Indirect genetic effects of siblings / Mathias VALSTAD in Journal of Child Psychology and Psychiatry, 67-8 (August 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-8 (August 2026) . - p.1269-1279 Titre : Indirect genetic effects of siblings Type de document : texte imprimé Auteurs : Mathias VALSTAD, Auteur ; Espen Moen EILERTSEN, Auteur ; Ziada AYORECH, Auteur ; Rosa CHEESMAN, Auteur ; Perline DEMANGE, Auteur ; Nikolai HAAHJEM EFTEDAL, Auteur ; Alexandra HAVDAHL, Auteur ; Eivind YSTROM, Auteur Article en page(s) : p.1269-1279 Langues : Anglais (eng) Mots-clés : ADHD  educational performance  indirect genetic effects  siblings  genome-based maximum likelihood  polygenic indices  MoBa Index. décimale : PER Périodiques Résumé : Background Within-family designs are increasingly used to decompose genotype?trait associations into direct and indirect genetic effects. Many such designs, including trio designs or within-sibship designs, assume an absence of sibling indirect genetic effects. Methods We expand two well-known molecular genetic within-family designs, one variance component (genome-based restricted maximum likelihood) and one trait-based (structural equation modeling with polygenic indices), to estimate sibling indirect genetic effects, along with direct genetic effects. We link the Norwegian Mother, Father, and Child Cohort Study (MoBa) to Norway's national education database to model genetic effects on national standardized testing results at ages 10, 13, and 14, and on parent-rated attention-deficit hyperactivity disorder (ADHD) symptoms at ages 3 and 8 in up to 15,971 genotyped and phenotyped siblings. Results Estimates of direct and indirect genetic effects from the genome-based restricted maximum likelihood and the structural equation modeling with polygenic indices approaches converge, albeit with the variance component estimates typically an order of magnitude greater than the trait-based estimates. We observe no indirect genetic effects of siblings on educational performance at any age, and only slightly negative indirect genetic effects of siblings on ADHD symptoms at age 3. We argue that the latter effect might reflect parental contrasting ratings. Conclusions The results suggest that within-family models of educational performance are unlikely to be drastically biased by an assumption of absent sibling indirect genetic effects. Combining trait-based analyses with variance component analyses can benefit understanding of indirect genetic effects, especially when the effects are not specific to a particular mechanism. En ligne : https://doi.org/10.1111/jcpp.70130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591 [article] Indirect genetic effects of siblings [texte imprimé] / Mathias VALSTAD, Auteur ; Espen Moen EILERTSEN, Auteur ; Ziada AYORECH, Auteur ; Rosa CHEESMAN, Auteur ; Perline DEMANGE, Auteur ; Nikolai HAAHJEM EFTEDAL, Auteur ; Alexandra HAVDAHL, Auteur ; Eivind YSTROM, Auteur . - p.1269-1279. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-8 (August 2026) . - p.1269-1279 Mots-clés : ADHD  educational performance  indirect genetic effects  siblings  genome-based maximum likelihood  polygenic indices  MoBa Index. décimale : PER Périodiques Résumé : Background Within-family designs are increasingly used to decompose genotype?trait associations into direct and indirect genetic effects. Many such designs, including trio designs or within-sibship designs, assume an absence of sibling indirect genetic effects. Methods We expand two well-known molecular genetic within-family designs, one variance component (genome-based restricted maximum likelihood) and one trait-based (structural equation modeling with polygenic indices), to estimate sibling indirect genetic effects, along with direct genetic effects. We link the Norwegian Mother, Father, and Child Cohort Study (MoBa) to Norway's national education database to model genetic effects on national standardized testing results at ages 10, 13, and 14, and on parent-rated attention-deficit hyperactivity disorder (ADHD) symptoms at ages 3 and 8 in up to 15,971 genotyped and phenotyped siblings. Results Estimates of direct and indirect genetic effects from the genome-based restricted maximum likelihood and the structural equation modeling with polygenic indices approaches converge, albeit with the variance component estimates typically an order of magnitude greater than the trait-based estimates. We observe no indirect genetic effects of siblings on educational performance at any age, and only slightly negative indirect genetic effects of siblings on ADHD symptoms at age 3. We argue that the latter effect might reflect parental contrasting ratings. Conclusions The results suggest that within-family models of educational performance are unlikely to be drastically biased by an assumption of absent sibling indirect genetic effects. Combining trait-based analyses with variance component analyses can benefit understanding of indirect genetic effects, especially when the effects are not specific to a particular mechanism. En ligne : https://doi.org/10.1111/jcpp.70130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=591

Multivariate maternal effects across the internalizing–externalizing spectrum in childhood: results from the Norwegian mother, father, and child cohort study / Espen Moen EILERTSEN in Journal of Child Psychology and Psychiatry, 67-7 (July 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-7 (July 2026) . - p.1040-1052 Titre : Multivariate maternal effects across the internalizing–externalizing spectrum in childhood: results from the Norwegian mother, father, and child cohort study Type de document : texte imprimé Auteurs : Espen Moen EILERTSEN, Auteur ; Nikolai HAAHJEM EFTEDAL, Auteur ; Rosa CHEESMAN, Auteur ; Ziada AYORECH, Auteur ; Joakim Coleman EBELTOFT, Auteur ; Hans Fredrik SUNDE, Auteur ; Anneli Desiré TANDBERG, Auteur ; Fartein Ask TORVIK, Auteur ; Eivind YSTROM, Auteur Article en page(s) : p.1040-1052 Langues : Anglais (eng) Mots-clés : Internalizing disorder  externalizing disorder  parenting  behavioral genetics Index. décimale : PER Périodiques Résumé : Background From a functionalist perspective, parenting behaviors have adaptive functions and are partly expressions of genetic variation. Maternal genes that have effects on children are often referred to as indirect maternal genetic effects. Indirect genetic effects provide a means for measuring the role of parenting without the need for specifying the relevant parental behaviors. We studied indirect maternal genetic effects to address both the importance and commonality of parenting across the internalizing?externalizing spectrum of behavior problems in childhood. We further addressed how indirect genetic effects impact our understanding of direct genetic effects if not accounted for. Methods Utilizing data from the Norwegian Mother, Father, and Child Cohort Study (MoBa), our analyses involved 42,423 children and their mothers. Both pedigree and genotype data were used to infer genetic relationships. We applied multivariate latent variable models to distinguish indirect maternal genetic effects and direct offspring genetic effects on seven measures of internalizing?externalizing behaviors. Results Our findings indicate significant maternal genetic influences, explaining 7%?18% of the variance across internalizing?externalizing behaviors. A general maternal effect common across behaviors could adequately account for most of the variability. The analyses further indicate that direct child genetic effects appear smaller and more complex when indirect maternal genetic effects are modeled simultaneously. Conclusions By summarizing the effects of parenting with indirect maternal genetic effects, we show a substantial contribution of parents with respect to internalizing?externalizing behaviors in childhood. Although parenting is multifaceted, the effects of parenting are general and can succinctly be described as a single common dimension. Further, our study demonstrates that direct genetic effects appear smaller and more complex when maternal genetic effects are accounted for, highlighting the confounding potential of parental effects in understanding the role of genetic differences in child psychopathology. En ligne : https://doi.org/10.1111/jcpp.70111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588 [article] Multivariate maternal effects across the internalizing–externalizing spectrum in childhood: results from the Norwegian mother, father, and child cohort study [texte imprimé] / Espen Moen EILERTSEN, Auteur ; Nikolai HAAHJEM EFTEDAL, Auteur ; Rosa CHEESMAN, Auteur ; Ziada AYORECH, Auteur ; Joakim Coleman EBELTOFT, Auteur ; Hans Fredrik SUNDE, Auteur ; Anneli Desiré TANDBERG, Auteur ; Fartein Ask TORVIK, Auteur ; Eivind YSTROM, Auteur . - p.1040-1052. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-7 (July 2026) . - p.1040-1052 Mots-clés : Internalizing disorder  externalizing disorder  parenting  behavioral genetics Index. décimale : PER Périodiques Résumé : Background From a functionalist perspective, parenting behaviors have adaptive functions and are partly expressions of genetic variation. Maternal genes that have effects on children are often referred to as indirect maternal genetic effects. Indirect genetic effects provide a means for measuring the role of parenting without the need for specifying the relevant parental behaviors. We studied indirect maternal genetic effects to address both the importance and commonality of parenting across the internalizing?externalizing spectrum of behavior problems in childhood. We further addressed how indirect genetic effects impact our understanding of direct genetic effects if not accounted for. Methods Utilizing data from the Norwegian Mother, Father, and Child Cohort Study (MoBa), our analyses involved 42,423 children and their mothers. Both pedigree and genotype data were used to infer genetic relationships. We applied multivariate latent variable models to distinguish indirect maternal genetic effects and direct offspring genetic effects on seven measures of internalizing?externalizing behaviors. Results Our findings indicate significant maternal genetic influences, explaining 7%?18% of the variance across internalizing?externalizing behaviors. A general maternal effect common across behaviors could adequately account for most of the variability. The analyses further indicate that direct child genetic effects appear smaller and more complex when indirect maternal genetic effects are modeled simultaneously. Conclusions By summarizing the effects of parenting with indirect maternal genetic effects, we show a substantial contribution of parents with respect to internalizing?externalizing behaviors in childhood. Although parenting is multifaceted, the effects of parenting are general and can succinctly be described as a single common dimension. Further, our study demonstrates that direct genetic effects appear smaller and more complex when maternal genetic effects are accounted for, highlighting the confounding potential of parental effects in understanding the role of genetic differences in child psychopathology. En ligne : https://doi.org/10.1111/jcpp.70111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588

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