Aberrant Neural Entrainment to Word-Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit / Laura J. BATTERINK in Autism Research, 19-8 (August 2026)  

Public ISBD [article]  inAutism Research > 19-8 (August 2026) . - p.e70312 Titre : Aberrant Neural Entrainment to Word-Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit Type de document : texte imprimé Auteurs : Laura J. BATTERINK, Auteur ; Yanchen LIU, Auteur ; Grace WESTERKAMP, Auteur ; Jae CITARELLA, Auteur ; Peyton SIEKIERSKI, Auteur ; Lynxie VOORHEES, Auteur ; Lauren E. ETHRIDGE, Auteur ; Elizabeth SMITH, Auteur ; Rana ELMAGHRABY, Auteur ; Craig A. ERICKSON, Auteur ; Zag ELSAYED, Auteur ; Anubhuti GOEL, Auteur ; Steve W. WU, Auteur ; Ernest V. PEDAPATI, Auteur Article en page(s) : p.e70312 Langues : Anglais (eng) Mots-clés : auditory processing  EEG  electroencephalography  fragile X syndrome  language development  neural entrainment  statistical learning Index. décimale : PER Périodiques Résumé : ABSTRACT Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism spectrum disorder, causes significant language and cognitive impairments. Statistical learning refers to the ability to extract patterns from sensory input through mere exposure and plays a central role in language acquisition. Surprisingly, statistical learning in FXS has not been explored. Given that children with FXS typically follow a delayed developmental trajectory for language, we hypothesized that they would show impaired statistical learning. To test this hypothesis, we used an EEG measure of neural entrainment to index statistical learning of hidden trisyllabic words within a continuous speech stream in children with FXS (n?=?17) and in typically developing controls (n?=?31). Children with FXS showed significantly reduced neural entrainment to words compared to controls, particularly in the superior temporal gyrus and transverse temporal gyrus (primary auditory cortex), providing evidence of statistical learning impairment. Notably, syllable-level entrainment was preserved or even enhanced in FXS, indicating that word-level deficits cannot be attributed to general auditory processing impairments. In addition, while typically developing controls showed an increase in word-level entrainment over the course of learning, children with FXS failed to show a similar increase over time. Taken together, this pattern of results demonstrates that children with FXS can process rapid, lower-order acoustic structure but struggle to integrate these syllables into longer, chunk-like word representations. Overall, these findings suggest that statistical learning is impaired in FXS and also suggest neural entrainment to statistical structure as a potential therapeutic target. En ligne : https://doi.org/10.1002/aur.70312 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] Aberrant Neural Entrainment to Word-Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit [texte imprimé] / Laura J. BATTERINK, Auteur ; Yanchen LIU, Auteur ; Grace WESTERKAMP, Auteur ; Jae CITARELLA, Auteur ; Peyton SIEKIERSKI, Auteur ; Lynxie VOORHEES, Auteur ; Lauren E. ETHRIDGE, Auteur ; Elizabeth SMITH, Auteur ; Rana ELMAGHRABY, Auteur ; Craig A. ERICKSON, Auteur ; Zag ELSAYED, Auteur ; Anubhuti GOEL, Auteur ; Steve W. WU, Auteur ; Ernest V. PEDAPATI, Auteur . - p.e70312. Langues : Anglais (eng) in Autism Research > 19-8 (August 2026) . - p.e70312 Mots-clés : auditory processing  EEG  electroencephalography  fragile X syndrome  language development  neural entrainment  statistical learning Index. décimale : PER Périodiques Résumé : ABSTRACT Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism spectrum disorder, causes significant language and cognitive impairments. Statistical learning refers to the ability to extract patterns from sensory input through mere exposure and plays a central role in language acquisition. Surprisingly, statistical learning in FXS has not been explored. Given that children with FXS typically follow a delayed developmental trajectory for language, we hypothesized that they would show impaired statistical learning. To test this hypothesis, we used an EEG measure of neural entrainment to index statistical learning of hidden trisyllabic words within a continuous speech stream in children with FXS (n?=?17) and in typically developing controls (n?=?31). Children with FXS showed significantly reduced neural entrainment to words compared to controls, particularly in the superior temporal gyrus and transverse temporal gyrus (primary auditory cortex), providing evidence of statistical learning impairment. Notably, syllable-level entrainment was preserved or even enhanced in FXS, indicating that word-level deficits cannot be attributed to general auditory processing impairments. In addition, while typically developing controls showed an increase in word-level entrainment over the course of learning, children with FXS failed to show a similar increase over time. Taken together, this pattern of results demonstrates that children with FXS can process rapid, lower-order acoustic structure but struggle to integrate these syllables into longer, chunk-like word representations. Overall, these findings suggest that statistical learning is impaired in FXS and also suggest neural entrainment to statistical structure as a potential therapeutic target. En ligne : https://doi.org/10.1002/aur.70312 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

Learning impairments in Fmr1(-/-)mice on an audio-visual temporal pattern discrimination task / William MOL in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Learning impairments in Fmr1(-/-)mice on an audio-visual temporal pattern discrimination task Type de document : texte imprimé Auteurs : William MOL, Auteur ; Sam POST, Auteur ; Megan LEE, Auteur ; Ritika THAPA, Auteur ; Michael ERICKSON, Auteur ; Anubhuti GOEL, Auteur Langues : Anglais (eng) Mots-clés : Animals  Fragile X Mental Retardation Protein/genetics  Mice  Male  Fragile X Syndrome/genetics/physiopathology  Disease Models, Animal  Mice, Knockout  Auditory Perception/physiology  Mice, Inbred C57BL  Learning Disabilities/genetics/physiopathology  Discrimination Learning/physiology  Time Perception/physiology  Acoustic Stimulation  Discrimination, Psychological/physiology  Visual Perception/physiology  Photic Stimulation Index. décimale : PER Périodiques Résumé : Estimating time and making predictions is integral to our experience of the world. Given the importance of timing to most behaviors, disruptions in temporal processing and timed performance are reported in a number of neuropsychiatric disorders such as Schizophrenia, Autism Spectrum Disorder (ASD), Fragile X Syndrome (FXS), and Attention-deficit Hyperactivity Disorder (ADHD). Symptoms that implicitly include disruption in timing are atypical turn-taking during social interactions, unusual verbal intonations, poor reading, speech and language skills, inattention, delays in learning, and difficulties making predictions. Currently, there are no viable treatments for these symptoms, the reason being the underlying neural dysfunction that contributes to timing deficits in neuropsychiatric disorders is unknown. To address this unknown, we have designed a novel Temporal Pattern Sensory Discrimination Task (TPSD) for awake-behaving mice. Stimuli consist of paired audiovisual stimuli that differ in duration. Compared to Wild-Type (WT) mice, Fmr1(-/-) mice, a well-established mouse model of FXS, showed significant impairment in learning the TPSD task, as evidenced by reduced discriminability indices and atypical licking patterns. Often sensory information is multimodal and, indeed, studies show that learning in humans and rodents improves with multimodal stimuli than with unimodal stimuli. To test how the multimodal nature of stimuli impacted performance of Fmr1(-/-) mice, following training on the audiovisual stimuli, we tested mice on audio-only or visual-only stimuli. While WT mice showed significant disruption in performance when tested on unimodal stimuli, Fmr1(-/-) mice displayed equivalent performance on visual-only stimuli when compared to the multimodal task. Our novel task captures timing difficulties and multisensory integration issues in Fmr1(-/-) mice and provides an assay to examine the associated neural dysfunction. En ligne : https://dx.doi.org/10.1186/s11689-025-09638-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Learning impairments in Fmr1(-/-)mice on an audio-visual temporal pattern discrimination task [texte imprimé] / William MOL, Auteur ; Sam POST, Auteur ; Megan LEE, Auteur ; Ritika THAPA, Auteur ; Michael ERICKSON, Auteur ; Anubhuti GOEL, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Animals  Fragile X Mental Retardation Protein/genetics  Mice  Male  Fragile X Syndrome/genetics/physiopathology  Disease Models, Animal  Mice, Knockout  Auditory Perception/physiology  Mice, Inbred C57BL  Learning Disabilities/genetics/physiopathology  Discrimination Learning/physiology  Time Perception/physiology  Acoustic Stimulation  Discrimination, Psychological/physiology  Visual Perception/physiology  Photic Stimulation Index. décimale : PER Périodiques Résumé : Estimating time and making predictions is integral to our experience of the world. Given the importance of timing to most behaviors, disruptions in temporal processing and timed performance are reported in a number of neuropsychiatric disorders such as Schizophrenia, Autism Spectrum Disorder (ASD), Fragile X Syndrome (FXS), and Attention-deficit Hyperactivity Disorder (ADHD). Symptoms that implicitly include disruption in timing are atypical turn-taking during social interactions, unusual verbal intonations, poor reading, speech and language skills, inattention, delays in learning, and difficulties making predictions. Currently, there are no viable treatments for these symptoms, the reason being the underlying neural dysfunction that contributes to timing deficits in neuropsychiatric disorders is unknown. To address this unknown, we have designed a novel Temporal Pattern Sensory Discrimination Task (TPSD) for awake-behaving mice. Stimuli consist of paired audiovisual stimuli that differ in duration. Compared to Wild-Type (WT) mice, Fmr1(-/-) mice, a well-established mouse model of FXS, showed significant impairment in learning the TPSD task, as evidenced by reduced discriminability indices and atypical licking patterns. Often sensory information is multimodal and, indeed, studies show that learning in humans and rodents improves with multimodal stimuli than with unimodal stimuli. To test how the multimodal nature of stimuli impacted performance of Fmr1(-/-) mice, following training on the audiovisual stimuli, we tested mice on audio-only or visual-only stimuli. While WT mice showed significant disruption in performance when tested on unimodal stimuli, Fmr1(-/-) mice displayed equivalent performance on visual-only stimuli when compared to the multimodal task. Our novel task captures timing difficulties and multisensory integration issues in Fmr1(-/-) mice and provides an assay to examine the associated neural dysfunction. En ligne : https://dx.doi.org/10.1186/s11689-025-09638-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

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