatsu Birth Cohort (HBC) Study during their mid-gestation (N = 841) and were followed up until 3 months after delivery. BAP was measured mainly during the 2nd trimester of the pregnancy by using the Broader Phenotype Autism Symptoms Scale. Participants scoring 9 points or higher on the Edinburgh Postnatal Depression Scale at least once during the first 3 months after childbirth were diagnosed with PPD. Among participants, 128 (15.2%) women were found to have PPD. Multiple logistic regression analyses showed that BAP were associated with PPD (OR = 1.19, 95% CI [1.07–1.31]), even after controlling for other potential confounders. In addition, the association was not moderated by history of depression and/or anxiety disorders, including concurrent depressive and anxiety symptoms during pregnancy. The findings suggest that pregnant women with BAP have an elevated risk for PPD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.08.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Broader autism phenotype as a risk factor for postpartum depression: Hamamatsu Birth Cohort (HBC) Study [Texte imprimé et/ou numérique] / Ryosuke ASANO, Auteur ; Kenji J. TSUCHIYA, Auteur ; Nori TAKEI, Auteur ; Taeko HARADA, Auteur ; Yumeno KUGIZAKI, Auteur ; Ryuji NAKAHARA, Auteur ; Chikako NAKAYASU, Auteur ; Akemi OKUMURA, Auteur ; Yukiko SUZUKI, Auteur ; Shu TAKAGAI, Auteur ; Norio MORI, Auteur . - p.1672-1678. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-12 (December 2014) . - p.1672-1678 Mots-clés : Postpartum depression  Broader autism phenotype  Epidemiology  Birth cohort  Pregnant women  Japan. Index. décimale : PER Périodiques Résumé : Abstract The broader autism phenotype (BAP), which refers to the expression of behavioral and cognitive propensities that are milder but qualitatively similar to those defining autism spectrum disorder, can play a crucial role in postpartum depression (PPD). We investigated whether pregnant women's BAP would increase the risk for PPD, using a representative birth cohort in Japan. Pregnant women were enrolled in the Hamamatsu Birth Cohort (HBC) Study during their mid-gestation (N = 841) and were followed up until 3 months after delivery. BAP was measured mainly during the 2nd trimester of the pregnancy by using the Broader Phenotype Autism Symptoms Scale. Participants scoring 9 points or higher on the Edinburgh Postnatal Depression Scale at least once during the first 3 months after childbirth were diagnosed with PPD. Among participants, 128 (15.2%) women were found to have PPD. Multiple logistic regression analyses showed that BAP were associated with PPD (OR = 1.19, 95% CI [1.07–1.31]), even after controlling for other potential confounders. In addition, the association was not moderated by history of depression and/or anxiety disorders, including concurrent depressive and anxiety symptoms during pregnancy. The findings suggest that pregnant women with BAP have an elevated risk for PPD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.08.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism / Shiro SUDA in Molecular Autism, (August 2011)  

Public ISBD [article]  inMolecular Autism > (August 2011) . - 5 p. Titre : Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism Type de document : Texte imprimé et/ou numérique Auteurs : Shiro SUDA, Auteur ; Keiko IWATA, Auteur ; Chie SHIMMURA, Auteur ; Yosuke KAMENO, Auteur ; Ayyappan ANITHA, Auteur ; Ismail THANSEEM, Auteur ; Kazuhiko NAKAMURA, Auteur ; Hideo MATSUZAKI, Auteur ; Kenji J. TSUCHIYA, Auteur ; Genichi SUGIHARA, Auteur ; Yasuhide IWATA, Auteur ; Katsuaki SUZUKI, Auteur ; Keita KOIZUMI, Auteur ; Haruhiro HIGASHIDA, Auteur ; Nori TAKEI, Auteur ; Norio MORI, Auteur Année de publication : 2011 Article en page(s) : 5 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND:Axon-guidance proteins play a crucial role in brain development. As the dysfunction of axon-guidance signaling is thought to underlie the microstructural abnormalities of the brain in people with autism, we examined the postmortem brains of people with autism to identify any changes in the expression of axon-guidance proteins.RESULTS:The mRNA and protein expression of axon-guidance proteins, including ephrin (EFN)A4, eEFNB3, plexin (PLXN)A4, roundabout 2 (ROBO)2 and ROBO3, were examined in the anterior cingulate cortex and primary motor cortex of autistic brains (n = 8 and n = 7, respectively) and control brains (n = 13 and n = 8, respectively) using real-time reverse-transcriptase PCR (RT-PCR) and western blotting. Real-time RT-PCR revealed that the relative expression levels of EFNB3, PLXNA4A and ROBO2 were significantly lower in the autistic group than in the control group. The protein levels of these three genes were further analyzed by western blotting, which showed that the immunoreactive values for PLXNA4 and ROBO2, but not for EFNB3, were significantly reduced in the ACC of the autistic brains compared with control brains.CONCLUSIONS:In this study, we found decreased expression of axon-guidance proteins such as PLXNA4 and ROBO2 in the brains of people with autism, and suggest that dysfunctional axon-guidance protein expression may play an important role in the pathophysiology of autism. En ligne : http://dx.doi.org/10.1186/2040-2392-2-14 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149 [article] Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism [Texte imprimé et/ou numérique] / Shiro SUDA, Auteur ; Keiko IWATA, Auteur ; Chie SHIMMURA, Auteur ; Yosuke KAMENO, Auteur ; Ayyappan ANITHA, Auteur ; Ismail THANSEEM, Auteur ; Kazuhiko NAKAMURA, Auteur ; Hideo MATSUZAKI, Auteur ; Kenji J. TSUCHIYA, Auteur ; Genichi SUGIHARA, Auteur ; Yasuhide IWATA, Auteur ; Katsuaki SUZUKI, Auteur ; Keita KOIZUMI, Auteur ; Haruhiro HIGASHIDA, Auteur ; Nori TAKEI, Auteur ; Norio MORI, Auteur . - 2011 . - 5 p. Langues : Anglais (eng) in Molecular Autism > (August 2011) . - 5 p. Index. décimale : PER Périodiques Résumé : BACKGROUND:Axon-guidance proteins play a crucial role in brain development. As the dysfunction of axon-guidance signaling is thought to underlie the microstructural abnormalities of the brain in people with autism, we examined the postmortem brains of people with autism to identify any changes in the expression of axon-guidance proteins.RESULTS:The mRNA and protein expression of axon-guidance proteins, including ephrin (EFN)A4, eEFNB3, plexin (PLXN)A4, roundabout 2 (ROBO)2 and ROBO3, were examined in the anterior cingulate cortex and primary motor cortex of autistic brains (n = 8 and n = 7, respectively) and control brains (n = 13 and n = 8, respectively) using real-time reverse-transcriptase PCR (RT-PCR) and western blotting. Real-time RT-PCR revealed that the relative expression levels of EFNB3, PLXNA4A and ROBO2 were significantly lower in the autistic group than in the control group. The protein levels of these three genes were further analyzed by western blotting, which showed that the immunoreactive values for PLXNA4 and ROBO2, but not for EFNB3, were significantly reduced in the ACC of the autistic brains compared with control brains.CONCLUSIONS:In this study, we found decreased expression of axon-guidance proteins such as PLXNA4 and ROBO2 in the brains of people with autism, and suggest that dysfunctional axon-guidance protein expression may play an important role in the pathophysiology of autism. En ligne : http://dx.doi.org/10.1186/2040-2392-2-14 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149

Distinguishing Broad Autism Phenotype from Schizophrenia-Spectrum Disorders / Genichi SUGIHARA in Journal of Autism and Developmental Disorders, 38-10 (November 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1998-1999 Titre : Distinguishing Broad Autism Phenotype from Schizophrenia-Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Genichi SUGIHARA, Auteur ; Kenji J. TSUCHIYA, Auteur ; Nori TAKEI, Auteur Année de publication : 2008 Article en page(s) : p.1998-1999 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-008-0638-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=642 [article] Distinguishing Broad Autism Phenotype from Schizophrenia-Spectrum Disorders [Texte imprimé et/ou numérique] / Genichi SUGIHARA, Auteur ; Kenji J. TSUCHIYA, Auteur ; Nori TAKEI, Auteur . - 2008 . - p.1998-1999. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1998-1999 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-008-0638-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=642

Reliability and Validity of Autism Diagnostic Interview-Revised, Japanese Version / Kenji J. TSUCHIYA in Journal of Autism and Developmental Disorders, 43-3 (March 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-3 (March 2013) . - p.643-662 Titre : Reliability and Validity of Autism Diagnostic Interview-Revised, Japanese Version Type de document : Texte imprimé et/ou numérique Auteurs : Kenji J. TSUCHIYA, Auteur ; Kaori MATSUMOTO, Auteur ; Atsuko YAGI, Auteur ; Naoko INADA, Auteur ; Miho KURODA, Auteur ; Eiko INOKUCHI, Auteur ; Tomonori KOYAMA, Auteur ; Yoko KAMIO, Auteur ; Masatsugu TSUJII, Auteur ; Saeko SAKAI, Auteur ; Ikuko MOHRI, Auteur ; Masako TANIIKE, Auteur ; Ryoichiro IWANAGA, Auteur ; Kei OGASAHARA, Auteur ; Taishi MIYACHI, Auteur ; Shunji NAKAJIMA, Auteur ; Iori TANI, Auteur ; Masafumi OHNISHI, Auteur ; Masahiko INOUE, Auteur ; Kazuyo NOMURA, Auteur ; Taku HAGIWARA, Auteur ; Tokio UCHIYAMA, Auteur ; Hironobu ICHIKAWA, Auteur ; Shuji KOBAYASHI, Auteur ; Ken MIYAMOTO, Auteur ; Kazuhiko NAKAMURA, Auteur ; Katsuaki SUZUKI, Auteur ; Norio MORI, Auteur ; Nori TAKEI, Auteur Article en page(s) : p.643-662 Langues : Anglais (eng) Mots-clés : Autism  ADI-R  Reliability  Validity  Japan Index. décimale : PER Périodiques Résumé : To examine the inter-rater reliability of Autism Diagnostic Interview-Revised, Japanese Version (ADI-R-JV), the authors recruited 51 individuals aged 3–19 years, interviewed by two independent raters. Subsequently, to assess the discriminant and diagnostic validity of ADI-R-JV, the authors investigated 317 individuals aged 2–19 years, who were divided into three diagnostic groups as follows: autistic disorder (AD), pervasive developmental disorder not otherwise specified, and other psychiatric diagnosis or no diagnosis, according to the consensus clinical diagnosis. As regards inter-rater reliability, intraclass correlation coefficients of greater than 0.80 were obtained for all three domains of ADI-R-JV. As regards discriminant validity, the mean scores of the three domains was significantly higher in individuals with AD than in those of other diagnostic groups. As regards diagnostic validity, sensitivity and specificity for correctly diagnosing AD were 0.92 and 0.89, respectively, but sensitivity was 0.55 for individuals younger than 5 years. Specificity was consistently high regardless of age and intelligence. ADI-R-JV was shown to be a reliable tool, and has sufficient discriminant validity and satisfactory diagnostic validity for correctly diagnosing AD, although the diagnostic validity appeared to be compromised with respect to the diagnosis of younger individuals. En ligne : http://dx.doi.org/10.1007/s10803-012-1606-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192 [article] Reliability and Validity of Autism Diagnostic Interview-Revised, Japanese Version [Texte imprimé et/ou numérique] / Kenji J. TSUCHIYA, Auteur ; Kaori MATSUMOTO, Auteur ; Atsuko YAGI, Auteur ; Naoko INADA, Auteur ; Miho KURODA, Auteur ; Eiko INOKUCHI, Auteur ; Tomonori KOYAMA, Auteur ; Yoko KAMIO, Auteur ; Masatsugu TSUJII, Auteur ; Saeko SAKAI, Auteur ; Ikuko MOHRI, Auteur ; Masako TANIIKE, Auteur ; Ryoichiro IWANAGA, Auteur ; Kei OGASAHARA, Auteur ; Taishi MIYACHI, Auteur ; Shunji NAKAJIMA, Auteur ; Iori TANI, Auteur ; Masafumi OHNISHI, Auteur ; Masahiko INOUE, Auteur ; Kazuyo NOMURA, Auteur ; Taku HAGIWARA, Auteur ; Tokio UCHIYAMA, Auteur ; Hironobu ICHIKAWA, Auteur ; Shuji KOBAYASHI, Auteur ; Ken MIYAMOTO, Auteur ; Kazuhiko NAKAMURA, Auteur ; Katsuaki SUZUKI, Auteur ; Norio MORI, Auteur ; Nori TAKEI, Auteur . - p.643-662. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-3 (March 2013) . - p.643-662 Mots-clés : Autism  ADI-R  Reliability  Validity  Japan Index. décimale : PER Périodiques Résumé : To examine the inter-rater reliability of Autism Diagnostic Interview-Revised, Japanese Version (ADI-R-JV), the authors recruited 51 individuals aged 3–19 years, interviewed by two independent raters. Subsequently, to assess the discriminant and diagnostic validity of ADI-R-JV, the authors investigated 317 individuals aged 2–19 years, who were divided into three diagnostic groups as follows: autistic disorder (AD), pervasive developmental disorder not otherwise specified, and other psychiatric diagnosis or no diagnosis, according to the consensus clinical diagnosis. As regards inter-rater reliability, intraclass correlation coefficients of greater than 0.80 were obtained for all three domains of ADI-R-JV. As regards discriminant validity, the mean scores of the three domains was significantly higher in individuals with AD than in those of other diagnostic groups. As regards diagnostic validity, sensitivity and specificity for correctly diagnosing AD were 0.92 and 0.89, respectively, but sensitivity was 0.55 for individuals younger than 5 years. Specificity was consistently high regardless of age and intelligence. ADI-R-JV was shown to be a reliable tool, and has sufficient discriminant validity and satisfactory diagnostic validity for correctly diagnosing AD, although the diagnostic validity appeared to be compromised with respect to the diagnosis of younger individuals. En ligne : http://dx.doi.org/10.1007/s10803-012-1606-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192

---

1 (1 - 4 / 4)