Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation / Takashi YAMADA in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 41p. Titre : Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation Type de document : texte imprimé Auteurs : Takashi YAMADA, Auteur ; Takashi ITAHASHI, Auteur ; Motoaki NAKAMURA, Auteur ; Hiromi WATANABE, Auteur ; Miho KURODA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur Article en page(s) : 41p. Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/diagnostic imaging/pathology/physiopathology  Brain Mapping/methods  Case-Control Studies  Cerebral Cortex/diagnostic imaging/pathology/physiopathology  Cluster Analysis  Functional Laterality  Humans  Image Interpretation, Computer-Assisted  Magnetic Resonance Imaging  Male  Middle Aged  Nerve Net/diagnostic imaging/pathology/physiopathology  Neural Pathways/diagnostic imaging/pathology/physiopathology  Autism spectrum disorder  Connectivity-based functional parcellation  Insula  Resting-state functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: The insular cortex comprises multiple functionally differentiated sub-regions, each of which has different patterns of connectivity with other brain regions. Such diverse connectivity patterns are thought to underlie a wide range of insular functions, including cognitive, affective, and sensorimotor processing, many of which are abnormal in autism spectrum disorder (ASD). Although past neuroimaging studies of ASD have shown structural and functional abnormalities in the insula, possible alterations in the sub-regional organization of the insula and the functional characteristics of each sub-region have not been examined in the ASD brain. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 36 adult males with ASD and 38 matched typically developed (TD) controls. A data-driven clustering analysis was applied to rs-fMRI data of voxels in the left and right insula to automatically group voxels with similar intrinsic connectivity pattern into a cluster. After determining the optimal number of clusters based on information theoretic measures of variation of information and mutual information, functional parcellation patterns in both the left and the right insula were compared between the TD and ASD groups. Furthermore, functional profiles of each sub-region were meta-analytically decoded using Neurosynth and were compared between the groups. RESULTS: We observed notable alterations in the anterior sector of the left insula and the middle ventral sub-region of the right insula in the ASD brain. Meta-analytic decoding revealed that whereas the anterior sector of the left insula contained two functionally differentiated sub-regions for cognitive, sensorimotor, and emotional/affective functions in TD brain, only a single functional cluster for cognitive and sensorimotor functions was identified in the anterior sector in the ASD brain. In the right insula, the middle ventral sub-region, which is primarily specialized for sensory- and auditory-related functions, showed a significant volumetric increase in the ASD brain compared with the TD brain. CONCLUSIONS: The results indicate an altered organization of sub-regions in specific parts of the left and right insula of the ASD brain. The alterations in the left and right insula may constitute neural substrates underlying abnormalities in emotional/affective and sensory functions in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0106-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation [texte imprimé] / Takashi YAMADA, Auteur ; Takashi ITAHASHI, Auteur ; Motoaki NAKAMURA, Auteur ; Hiromi WATANABE, Auteur ; Miho KURODA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur . - 41p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 41p. Mots-clés : Adult  Autism Spectrum Disorder/diagnostic imaging/pathology/physiopathology  Brain Mapping/methods  Case-Control Studies  Cerebral Cortex/diagnostic imaging/pathology/physiopathology  Cluster Analysis  Functional Laterality  Humans  Image Interpretation, Computer-Assisted  Magnetic Resonance Imaging  Male  Middle Aged  Nerve Net/diagnostic imaging/pathology/physiopathology  Neural Pathways/diagnostic imaging/pathology/physiopathology  Autism spectrum disorder  Connectivity-based functional parcellation  Insula  Resting-state functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: The insular cortex comprises multiple functionally differentiated sub-regions, each of which has different patterns of connectivity with other brain regions. Such diverse connectivity patterns are thought to underlie a wide range of insular functions, including cognitive, affective, and sensorimotor processing, many of which are abnormal in autism spectrum disorder (ASD). Although past neuroimaging studies of ASD have shown structural and functional abnormalities in the insula, possible alterations in the sub-regional organization of the insula and the functional characteristics of each sub-region have not been examined in the ASD brain. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 36 adult males with ASD and 38 matched typically developed (TD) controls. A data-driven clustering analysis was applied to rs-fMRI data of voxels in the left and right insula to automatically group voxels with similar intrinsic connectivity pattern into a cluster. After determining the optimal number of clusters based on information theoretic measures of variation of information and mutual information, functional parcellation patterns in both the left and the right insula were compared between the TD and ASD groups. Furthermore, functional profiles of each sub-region were meta-analytically decoded using Neurosynth and were compared between the groups. RESULTS: We observed notable alterations in the anterior sector of the left insula and the middle ventral sub-region of the right insula in the ASD brain. Meta-analytic decoding revealed that whereas the anterior sector of the left insula contained two functionally differentiated sub-regions for cognitive, sensorimotor, and emotional/affective functions in TD brain, only a single functional cluster for cognitive and sensorimotor functions was identified in the anterior sector in the ASD brain. In the right insula, the middle ventral sub-region, which is primarily specialized for sensory- and auditory-related functions, showed a significant volumetric increase in the ASD brain compared with the TD brain. CONCLUSIONS: The results indicate an altered organization of sub-regions in specific parts of the left and right insula of the ASD brain. The alterations in the left and right insula may constitute neural substrates underlying abnormalities in emotional/affective and sensory functions in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0106-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Determining differences in social cognition between high-functioning autistic disorder and other pervasive developmental disorders using new advanced “mind-reading” tasks / Miho KURODA in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.554-561 Titre : Determining differences in social cognition between high-functioning autistic disorder and other pervasive developmental disorders using new advanced “mind-reading” tasks Type de document : texte imprimé Auteurs : Miho KURODA, Auteur ; Tokio UCHIYAMA, Auteur ; Akio WAKABAYASHI, Auteur ; Yuko YOSHIDA, Auteur ; Yoko KAMIO, Auteur ; Tomonori KOYAMA, Auteur Année de publication : 2011 Article en page(s) : p.554-561 Langues : Anglais (eng) Mots-clés : Mind-reading High-functioning-pervasive-developmental-disorders DSM-IV-TR Subgroup Modality Index. décimale : PER Périodiques Résumé : Deficits in understanding the mental state of others (“mind-reading”) have been well documented in individuals with pervasive developmental disorders (PDD). However, it is unclear whether this deficit in social cognition differs between the subgroups of PDD defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. In this study, PDD was divided into high-functioning autistic disorder (HFA) (n = 17) and other PDD (n = 11) consisting of Asperger's disorder (n = 8) and PDD-NOS (n = 3), and differences in mind-reading ability was examined between the two clinical groups and controls (n = 50) using a new advanced naturalistic task consisting of short scenes from a TV drama showing communication in social situations. The task was divided into visual and auditory tasks to investigate which modality was more valuable for individuals with PDD to understand the mental state of others. The results suggest that social cognition differs significantly between individuals with HFA and those with other PDD, with no difference being found between those with other PDD and controls. Neither the auditory or visual modality was found to be dominant in subjects with PDD in the mind-reading task. Taken together, complex mind-reading tasks appear to be effective for distinguishing individuals with HFA from those with other PDD. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.06.022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111 [article] Determining differences in social cognition between high-functioning autistic disorder and other pervasive developmental disorders using new advanced “mind-reading” tasks [texte imprimé] / Miho KURODA, Auteur ; Tokio UCHIYAMA, Auteur ; Akio WAKABAYASHI, Auteur ; Yuko YOSHIDA, Auteur ; Yoko KAMIO, Auteur ; Tomonori KOYAMA, Auteur . - 2011 . - p.554-561. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.554-561 Mots-clés : Mind-reading High-functioning-pervasive-developmental-disorders DSM-IV-TR Subgroup Modality Index. décimale : PER Périodiques Résumé : Deficits in understanding the mental state of others (“mind-reading”) have been well documented in individuals with pervasive developmental disorders (PDD). However, it is unclear whether this deficit in social cognition differs between the subgroups of PDD defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. In this study, PDD was divided into high-functioning autistic disorder (HFA) (n = 17) and other PDD (n = 11) consisting of Asperger's disorder (n = 8) and PDD-NOS (n = 3), and differences in mind-reading ability was examined between the two clinical groups and controls (n = 50) using a new advanced naturalistic task consisting of short scenes from a TV drama showing communication in social situations. The task was divided into visual and auditory tasks to investigate which modality was more valuable for individuals with PDD to understand the mental state of others. The results suggest that social cognition differs significantly between individuals with HFA and those with other PDD, with no difference being found between those with other PDD and controls. Neither the auditory or visual modality was found to be dominant in subjects with PDD in the mind-reading task. Taken together, complex mind-reading tasks appear to be effective for distinguishing individuals with HFA from those with other PDD. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.06.022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111

Effectiveness of Using the Modified Checklist for Autism in Toddlers in Two-Stage Screening of Autism Spectrum Disorder at the 18-Month Health Check-Up in Japan / Yoko KAMIO in Journal of Autism and Developmental Disorders, 44-1 (January 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-1 (January 2014) . - p.194-203 Titre : Effectiveness of Using the Modified Checklist for Autism in Toddlers in Two-Stage Screening of Autism Spectrum Disorder at the 18-Month Health Check-Up in Japan Type de document : texte imprimé Auteurs : Yoko KAMIO, Auteur ; Naoko INADA, Auteur ; Tomonori KOYAMA, Auteur ; Eiko INOKUCHI, Auteur ; Kenji TSUCHIYA, Auteur ; Miho KURODA, Auteur Article en page(s) : p.194-203 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Community-based surveillance  Early detection  Modified Checklist for Autism in Toddlers (M-CHAT)  Screening Index. décimale : PER Périodiques Résumé : To determine whether the Modified Checklist for Autism in Toddlers (M-CHAT) in conjunction with the routine 18-month health check-up identifies Japanese toddlers with autism spectrum disorder (ASD). Two-stage screening using the M-CHAT was conducted with 1,851 children attending the check-up. Final ASD diagnosis was confirmed at age ≥3 years. Screening identified 20/51 children with ASD: 12/20 true positives were developmentally delayed, whereas 16/22 false negatives were high-functioning. Sensitivity was 0.476, specificity 0.986, positive predictive value 0.455, and likelihood ratio 33.4 for children with ASD. With a few modifications, M-CHAT screening successfully detected toddlers with ASD with and without developmental delay and is a promising screening tool to complement existing community surveillance. En ligne : http://dx.doi.org/10.1007/s10803-013-1864-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220 [article] Effectiveness of Using the Modified Checklist for Autism in Toddlers in Two-Stage Screening of Autism Spectrum Disorder at the 18-Month Health Check-Up in Japan [texte imprimé] / Yoko KAMIO, Auteur ; Naoko INADA, Auteur ; Tomonori KOYAMA, Auteur ; Eiko INOKUCHI, Auteur ; Kenji TSUCHIYA, Auteur ; Miho KURODA, Auteur . - p.194-203. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-1 (January 2014) . - p.194-203 Mots-clés : Autism spectrum disorder  Community-based surveillance  Early detection  Modified Checklist for Autism in Toddlers (M-CHAT)  Screening Index. décimale : PER Périodiques Résumé : To determine whether the Modified Checklist for Autism in Toddlers (M-CHAT) in conjunction with the routine 18-month health check-up identifies Japanese toddlers with autism spectrum disorder (ASD). Two-stage screening using the M-CHAT was conducted with 1,851 children attending the check-up. Final ASD diagnosis was confirmed at age ≥3 years. Screening identified 20/51 children with ASD: 12/20 true positives were developmentally delayed, whereas 16/22 false negatives were high-functioning. Sensitivity was 0.476, specificity 0.986, positive predictive value 0.455, and likelihood ratio 33.4 for children with ASD. With a few modifications, M-CHAT screening successfully detected toddlers with ASD with and without developmental delay and is a promising screening tool to complement existing community surveillance. En ligne : http://dx.doi.org/10.1007/s10803-013-1864-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220

Empathizing and Systemizing in Adults with and without Autism Spectrum Conditions: Cross-Cultural Stability / Akio WAKABAYASHI in Journal of Autism and Developmental Disorders, 37-10 (November 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-10 (November 2007) . - p.1823-1832 Titre : Empathizing and Systemizing in Adults with and without Autism Spectrum Conditions: Cross-Cultural Stability Type de document : texte imprimé Auteurs : Akio WAKABAYASHI, Auteur ; Simon BARON-COHEN, Auteur ; Sally WHEELWRIGHT, Auteur ; Tokio UCHIYAMA, Auteur ; Yuko YOSHIDA, Auteur ; Miho KURODA, Auteur Année de publication : 2007 Article en page(s) : p.1823-1832 Langues : Anglais (eng) Mots-clés : Empathizing Systemizing Autism Asperger-syndrome Autism-spectrum-conditions Cognitive-style Sex-differences Index. décimale : PER Périodiques Résumé : This study tests the empathizing-systemizing (E-S) theory of sex differences and the extreme male brain (EMB) theory of autism. Three groups of participants took part: n = 48 people with autism spectrum, n = 137 general population controls, and n = 1,250 university student controls. Each participant completed the Empathy Quotient (EQ) and the Systemizing Quotient (SQ). Results: The autism spectrum condition (ASC) group scored significantly lower than controls on the EQ, and significantly higher on the SQ. Among both control groups, females scored significantly higher than males on the EQ, whilst males scored significantly higher than females on the SQ. The distribution of ‘brain types’, based on the difference between EQ and SQ scores, showed distinct profiles for people with ASC, control males and control females. En ligne : http://dx.doi.org/10.1007/s10803-006-0316-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218 [article] Empathizing and Systemizing in Adults with and without Autism Spectrum Conditions: Cross-Cultural Stability [texte imprimé] / Akio WAKABAYASHI, Auteur ; Simon BARON-COHEN, Auteur ; Sally WHEELWRIGHT, Auteur ; Tokio UCHIYAMA, Auteur ; Yuko YOSHIDA, Auteur ; Miho KURODA, Auteur . - 2007 . - p.1823-1832. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-10 (November 2007) . - p.1823-1832 Mots-clés : Empathizing Systemizing Autism Asperger-syndrome Autism-spectrum-conditions Cognitive-style Sex-differences Index. décimale : PER Périodiques Résumé : This study tests the empathizing-systemizing (E-S) theory of sex differences and the extreme male brain (EMB) theory of autism. Three groups of participants took part: n = 48 people with autism spectrum, n = 137 general population controls, and n = 1,250 university student controls. Each participant completed the Empathy Quotient (EQ) and the Systemizing Quotient (SQ). Results: The autism spectrum condition (ASC) group scored significantly lower than controls on the EQ, and significantly higher on the SQ. Among both control groups, females scored significantly higher than males on the EQ, whilst males scored significantly higher than females on the SQ. The distribution of ‘brain types’, based on the difference between EQ and SQ scores, showed distinct profiles for people with ASC, control males and control females. En ligne : http://dx.doi.org/10.1007/s10803-006-0316-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218

Objective assessment of autism spectrum disorder based on performance in structured interpersonal acting-out tasks with prosodic stability and variability / Keiko OCHI in Autism Research, 17-2 (February 2024)  

Public ISBD [article]  inAutism Research > 17-2 (February 2024) . - p.395-409 Titre : Objective assessment of autism spectrum disorder based on performance in structured interpersonal acting-out tasks with prosodic stability and variability Type de document : texte imprimé Auteurs : Keiko OCHI, Auteur ; Masaki KOJIMA, Auteur ; Nobutaka ONO, Auteur ; Miho KURODA, Auteur ; Keiho OWADA, Auteur ; Shigeki SAGAYAMA, Auteur ; Hidenori YAMASUE, Auteur Article en page(s) : p.395-409 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract In this study, we sought to objectively and quantitatively characterize the prosodic features of autism spectrum disorder (ASD) via the characteristics of prosody in a newly developed structured speech experiment. Male adults with high-functioning ASD and age/intelligence-matched men with typical development (TD) were asked to read 29 brief scripts aloud in response to preceding auditory stimuli. To investigate whether (1) highly structured acting-out tasks can uncover the prosodic of difference between those with ASD and TD, and (2) the prosodic stableness and flexibleness can be used for objective automatic assessment of ASD, we compared prosodic features such as fundamental frequency, intensity, and mora duration. The results indicate that individuals with ASD exhibit stable pitch registers or volume levels in some affective vocal-expression scenarios, such as those involving anger or sadness, compared with TD and those with TD. However, unstable prosody was observed in some timing control or emphasis tasks in the participants with ASD. Automatic classification of the ASD and TD groups using a support vector machine (SVM) with speech features exhibited an accuracy of 90.4%. A machine learning-based assessment of the degree of ASD core symptoms using support vector regression (SVR) also had good performance. These results may inform the development of a new easy-to-use assessment tool for ASD core symptoms using recorded audio signals. En ligne : https://doi.org/10.1002/aur.3080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=522 [article] Objective assessment of autism spectrum disorder based on performance in structured interpersonal acting-out tasks with prosodic stability and variability [texte imprimé] / Keiko OCHI, Auteur ; Masaki KOJIMA, Auteur ; Nobutaka ONO, Auteur ; Miho KURODA, Auteur ; Keiho OWADA, Auteur ; Shigeki SAGAYAMA, Auteur ; Hidenori YAMASUE, Auteur . - p.395-409. Langues : Anglais (eng) in Autism Research > 17-2 (February 2024) . - p.395-409 Index. décimale : PER Périodiques Résumé : Abstract In this study, we sought to objectively and quantitatively characterize the prosodic features of autism spectrum disorder (ASD) via the characteristics of prosody in a newly developed structured speech experiment. Male adults with high-functioning ASD and age/intelligence-matched men with typical development (TD) were asked to read 29 brief scripts aloud in response to preceding auditory stimuli. To investigate whether (1) highly structured acting-out tasks can uncover the prosodic of difference between those with ASD and TD, and (2) the prosodic stableness and flexibleness can be used for objective automatic assessment of ASD, we compared prosodic features such as fundamental frequency, intensity, and mora duration. The results indicate that individuals with ASD exhibit stable pitch registers or volume levels in some affective vocal-expression scenarios, such as those involving anger or sadness, compared with TD and those with TD. However, unstable prosody was observed in some timing control or emphasis tasks in the participants with ASD. Automatic classification of the ASD and TD groups using a support vector machine (SVM) with speech features exhibited an accuracy of 90.4%. A machine learning-based assessment of the degree of ASD core symptoms using support vector regression (SVR) also had good performance. These results may inform the development of a new easy-to-use assessment tool for ASD core symptoms using recorded audio signals. En ligne : https://doi.org/10.1002/aur.3080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=522

Oxytocin-induced increase in N,N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms / Yasuhiko KATO in Molecular Autism, 12 (2021)  

Permalink

Psychometric properties of the Repetitive Behavior Scale-Revised for individuals with autism spectrum disorder in Japan / Naoko INADA in Research in Autism Spectrum Disorders, 15-16 (July 2015)  

Permalink

Reliability and Validity of Autism Diagnostic Interview-Revised, Japanese Version / Kenji J. TSUCHIYA in Journal of Autism and Developmental Disorders, 43-3 (March 2013)  

Permalink

Reliability and validity of the Japanese version of the Modified Checklist for autism in toddlers (M-CHAT) / Naoko INADA in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)  

Permalink

The Autism-Spectrum Quotient (AQ) Children’s Version in Japan: A Cross-Cultural Comparison / Akio WAKABAYASHI in Journal of Autism and Developmental Disorders, 37-3 (March 2007)  

Permalink

---

1 (1 - 10 / 10) Par page : 25 50 100 200