Protein Kinase A in neurological disorders / Alexander G.P. GLEBOV-MCCLOUD in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Protein Kinase A in neurological disorders Type de document : texte imprimé Auteurs : Alexander G.P. GLEBOV-MCCLOUD, Auteur ; Walter S. SAIDE, Auteur ; Marie E. GAINE, Auteur ; Stefan STRACK, Auteur Langues : Anglais (eng) Mots-clés : Humans  Cyclic AMP-Dependent Protein Kinases/genetics/metabolism  Phosphorylation  Signal Transduction  Nervous System Diseases  Creb  Cognition  Endocrine Systems  Gene transcription  Kinases  Learning  Mapk  Memory  Metabolic Disorders  Movement Disorders  Neurodegeneration  Neurodevelopment  Pka  Protein phosphorylation  cAMP Index. décimale : PER Périodiques Résumé : Cyclic adenosine 3', 5' monophosphate (cAMP)-dependent Protein Kinase A (PKA) is a multi-functional serine/threonine kinase that regulates a wide variety of physiological processes including gene transcription, metabolism, and synaptic plasticity. Genomic sequencing studies have identified both germline and somatic variants of the catalytic and regulatory subunits of PKA in patients with metabolic and neurodevelopmental disorders. In this review we discuss the classical cAMP/PKA signaling pathway and the disease phenotypes that result from PKA variants. This review highlights distinct isoform-specific cognitive deficits that occur in both PKA catalytic and regulatory subunits, and how tissue-specific distribution of these isoforms may contribute to neurodevelopmental disorders in comparison to more generalized endocrine dysfunction. En ligne : https://dx.doi.org/10.1186/s11689-024-09525-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Protein Kinase A in neurological disorders [texte imprimé] / Alexander G.P. GLEBOV-MCCLOUD, Auteur ; Walter S. SAIDE, Auteur ; Marie E. GAINE, Auteur ; Stefan STRACK, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Cyclic AMP-Dependent Protein Kinases/genetics/metabolism  Phosphorylation  Signal Transduction  Nervous System Diseases  Creb  Cognition  Endocrine Systems  Gene transcription  Kinases  Learning  Mapk  Memory  Metabolic Disorders  Movement Disorders  Neurodegeneration  Neurodevelopment  Pka  Protein phosphorylation  cAMP Index. décimale : PER Périodiques Résumé : Cyclic adenosine 3', 5' monophosphate (cAMP)-dependent Protein Kinase A (PKA) is a multi-functional serine/threonine kinase that regulates a wide variety of physiological processes including gene transcription, metabolism, and synaptic plasticity. Genomic sequencing studies have identified both germline and somatic variants of the catalytic and regulatory subunits of PKA in patients with metabolic and neurodevelopmental disorders. In this review we discuss the classical cAMP/PKA signaling pathway and the disease phenotypes that result from PKA variants. This review highlights distinct isoform-specific cognitive deficits that occur in both PKA catalytic and regulatory subunits, and how tissue-specific distribution of these isoforms may contribute to neurodevelopmental disorders in comparison to more generalized endocrine dysfunction. En ligne : https://dx.doi.org/10.1186/s11689-024-09525-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

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